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The map label for this gene is argH [H]

Identifier: 119357138

GI number: 119357138

Start: 1520304

End: 1521710

Strand: Direct

Name: argH [H]

Synonym: Cpha266_1327

Alternate gene names: 119357138

Gene position: 1520304-1521710 (Clockwise)

Preceding gene: 119357136

Following gene: 119357140

Centisome position: 48.51

GC content: 53.8

Gene sequence:

>1407_bases
ATGGACACTCCTATGAGCGACAAGAAAGAACTTCTCTGGCAGAGCCGGTTTTCCGAACCTTTTGATCGTGATGCGCTCCG
GTTCTCGTCATCGGTTCATATCGATAAAGCGTTGTTCCGCGAAGATATCGAGGGGTCGATCGCTCATGTCACCATGCTTG
CCGAACAGGATATCATCAGTGATGCCGAATGTGCCGATCTGGTTCAGGGGCTCAGGGAGATCGAGGAGGAACTTGCCTCC
GGGACTCTTGTTCCGCACTGGGAGGACGAGGATATTCATACGGTTATTGAAAACCGGCTGAAGGAAAAAATAGGTCAGAC
AGCCGGAAAAATCCATTCGGGAAGAAGCCGAAACGACCAGGTTGCCACCGATACGCGGCTCTATCTGAGAAAAAAGATCG
CCGAACTGCAGGATGCGGTGCAGGCCATGCAGCAGATGCTGATCGGGAAAGCCGAAACATACAAGGAGACGATTATTTTC
GGCTATACCCACCTGCAGCGGGCGCAGCCGATCTCTGCCGGCCACTACTATCTCGCCTGGTTCAGCATGTTCAGACGCGA
CAGGGAGCGGCTCCGTGATCTTCTCCGACGGGTGAACATCTCTCCGCTCGGAGCGGCGGCATTTGCCGGAAGCACGCTCC
CGCTCAATCCGGCACGAACGGCCGAGCTGCTTGCGTTTGACGATATATTTTCGAACAGCATCGATGCCGTAAGCGACAGG
GATATTCTGATCGAGTTTATCTCCGCCTGCTCGATCATGATGATGCATCTGTCGCGATTTGCCGAAGACCTGATTCTCTG
GAGCTCCTACGAGTTCGGCTATCTTGAAATCAGCGATGCCTTTGCAACAGGTTCGTCCCTGATGCCGCAGAAAAAAAACG
CCGATATTGCCGAACTGGTGAGGGGAAAAACAGGAAGGGTTTACGGTAACCTCGTGAGCATGCTGACCATCATGAAAGGG
CTTCCGCTCTCCTACAACCGCGACATGCAGGAGGACAAGCAGCCGCTTTTTGATACGGCTGAAACCACCATCAGCAGCAT
GCGGATTTTCACCAAACTGATCGGTCATACGACGCTGAAGGTGGAACGGCTCAGATCGCTGACATCGGAGGATCTGAGCC
TTGCGACCGAGATTGCCGAGTACCTCGTTTCCAGAAACCTTCCCTTCCGCGAGGCTCACCGGATAACGGGCAAAATCGTC
ACCTTCAGCATCGGCGAAGGCATTACGCTTCCAAGAATCACGCTGGAGCAGTTCAGAACGTTTTCGCCCCTTTTCGACAG
CGCCATCTACGACTCGCTTAAACCTGAAGCGAGCGTGAACTCAAAGAAATCGCACGGAAGCTGCTCGTTCCGATCCGTTG
AAGCACAGCTTGCCGAAGCGAGAGCGCAGATGCAGGAAAACAGGTAG

Upstream 100 bases:

>100_bases
GCATTCCTGATCGTATTGAAATGGTTAACCAGAGAGAAGAGTCGTAGAGTGATGATTGGTGAAATTTGTTATTTTGCGGG
CAAATTAATTCCCGTAATCA

Downstream 100 bases:

>100_bases
CGATATGCGGCACAGGAAAACGACCCGATATCGAGTGCCGGGATAACGGGATTTACGATGCCTTGCAGGTTTTTCCTTAC
TTCAATGCCTGCGATCCGCT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MDTPMSDKKELLWQSRFSEPFDRDALRFSSSVHIDKALFREDIEGSIAHVTMLAEQDIISDAECADLVQGLREIEEELAS
GTLVPHWEDEDIHTVIENRLKEKIGQTAGKIHSGRSRNDQVATDTRLYLRKKIAELQDAVQAMQQMLIGKAETYKETIIF
GYTHLQRAQPISAGHYYLAWFSMFRRDRERLRDLLRRVNISPLGAAAFAGSTLPLNPARTAELLAFDDIFSNSIDAVSDR
DILIEFISACSIMMMHLSRFAEDLILWSSYEFGYLEISDAFATGSSLMPQKKNADIAELVRGKTGRVYGNLVSMLTIMKG
LPLSYNRDMQEDKQPLFDTAETTISSMRIFTKLIGHTTLKVERLRSLTSEDLSLATEIAEYLVSRNLPFREAHRITGKIV
TFSIGEGITLPRITLEQFRTFSPLFDSAIYDSLKPEASVNSKKSHGSCSFRSVEAQLAEARAQMQENR

Sequences:

