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The map label for this gene is glkA [H]

Identifier: 119717332

GI number: 119717332

Start: 3310827

End: 3311834

Strand: Reverse

Name: glkA [H]

Synonym: Noca_3108

Alternate gene names: 119717332

Gene position: 3311834-3310827 (Counterclockwise)

Preceding gene: 119717333

Following gene: 119717328

Centisome position: 66.42

GC content: 77.28

Gene sequence:

>1008_bases
GTGCCACTCTTCATCGGGGTCGACATCGGCGGGACGAAGGTGCTGGCCACGGCGGTCTCGCGCTCGGGCCGGGTGCTGCG
CACCGCCCGTCGTACGACGCCGGGCCGGCGGGTGGAGGCCCGGCTGGTCGAGGACGCGCTGACCGAGGCGGTCCAGGAGA
TCGCCGGCCTCCGCCGGATCGGCGCGATCGGGATCGCGGCCGCCGGCTTCGTCGACGCCCAGGGGGAGCGGGTCCGGTTC
GCGCCGCACCTGCCGTGGCGTGACGAGGGCGTCCGGGCCCGGCTCGCGGAGCGCTGGAGCGCACCGGTCGTGCTCGACAA
CGACGCCAACTGCGCGGCCCGCGCCGAGCTGACCTACGGCGCCGTGGGGAACGCCGCCGACGCGATCGTGGTGACGATGG
GCACCGGCATCGGTGGCGCGGTGGTGCTCGGCGGCGCGGTCCACCGGGGCCACAACGGGATGGCCGGAGAGTTCGGGCAC
ATGCAGGTGGTCCCCGGCGGTCAGGCGTGCGAGTGCGGGGGCACCGGCTGCTGGGAGCAGTACGCCAGCGGCAACGCGCT
GGTGCGGCACGCGCGGGCCCGGATCGGCAGCCGGCCGACCGCGCTCGAGGCCGCCTGCGCCGGCGAGCCCGACCGGCTCA
CCGGGCCGATGGTCACCGCGGCGGCCGAGGCCGGGGACGCGGTCGCGCTCGAGGCCTTCGCCGACGTCGGCGGGTGGCTG
GGGGTCGGGGTCGCGAACCTGGTCGCGGCGTTCGACCCCGAGATCGTGGTCGTGGGCGGCGGCCTGTCCGCGGCCGGCGA
CCTGCTGCTCGAGCCGGCCCGGGTCGCGATGCGTGAGTCGCTGGTGGGCGCCGCCCACCGCACCGTGCCGCCGGTGGTCC
GCGCCGCCCTCGGCCCCGAGGCGGGTGCGATCGGGGCCGCCGAGCTGGCCCGGCAGACGTTCAGGAGCGCCGGTACTCGG
GCACGAGCTCGACGGCGAGCTGCTCGAGGAACAGCCCGACGTCGGTGA

Upstream 100 bases:

>100_bases
GCTTCCGGCCGATCCCCGAGATCCGCAAGGCCCGGCTCGGCAACCGCGCCGGGCTGATCGGCGCGGCCGACCTGTCCCGG
CGCTAGACGGGACCGACGGG

Downstream 100 bases:

>100_bases
CGATGCCACGGGCCTGCGCGGACCCGCGATCGGCCAGCTTGGTGACGGTCGCCGGGTTGATGTCCACGCAGACGAGCGGC
ACCGAGGCCGGGAGGATGTT

Product: glucokinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MPLFIGVDIGGTKVLATAVSRSGRVLRTARRTTPGRRVEARLVEDALTEAVQEIAGLRRIGAIGIAAAGFVDAQGERVRF
APHLPWRDEGVRARLAERWSAPVVLDNDANCAARAELTYGAVGNAADAIVVTMGTGIGGAVVLGGAVHRGHNGMAGEFGH
MQVVPGGQACECGGTGCWEQYASGNALVRHARARIGSRPTALEAACAGEPDRLTGPMVTAAAEAGDAVALEAFADVGGWL
GVGVANLVAAFDPEIVVVGGGLSAAGDLLLEPARVAMRESLVGAAHRTVPPVVRAALGPEAGAIGAAELARQTFRSAGTR
ARARRRAARGTARRR

Sequences:

>Translated_335_residues
MPLFIGVDIGGTKVLATAVSRSGRVLRTARRTTPGRRVEARLVEDALTEAVQEIAGLRRIGAIGIAAAGFVDAQGERVRF
APHLPWRDEGVRARLAERWSAPVVLDNDANCAARAELTYGAVGNAADAIVVTMGTGIGGAVVLGGAVHRGHNGMAGEFGH
MQVVPGGQACECGGTGCWEQYASGNALVRHARARIGSRPTALEAACAGEPDRLTGPMVTAAAEAGDAVALEAFADVGGWL
GVGVANLVAAFDPEIVVVGGGLSAAGDLLLEPARVAMRESLVGAAHRTVPPVVRAALGPEAGAIGAAELARQTFRSAGTR
ARARRRAARGTARRR
>Mature_334_residues
PLFIGVDIGGTKVLATAVSRSGRVLRTARRTTPGRRVEARLVEDALTEAVQEIAGLRRIGAIGIAAAGFVDAQGERVRFA
PHLPWRDEGVRARLAERWSAPVVLDNDANCAARAELTYGAVGNAADAIVVTMGTGIGGAVVLGGAVHRGHNGMAGEFGHM
QVVPGGQACECGGTGCWEQYASGNALVRHARARIGSRPTALEAACAGEPDRLTGPMVTAAAEAGDAVALEAFADVGGWLG
VGVANLVAAFDPEIVVVGGGLSAAGDLLLEPARVAMRESLVGAAHRTVPPVVRAALGPEAGAIGAAELARQTFRSAGTRA
RARRRAARGTARRR

Specific function: Required for glucose repression of many different genes [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=264, Percent_Identity=30.6818181818182, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI298566325, Length=264, Percent_Identity=30.6818181818182, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4885285, Length=264, Percent_Identity=30.6818181818182, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI190014632, Length=264, Percent_Identity=30.6818181818182, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1786891, Length=315, Percent_Identity=31.1111111111111, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787363, Length=325, Percent_Identity=31.3846153846154, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87081733, Length=323, Percent_Identity=29.7213622291022, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787878, Length=251, Percent_Identity=28.6852589641434, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082127, Length=250, Percent_Identity=26.4, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790522, Length=329, Percent_Identity=27.0516717325228, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 34304; Mature: 34172

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLFIGVDIGGTKVLATAVSRSGRVLRTARRTTPGRRVEARLVEDALTEAVQEIAGLRRI
CCEEEEECCCCHHHHHHHHHCCCCEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GAIGIAAAGFVDAQGERVRFAPHLPWRDEGVRARLAERWSAPVVLDNDANCAARAELTYG
HHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCCCEEEEEEEEC
AVGNAADAIVVTMGTGIGGAVVLGGAVHRGHNGMAGEFGHMQVVPGGQACECGGTGCWEQ
CCCCCCCEEEEEECCCCCCCEEECCHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHH
YASGNALVRHARARIGSRPTALEAACAGEPDRLTGPMVTAAAEAGDAVALEAFADVGGWL
HCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHCCCCCEEHHHHHHCCHHH
GVGVANLVAAFDPEIVVVGGGLSAAGDLLLEPARVAMRESLVGAAHRTVPPVVRAALGPE
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC
AGAIGAAELARQTFRSAGTRARARRRAARGTARRR
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PLFIGVDIGGTKVLATAVSRSGRVLRTARRTTPGRRVEARLVEDALTEAVQEIAGLRRI
CEEEEECCCCHHHHHHHHHCCCCEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GAIGIAAAGFVDAQGERVRFAPHLPWRDEGVRARLAERWSAPVVLDNDANCAARAELTYG
HHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCCCEEEEEEEEC
AVGNAADAIVVTMGTGIGGAVVLGGAVHRGHNGMAGEFGHMQVVPGGQACECGGTGCWEQ
CCCCCCCEEEEEECCCCCCCEEECCHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHH
YASGNALVRHARARIGSRPTALEAACAGEPDRLTGPMVTAAAEAGDAVALEAFADVGGWL
HCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHCCCCCEEHHHHHHCCHHH
GVGVANLVAAFDPEIVVVGGGLSAAGDLLLEPARVAMRESLVGAAHRTVPPVVRAALGPE
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC
AGAIGAAELARQTFRSAGTRARARRRAARGTARRR
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1435260; 12000953 [H]