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The map label for this gene is folD1

Identifier: 119714889

GI number: 119714889

Start: 678430

End: 679320

Strand: Reverse

Name: folD1

Synonym: Noca_0641

Alternate gene names: 119714889

Gene position: 679320-678430 (Counterclockwise)

Preceding gene: 119714892

Following gene: 119714888

Centisome position: 13.62

GC content: 61.84

Gene sequence:

>891_bases
GTGGATCGCAAGGCAACCGTCATCGACGGGAAGCTGGCTGCGCAGCACGTCAAAGATTCCCTGCGCACGCGCGTCGCTGC
ACTTGAAGCGATTGGTCAGCGTCCAGGCCTCGGAACGATCCTTGTCGGCGATGACGCTGGCTCGCAGTCGTACGTCGCCG
GGAAGCATCGCGACTGTGCGGAAGTAGGGATCGACTCTTTCCGGATTGACATGTCCGCGGAGGCGTCTCAGGAGCGCGTC
TTGGATGCCGTTGGACGTCTGAACGAAGACGAGCGTTGCTCCGGATTCATCGTGCAACTTCCATTGCCGGCACACATCGA
CATGCACCTCGTTCTGAACGCCATTGATCCCGAAAAGGATGCCGATGGTCTGCACCCAGTGAACCTGGGTCGTCTCGTTC
TGAACCAGGAAGGAACGCTGCCCTGTACCCCTCGCGGGATCCTTGAGTTGCTGCGCGGCAACGACGTTCCGATCACAGGG
TCTCAGTTTTGCGTGATCGGGTGCGGCACCACGGTGGGTCGTCCGCTCGGGCTCATGCTCACGCGACCGAGCGAGCATGC
GACGGTCACCATGGTGAACGAGGCGACCATCGATGTCGCTGCGCACACGCGCGTTGCCGACGTCGTGATTGCTGCCGCAG
GAGTGGCCAACCTCGTCAAGCCGTACTGGATCAAGCCCGGCGCCACTGTTCTCTCGGTCGGGATCACTCGCACTGTTGAA
GGAATTCTTGGAGACGTCGATCCGGGTGTCGAGAATGTCGCAGGGAAGTGGACACGCGCCGCGGGCGGGGTCGGCCCGAT
GACTCGCGCCATGCTCCTCAAGAACGTCGTAGAACTCGCCGAACGCGCAGCGGGCATCACTTCAGAAGCCAGCACCAAGA
TCGCGTCCTGA

Upstream 100 bases:

>100_bases
CGTGCGCGTTCTATTCACTCCCGCGTCCAGCGAGTCGATAGCAATCATCGTGCGCGTGGGATCTGCCACAGCACACGCGG
ATGACAGAAAGGGCGACCTG

Downstream 100 bases:

>100_bases
CGAAGCACCCGAAAGCGAAACCAGCACGTGAACATTGTCGTCTGTGTGAAGTACGTCCCCGACGCCACTGCCGATCGGCA
GTTCGAGTCGGACAACACCC

Product: methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MDRKATVIDGKLAAQHVKDSLRTRVAALEAIGQRPGLGTILVGDDAGSQSYVAGKHRDCAEVGIDSFRIDMSAEASQERV
LDAVGRLNEDERCSGFIVQLPLPAHIDMHLVLNAIDPEKDADGLHPVNLGRLVLNQEGTLPCTPRGILELLRGNDVPITG
SQFCVIGCGTTVGRPLGLMLTRPSEHATVTMVNEATIDVAAHTRVADVVIAAAGVANLVKPYWIKPGATVLSVGITRTVE
GILGDVDPGVENVAGKWTRAAGGVGPMTRAMLLKNVVELAERAAGITSEASTKIAS

Sequences:

