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The map label for this gene is devR [H]

Identifier: 119715190

GI number: 119715190

Start: 994232

End: 994882

Strand: Direct

Name: devR [H]

Synonym: Noca_0945

Alternate gene names: 119715190

Gene position: 994232-994882 (Clockwise)

Preceding gene: 119715189

Following gene: 119715193

Centisome position: 19.94

GC content: 70.51

Gene sequence:

>651_bases
ATGACCGAGGGCCCGGGGAAGATCCGCGTCTACCTCCTCGACGACCACGAGGTCGTGCGACAGGGGTTGCGCGCGCTGCT
GGAGAGCTCTGGTGACATCGAGGTCGTCGGCGAGTCCGGCTCCGCGGTGGACGCCAGCAACCGGATCCCGGCGCTGCGCC
CGGACGTGGCCGTGCTGGACGCGCGGCTGCCCGACGGGTCGGGGATCGAGGTGTGCCGCACCGTGCGCGCCGTCGACCCG
ACCATCTCCGCGCTGATCCTGACCTCGTACGACGACGACGAGGCCCTCTTCGCGGCGATCATGGCCGGCGCCGCCGGCTA
CGTGCTCAAGGAGATCAAGGGCTCCGACCTGGTCTCGGCGATCCGCCAGGTCGCGGCCGGCAACTCGCTGATCGACCCGA
CGCTGACCGCGCGGGTGCTGGAGCGGGTGCGGCACCCACCGACGACCGCCCCCGAGCTGGCCGAGCTGACCGAGCAGGAG
CTCAAGCTGCTCGGCTACATCGCCGAGGGCCTGACCAACCGGCAGATCGGGGAGCGGATGTACCTCGCCGAGAAGACCGT
GAAGAACTACGTATCCAGCATCCTCGCGAAGCTCGGCCTGGAGCGCCGCACCCAGGCCGCGGTGCTCGCCAGCAAGCTGC
TCGGCAACTGA

Upstream 100 bases:

>100_bases
ACGGCGAGCAGCAGCGCACGGTCCTGTGGATCACGCACGCCGCGGCCGGACTCGACCGGGTCGACCGCGTGCTCGACCTC
GGGACTGGTAGAAAAGGGGC

Downstream 100 bases:

>100_bases
CCCCCTCCGGCGCTCAGCGGATCGCGCTCAGCGCAGCGGCACCCGCCACACGAACGAGGTGCCGCGCGGCTGGCGTGGGC
CGAGCTCGAAGGAGCCGCCG

Product: response regulator receiver

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTEGPGKIRVYLLDDHEVVRQGLRALLESSGDIEVVGESGSAVDASNRIPALRPDVAVLDARLPDGSGIEVCRTVRAVDP
TISALILTSYDDDEALFAAIMAGAAGYVLKEIKGSDLVSAIRQVAAGNSLIDPTLTARVLERVRHPPTTAPELAELTEQE
LKLLGYIAEGLTNRQIGERMYLAEKTVKNYVSSILAKLGLERRTQAAVLASKLLGN

Sequences:

>Translated_216_residues
MTEGPGKIRVYLLDDHEVVRQGLRALLESSGDIEVVGESGSAVDASNRIPALRPDVAVLDARLPDGSGIEVCRTVRAVDP
TISALILTSYDDDEALFAAIMAGAAGYVLKEIKGSDLVSAIRQVAAGNSLIDPTLTARVLERVRHPPTTAPELAELTEQE
LKLLGYIAEGLTNRQIGERMYLAEKTVKNYVSSILAKLGLERRTQAAVLASKLLGN
>Mature_215_residues
TEGPGKIRVYLLDDHEVVRQGLRALLESSGDIEVVGESGSAVDASNRIPALRPDVAVLDARLPDGSGIEVCRTVRAVDPT
ISALILTSYDDDEALFAAIMAGAAGYVLKEIKGSDLVSAIRQVAAGNSLIDPTLTARVLERVRHPPTTAPELAELTEQEL
KLLGYIAEGLTNRQIGERMYLAEKTVKNYVSSILAKLGLERRTQAAVLASKLLGN

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. When phosphorylated binds the promoter of at least its own and Acr (hspX) gene in response to hypoxia. Activates its own transcription under hy

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=36.0975609756098, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1788222, Length=194, Percent_Identity=31.9587628865979, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786747, Length=197, Percent_Identity=27.4111675126904, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1787473, Length=204, Percent_Identity=31.8627450980392, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790102, Length=201, Percent_Identity=29.8507462686567, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1788712, Length=187, Percent_Identity=28.3422459893048, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788546, Length=202, Percent_Identity=27.2277227722772, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI87082052, Length=142, Percent_Identity=31.6901408450704, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23103; Mature: 22972

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEGPGKIRVYLLDDHEVVRQGLRALLESSGDIEVVGESGSAVDASNRIPALRPDVAVLD
CCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHC
ARLPDGSGIEVCRTVRAVDPTISALILTSYDDDEALFAAIMAGAAGYVLKEIKGSDLVSA
CCCCCCCCHHHHHHHHHCCHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IRQVAAGNSLIDPTLTARVLERVRHPPTTAPELAELTEQELKLLGYIAEGLTNRQIGERM
HHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
YLAEKTVKNYVSSILAKLGLERRTQAAVLASKLLGN
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEGPGKIRVYLLDDHEVVRQGLRALLESSGDIEVVGESGSAVDASNRIPALRPDVAVLD
CCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHC
ARLPDGSGIEVCRTVRAVDPTISALILTSYDDDEALFAAIMAGAAGYVLKEIKGSDLVSA
CCCCCCCCHHHHHHHHHCCHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IRQVAAGNSLIDPTLTARVLERVRHPPTTAPELAELTEQELKLLGYIAEGLTNRQIGERM
HHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
YLAEKTVKNYVSSILAKLGLERRTQAAVLASKLLGN
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]