Click here to switch to the map view.

The map label for this gene is hisD [H]

Identifier: 119717269

GI number: 119717269

Start: 3241998

End: 3243296

Strand: Reverse

Name: hisD [H]

Synonym: Noca_3045

Alternate gene names: 119717269

Gene position: 3243296-3241998 (Counterclockwise)

Preceding gene: 119717272

Following gene: 119717268

Centisome position: 65.05

GC content: 74.98

Gene sequence:

>1299_bases
ATGATCCGCCGCATCGACCTGCGAGGCGCCGACCCGGGTGTCGACTACCGGGCAGCCGTGCCCCGTGCCGACTTCGACAT
CGAGGCCGCGGTCCCGGCGGTGCATGCGATCTGCGAGGACGTCCGGACCCGCGGGCTGGACGCGATCCGCGAGCTCTCGG
AGCGCTTCGACGGCGTCGCCGTGGACGACATCCGGGTCGCCCCGGAGGCGCTGGCCACCGCGCTCGAGCGGCTCGACCCC
GACATCCGGGCCGCCCTGGAGGAGTCGATCGCGCGGCTGCGGGCCACCTGCGCGAACGAGCTCGAGCAGGACGCCGTCAC
CGACCTCGGCCCCGGCGCCCGGGTCACCCACCGCAAGGTGCCGGTCGGCCGGGTCGGCCTCTACGTCCCCGGCGGGCTGG
CCCCGCTGGTCTCCAGCGTGCTGATGAACGTCGTGCCGGCCCAGACCGCCGGCGTCGGGTCGATCGCGCTCGCGAGCCCG
CCCCAGCGTGAGTTCGCAGGCGCGGTGCACCCGACGATCCTGGCGGCGTGCGCGCTGCTGGGGGTCGAGGAGGTGTACGC
CGTCGGCGGCGCCCAGGCGATCGCGATGTTCGCCTACGGCACCGGGCCGTGCCGGCGGGTCGACCTGGTGACCGGGCCCG
GCAACATCTACACGGTCACCGCCAAGCGGCTGCTCAAGGGCCTGGTCGGTATCGACTCGGAGGCGGGCCCCACCGAGATC
GCGATCCTCGCCGACGACACGGCGGACCCGGCGTACGTCGCCGCCGACCTGCTCAGCCAGGCCGAGCACGACCCGCTCGC
CGCCGCCGTGCTCGTCACGCCCTCCGACCGGCTGGCCGACGCGGTCGCGGCCGAGCTCGAGACGCAGGTCGCGGCCACCA
AGCACGTCGAACGGATCCGCACCAGCCTCTCCGGGCGGCAGTCCGGGGTCGTCCTCGTCGACGACCTCGAGCAGGGCCTC
GAGGTCGTGAACGCCTACGCCGCCGAGCACCTCGAGATCCACACCGAGGACGCCGCGGCGTACGCCGCCCGGGTCCGCAA
CGCCGGCGCGATCTTCGTCGGCCCCTACGCCCCGGTCAGCCTCGGCGACTACTGCGCCGGCTCCAACCACGTGCTGCCGA
CCGCCGGCTGCGCCTGCCACTCCTCGGGCCTCTCGGTGCGCGCGTTCACCAAGTCGGTCCACGTGGTCGACTACTCCCGC
GCGGCGCTCGACGCCGTGGCCGGGCACGTCGTCACGCTGGCCGAGGCCGAGGACCTCCCCGGCCACGGCGCGGCCGTCCG
GGTGCGGTTCGGGGGCTGA

Upstream 100 bases:

>100_bases
AGCCGCTGGGGAGGTCCGGGGTTTCCAGGCTCGCTGCGCGCGCACCTCAACCGCCGGACGGAATCGGGGCCGGGCGGCGC
GCGCTCGTAGAATCGGGGCC

Downstream 100 bases:

>100_bases
GCGGTGACCTTCCCACCCCTGCGCGAGGAGCTGCGGGGCATCGAGCCCTACGGCGCGCCGCAGCTGGACGTTCCCGTCCA
GCTCAACGTCAACGAGAACC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MIRRIDLRGADPGVDYRAAVPRADFDIEAAVPAVHAICEDVRTRGLDAIRELSERFDGVAVDDIRVAPEALATALERLDP
DIRAALEESIARLRATCANELEQDAVTDLGPGARVTHRKVPVGRVGLYVPGGLAPLVSSVLMNVVPAQTAGVGSIALASP
PQREFAGAVHPTILAACALLGVEEVYAVGGAQAIAMFAYGTGPCRRVDLVTGPGNIYTVTAKRLLKGLVGIDSEAGPTEI
AILADDTADPAYVAADLLSQAEHDPLAAAVLVTPSDRLADAVAAELETQVAATKHVERIRTSLSGRQSGVVLVDDLEQGL
EVVNAYAAEHLEIHTEDAAAYAARVRNAGAIFVGPYAPVSLGDYCAGSNHVLPTAGCACHSSGLSVRAFTKSVHVVDYSR
AALDAVAGHVVTLAEAEDLPGHGAAVRVRFGG

Sequences:

>Translated_432_residues
MIRRIDLRGADPGVDYRAAVPRADFDIEAAVPAVHAICEDVRTRGLDAIRELSERFDGVAVDDIRVAPEALATALERLDP
DIRAALEESIARLRATCANELEQDAVTDLGPGARVTHRKVPVGRVGLYVPGGLAPLVSSVLMNVVPAQTAGVGSIALASP
PQREFAGAVHPTILAACALLGVEEVYAVGGAQAIAMFAYGTGPCRRVDLVTGPGNIYTVTAKRLLKGLVGIDSEAGPTEI
AILADDTADPAYVAADLLSQAEHDPLAAAVLVTPSDRLADAVAAELETQVAATKHVERIRTSLSGRQSGVVLVDDLEQGL
EVVNAYAAEHLEIHTEDAAAYAARVRNAGAIFVGPYAPVSLGDYCAGSNHVLPTAGCACHSSGLSVRAFTKSVHVVDYSR
AALDAVAGHVVTLAEAEDLPGHGAAVRVRFGG
>Mature_432_residues
MIRRIDLRGADPGVDYRAAVPRADFDIEAAVPAVHAICEDVRTRGLDAIRELSERFDGVAVDDIRVAPEALATALERLDP
DIRAALEESIARLRATCANELEQDAVTDLGPGARVTHRKVPVGRVGLYVPGGLAPLVSSVLMNVVPAQTAGVGSIALASP
PQREFAGAVHPTILAACALLGVEEVYAVGGAQAIAMFAYGTGPCRRVDLVTGPGNIYTVTAKRLLKGLVGIDSEAGPTEI
AILADDTADPAYVAADLLSQAEHDPLAAAVLVTPSDRLADAVAAELETQVAATKHVERIRTSLSGRQSGVVLVDDLEQGL
EVVNAYAAEHLEIHTEDAAAYAARVRNAGAIFVGPYAPVSLGDYCAGSNHVLPTAGCACHSSGLSVRAFTKSVHVVDYSR
AALDAVAGHVVTLAEAEDLPGHGAAVRVRFGG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=405, Percent_Identity=38.5185185185185, Blast_Score=266, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6319819, Length=404, Percent_Identity=36.6336633663366, Blast_Score=239, Evalue=5e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 44821; Mature: 44821

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRIDLRGADPGVDYRAAVPRADFDIEAAVPAVHAICEDVRTRGLDAIRELSERFDGVA
CCEEEECCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEE
VDDIRVAPEALATALERLDPDIRAALEESIARLRATCANELEQDAVTDLGPGARVTHRKV
ECHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
PVGRVGLYVPGGLAPLVSSVLMNVVPAQTAGVGSIALASPPQREFAGAVHPTILAACALL
CCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHCCCCCHHHHHHHHHH
GVEEVYAVGGAQAIAMFAYGTGPCRRVDLVTGPGNIYTVTAKRLLKGLVGIDSEAGPTEI
HHHHHHHCCCHHEEEEEEECCCCCEEEEEEECCCCEEEEEHHHHHHHHHCCCCCCCCCEE
AILADDTADPAYVAADLLSQAEHDPLAAAVLVTPSDRLADAVAAELETQVAATKHVERIR
EEEECCCCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
TSLSGRQSGVVLVDDLEQGLEVVNAYAAEHLEIHTEDAAAYAARVRNAGAIFVGPYAPVS
HHHCCCCCCEEEEHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHCCCCEEEECCCCCCC
LGDYCAGSNHVLPTAGCACHSSGLSVRAFTKSVHVVDYSRAALDAVAGHVVTLAEAEDLP
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECEEEEEEHHHHHHHHHHHHEEEEECCCCCC
GHGAAVRVRFGG
CCCCEEEEEECC
>Mature Secondary Structure
MIRRIDLRGADPGVDYRAAVPRADFDIEAAVPAVHAICEDVRTRGLDAIRELSERFDGVA
CCEEEECCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEE
VDDIRVAPEALATALERLDPDIRAALEESIARLRATCANELEQDAVTDLGPGARVTHRKV
ECHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
PVGRVGLYVPGGLAPLVSSVLMNVVPAQTAGVGSIALASPPQREFAGAVHPTILAACALL
CCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHCCCCCHHHHHHHHHH
GVEEVYAVGGAQAIAMFAYGTGPCRRVDLVTGPGNIYTVTAKRLLKGLVGIDSEAGPTEI
HHHHHHHCCCHHEEEEEEECCCCCEEEEEEECCCCEEEEEHHHHHHHHHCCCCCCCCCEE
AILADDTADPAYVAADLLSQAEHDPLAAAVLVTPSDRLADAVAAELETQVAATKHVERIR
EEEECCCCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
TSLSGRQSGVVLVDDLEQGLEVVNAYAAEHLEIHTEDAAAYAARVRNAGAIFVGPYAPVS
HHHCCCCCCEEEEHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHCCCCEEEECCCCCCC
LGDYCAGSNHVLPTAGCACHSSGLSVRAFTKSVHVVDYSRAALDAVAGHVVTLAEAEDLP
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECEEEEEEHHHHHHHHHHHHEEEEECCCCCC
GHGAAVRVRFGG
CCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA