Click here to switch to the map view.

The map label for this gene is fba [H]

Identifier: 119357140

GI number: 119357140

Start: 1524013

End: 1524987

Strand: Direct

Name: fba [H]

Synonym: Cpha266_1329

Alternate gene names: 119357140

Gene position: 1524013-1524987 (Clockwise)

Preceding gene: 119357138

Following gene: 119357146

Centisome position: 48.63

GC content: 48.92

Gene sequence:

>975_bases
ATGCAAAACATTTCAGTCGGCTTTAAAGAACTGGGACTTGTCAACAGCAGGGACCTGTTTGCTAAAGCTGTCAGCGGGGG
TTACGCGATTCCCGCATATAATTTCAATAATCTCGAACAGCTCCAGGCAATCATCATGGCCTGTGCCGAAACCGCTTCGC
CGGTAATTTTACAGGTATCCAAAGGCGCAAGAAGCTATGCCAACGAAACGCTTCTGCGTTTTCTTGCCCAGGGTGCCGTG
GCCTATGCTGCAGAACTTGGAACACCTGTTCCTATTGTCCTTCATCTCGATCATGGCGACAGTTTTGAACTGTGCAAGGA
TTGTATCGAGTCGGGGTTTTCATCGGTCATGATCGATGGTTCGCATCTTCCCTATGAAGAAAACGTCGCTCTCACGAAAA
AAGTTGTCGAATATGCTCATCAGTTCGATGTGACGGTTGAAGGCGAACTTGGCGTTCTTGCCGGCATCGAAGACGAGATT
TCGGCTGCGCACCATACCTATACACAGCCTGAAGAGGTTGAGGATTTTGTGGCAAAAACCGGCGTTGACAGTCTTGCCAT
CTCAATTGGTACATCACACGGCGCATTCAAGTTCAAACCAGGCGAAGACCCGAAAATCCGTCTTGATATTCTGACCGAAA
TTGAACGCCGCATTCCCGGATTTCCCATCGTGCTGCATGGCTCCTCTTCCGTTCCGCAGGACCTTGTTAAAACCATCAAC
GAGCATGGCGGAAAACTGAAGGATGCTATCGGTATCAGCGAAGACCAGCTTCGTCTGGCTGCAAAGTCGGCGGTTTGCAA
AATCAACATCGATTCCGATGGACGTCTTGCCATGACTGCGGCAATTCGCAAAGTGCTCGATGAAAAGCCTGAAGAGTTTG
ACCCAAGAAAATATCTTGGTCCTGCAAGGGATGCGCTGAAACAGCTTTATATCCACAAGATCATCAACGTTCTCGGATCG
AACAACAAAGCCTGA

Upstream 100 bases:

>100_bases
AACTATTATATTGCAATTCTCTATAAATCAATTTACTGTTTTTTCATAAACCGGCTAAAAAAAACAGCGGCGGATAATAA
CAATTAAAGGAGACCTTTCA

Downstream 100 bases:

>100_bases
CTTATCTGAAATCAGTCAAAAAAGGCGCTCAACGGGCGCCTTTTTTGTTGGGGGAAAAGGGATTTTCTGCTAAGAGCGTA
AAAGATCGAGAAAACGGGCT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MQNISVGFKELGLVNSRDLFAKAVSGGYAIPAYNFNNLEQLQAIIMACAETASPVILQVSKGARSYANETLLRFLAQGAV
AYAAELGTPVPIVLHLDHGDSFELCKDCIESGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGIEDEI
SAAHHTYTQPEEVEDFVAKTGVDSLAISIGTSHGAFKFKPGEDPKIRLDILTEIERRIPGFPIVLHGSSSVPQDLVKTIN
EHGGKLKDAIGISEDQLRLAAKSAVCKINIDSDGRLAMTAAIRKVLDEKPEEFDPRKYLGPARDALKQLYIHKIINVLGS
NNKA

Sequences:

>Translated_324_residues
MQNISVGFKELGLVNSRDLFAKAVSGGYAIPAYNFNNLEQLQAIIMACAETASPVILQVSKGARSYANETLLRFLAQGAV
AYAAELGTPVPIVLHLDHGDSFELCKDCIESGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGIEDEI
SAAHHTYTQPEEVEDFVAKTGVDSLAISIGTSHGAFKFKPGEDPKIRLDILTEIERRIPGFPIVLHGSSSVPQDLVKTIN
EHGGKLKDAIGISEDQLRLAAKSAVCKINIDSDGRLAMTAAIRKVLDEKPEEFDPRKYLGPARDALKQLYIHKIINVLGS
NNKA
>Mature_324_residues
MQNISVGFKELGLVNSRDLFAKAVSGGYAIPAYNFNNLEQLQAIIMACAETASPVILQVSKGARSYANETLLRFLAQGAV
AYAAELGTPVPIVLHLDHGDSFELCKDCIESGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGIEDEI
SAAHHTYTQPEEVEDFVAKTGVDSLAISIGTSHGAFKFKPGEDPKIRLDILTEIERRIPGFPIVLHGSSSVPQDLVKTIN
EHGGKLKDAIGISEDQLRLAAKSAVCKINIDSDGRLAMTAAIRKVLDEKPEEFDPRKYLGPARDALKQLYIHKIINVLGS
NNKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=316, Percent_Identity=36.7088607594937, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI87082041, Length=315, Percent_Identity=34.6031746031746, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1788072, Length=305, Percent_Identity=30.4918032786885, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1789293, Length=315, Percent_Identity=26.031746031746, Blast_Score=78, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322790, Length=343, Percent_Identity=26.530612244898, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 35126; Mature: 35126

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00602 ALDOLASE_CLASS_II_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNISVGFKELGLVNSRDLFAKAVSGGYAIPAYNFNNLEQLQAIIMACAETASPVILQVS
CCCCCCCHHHHCCCCCHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEC
KGARSYANETLLRFLAQGAVAYAAELGTPVPIVLHLDHGDSFELCKDCIESGFSSVMIDG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECC
SHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGIEDEISAAHHTYTQPEEVEDFVAKT
CCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEEECCHHHHHHHHCCCCCHHHHHHHHHHC
GVDSLAISIGTSHGAFKFKPGEDPKIRLDILTEIERRIPGFPIVLHGSSSVPQDLVKTIN
CCCCEEEEEECCCCEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
EHGGKLKDAIGISEDQLRLAAKSAVCKINIDSDGRLAMTAAIRKVLDEKPEEFDPRKYLG
HCCCCCHHHCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHCC
PARDALKQLYIHKIINVLGSNNKA
HHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQNISVGFKELGLVNSRDLFAKAVSGGYAIPAYNFNNLEQLQAIIMACAETASPVILQVS
CCCCCCCHHHHCCCCCHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEC
KGARSYANETLLRFLAQGAVAYAAELGTPVPIVLHLDHGDSFELCKDCIESGFSSVMIDG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECC
SHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGIEDEISAAHHTYTQPEEVEDFVAKT
CCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEEECCHHHHHHHHCCCCCHHHHHHHHHHC
GVDSLAISIGTSHGAFKFKPGEDPKIRLDILTEIERRIPGFPIVLHGSSSVPQDLVKTIN
CCCCEEEEEECCCCEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
EHGGKLKDAIGISEDQLRLAAKSAVCKINIDSDGRLAMTAAIRKVLDEKPEEFDPRKYLG
HCCCCCHHHCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHCC
PARDALKQLYIHKIINVLGSNNKA
HHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]