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The map label for this gene is hutU [H]

Identifier: 119386228

GI number: 119386228

Start: 662681

End: 664339

Strand: Direct

Name: hutU [H]

Synonym: Pden_3517

Alternate gene names: 119386228

Gene position: 662681-664339 (Clockwise)

Preceding gene: 119386227

Following gene: 119386229

Centisome position: 38.3

GC content: 66.97

Gene sequence:

>1659_bases
ATGCCCAGGGACAATCCACGCAATCCCGGCTTCCCGATCCCTTCGGGATCCGAACTGCGCGCCAAGGGCTGGCGGCAAGA
GGCGCTGCTGCGGCTGATGGAAAACGTGCTGGCGGTAGGCGAGGATCCAGATAACCTTGTCGTTTACGCAGCACTCGGCA
AGGCTGCGCGCGACAAGGCCGCCCATGACGCCATCGTCCGCGCGCTGACCGTCATGGACGAGGACCAGACGCTGGTCATC
CAGTCCGGCAAGCCGGTCGGGTTGATGAAGACCTCGGCCGAGGCGCCAAAGGTGATCATGGCCAACTGCAATATCGTCGG
GCAATGGGCCAATGCTGAGACCTTCTACGACCTGGAACGCAAGGGCCTGGTCTGCTGGGGCGGGCTGACCGCCGGAGCAT
GGCAGTATATCGGCTCGCAAGGGGTCATCCAGGGCACCTATGAAATCTTCATGCGCATCGCCGAGCGTCGCTTCGGCGGC
ACGCTGGAGGGGCGCTTCGTCCTGACGGCGGGCCTTGGCGGCATGGGCGGAGCGCAGCCCTTGGCCGGACGCATGGCGGG
CGCCGCGATCCTGTGCGTCGAAATCGATCCAGAACGGGCCCGCAAGCGCCGGGAAATCGGCTATCTCGACGAAATCGCCC
CCGATCTTGACGGTGCGCTGGCGCGGATCGAGCAGGCGCGGGCAAAGGGGCAGGCGCTGTCCGTCGGCCTTGTCGGCAAC
GCGGCCGAGATCTATCCTAGGATCGCTGCGCGCGGGATCGTGCCGGATATCGTGACCGACCAGACCTCGGCCCACGATCT
GGTCTATGGCTATGTCCCGGTCGGCTACGATCTGGAGCGGGTGCGCCGGTTGCGCAGTCAGAATCCCTCGGAACTGATCC
CGGCGGGGCGGGCGTCGATTGCGCAGCATGTGAGGGCGATGCTGCACTTCCAGCGCGCGGGGGCCGAGGTCTTTGACAAC
GGCAACCTGATCCGCACCCAGGCGCAGGCCGGCGGCGTCGCGGATGCCTTCGACATCCCCGTCTTTACCGAGGCCTATCT
GCGTCCGCTCTTCTGCCGCGCCATCGGGCCGTTCCGCTGGATGGCCCTGTCGGGGGATCCGGCCGATATCGCGCGCATCG
ACGATCTGGTGCTGGAAATGTTCCCGGACAACAGGATCGTCACCAACTGGATCCGGCTAGCGCGCGAGAACGTCCCCTTC
GAGGGGCTGCCCGCCCGCATCGCATGGCTTGGCCATGGCGAGCGCAGCGCCCTGGCCCGGCGGGTCAACGAACTCGTCGC
CGCGGGAGAGCTGAAGGGGCCGGTCGCCTTCTCGCGCGATCACCTCGACTCGGCGGGCATGGCGCATCCGAACATCATGA
CGGAGAACATGCGCGACGGCTCGGACGCTATCGCCGACTGGCCGCTGCTGGATGCGATGCTGCTTTGCGCCTCGCGCGCC
GACCTGGTCGCGATCCATTCGGGGGGCGGGGGCTATGCGGGCTACATGACCTCGGCGGGCGTCACGATCATCGCGGACGG
CACCGCGGCGGCGGACGTGCGGCTGGAGCAGGCGATCGACAACGACACCGGGCTTGGCGTCATCCGCTACGCCGATGCGG
GCTATCCCGAGGCGCAGGACGAAGTCGCCCGCAAGGGCATCAACCACCTGAAACTCTGA

