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The map label for this gene is betP [H]

Identifier: 119716835

GI number: 119716835

Start: 2776113

End: 2777834

Strand: Reverse

Name: betP [H]

Synonym: Noca_2609

Alternate gene names: 119716835

Gene position: 2777834-2776113 (Counterclockwise)

Preceding gene: 119716836

Following gene: 119716833

Centisome position: 55.71

GC content: 70.38

Gene sequence:

>1722_bases
ATGACCACTCGCTACGACCACCCCCGTGCCCACCGAGTGGCGGACGCCGTACGCAGCCCCGCGGCCGACGTCGTCCCCCA
CCCCGCTCTCGACCAGCCGGTGGAGGCCGCCGCTCCCGACCGGGCCGGGTTGGACCGGGTCGTCTTCGGCGTGACGGCGG
CCATCGCGGTCGCGTTCCTCGTGTGGGGCTTCGTGAGCACGTCCACCCTGGCCTCGGCGTCGTCCGACGCGCTCGGCTGG
ACGATGACCAACACCGGGTGGCTGTTCGTCCTCACCGCGAGCGGGTTCGTGGTGTTCGTGCTCTGGCTCGCGCTCAGCCG
GTTCGGCAACATCCCGCTGGGTCGCGACGACGAGGAGCCCGAGTTCCGCACCGTCTCGTGGGTCGCGATGATGTTCAGCG
CCGGGATGGGCATCGGATTGATGTTCTACGGGGTCAGCGAGCCGCTGACCCACTACGTCGCTCCGCCGCCCGGCACCGGC
GCCGAGGGCAACCCGCAGGCCGTCCAGCACGCGATGGCGACGACGCTGTTCCACTGGACGCTCCACCCGTGGGCGATCTA
CGCGGTGGTCGGGCTCGCGATCGCGTACGGCGTGTACCGCAAGGGCCGGCTCCAGCTGATCTCGGCGGCCTTCGAGCCGC
TCCTGGGCCGCCACGCCAAGGGAGGCTGGGGCCGGGTCATCGACATGCTCGCCATCTTCGCCACGCTGTTCGGGTCCGCG
GCGTCGCTCGGCCTGGGGGCGCTCCAGATCCAGAGCGGCCTGGAGATCGTCGGTGGGCTCGGCGAGGTCGGCAACGGTGT
CCTGGTCGGCATCATCACGGTGCTGACCGTCGCGTTCGTGCTCTCCGCGGTCTCGGGTGTCGCGAAGGGCATCCAGTGGC
TCTCGAACATCAACATGGTCCTGGCGATCGCACTCGCGGCGTTCGTCTTCGTGCTGGGCCCGACCGTGTTCATCCTCAAC
CTGGTGCCGACCTCGATCGGGAGCTTCGTCCAGGACCTGCCGATGATGGCCGCGCGCACCAGCGCGGAGGGATCGGAGAC
CAGCACCTGGCTGCAGTCCTGGACGGTCTTCTACTGGGCGTGGTGGCTGTCCTGGACCCCGTTCGTCGGCATGTTCATCG
CCCGGATCTCCCGCGGTCGCACGATCCGGCAGTTCGTCAGCGGCGTGCTGCTGGTGCCGAGCCTGGTCAGCCTGGTGTGG
TTCTGCATCTTCGGGGGCGCCGCCATCGACCTGCAGAGGTCGGGCACCGACCTCGCCGGCGCGAGCGGCGTCGAGTCGCA
GCTCTTCGGGACCCTCGAGGCCTATCCGCTCGCCACCGTCGCCAGCATGGTCGTCATGCTGCTGGTCGCGATCTTCTTCG
TCTCCGGTGCGGACGCGGCGTCGATCGTGATGGGCACCCTCTCCGAACGCGGCACCCAGGAGCCCAGCCGGGCGACCGTG
GTCTTCTGGGGCGTCGCCACCGGGGCGGTCGCCGCGGTGATGCTGCTGGTCGGCGGCGACCAGGCACTCACCGGCCTGCA
GACGATCACCATCGTCGCCGCGCTGCCGTTCGTCGTGGTGATGGTGGGGCTGGCCGTCGCGCTCGTGAGAGACCTGCGCA
CGGACCCGTTGATGGTGCGCCGCCGGTACGCCGCTGAGGCGGTCGAGCAGGCCGTCATCGCCGGCGTCACCGAGCACGGC
GACGACTTCGTGCTGGCCGTGGACCGCGACCCGCAGGCCTAG

Upstream 100 bases:

>100_bases
CAGCGGTTCATCGGGATCGTGCGCGGCCGGACGGAGCGCAGCTCCCGGGGGTGACCGGGCTCACCGTTTCGGGGTCGGGC
ACCGGTGGTACCGGAAGCCG

Downstream 100 bases:

>100_bases
AACCGGCGGCGCGCGTCGACGGTTCCTCGGCCCGGCCGCCGGGGGCTGAGCCCGGCCGACCTCGGCCAGGATCCGGGGGC
GCCGCAGGCGCTCCCGGTCA

Product: choline/carnitine/betaine transporter

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MTTRYDHPRAHRVADAVRSPAADVVPHPALDQPVEAAAPDRAGLDRVVFGVTAAIAVAFLVWGFVSTSTLASASSDALGW
TMTNTGWLFVLTASGFVVFVLWLALSRFGNIPLGRDDEEPEFRTVSWVAMMFSAGMGIGLMFYGVSEPLTHYVAPPPGTG
AEGNPQAVQHAMATTLFHWTLHPWAIYAVVGLAIAYGVYRKGRLQLISAAFEPLLGRHAKGGWGRVIDMLAIFATLFGSA
ASLGLGALQIQSGLEIVGGLGEVGNGVLVGIITVLTVAFVLSAVSGVAKGIQWLSNINMVLAIALAAFVFVLGPTVFILN
LVPTSIGSFVQDLPMMAARTSAEGSETSTWLQSWTVFYWAWWLSWTPFVGMFIARISRGRTIRQFVSGVLLVPSLVSLVW
FCIFGGAAIDLQRSGTDLAGASGVESQLFGTLEAYPLATVASMVVMLLVAIFFVSGADAASIVMGTLSERGTQEPSRATV
VFWGVATGAVAAVMLLVGGDQALTGLQTITIVAALPFVVVMVGLAVALVRDLRTDPLMVRRRYAAEAVEQAVIAGVTEHG
DDFVLAVDRDPQA

Sequences:

>Translated_573_residues
MTTRYDHPRAHRVADAVRSPAADVVPHPALDQPVEAAAPDRAGLDRVVFGVTAAIAVAFLVWGFVSTSTLASASSDALGW
TMTNTGWLFVLTASGFVVFVLWLALSRFGNIPLGRDDEEPEFRTVSWVAMMFSAGMGIGLMFYGVSEPLTHYVAPPPGTG
AEGNPQAVQHAMATTLFHWTLHPWAIYAVVGLAIAYGVYRKGRLQLISAAFEPLLGRHAKGGWGRVIDMLAIFATLFGSA
ASLGLGALQIQSGLEIVGGLGEVGNGVLVGIITVLTVAFVLSAVSGVAKGIQWLSNINMVLAIALAAFVFVLGPTVFILN
LVPTSIGSFVQDLPMMAARTSAEGSETSTWLQSWTVFYWAWWLSWTPFVGMFIARISRGRTIRQFVSGVLLVPSLVSLVW
FCIFGGAAIDLQRSGTDLAGASGVESQLFGTLEAYPLATVASMVVMLLVAIFFVSGADAASIVMGTLSERGTQEPSRATV
VFWGVATGAVAAVMLLVGGDQALTGLQTITIVAALPFVVVMVGLAVALVRDLRTDPLMVRRRYAAEAVEQAVIAGVTEHG
DDFVLAVDRDPQA
>Mature_572_residues
TTRYDHPRAHRVADAVRSPAADVVPHPALDQPVEAAAPDRAGLDRVVFGVTAAIAVAFLVWGFVSTSTLASASSDALGWT
MTNTGWLFVLTASGFVVFVLWLALSRFGNIPLGRDDEEPEFRTVSWVAMMFSAGMGIGLMFYGVSEPLTHYVAPPPGTGA
EGNPQAVQHAMATTLFHWTLHPWAIYAVVGLAIAYGVYRKGRLQLISAAFEPLLGRHAKGGWGRVIDMLAIFATLFGSAA
SLGLGALQIQSGLEIVGGLGEVGNGVLVGIITVLTVAFVLSAVSGVAKGIQWLSNINMVLAIALAAFVFVLGPTVFILNL
VPTSIGSFVQDLPMMAARTSAEGSETSTWLQSWTVFYWAWWLSWTPFVGMFIARISRGRTIRQFVSGVLLVPSLVSLVWF
CIFGGAAIDLQRSGTDLAGASGVESQLFGTLEAYPLATVASMVVMLLVAIFFVSGADAASIVMGTLSERGTQEPSRATVV
FWGVATGAVAAVMLLVGGDQALTGLQTITIVAALPFVVVMVGLAVALVRDLRTDPLMVRRRYAAEAVEQAVIAGVTEHGD
DFVLAVDRDPQA

Specific function: High-affinity uptake of glycine betaine [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=513, Percent_Identity=34.6978557504873, Blast_Score=308, Evalue=6e-85,
Organism=Escherichia coli, GI1788102, Length=496, Percent_Identity=30.8467741935484, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI1786224, Length=507, Percent_Identity=28.0078895463511, Blast_Score=176, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 60617; Mature: 60486

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
>Mature Secondary Structure 
TTRYDHPRAHRVADAVRSPAADVVPHPALDQPVEAAAPDRAGLDRVVFGVTAAIAVAFL
CCCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]