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The map label for this gene is glkA [H]

Identifier: 119717333

GI number: 119717333

Start: 3311849

End: 3312790

Strand: Reverse

Name: glkA [H]

Synonym: Noca_3109

Alternate gene names: 119717333

Gene position: 3312790-3311849 (Counterclockwise)

Preceding gene: 119717334

Following gene: 119717332

Centisome position: 66.44

GC content: 72.4

Gene sequence:

>942_bases
ATGAGCCTGGCGTGTGGCATCGACGTCGGAGGGACGAAGATCGCCGGAGGAGTGGTCGACGAGTCGGGCACGATCCTCGA
GGAGCTGCGCGTGGAGTCGCCCGCCACGGACGCGGAGGCGATCGAGGAGGCCATCGCTGGCCTCGTGGTCGAGCTCCGCG
AGCGCCATCCGATCGAGACGGTCGGCGTCGGCGCAGCGGGGTACGTCGACAAGGCACGCGCGGTGGTGCTGTTCGCGCCC
AACGTCGCGTGGCGCAACGAGGACCTCAAGGGTGAGCTCGAGAAGCGGATCGACCTCCCGGTCGTCATCGAGAACGACGC
GAACGCCGCCGCCTGGGGCGAGTTCACCTACGGCGCGGGCCACGATGTCGACGACCTGCTGCTGGTGACCGTCGGCACCG
GCGTCGGCGGTGGGCTGGTGCTCGACGGCGAGGTCTACCGCGGCGCCAACGGCGTCGGCGCCGAGATCGGCCACATGCGG
GTCGTGCCCAACGGCATCCTGTGCGGCTGTGGCAAGCACGGCTGCTTCGAGCAGTACGCGAGCGGCTCGGCCCTGGTCCG
CGAGGCTCGGGCCCAGGCGATGTCGGGGGCGCTGATCGCCCAGGGCATGTTCGAGCGGGCCGGCGGCGACATCTCGAAGA
TCACCGGGCCGTTGATCACCGAGGCGGCCCGGCACGGGGACGAAGGCGCCCGCCAGCAGCTCGCGGAGCTCGGCCGCTGG
CTGGGCGAGGGGATCGCGTCGCTGACCGAGATCATCGACCCTGGCGTGGTGGTGGTCGGCGGCGGCGTCAGCGAGGCCGA
CGACCTGCTGCTGGAGCCGACCCGGGTGGCCTTCTCCGGCCAGCTGGTCGGTCGCGGCTTCCGGCCGATCCCCGAGATCC
GCAAGGCCCGGCTCGGCAACCGCGCCGGGCTGATCGGCGCGGCCGACCTGTCCCGGCGCTAG

Upstream 100 bases:

>100_bases
TCGAGCGGATCGATCTCGATGACGATCCCGGCTCCTGGCCGGAGGACCCGGACGACCCGGACCAGCCGGACACCCCGGGT
GGACCTGAGGATGGAGACAG

Downstream 100 bases:

>100_bases
ACGGGACCGACGGGGTGCCACTCTTCATCGGGGTCGACATCGGCGGGACGAAGGTGCTGGCCACGGCGGTCTCGCGCTCG
GGCCGGGTGCTGCGCACCGC

Product: glucokinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSLACGIDVGGTKIAGGVVDESGTILEELRVESPATDAEAIEEAIAGLVVELRERHPIETVGVGAAGYVDKARAVVLFAP
NVAWRNEDLKGELEKRIDLPVVIENDANAAAWGEFTYGAGHDVDDLLLVTVGTGVGGGLVLDGEVYRGANGVGAEIGHMR
VVPNGILCGCGKHGCFEQYASGSALVREARAQAMSGALIAQGMFERAGGDISKITGPLITEAARHGDEGARQQLAELGRW
LGEGIASLTEIIDPGVVVVGGGVSEADDLLLEPTRVAFSGQLVGRGFRPIPEIRKARLGNRAGLIGAADLSRR

Sequences:

>Translated_313_residues
MSLACGIDVGGTKIAGGVVDESGTILEELRVESPATDAEAIEEAIAGLVVELRERHPIETVGVGAAGYVDKARAVVLFAP
NVAWRNEDLKGELEKRIDLPVVIENDANAAAWGEFTYGAGHDVDDLLLVTVGTGVGGGLVLDGEVYRGANGVGAEIGHMR
VVPNGILCGCGKHGCFEQYASGSALVREARAQAMSGALIAQGMFERAGGDISKITGPLITEAARHGDEGARQQLAELGRW
LGEGIASLTEIIDPGVVVVGGGVSEADDLLLEPTRVAFSGQLVGRGFRPIPEIRKARLGNRAGLIGAADLSRR
>Mature_312_residues
SLACGIDVGGTKIAGGVVDESGTILEELRVESPATDAEAIEEAIAGLVVELRERHPIETVGVGAAGYVDKARAVVLFAPN
VAWRNEDLKGELEKRIDLPVVIENDANAAAWGEFTYGAGHDVDDLLLVTVGTGVGGGLVLDGEVYRGANGVGAEIGHMRV
VPNGILCGCGKHGCFEQYASGSALVREARAQAMSGALIAQGMFERAGGDISKITGPLITEAARHGDEGARQQLAELGRWL
GEGIASLTEIIDPGVVVVGGGVSEADDLLLEPTRVAFSGQLVGRGFRPIPEIRKARLGNRAGLIGAADLSRR

Specific function: Required for glucose repression of many different genes [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566325, Length=269, Percent_Identity=31.9702602230483, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI298566315, Length=269, Percent_Identity=31.9702602230483, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI190014632, Length=269, Percent_Identity=31.9702602230483, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4885285, Length=269, Percent_Identity=31.9702602230483, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI298566312, Length=121, Percent_Identity=34.7107438016529, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787363, Length=323, Percent_Identity=31.2693498452012, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786891, Length=315, Percent_Identity=28.8888888888889, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI87082230, Length=290, Percent_Identity=32.7586206896552, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI87081733, Length=317, Percent_Identity=30.5993690851735, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1787878, Length=255, Percent_Identity=26.2745098039216, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082127, Length=192, Percent_Identity=28.125, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790522, Length=293, Percent_Identity=25.5972696245734, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 32435; Mature: 32304

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLACGIDVGGTKIAGGVVDESGTILEELRVESPATDAEAIEEAIAGLVVELRERHPIET
CCEEECCCCCCCEEECCEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
VGVGAAGYVDKARAVVLFAPNVAWRNEDLKGELEKRIDLPVVIENDANAAAWGEFTYGAG
ECCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCC
HDVDDLLLVTVGTGVGGGLVLDGEVYRGANGVGAEIGHMRVVPNGILCGCGKHGCFEQYA
CCCCCEEEEEECCCCCCCEEECCCEECCCCCCCCCCCCEEECCCCEEECCCCCHHHHHHC
SGSALVREARAQAMSGALIAQGMFERAGGDISKITGPLITEAARHGDEGARQQLAELGRW
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LGEGIASLTEIIDPGVVVVGGGVSEADDLLLEPTRVAFSGQLVGRGFRPIPEIRKARLGN
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCCHHEEECHHHCCCCCCCHHHHHHHCCC
RAGLIGAADLSRR
CCCEEECCCCCCC
>Mature Secondary Structure 
SLACGIDVGGTKIAGGVVDESGTILEELRVESPATDAEAIEEAIAGLVVELRERHPIET
CEEECCCCCCCEEECCEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
VGVGAAGYVDKARAVVLFAPNVAWRNEDLKGELEKRIDLPVVIENDANAAAWGEFTYGAG
ECCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCC
HDVDDLLLVTVGTGVGGGLVLDGEVYRGANGVGAEIGHMRVVPNGILCGCGKHGCFEQYA
CCCCCEEEEEECCCCCCCEEECCCEECCCCCCCCCCCCEEECCCCEEECCCCCHHHHHHC
SGSALVREARAQAMSGALIAQGMFERAGGDISKITGPLITEAARHGDEGARQQLAELGRW
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LGEGIASLTEIIDPGVVVVGGGVSEADDLLLEPTRVAFSGQLVGRGFRPIPEIRKARLGN
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCCHHEEECHHHCCCCCCCHHHHHHHCCC
RAGLIGAADLSRR
CCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1435260; 12000953 [H]