Upstream 100 bases:

>100_bases
TGATCCCGGTCGGCGCGGGGCTGATGGACCCCGCGATCTATGTTCACCCCGAAAAGGTCATGGGCATCAACCTGACCGAT
TATGCGTTGGCGGTTTGAGC

Downstream 100 bases:

>100_bases
TCCTCTGCCGGGCGCGGCAGCCAGAACCCGCCAAGGGTCCGCCTGCGCCCGGAAGAAGCCAAACAGCAATCAACCAGCGC
CCGCGGTTACCGACGGGCAA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MPRDNPRNPGFPIPSGSELRAKGWRQEALLRLMENVLAVGEDPDNLVVYAALGKAARDKAAHDAIVRALTVMDEDQTLVI
QSGKPVGLMKTSAEAPKVIMANCNIVGQWANAETFYDLERKGLVCWGGLTAGAWQYIGSQGVIQGTYEIFMRIAERRFGG
TLEGRFVLTAGLGGMGGAQPLAGRMAGAAILCVEIDPERARKRREIGYLDEIAPDLDGALARIEQARAKGQALSVGLVGN
AAEIYPRIAARGIVPDIVTDQTSAHDLVYGYVPVGYDLERVRRLRSQNPSELIPAGRASIAQHVRAMLHFQRAGAEVFDN
GNLIRTQAQAGGVADAFDIPVFTEAYLRPLFCRAIGPFRWMALSGDPADIARIDDLVLEMFPDNRIVTNWIRLARENVPF
EGLPARIAWLGHGERSALARRVNELVAAGELKGPVAFSRDHLDSAGMAHPNIMTENMRDGSDAIADWPLLDAMLLCASRA
DLVAIHSGGGGYAGYMTSAGVTIIADGTAAADVRLEQAIDNDTGLGVIRYADAGYPEAQDEVARKGINHLKL

Sequences:

>Translated_552_residues
MPRDNPRNPGFPIPSGSELRAKGWRQEALLRLMENVLAVGEDPDNLVVYAALGKAARDKAAHDAIVRALTVMDEDQTLVI
QSGKPVGLMKTSAEAPKVIMANCNIVGQWANAETFYDLERKGLVCWGGLTAGAWQYIGSQGVIQGTYEIFMRIAERRFGG
TLEGRFVLTAGLGGMGGAQPLAGRMAGAAILCVEIDPERARKRREIGYLDEIAPDLDGALARIEQARAKGQALSVGLVGN
AAEIYPRIAARGIVPDIVTDQTSAHDLVYGYVPVGYDLERVRRLRSQNPSELIPAGRASIAQHVRAMLHFQRAGAEVFDN
GNLIRTQAQAGGVADAFDIPVFTEAYLRPLFCRAIGPFRWMALSGDPADIARIDDLVLEMFPDNRIVTNWIRLARENVPF
EGLPARIAWLGHGERSALARRVNELVAAGELKGPVAFSRDHLDSAGMAHPNIMTENMRDGSDAIADWPLLDAMLLCASRA
DLVAIHSGGGGYAGYMTSAGVTIIADGTAAADVRLEQAIDNDTGLGVIRYADAGYPEAQDEVARKGINHLKL
>Mature_551_residues
PRDNPRNPGFPIPSGSELRAKGWRQEALLRLMENVLAVGEDPDNLVVYAALGKAARDKAAHDAIVRALTVMDEDQTLVIQ
SGKPVGLMKTSAEAPKVIMANCNIVGQWANAETFYDLERKGLVCWGGLTAGAWQYIGSQGVIQGTYEIFMRIAERRFGGT
LEGRFVLTAGLGGMGGAQPLAGRMAGAAILCVEIDPERARKRREIGYLDEIAPDLDGALARIEQARAKGQALSVGLVGNA
AEIYPRIAARGIVPDIVTDQTSAHDLVYGYVPVGYDLERVRRLRSQNPSELIPAGRASIAQHVRAMLHFQRAGAEVFDNG
NLIRTQAQAGGVADAFDIPVFTEAYLRPLFCRAIGPFRWMALSGDPADIARIDDLVLEMFPDNRIVTNWIRLARENVPFE
GLPARIAWLGHGERSALARRVNELVAAGELKGPVAFSRDHLDSAGMAHPNIMTENMRDGSDAIADWPLLDAMLLCASRAD
LVAIHSGGGGYAGYMTSAGVTIIADGTAAADVRLEQAIDNDTGLGVIRYADAGYPEAQDEVARKGINHLKL

