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The map label for this gene is cbrB [H]

Identifier: 119386243

GI number: 119386243

Start: 682508

End: 683215

Strand: Direct

Name: cbrB [H]

Synonym: Pden_3532

Alternate gene names: 119386243

Gene position: 682508-683215 (Clockwise)

Preceding gene: 119386242

Following gene: 119386244

Centisome position: 39.45

GC content: 72.46

Gene sequence:

>708_bases
ATGACCCCGCAAGGCCCGATCCCGCATCCTCCGCTGCTGCGGCAGGCCCCGGCGGGCCGGCATTATGCGCTGGGGATCGC
GGTGCTGGCTGTGCTGGCGCTGGCCAGCCTTGCCATCGGCTCGCGCGCGGTGCCGCCCGGACAGGTGCTTGCGGCGATGT
TCGACTTCGATCCCGGCAACGACCTGCATCTGATCGTGCGCGAATTGCGCCTGCCCCGGACCCTGCTGGCGGTTTTCGCA
GGGGCGGCGCTTGGCCTTGCCGGGGCGGTCATGCAGGCCGTCACCCGCAATCCGCTGGCCGAACCGGGGTTGCTGGGCGT
GAACTCGGGGGCCGCGATCGCGGTGGTGCTGGGCGCCTCGGCGCTGGGGCTGACGCAGATGGCGCAATATGTCTGGTTCG
GTTTTCTGGGCGCGGGGCTGGCGGGCGTCGCGGTGTTCCTGCTGGGACGGGCGCATGAAAGCGGCACCGATCCGGTCCGG
CTGGTGCTGGCGGGGGCAGGAATCTCGGTCCTGCTGGGGGCGGCGGCCAGCCTGGTCATCCTGAATTCGGCGCTGGAGGT
GCTGGACCTGTTTCGCAACTGGGGCGCCGGCGCCCTGGAGGGGCGCGGCCGCGCCGTCGCGCTGACCATGGGCGTGACGC
TGGTCCTGGGGGGGGGCGCTGGCCCTGGCGCTGGCGCCGGGGCTGAACGCCATGGCGCTGGGACATGA

Upstream 100 bases:

>100_bases
TGCGCGCGGGCCGGGTCTATCCGCTGGGTCCGACCTCGTTCCGGGTGGATTACTATTCCGGCCTGCAGATCGTCGAGACC
GTCCGGCAAATCTTTGCGAA

Downstream 100 bases:

>100_bases
CACCGGCCGCGCGCTGGGGCTGAGGCCGGAACGCTTCTGGGCGGCCGCCTGCCTGTCGGTGATGATCCTTGCCGGCGCCG
CCACCGCCGCCGCCGGTCCC

Product: transport system permease protein

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MTPQGPIPHPPLLRQAPAGRHYALGIAVLAVLALASLAIGSRAVPPGQVLAAMFDFDPGNDLHLIVRELRLPRTLLAVFA
GAALGLAGAVMQAVTRNPLAEPGLLGVNSGAAIAVVLGASALGLTQMAQYVWFGFLGAGLAGVAVFLLGRAHESGTDPVR
LVLAGAGISVLLGAAASLVILNSALEVLDLFRNWGAGALEGRGRAVALTMGVTLVLGGGAGPGAGAGAERHGAGT

Sequences:

>Translated_235_residues
MTPQGPIPHPPLLRQAPAGRHYALGIAVLAVLALASLAIGSRAVPPGQVLAAMFDFDPGNDLHLIVRELRLPRTLLAVFA
GAALGLAGAVMQAVTRNPLAEPGLLGVNSGAAIAVVLGASALGLTQMAQYVWFGFLGAGLAGVAVFLLGRAHESGTDPVR
LVLAGAGISVLLGAAASLVILNSALEVLDLFRNWGAGALEGRGRAVALTMGVTLVLGGGAGPGAGAGAERHGAGT
>Mature_234_residues
TPQGPIPHPPLLRQAPAGRHYALGIAVLAVLALASLAIGSRAVPPGQVLAAMFDFDPGNDLHLIVRELRLPRTLLAVFAG
AALGLAGAVMQAVTRNPLAEPGLLGVNSGAAIAVVLGASALGLTQMAQYVWFGFLGAGLAGVAVFLLGRAHESGTDPVRL
VLAGAGISVLLGAAASLVILNSALEVLDLFRNWGAGALEGRGRAVALTMGVTLVLGGGAGPGAGAGAERHGAGT

Specific function: Part of the binding-protein-dependent transport system CbrABCD for uptake of the siderophore achromobactin. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786805, Length=169, Percent_Identity=44.3786982248521, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1786804, Length=164, Percent_Identity=34.7560975609756, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1790740, Length=171, Percent_Identity=34.5029239766082, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790741, Length=108, Percent_Identity=45.3703703703704, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788004, Length=162, Percent_Identity=34.5679012345679, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786347, Length=167, Percent_Identity=33.5329341317365, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 23299; Mature: 23167

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPQGPIPHPPLLRQAPAGRHYALGIAVLAVLALASLAIGSRAVPPGQVLAAMFDFDPGN
CCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCC
DLHLIVRELRLPRTLLAVFAGAALGLAGAVMQAVTRNPLAEPGLLGVNSGAAIAVVLGAS
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEEEECCCH
ALGLTQMAQYVWFGFLGAGLAGVAVFLLGRAHESGTDPVRLVLAGAGISVLLGAAASLVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
LNSALEVLDLFRNWGAGALEGRGRAVALTMGVTLVLGGGAGPGAGAGAERHGAGT
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEECEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPQGPIPHPPLLRQAPAGRHYALGIAVLAVLALASLAIGSRAVPPGQVLAAMFDFDPGN
CCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCC
DLHLIVRELRLPRTLLAVFAGAALGLAGAVMQAVTRNPLAEPGLLGVNSGAAIAVVLGAS
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEEEECCCH
ALGLTQMAQYVWFGFLGAGLAGVAVFLLGRAHESGTDPVRLVLAGAGISVLLGAAASLVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
LNSALEVLDLFRNWGAGALEGRGRAVALTMGVTLVLGGGAGPGAGAGAERHGAGT
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEECEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8596459 [H]