>Translated_468_residues
MDTPMSDKKELLWQSRFSEPFDRDALRFSSSVHIDKALFREDIEGSIAHVTMLAEQDIISDAECADLVQGLREIEEELAS
GTLVPHWEDEDIHTVIENRLKEKIGQTAGKIHSGRSRNDQVATDTRLYLRKKIAELQDAVQAMQQMLIGKAETYKETIIF
GYTHLQRAQPISAGHYYLAWFSMFRRDRERLRDLLRRVNISPLGAAAFAGSTLPLNPARTAELLAFDDIFSNSIDAVSDR
DILIEFISACSIMMMHLSRFAEDLILWSSYEFGYLEISDAFATGSSLMPQKKNADIAELVRGKTGRVYGNLVSMLTIMKG
LPLSYNRDMQEDKQPLFDTAETTISSMRIFTKLIGHTTLKVERLRSLTSEDLSLATEIAEYLVSRNLPFREAHRITGKIV
TFSIGEGITLPRITLEQFRTFSPLFDSAIYDSLKPEASVNSKKSHGSCSFRSVEAQLAEARAQMQENR
>Mature_468_residues
MDTPMSDKKELLWQSRFSEPFDRDALRFSSSVHIDKALFREDIEGSIAHVTMLAEQDIISDAECADLVQGLREIEEELAS
GTLVPHWEDEDIHTVIENRLKEKIGQTAGKIHSGRSRNDQVATDTRLYLRKKIAELQDAVQAMQQMLIGKAETYKETIIF
GYTHLQRAQPISAGHYYLAWFSMFRRDRERLRDLLRRVNISPLGAAAFAGSTLPLNPARTAELLAFDDIFSNSIDAVSDR
DILIEFISACSIMMMHLSRFAEDLILWSSYEFGYLEISDAFATGSSLMPQKKNADIAELVRGKTGRVYGNLVSMLTIMKG
LPLSYNRDMQEDKQPLFDTAETTISSMRIFTKLIGHTTLKVERLRSLTSEDLSLATEIAEYLVSRNLPFREAHRITGKIV
TFSIGEGITLPRITLEQFRTFSPLFDSAIYDSLKPEASVNSKKSHGSCSFRSVEAQLAEARAQMQENR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=461, Percent_Identity=40.1301518438178, Blast_Score=358, Evalue=8e-99,
Organism=Homo sapiens, GI68303542, Length=461, Percent_Identity=40.1301518438178, Blast_Score=358, Evalue=8e-99,
Organism=Homo sapiens, GI68303549, Length=461, Percent_Identity=37.9609544468547, Blast_Score=325, Evalue=7e-89,
Organism=Homo sapiens, GI68303547, Length=461, Percent_Identity=38.177874186551, Blast_Score=323, Evalue=2e-88,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=39.8678414096916, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321806, Length=464, Percent_Identity=40.948275862069, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221473854, Length=446, Percent_Identity=36.5470852017937, Blast_Score=301, Evalue=8e-82,
Organism=Drosophila melanogaster, GI78706858, Length=446, Percent_Identity=36.5470852017937, Blast_Score=301, Evalue=8e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 52956; Mature: 52956

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTPMSDKKELLWQSRFSEPFDRDALRFSSSVHIDKALFREDIEGSIAHVTMLAEQDIIS
CCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
DAECADLVQGLREIEEELASGTLVPHWEDEDIHTVIENRLKEKIGQTAGKIHSGRSRNDQ
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
VATDTRLYLRKKIAELQDAVQAMQQMLIGKAETYKETIIFGYTHLQRAQPISAGHYYLAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECHHHHHHCCCCCCCHHHHHH
FSMFRRDRERLRDLLRRVNISPLGAAAFAGSTLPLNPARTAELLAFDDIFSNSIDAVSDR
HHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCH
DILIEFISACSIMMMHLSRFAEDLILWSSYEFGYLEISDAFATGSSLMPQKKNADIAELV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCCCCCCCCCCCCHHHHH
RGKTGRVYGNLVSMLTIMKGLPLSYNRDMQEDKQPLFDTAETTISSMRIFTKLIGHTTLK
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHH
VERLRSLTSEDLSLATEIAEYLVSRNLPFREAHRITGKIVTFSIGEGITLPRITLEQFRT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEEEECCCCCCCCHHHHHHHHH
FSPLFDSAIYDSLKPEASVNSKKSHGSCSFRSVEAQLAEARAQMQENR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDTPMSDKKELLWQSRFSEPFDRDALRFSSSVHIDKALFREDIEGSIAHVTMLAEQDIIS
CCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
DAECADLVQGLREIEEELASGTLVPHWEDEDIHTVIENRLKEKIGQTAGKIHSGRSRNDQ
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
VATDTRLYLRKKIAELQDAVQAMQQMLIGKAETYKETIIFGYTHLQRAQPISAGHYYLAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECHHHHHHCCCCCCCHHHHHH
FSMFRRDRERLRDLLRRVNISPLGAAAFAGSTLPLNPARTAELLAFDDIFSNSIDAVSDR
HHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCH
DILIEFISACSIMMMHLSRFAEDLILWSSYEFGYLEISDAFATGSSLMPQKKNADIAELV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCCCCCCCCCCCCHHHHH
RGKTGRVYGNLVSMLTIMKGLPLSYNRDMQEDKQPLFDTAETTISSMRIFTKLIGHTTLK
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHH
VERLRSLTSEDLSLATEIAEYLVSRNLPFREAHRITGKIVTFSIGEGITLPRITLEQFRT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEEEECCCCCCCCHHHHHHHHH
FSPLFDSAIYDSLKPEASVNSKKSHGSCSFRSVEAQLAEARAQMQENR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA