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The map label for this gene is 119715193

Identifier: 119715193

GI number: 119715193

Start: 997118

End: 997990

Strand: Direct

Name: 119715193

Synonym: Noca_0948

Alternate gene names: NA

Gene position: 997118-997990 (Clockwise)

Preceding gene: 119715190

Following gene: 119715194

Centisome position: 20.0

GC content: 73.42

Gene sequence:

>873_bases
ATGGAGACCACCGCGATTCCCTCGGGGACCGTCGTCGTCGGCCTGGACGGCTCGCCGTCGGCCGAGCGCGCCCTCGAGTG
GGCGATCGACCAGGCGCTGCTGGAGTCTCGCCAGCTGACCCTGGCCCACGGCGTGGACCCCTCCGGTTCCGTCTGGGTCG
ACCCGGCCGCCATCGACCACCGGGCGGTGCTCGAGGCCCTGCAGGCCGACGCCGAGGTGATGCTCGACCACGCCCGCGAG
CAGGTCGCGAGGCGGGCCCCCGACCTCGTGGTGCACCAGGTCATCCGGATGTCCGACGCCCGGGTCACCCTGCTCGAGCT
CTCCGGCCAGGCGGCGATGGTCGTCGTCGGCTCCCGTGGTCGCGGACCGATCAAGACCCTGCTGCTCGGCTCGGTGAGCC
TCGCGGTCTCCCGGGAGGCGCTCTGCCCCGTGGTGGTGCTGCGACCGGGTCACCCCGGCGTGGTCCGCAACGGCGTGCTG
GTCGGCGCCGACGGGACCGACCGGTCCCTGGCCACGCTGGAGTTCGCCTACCGGCAGGCCTCCTTGCACCGGCTTCCGCT
GACGATCATGCACTGCTTCTGGGACGCCCGGCCGGCCACCGAGGGGGAGCCGGTCGCCAGCGACGTCCGGCTGGTGCTCG
CCGAGTCGCTCGCCGGACTGGGCGAGAAGTTCCCAGACGTCCAGGCGCGGACCGAGCTGGTGCGGGGGATGGCCGACGAG
CGCTTGGTGCGGGCCTCGCAGCGGATGGACCTGGTCGTGGTCGGCGCCCATCACGGCGGCACGCTGACGACCCTGCTCTA
CGGGTCGATCGCGAACGCGGTGCTGGAGCACGCCACCTGCCCGGTCGCGATCGTCCCGGAGTCGGAGGGCTGA

Upstream 100 bases:

>100_bases
CATGCTGACGAGGGGTCGTGGGGGTCAGCAGGGTCGATGGTCCTGACATGCGGGGCCTTCGGCGCTACTCGCTCCAGACC
CCCCGGCGCACGGTGGATCC

Downstream 100 bases:

>100_bases
CCCGTGATCGCGGTGTCGACGATCATGTCGCGCCGCCTGGTCGCCATCCTGTCCGACTGCGACCTGACGGTCGCGGTCGA
CACCTTCCTGGCCGCCGGCG

Product: UspA domain-containing protein

Products: NA

Alternate protein names: USP Rv2623 [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
METTAIPSGTVVVGLDGSPSAERALEWAIDQALLESRQLTLAHGVDPSGSVWVDPAAIDHRAVLEALQADAEVMLDHARE
QVARRAPDLVVHQVIRMSDARVTLLELSGQAAMVVVGSRGRGPIKTLLLGSVSLAVSREALCPVVVLRPGHPGVVRNGVL
VGADGTDRSLATLEFAYRQASLHRLPLTIMHCFWDARPATEGEPVASDVRLVLAESLAGLGEKFPDVQARTELVRGMADE
RLVRASQRMDLVVVGAHHGGTLTTLLYGSIANAVLEHATCPVAIVPESEG

Sequences:

>Translated_290_residues
METTAIPSGTVVVGLDGSPSAERALEWAIDQALLESRQLTLAHGVDPSGSVWVDPAAIDHRAVLEALQADAEVMLDHARE
QVARRAPDLVVHQVIRMSDARVTLLELSGQAAMVVVGSRGRGPIKTLLLGSVSLAVSREALCPVVVLRPGHPGVVRNGVL
VGADGTDRSLATLEFAYRQASLHRLPLTIMHCFWDARPATEGEPVASDVRLVLAESLAGLGEKFPDVQARTELVRGMADE
RLVRASQRMDLVVVGAHHGGTLTTLLYGSIANAVLEHATCPVAIVPESEG
>Mature_290_residues
METTAIPSGTVVVGLDGSPSAERALEWAIDQALLESRQLTLAHGVDPSGSVWVDPAAIDHRAVLEALQADAEVMLDHARE
QVARRAPDLVVHQVIRMSDARVTLLELSGQAAMVVVGSRGRGPIKTLLLGSVSLAVSREALCPVVVLRPGHPGVVRNGVL
VGADGTDRSLATLEFAYRQASLHRLPLTIMHCFWDARPATEGEPVASDVRLVLAESLAGLGEKFPDVQARTELVRGMADE
RLVRASQRMDLVVVGAHHGGTLTTLLYGSIANAVLEHATCPVAIVPESEG

Specific function: May play a role in the establisment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not sho

COG id: COG0589

COG function: function code T; Universal stress protein UspA and related nucleotide-binding proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the universal stress protein A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014729
- InterPro:   IPR006015
- InterPro:   IPR006016 [H]

Pfam domain/function: PF00582 Usp [H]

EC number: NA

Molecular weight: Translated: 30743; Mature: 30743

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTAIPSGTVVVGLDGSPSAERALEWAIDQALLESRQLTLAHGVDPSGSVWVDPAAIDH
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECCHHHHH
RAVLEALQADAEVMLDHAREQVARRAPDLVVHQVIRMSDARVTLLELSGQAAMVVVGSRG
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEEEECCCEEEEEEECCC
RGPIKTLLLGSVSLAVSREALCPVVVLRPGHPGVVRNGVLVGADGTDRSLATLEFAYRQA
CCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEECCEEEECCCCCCHHHHHHHHHHHH
SLHRLPLTIMHCFWDARPATEGEPVASDVRLVLAESLAGLGEKFPDVQARTELVRGMADE
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RLVRASQRMDLVVVGAHHGGTLTTLLYGSIANAVLEHATCPVAIVPESEG
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
>Mature Secondary Structure
METTAIPSGTVVVGLDGSPSAERALEWAIDQALLESRQLTLAHGVDPSGSVWVDPAAIDH
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECCHHHHH
RAVLEALQADAEVMLDHAREQVARRAPDLVVHQVIRMSDARVTLLELSGQAAMVVVGSRG
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEEEECCCEEEEEEECCC
RGPIKTLLLGSVSLAVSREALCPVVVLRPGHPGVVRNGVLVGADGTDRSLATLEFAYRQA
CCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEECCEEEECCCCCCHHHHHHHHHHHH
SLHRLPLTIMHCFWDARPATEGEPVASDVRLVLAESLAGLGEKFPDVQARTELVRGMADE
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RLVRASQRMDLVVVGAHHGGTLTTLLYGSIANAVLEHATCPVAIVPESEG
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]