>Translated_296_residues
MDRKATVIDGKLAAQHVKDSLRTRVAALEAIGQRPGLGTILVGDDAGSQSYVAGKHRDCAEVGIDSFRIDMSAEASQERV
LDAVGRLNEDERCSGFIVQLPLPAHIDMHLVLNAIDPEKDADGLHPVNLGRLVLNQEGTLPCTPRGILELLRGNDVPITG
SQFCVIGCGTTVGRPLGLMLTRPSEHATVTMVNEATIDVAAHTRVADVVIAAAGVANLVKPYWIKPGATVLSVGITRTVE
GILGDVDPGVENVAGKWTRAAGGVGPMTRAMLLKNVVELAERAAGITSEASTKIAS
>Mature_296_residues
MDRKATVIDGKLAAQHVKDSLRTRVAALEAIGQRPGLGTILVGDDAGSQSYVAGKHRDCAEVGIDSFRIDMSAEASQERV
LDAVGRLNEDERCSGFIVQLPLPAHIDMHLVLNAIDPEKDADGLHPVNLGRLVLNQEGTLPCTPRGILELLRGNDVPITG
SQFCVIGCGTTVGRPLGLMLTRPSEHATVTMVNEATIDVAAHTRVADVVIAAAGVANLVKPYWIKPGATVLSVGITRTVE
GILGDVDPGVENVAGKWTRAAGGVGPMTRAMLLKNVVELAERAAGITSEASTKIAS

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI94721354, Length=295, Percent_Identity=41.6949152542373, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI222418558, Length=295, Percent_Identity=39.3220338983051, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI222136639, Length=294, Percent_Identity=35.7142857142857, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI36796743, Length=202, Percent_Identity=27.7227722772277, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1786741, Length=279, Percent_Identity=40.8602150537634, Blast_Score=181, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17568735, Length=258, Percent_Identity=36.4341085271318, Blast_Score=136, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321643, Length=301, Percent_Identity=36.5448504983389, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6319558, Length=288, Percent_Identity=34.0277777777778, Blast_Score=155, Evalue=8e-39,
Organism=Drosophila melanogaster, GI17136818, Length=294, Percent_Identity=37.7551020408163, Blast_Score=187, Evalue=6e-48,
Organism=Drosophila melanogaster, GI17136816, Length=294, Percent_Identity=37.7551020408163, Blast_Score=187, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24645718, Length=291, Percent_Identity=39.8625429553265, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17137370, Length=291, Percent_Identity=39.8625429553265, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI62472483, Length=291, Percent_Identity=39.8625429553265, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI45551871, Length=291, Percent_Identity=39.8625429553265, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD1_NOCSJ (A1SED2)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_921854.1
- ProteinModelPortal:   A1SED2
- SMR:   A1SED2
- STRING:   A1SED2
- GeneID:   4596058
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_0641
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   HTKIADI
- BioCyc:   NSP35761:NOCA_0641-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 31055; Mature: 31055

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRKATVIDGKLAAQHVKDSLRTRVAALEAIGQRPGLGTILVGDDAGSQSYVAGKHRDCA
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEECCCCCCHH
EVGIDSFRIDMSAEASQERVLDAVGRLNEDERCSGFIVQLPLPAHIDMHLVLNAIDPEKD
HHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCC
ADGLHPVNLGRLVLNQEGTLPCTPRGILELLRGNDVPITGSQFCVIGCGTTVGRPLGLML
CCCCCCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCEEEE
TRPSEHATVTMVNEATIDVAAHTRVADVVIAAAGVANLVKPYWIKPGATVLSVGITRTVE
ECCCCCEEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEHHHHHHHH
GILGDVDPGVENVAGKWTRAAGGVGPMTRAMLLKNVVELAERAAGITSEASTKIAS
HHHCCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCC
>Mature Secondary Structure
MDRKATVIDGKLAAQHVKDSLRTRVAALEAIGQRPGLGTILVGDDAGSQSYVAGKHRDCA
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEECCCCCCHH
EVGIDSFRIDMSAEASQERVLDAVGRLNEDERCSGFIVQLPLPAHIDMHLVLNAIDPEKD
HHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCC
ADGLHPVNLGRLVLNQEGTLPCTPRGILELLRGNDVPITGSQFCVIGCGTTVGRPLGLML
CCCCCCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCEEEE
TRPSEHATVTMVNEATIDVAAHTRVADVVIAAAGVANLVKPYWIKPGATVLSVGITRTVE
ECCCCCEEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEHHHHHHHH
GILGDVDPGVENVAGKWTRAAGGVGPMTRAMLLKNVVELAERAAGITSEASTKIAS
HHHCCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA