Click here to switch to the map view.

The map label for this gene is mraY

Identifier: 119773492

GI number: 119773492

Start: 420757

End: 421839

Strand: Direct

Name: mraY

Synonym: Sama_0351

Alternate gene names: 119773492

Gene position: 420757-421839 (Clockwise)

Preceding gene: 119773491

Following gene: 119773493

Centisome position: 9.77

GC content: 54.48

Gene sequence:

>1083_bases
ATGCTGGTTTATCTGGCCGAATATCTGACCCAGTTTTACACCGGGTTTAACGTGTTTTCCTATGTGACCTTCAGAGCCAT
TCTGGCGCTGCTGACGGCACTCATGTTCAGCCTCTGGTGGGGCCCCAAGTTGATTGAGCGTCTGCAGGTGCTGCAGATTG
GTCAGGTAGTGCGTAACGATGGCCCAGAATCACATTTCAGCAAGCGCGGCACCCCAACCATGGGTGGCTTGTTGATTTTG
GCCGGCATCTTTATCGGCGTATTGCTGTGGGGTGATTTGGGTAGCCGCTACGTGTGGGTCATGCTGTTTGTGCTTGGCTC
TTTTGGCCTGATAGGCTTTATCGACGACTACCGCAAGGTGGTCCGCAAAGACCCCAAGGGACTGATTGCCCGCTGGAAAT
ACATTTTTCAGTCGCTGGCGGCACTCGTGGTGGCCTTTTACCTGTTTTACTCGACCAAGCATCCGGGTGAAACCCAGTTG
GTGGTGCCTTTCTTTAAAGACATTCTGCCGCAGCTTGGCCTGATGTTTATTGTGCTGACCTATTTCACCATTGTGGGCGC
CAGTAACGCCGTGAACCTGACCGATGGCCTGGATGGGCTCGCTATTATGCCAACCGTGATGGTGGCTGCGGCCTTCGCGC
TGATTGCTTACCTGTCGGGTCACGTTCAGTTTGCCAACTACTTGCATATCCCTTATTTGCCAGGCTCGGGGGAACTGGTC
ATTGTCTGTACCGCCATTGTTGGTGCGGGCCTCGGCTTTTTGTGGTTCAACACCTATCCCGCACAGGTTTTTATGGGTGA
CGTGGGCTCGCTGTCACTTGGTGCAGCACTCGGCACCATCGCCGTGCTGGTACGTCAGGAAATCCTGCTGGTGATCATGG
GCGGTGTGTTTGTGATGGAAACCCTGTCGGTAATTTTACAGGTGGGTTCTTACAAGCTCCGTGGCCAGCGGATTTTCCGC
ATGGCGCCGATTCACCACCACTATGAGCTCAAAGGCTGGCCGGAACCCCGGGTAATTGTCCGCTTCTGGATTATCTCCCT
GTTCCTGGTGCTGCTGGGTCTGGCCACGCTGAAGCTGAGGTAA

Upstream 100 bases:

>100_bases
GGGAGATGTGACCCTGTTGGTGAAAGGGTCTCGCAGCGCCGCCATGGAGCGGGTTGTAGAGGCCTTAACAGCCGCCCATG
GGCGCGGGGAGCTGAAATAA

Downstream 100 bases:

>100_bases
TTATGGGTCTGCCACTGGATAAGCCACACTCACACGTCGTTCTGGGCCTTGGTGCCACGGGACTGTCTGTGGTGCGCTTT
CTGGCACGCAAAGGCATAGT

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MLVYLAEYLTQFYTGFNVFSYVTFRAILALLTALMFSLWWGPKLIERLQVLQIGQVVRNDGPESHFSKRGTPTMGGLLIL
AGIFIGVLLWGDLGSRYVWVMLFVLGSFGLIGFIDDYRKVVRKDPKGLIARWKYIFQSLAALVVAFYLFYSTKHPGETQL
VVPFFKDILPQLGLMFIVLTYFTIVGASNAVNLTDGLDGLAIMPTVMVAAAFALIAYLSGHVQFANYLHIPYLPGSGELV
IVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLSLGAALGTIAVLVRQEILLVIMGGVFVMETLSVILQVGSYKLRGQRIFR
MAPIHHHYELKGWPEPRVIVRFWIISLFLVLLGLATLKLR

Sequences:

>Translated_360_residues
MLVYLAEYLTQFYTGFNVFSYVTFRAILALLTALMFSLWWGPKLIERLQVLQIGQVVRNDGPESHFSKRGTPTMGGLLIL
AGIFIGVLLWGDLGSRYVWVMLFVLGSFGLIGFIDDYRKVVRKDPKGLIARWKYIFQSLAALVVAFYLFYSTKHPGETQL
VVPFFKDILPQLGLMFIVLTYFTIVGASNAVNLTDGLDGLAIMPTVMVAAAFALIAYLSGHVQFANYLHIPYLPGSGELV
IVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLSLGAALGTIAVLVRQEILLVIMGGVFVMETLSVILQVGSYKLRGQRIFR
MAPIHHHYELKGWPEPRVIVRFWIISLFLVLLGLATLKLR
>Mature_360_residues
MLVYLAEYLTQFYTGFNVFSYVTFRAILALLTALMFSLWWGPKLIERLQVLQIGQVVRNDGPESHFSKRGTPTMGGLLIL
AGIFIGVLLWGDLGSRYVWVMLFVLGSFGLIGFIDDYRKVVRKDPKGLIARWKYIFQSLAALVVAFYLFYSTKHPGETQL
VVPFFKDILPQLGLMFIVLTYFTIVGASNAVNLTDGLDGLAIMPTVMVAAAFALIAYLSGHVQFANYLHIPYLPGSGELV
IVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLSLGAALGTIAVLVRQEILLVIMGGVFVMETLSVILQVGSYKLRGQRIFR
MAPIHHHYELKGWPEPRVIVRFWIISLFLVLLGLATLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=360, Percent_Identity=75.5555555555556, Blast_Score=536, Evalue=1e-154,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_SHEAM (A1S2F6)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926232.1
- STRING:   A1S2F6
- GeneID:   4602607
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0351
- NMPDR:   fig|326297.7.peg.332
- eggNOG:   COG0472
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- PhylomeDB:   A1S2F6
- ProtClustDB:   PRK00108
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 40059; Mature: 40059

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc9df490)-; HASH(0xee57f34)-; HASH(0x116127e0)-; HASH(0x1196cf9c)-; HASH(0x11971df8)-; HASH(0x11971d44)-; HASH(0x109f4ea4)-; HASH(0x10098950)-; HASH(0x10d01f34)-; HASH(0x10cd6454)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVYLAEYLTQFYTGFNVFSYVTFRAILALLTALMFSLWWGPKLIERLQVLQIGQVVRND
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
GPESHFSKRGTPTMGGLLILAGIFIGVLLWGDLGSRYVWVMLFVLGSFGLIGFIDDYRKV
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
VRKDPKGLIARWKYIFQSLAALVVAFYLFYSTKHPGETQLVVPFFKDILPQLGLMFIVLT
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
YFTIVGASNAVNLTDGLDGLAIMPTVMVAAAFALIAYLSGHVQFANYLHIPYLPGSGELV
HHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEEECCCCCEE
IVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLSLGAALGTIAVLVRQEILLVIMGGVFVME
EEHHHHHHCCHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLSVILQVGSYKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLFLVLLGLATLKLR
HHHHHHHHCCCCCCCCHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MLVYLAEYLTQFYTGFNVFSYVTFRAILALLTALMFSLWWGPKLIERLQVLQIGQVVRND
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
GPESHFSKRGTPTMGGLLILAGIFIGVLLWGDLGSRYVWVMLFVLGSFGLIGFIDDYRKV
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
VRKDPKGLIARWKYIFQSLAALVVAFYLFYSTKHPGETQLVVPFFKDILPQLGLMFIVLT
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
YFTIVGASNAVNLTDGLDGLAIMPTVMVAAAFALIAYLSGHVQFANYLHIPYLPGSGELV
HHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEEECCCCCEE
IVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLSLGAALGTIAVLVRQEILLVIMGGVFVME
EEHHHHHHCCHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLSVILQVGSYKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLFLVLLGLATLKLR
HHHHHHHHCCCCCCCCHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA