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The map label for this gene is catF [H]

Identifier: 119715254

GI number: 119715254

Start: 1065288

End: 1066502

Strand: Direct

Name: catF [H]

Synonym: Noca_1013

Alternate gene names: 119715254

Gene position: 1065288-1066502 (Clockwise)

Preceding gene: 119715252

Following gene: 119715255

Centisome position: 21.37

GC content: 75.72

Gene sequence:

>1215_bases
ATGAGCACGCCTGCGTTCGTGTACGCCGCCGTCCGCACCCCGTTCGGCCGGCTCGGCGGGGCCCTGGCCGGGGTCCGCCC
CGACGACCTCGCGGCGACCGCGGTGACCGGGGCGCTGGCGCAGGCGCCCGACCTCGACCCGGCCGCGATCGCCGACGTGG
TGTGGGGGTGCGCCAACCAGGCGGGCGAGGACAACCGCAACGTCGGCCGGATGGCGGTGCTGCTCGCCGGCCTGCCCGTC
TCGGTGCCGGCCGTCACCCTCAACCGGCTGTGCGGGTCGTCGCTGGACGCCGCGATCGCCGGATCACGGTCCATCGAGTC
CGGGGACGCCGAGGTCGTCCTGACCGGCGGCGTCGAGTCGATGAGCCGGGCGCCGTGGGTGCTGCCCAAGCCGGAGCGTG
CCTACCCCGCGGGCAACGTCACCGCCGTCTCCACCACGCTGGGCTGGCGTCTGGTCAACGAGCGGATGCCCGCGGAGTGG
ACGGTCTCGCTGGGCGAGGCGAACGAGCTGCTGGCCGAGAGGTTCGAGGTCTCCCGGGAGCGTCAGGACGAGTTCGCCGC
CCGGTCGCACCGGCTGGCCGACGCCGCCTGGACGTCCGGCTTCTACGACGACCTCGTGGTGCCGGTCGAGGGCGTCGACC
TCGACCGGGACGAGGGCATCCGTCCCGGATCGAGCGCCGAGCGGCTCGCCGGACTCAGGCCGGTGTTCCGCCCAGAGGGC
ACCATCACTGCCGGCAACGCCTCGCCGCTCAACGACGGGGCCTCCGCCGTGCTGCTCGGCTCCGAGGCGGCCGCCGCCAC
CATCGGACGCGACCCGGTCGCGCGGATCGCCGGGCGCGGCGCGAGCGCGGTGGAGCCGCAGTGGTTCGGCTACGCGCCCG
TCGAGGCCGCCGACCGGGCGCTCGCGCGAGCCGGCATCGGCTGGGCCGACGTGCGCGCGGTCGAGCTCAACGAGGCGTTC
GCCGTACAGTCCGTGGCCTGTGTGGATGCCTGGGCGGAGCAGGGCCTCGATCCAGAGGTCGTCAACGCCAAGGGCGGCGC
GATCGCCATCGGCCACCCGCTCGGCGCCTCCGGCGGCCGCGTCCTCGGCACCCTCGCCGCCCGGCTGCGCGAGTCCGGCG
AGCGCTGGGGCGTGGCCGCGATCTGCATCGGGGTCGGCCAGGCCCTGGCCGTCGTCCTGGAGAACGTGTCCACGCAGACC
GGGGCGCGGGCGTGA

Upstream 100 bases:

>100_bases
CGTGCCGCAGCTCCATGGCCACAATCCTATCGGCCGTAGCGATGAATCGAGCACCAATGAGTATTGGACCCGATAGATCA
CCCGGTCTAGCGTCGGGAGC

Downstream 100 bases:

>100_bases
CCGCCACCATCTGCGCCACGGCCGCGGAGGCGGTGGCCGACATCCGGGACGGCGCCGTCGTCCTCGTCGGCGGCTTCGGC
ATGGCCGGGATGCCGGTCGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSTPAFVYAAVRTPFGRLGGALAGVRPDDLAATAVTGALAQAPDLDPAAIADVVWGCANQAGEDNRNVGRMAVLLAGLPV
SVPAVTLNRLCGSSLDAAIAGSRSIESGDAEVVLTGGVESMSRAPWVLPKPERAYPAGNVTAVSTTLGWRLVNERMPAEW
TVSLGEANELLAERFEVSRERQDEFAARSHRLADAAWTSGFYDDLVVPVEGVDLDRDEGIRPGSSAERLAGLRPVFRPEG
TITAGNASPLNDGASAVLLGSEAAAATIGRDPVARIAGRGASAVEPQWFGYAPVEAADRALARAGIGWADVRAVELNEAF
AVQSVACVDAWAEQGLDPEVVNAKGGAIAIGHPLGASGGRVLGTLAARLRESGERWGVAAICIGVGQALAVVLENVSTQT
GARA

Sequences:

>Translated_404_residues
MSTPAFVYAAVRTPFGRLGGALAGVRPDDLAATAVTGALAQAPDLDPAAIADVVWGCANQAGEDNRNVGRMAVLLAGLPV
SVPAVTLNRLCGSSLDAAIAGSRSIESGDAEVVLTGGVESMSRAPWVLPKPERAYPAGNVTAVSTTLGWRLVNERMPAEW
TVSLGEANELLAERFEVSRERQDEFAARSHRLADAAWTSGFYDDLVVPVEGVDLDRDEGIRPGSSAERLAGLRPVFRPEG
TITAGNASPLNDGASAVLLGSEAAAATIGRDPVARIAGRGASAVEPQWFGYAPVEAADRALARAGIGWADVRAVELNEAF
AVQSVACVDAWAEQGLDPEVVNAKGGAIAIGHPLGASGGRVLGTLAARLRESGERWGVAAICIGVGQALAVVLENVSTQT
GARA
>Mature_403_residues
STPAFVYAAVRTPFGRLGGALAGVRPDDLAATAVTGALAQAPDLDPAAIADVVWGCANQAGEDNRNVGRMAVLLAGLPVS
VPAVTLNRLCGSSLDAAIAGSRSIESGDAEVVLTGGVESMSRAPWVLPKPERAYPAGNVTAVSTTLGWRLVNERMPAEWT
VSLGEANELLAERFEVSRERQDEFAARSHRLADAAWTSGFYDDLVVPVEGVDLDRDEGIRPGSSAERLAGLRPVFRPEGT
ITAGNASPLNDGASAVLLGSEAAAATIGRDPVARIAGRGASAVEPQWFGYAPVEAADRALARAGIGWADVRAVELNEAFA
VQSVACVDAWAEQGLDPEVVNAKGGAIAIGHPLGASGGRVLGTLAARLRESGERWGVAAICIGVGQALAVVLENVSTQTG
ARA

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=37.5621890547264, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI148539872, Length=401, Percent_Identity=38.4039900249377, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=35.6060606060606, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI4557237, Length=402, Percent_Identity=33.5820895522388, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI4504327, Length=415, Percent_Identity=35.1807228915663, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI194353979, Length=385, Percent_Identity=27.5324675324675, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=47.5124378109453, Blast_Score=334, Evalue=6e-93,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=41.25, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=38.4422110552764, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI87082165, Length=399, Percent_Identity=38.5964912280702, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=31.2056737588652, Blast_Score=151, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI25147385, Length=400, Percent_Identity=35.75, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI133906874, Length=397, Percent_Identity=33.2493702770781, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17535921, Length=399, Percent_Identity=35.0877192982456, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=418, Percent_Identity=32.7751196172249, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=30.5555555555556, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6325229, Length=417, Percent_Identity=37.1702637889688, Blast_Score=219, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=32.6683291770574, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24655093, Length=400, Percent_Identity=40.25, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI17648125, Length=407, Percent_Identity=34.8894348894349, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24640423, Length=399, Percent_Identity=34.5864661654135, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI17137578, Length=416, Percent_Identity=36.0576923076923, Blast_Score=183, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 41542; Mature: 41411

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPAFVYAAVRTPFGRLGGALAGVRPDDLAATAVTGALAQAPDLDPAAIADVVWGCANQ
CCCCCEEEEEHHCCHHHHCCHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
AGEDNRNVGRMAVLLAGLPVSVPAVTLNRLCGSSLDAAIAGSRSIESGDAEVVLTGGVES
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEEEECCHHH
MSRAPWVLPKPERAYPAGNVTAVSTTLGWRLVNERMPAEWTVSLGEANELLAERFEVSRE
HCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHH
RQDEFAARSHRLADAAWTSGFYDDLVVPVEGVDLDRDEGIRPGSSAERLAGLRPVFRPEG
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
TITAGNASPLNDGASAVLLGSEAAAATIGRDPVARIAGRGASAVEPQWFGYAPVEAADRA
CEECCCCCCCCCCCCEEEECCCHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LARAGIGWADVRAVELNEAFAVQSVACVDAWAEQGLDPEVVNAKGGAIAIGHPLGASGGR
HHHCCCCHHHEEEEECCHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEECCCCCCCCCH
VLGTLAARLRESGERWGVAAICIGVGQALAVVLENVSTQTGARA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STPAFVYAAVRTPFGRLGGALAGVRPDDLAATAVTGALAQAPDLDPAAIADVVWGCANQ
CCCCEEEEEHHCCHHHHCCHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
AGEDNRNVGRMAVLLAGLPVSVPAVTLNRLCGSSLDAAIAGSRSIESGDAEVVLTGGVES
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEEEECCHHH
MSRAPWVLPKPERAYPAGNVTAVSTTLGWRLVNERMPAEWTVSLGEANELLAERFEVSRE
HCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHH
RQDEFAARSHRLADAAWTSGFYDDLVVPVEGVDLDRDEGIRPGSSAERLAGLRPVFRPEG
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
TITAGNASPLNDGASAVLLGSEAAAATIGRDPVARIAGRGASAVEPQWFGYAPVEAADRA
CEECCCCCCCCCCCCEEEECCCHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LARAGIGWADVRAVELNEAFAVQSVACVDAWAEQGLDPEVVNAKGGAIAIGHPLGASGGR
HHHCCCCHHHEEEEECCHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEECCCCCCCCCH
VLGTLAARLRESGERWGVAAICIGVGQALAVVLENVSTQTGARA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]