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The map label for this gene is galK [H]

Identifier: 119716833

GI number: 119716833

Start: 2773337

End: 2774536

Strand: Reverse

Name: galK [H]

Synonym: Noca_2607

Alternate gene names: 119716833

Gene position: 2774536-2773337 (Counterclockwise)

Preceding gene: 119716835

Following gene: 119716831

Centisome position: 55.65

GC content: 77.0

Gene sequence:

>1200_bases
ATGGCCTTCGTCGAACCAGGTGACCCCCCCGAGCTCGCGGACCGGGTCCGCGCGGCGTTCGCCGAGGCGTACGGCGGCCC
GGCGGTCGCGGTCGGGCGTGCCCCCGGGCGGGTGAACCTGATCGGCGAGCACACCGACTACAACCACGGCCTGGTGCTGC
CGGTCGCGCTCCCCCACGCCACCTACGCGGCGATGGCGCCGCGCACCGACGGCCGGATCCGGATCGGCAGCCTGGAGGAG
GCCACTCCGTGGAGCGGGTCGCTCGAGGACGTGGGTCCGGGCTCGGTCGACGGCTGGGCGGCGTACGCCGCGGGCGTGCT
GTGGGCGATGCGCGAGGACGGGTACGGCGTCCCCGGGGTGGACCTGCTGGTCCACGGCACGGTGCCGCTCGGCGCCGGCC
TGTCCAGCTCGGCAGCCCTGGAGTGCTCGGTCGCGCTCGCGGCGTGCGGGCTGCTCGGGGTCGAGCCGGACGCCGGCGTA
CGGCAGCGCCTCGTCGCCGCCTGCATGCGCGCCGAGACCGAGGTGGCCGGGGCCCCGACGGGCGGGATGGACCAGACGGT
GTCCCTCCTGGCGTCGGCGGGATCGGCGCTGCTCATCGACTTCGACGTCGCGGCGGAGACGGAGGGCGCGACCCAGGACG
TCGCGCTCGGCCTCGACGCCGCGGGGCTCGCGCTGCTGGTGACCGACACCCGGGTCTCGCACGCGCTCGTGGACGGCGGG
TACGCCGCACGCCGGGCCGACTGCGAGGCGGCCGCCGAGGCGCTCGGGGTGCCGTCGCTGCGCCGGGCCTCGCTCACCGA
GGTCGAGGGGCTCGACGACGAGCGGGTGCGCCGGCGCGCCCGGCACATCGTCACCGAGATCGACCGGGTCCGGGCCACGG
TCGCCGCCCTCGGCGCCGGCGACTGGCAGGGGGTCGGCCGCGCCTTCCGTGACTCGCACGTGTCGATGCGCGATGACTTC
GAGATCTCCTGCCCGGAGCTGGACGTGGCGGTCACCACCGCCGTCGAGGCCGGGGCGATCGGGGCCCGGATGACCGGCGG
CGGCTTCGGCGGCTCCTCCATCGCGCTCGTCCCGGTCGAGCGCGTCGACGCCGCTGTCCGGGCGATCGACGCCGCATTCG
TCGCCGCCGGCTTCGGGCCGCCGCAGCACCTGCGCGCCGTCCCCTCGAGCGCCGCCGACCTGGTGGACGCACCCGCCTGA

Upstream 100 bases:

>100_bases
TGAACACGTCGTCGTAGGTCAGGTCGTGGTGCGGGGTCACCGCGTCGAGGAACTGCACGTCGCGTCACTCTACGTCGCAG
CGGCTCCCTAGGGTGATCCC

Downstream 100 bases:

>100_bases
CCGACCGACCAGCCCGCTCCTCGCCGTACCTGCCGTTTGGTCACCAACGACAGCTCAGAGCGTCCGCTTCCTGTCGTTGG
TGACCAAACGACAGGAGATC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MAFVEPGDPPELADRVRAAFAEAYGGPAVAVGRAPGRVNLIGEHTDYNHGLVLPVALPHATYAAMAPRTDGRIRIGSLEE
ATPWSGSLEDVGPGSVDGWAAYAAGVLWAMREDGYGVPGVDLLVHGTVPLGAGLSSSAALECSVALAACGLLGVEPDAGV
RQRLVAACMRAETEVAGAPTGGMDQTVSLLASAGSALLIDFDVAAETEGATQDVALGLDAAGLALLVTDTRVSHALVDGG
YAARRADCEAAAEALGVPSLRRASLTEVEGLDDERVRRRARHIVTEIDRVRATVAALGAGDWQGVGRAFRDSHVSMRDDF
EISCPELDVAVTTAVEAGAIGARMTGGGFGGSSIALVPVERVDAAVRAIDAAFVAAGFGPPQHLRAVPSSAADLVDAPA

Sequences:

>Translated_399_residues
MAFVEPGDPPELADRVRAAFAEAYGGPAVAVGRAPGRVNLIGEHTDYNHGLVLPVALPHATYAAMAPRTDGRIRIGSLEE
ATPWSGSLEDVGPGSVDGWAAYAAGVLWAMREDGYGVPGVDLLVHGTVPLGAGLSSSAALECSVALAACGLLGVEPDAGV
RQRLVAACMRAETEVAGAPTGGMDQTVSLLASAGSALLIDFDVAAETEGATQDVALGLDAAGLALLVTDTRVSHALVDGG
YAARRADCEAAAEALGVPSLRRASLTEVEGLDDERVRRRARHIVTEIDRVRATVAALGAGDWQGVGRAFRDSHVSMRDDF
EISCPELDVAVTTAVEAGAIGARMTGGGFGGSSIALVPVERVDAAVRAIDAAFVAAGFGPPQHLRAVPSSAADLVDAPA
>Mature_398_residues
AFVEPGDPPELADRVRAAFAEAYGGPAVAVGRAPGRVNLIGEHTDYNHGLVLPVALPHATYAAMAPRTDGRIRIGSLEEA
TPWSGSLEDVGPGSVDGWAAYAAGVLWAMREDGYGVPGVDLLVHGTVPLGAGLSSSAALECSVALAACGLLGVEPDAGVR
QRLVAACMRAETEVAGAPTGGMDQTVSLLASAGSALLIDFDVAAETEGATQDVALGLDAAGLALLVTDTRVSHALVDGGY
AARRADCEAAAEALGVPSLRRASLTEVEGLDDERVRRRARHIVTEIDRVRATVAALGAGDWQGVGRAFRDSHVSMRDDFE
ISCPELDVAVTTAVEAGAIGARMTGGGFGGSSIALVPVERVDAAVRAIDAAFVAAGFGPPQHLRAVPSSAADLVDAPA

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=376, Percent_Identity=40.6914893617021, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI48527957, Length=422, Percent_Identity=27.4881516587678, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI4503897, Length=425, Percent_Identity=27.0588235294118, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786972, Length=380, Percent_Identity=37.1052631578947, Blast_Score=216, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71989053, Length=424, Percent_Identity=28.7735849056604, Blast_Score=131, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6319494, Length=220, Percent_Identity=31.8181818181818, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24661292, Length=455, Percent_Identity=25.7142857142857, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355577, Length=455, Percent_Identity=25.7142857142857, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24661285, Length=455, Percent_Identity=25.7142857142857, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 40610; Mature: 40479

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFVEPGDPPELADRVRAAFAEAYGGPAVAVGRAPGRVNLIGEHTDYNHGLVLPVALPHA
CCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCCEEEEEECCCC
TYAAMAPRTDGRIRIGSLEEATPWSGSLEDVGPGSVDGWAAYAAGVLWAMREDGYGVPGV
HHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCCCCCC
DLLVHGTVPLGAGLSSSAALECSVALAACGLLGVEPDAGVRQRLVAACMRAETEVAGAPT
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
GGMDQTVSLLASAGSALLIDFDVAAETEGATQDVALGLDAAGLALLVTDTRVSHALVDGG
CCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEECCCCCCEEEEEECCHHHHHHHCCC
YAARRADCEAAAEALGVPSLRRASLTEVEGLDDERVRRRARHIVTEIDRVRATVAALGAG
CHHHHCCHHHHHHHHCCCCHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DWQGVGRAFRDSHVSMRDDFEISCPELDVAVTTAVEAGAIGARMTGGGFGGSSIALVPVE
CHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEEHHHCCCCCCEECCCCCCCCCEEEEEHH
RVDAAVRAIDAAFVAAGFGPPQHLRAVPSSAADLVDAPA
HHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHCCCC
>Mature Secondary Structure 
AFVEPGDPPELADRVRAAFAEAYGGPAVAVGRAPGRVNLIGEHTDYNHGLVLPVALPHA
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCCEEEEEECCCC
TYAAMAPRTDGRIRIGSLEEATPWSGSLEDVGPGSVDGWAAYAAGVLWAMREDGYGVPGV
HHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCCCCCC
DLLVHGTVPLGAGLSSSAALECSVALAACGLLGVEPDAGVRQRLVAACMRAETEVAGAPT
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
GGMDQTVSLLASAGSALLIDFDVAAETEGATQDVALGLDAAGLALLVTDTRVSHALVDGG
CCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEECCCCCCEEEEEECCHHHHHHHCCC
YAARRADCEAAAEALGVPSLRRASLTEVEGLDDERVRRRARHIVTEIDRVRATVAALGAG
CHHHHCCHHHHHHHHCCCCHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DWQGVGRAFRDSHVSMRDDFEISCPELDVAVTTAVEAGAIGARMTGGGFGGSSIALVPVE
CHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEEHHHCCCCCCEECCCCCCCCCEEEEEHH
RVDAAVRAIDAAFVAAGFGPPQHLRAVPSSAADLVDAPA
HHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]