Click here to switch to the map view.

The map label for this gene is purP [H]

Identifier: 119386503

GI number: 119386503

Start: 930848

End: 932212

Strand: Direct

Name: purP [H]

Synonym: Pden_3796

Alternate gene names: 119386503

Gene position: 930848-932212 (Clockwise)

Preceding gene: 119386500

Following gene: 119386505

Centisome position: 53.8

GC content: 66.23

Gene sequence:

>1365_bases
ATGCCAGACAAGCAATCCGGCCTGACGGCCAGCGGCGCCAGCATCAGTCCAGGGGAAGGAACCGTGCTAGACAAGCAGTT
CGGCCTGACGGCCCATGGCACAACCGTAAGGACGGAAGTGATCGCAGGGATTACCACCTTCCTGACGATGGCCTATATCA
TCTTCGTGAACCCCGAGATCCTGTCCTCGACCGGCATGGACCGCAACGCGGTCTTCGTCGCGACCTGCCTTGCCGCGGCG
CTGGGATCGGCGATCATGGCGCTGTGGGCCAACTGGCCCATCGGCATGGCGCCGGGCATGGGGCTGAACGCCTTTTTCGC
CTTTACCGTGGTCGGCGCGCTGGGGTTCACCTGGCAGCAGGCGCTGGGGGCGGTGTTCATCTCGGGCCTGATATTCCTGT
TCCTGTCGGTGACAGGCATCCGGCGCTGGCTGATCGCGGGCATTCCGACATCCATGCGCAGCGCCATCGCCGCCGGCATC
GGCATGTTCCTGGGGCTGATCGCGCTGAAGAACTCGGGCATCGTGGTCGACAATCCGGCGACGCTGGTGGGCCTGGGCGA
CCTGACCCAGACCGGCACGCTGCTGGCCATCGTCGGCTTCTTCATCATCGCGGCGCTGGACGCGCTGAAGGTGCGCGGCT
CGATCCTGATCGGCATCATGGTCATCACGGTCGTGTCCATCGCCATCGGCGCCAGCCCCTTCGGCGGGGTGATCTCGATG
CCGCCCTCGATCATGCCGACCTTCCTGCAACTCGACGTCGCAGGCGCGCTGACCGTGGGCATCTTCCACGTCATCCTGGT
CATGGTGCTGGTCGAGGTCTTCGACGCCACCGGCACGCTGATCGGCGTGGCCAAGCGCGCCGGATTGCTGACCGAGGGGC
CGACCCATACCAACAAGAACCTCGGCCGGGCGCTGATGGCGGATTCGACGGCGATCCTGGCAGGCTCGATGCTGGGCACC
AGCTCGACCACCGCCTATGTCGAAAGCGCCTCGGGCGTGCAGGCGGGCGGGCGCACCGGGCTGACCGCGCTGGTCGTCGC
GGGGCTGTTCCTGCTGGCGGTGTTCTTCGCGCCGCTGGCGGGCTCGGTTCCGGCCTATGCCACCGCGCCGGCGCTGCTTT
ACGTCGCCTGCCTGATGGTGCGCGAATTCGAGGAAATCCAGTGGAGCGACGTCACCGAAAGCGCGCCGGCGGTGCTGACC
GCGCTGATGATGCCCTTTACCTATTCCATCGCCAACGGCCTGGCCTTCGGCTTTGTCAGCTATGCCGCGATCAAGCTGGC
GACCGGCCGCGCGCGCGAGGTGCATGCAGCGACCTGGATCGTCGCCGCGCTGTTCGTCATCCGCTTCGCCTTCTTCATGG
AGTGA

Upstream 100 bases:

>100_bases
CATCTCATTGAAACTCTGTCGCTATACCTTGCATTCTCGTTGAAGATCACCGGGCATATTCTGGCCAGCACGGCGGGCAA
GCCGCCAATTGGGAGGAAAC

Downstream 100 bases:

>100_bases
CCTTCGTTCTTGGTGGGGCGGATCGTCCGCCAGCCGGAGCGTAAAAGAACAAGGCCCGCCGCTTTGGCGGGCCTTTCCAG
TTCCGGGTCCAGGCAGCGCC

Product: xanthine/uracil/vitamin C permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MPDKQSGLTASGASISPGEGTVLDKQFGLTAHGTTVRTEVIAGITTFLTMAYIIFVNPEILSSTGMDRNAVFVATCLAAA
LGSAIMALWANWPIGMAPGMGLNAFFAFTVVGALGFTWQQALGAVFISGLIFLFLSVTGIRRWLIAGIPTSMRSAIAAGI
GMFLGLIALKNSGIVVDNPATLVGLGDLTQTGTLLAIVGFFIIAALDALKVRGSILIGIMVITVVSIAIGASPFGGVISM
PPSIMPTFLQLDVAGALTVGIFHVILVMVLVEVFDATGTLIGVAKRAGLLTEGPTHTNKNLGRALMADSTAILAGSMLGT
SSTTAYVESASGVQAGGRTGLTALVVAGLFLLAVFFAPLAGSVPAYATAPALLYVACLMVREFEEIQWSDVTESAPAVLT
ALMMPFTYSIANGLAFGFVSYAAIKLATGRAREVHAATWIVAALFVIRFAFFME

Sequences:

>Translated_454_residues
MPDKQSGLTASGASISPGEGTVLDKQFGLTAHGTTVRTEVIAGITTFLTMAYIIFVNPEILSSTGMDRNAVFVATCLAAA
LGSAIMALWANWPIGMAPGMGLNAFFAFTVVGALGFTWQQALGAVFISGLIFLFLSVTGIRRWLIAGIPTSMRSAIAAGI
GMFLGLIALKNSGIVVDNPATLVGLGDLTQTGTLLAIVGFFIIAALDALKVRGSILIGIMVITVVSIAIGASPFGGVISM
PPSIMPTFLQLDVAGALTVGIFHVILVMVLVEVFDATGTLIGVAKRAGLLTEGPTHTNKNLGRALMADSTAILAGSMLGT
SSTTAYVESASGVQAGGRTGLTALVVAGLFLLAVFFAPLAGSVPAYATAPALLYVACLMVREFEEIQWSDVTESAPAVLT
ALMMPFTYSIANGLAFGFVSYAAIKLATGRAREVHAATWIVAALFVIRFAFFME
>Mature_453_residues
PDKQSGLTASGASISPGEGTVLDKQFGLTAHGTTVRTEVIAGITTFLTMAYIIFVNPEILSSTGMDRNAVFVATCLAAAL
GSAIMALWANWPIGMAPGMGLNAFFAFTVVGALGFTWQQALGAVFISGLIFLFLSVTGIRRWLIAGIPTSMRSAIAAGIG
MFLGLIALKNSGIVVDNPATLVGLGDLTQTGTLLAIVGFFIIAALDALKVRGSILIGIMVITVVSIAIGASPFGGVISMP
PSIMPTFLQLDVAGALTVGIFHVILVMVLVEVFDATGTLIGVAKRAGLLTEGPTHTNKNLGRALMADSTAILAGSMLGTS
STTAYVESASGVQAGGRTGLTALVVAGLFLLAVFFAPLAGSVPAYATAPALLYVACLMVREFEEIQWSDVTESAPAVLTA
LMMPFTYSIANGLAFGFVSYAAIKLATGRAREVHAATWIVAALFVIRFAFFME

Specific function: High-affinity uptake of adenine [H]

COG id: COG2252

COG function: function code R; Permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790150, Length=436, Percent_Identity=50.2293577981651, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI87082309, Length=430, Percent_Identity=48.8372093023256, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1790499, Length=438, Percent_Identity=38.8127853881278, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI48994909, Length=442, Percent_Identity=37.3303167420815, Blast_Score=257, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46905; Mature: 46774

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDKQSGLTASGASISPGEGTVLDKQFGLTAHGTTVRTEVIAGITTFLTMAYIIFVNPEI
CCCCCCCCCCCCCCCCCCCCCEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCHHH
LSSTGMDRNAVFVATCLAAALGSAIMALWANWPIGMAPGMGLNAFFAFTVVGALGFTWQQ
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ALGAVFISGLIFLFLSVTGIRRWLIAGIPTSMRSAIAAGIGMFLGLIALKNSGIVVDNPA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
TLVGLGDLTQTGTLLAIVGFFIIAALDALKVRGSILIGIMVITVVSIAIGASPFGGVISM
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PPSIMPTFLQLDVAGALTVGIFHVILVMVLVEVFDATGTLIGVAKRAGLLTEGPTHTNKN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHH
LGRALMADSTAILAGSMLGTSSTTAYVESASGVQAGGRTGLTALVVAGLFLLAVFFAPLA
HHHHHHCCCHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GSVPAYATAPALLYVACLMVREFEEIQWSDVTESAPAVLTALMMPFTYSIANGLAFGFVS
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAAIKLATGRAREVHAATWIVAALFVIRFAFFME
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PDKQSGLTASGASISPGEGTVLDKQFGLTAHGTTVRTEVIAGITTFLTMAYIIFVNPEI
CCCCCCCCCCCCCCCCCCCCEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCHHH
LSSTGMDRNAVFVATCLAAALGSAIMALWANWPIGMAPGMGLNAFFAFTVVGALGFTWQQ
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ALGAVFISGLIFLFLSVTGIRRWLIAGIPTSMRSAIAAGIGMFLGLIALKNSGIVVDNPA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
TLVGLGDLTQTGTLLAIVGFFIIAALDALKVRGSILIGIMVITVVSIAIGASPFGGVISM
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PPSIMPTFLQLDVAGALTVGIFHVILVMVLVEVFDATGTLIGVAKRAGLLTEGPTHTNKN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHH
LGRALMADSTAILAGSMLGTSSTTAYVESASGVQAGGRTGLTALVVAGLFLLAVFFAPLA
HHHHHHCCCHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GSVPAYATAPALLYVACLMVREFEEIQWSDVTESAPAVLTALMMPFTYSIANGLAFGFVS
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAAIKLATGRAREVHAATWIVAALFVIRFAFFME
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]