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=551, Percent_Identity=30.8529945553539, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI260306182, Length=351, Percent_Identity=29.6296296296296, Blast_Score=131, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71997891, Length=568, Percent_Identity=29.9295774647887, Blast_Score=247, Evalue=9e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 59494; Mature: 59362

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRDNPRNPGFPIPSGSELRAKGWRQEALLRLMENVLAVGEDPDNLVVYAALGKAARDKA
CCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHH
AHDAIVRALTVMDEDQTLVIQSGKPVGLMKTSAEAPKVIMANCNIVGQWANAETFYDLER
HHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCCEEEEECCCEEEECCCCCCEEECCC
KGLVCWGGLTAGAWQYIGSQGVIQGTYEIFMRIAERRFGGTLEGRFVLTAGLGGMGGAQP
CCEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCC
LAGRMAGAAILCVEIDPERARKRREIGYLDEIAPDLDGALARIEQARAKGQALSVGLVGN
HHHHCCCEEEEEEEECHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECC
AAEIYPRIAARGIVPDIVTDQTSAHDLVYGYVPVGYDLERVRRLRSQNPSELIPAGRASI
HHHHHHHHHHCCCCCCHHCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCHHHCCCCHHHH
AQHVRAMLHFQRAGAEVFDNGNLIRTQAQAGGVADAFDIPVFTEAYLRPLFCRAIGPFRW
HHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEE
MALSGDPADIARIDDLVLEMFPDNRIVTNWIRLARENVPFEGLPARIAWLGHGERSALAR
EEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHH
RVNELVAAGELKGPVAFSRDHLDSAGMAHPNIMTENMRDGSDAIADWPLLDAMLLCASRA
HHHHHHHHCCCCCCCEECHHCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHCCCC
DLVAIHSGGGGYAGYMTSAGVTIIADGTAAADVRLEQAIDNDTGLGVIRYADAGYPEAQD
CEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCHHH
EVARKGINHLKL
HHHHCCHHHCCC
>Mature Secondary Structure 
PRDNPRNPGFPIPSGSELRAKGWRQEALLRLMENVLAVGEDPDNLVVYAALGKAARDKA
CCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHH
AHDAIVRALTVMDEDQTLVIQSGKPVGLMKTSAEAPKVIMANCNIVGQWANAETFYDLER
HHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCCEEEEECCCEEEECCCCCCEEECCC
KGLVCWGGLTAGAWQYIGSQGVIQGTYEIFMRIAERRFGGTLEGRFVLTAGLGGMGGAQP
CCEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCC
LAGRMAGAAILCVEIDPERARKRREIGYLDEIAPDLDGALARIEQARAKGQALSVGLVGN
HHHHCCCEEEEEEEECHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECC
AAEIYPRIAARGIVPDIVTDQTSAHDLVYGYVPVGYDLERVRRLRSQNPSELIPAGRASI
HHHHHHHHHHCCCCCCHHCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCHHHCCCCHHHH
AQHVRAMLHFQRAGAEVFDNGNLIRTQAQAGGVADAFDIPVFTEAYLRPLFCRAIGPFRW
HHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEE
MALSGDPADIARIDDLVLEMFPDNRIVTNWIRLARENVPFEGLPARIAWLGHGERSALAR
EEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHH
RVNELVAAGELKGPVAFSRDHLDSAGMAHPNIMTENMRDGSDAIADWPLLDAMLLCASRA
HHHHHHHHCCCCCCCEECHHCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHCCCC
DLVAIHSGGGGYAGYMTSAGVTIIADGTAAADVRLEQAIDNDTGLGVIRYADAGYPEAQD
CEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCHHH
EVARKGINHLKL
HHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA