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The map label for this gene is fumA [H]

Identifier: 119357007

GI number: 119357007

Start: 1345783

End: 1347312

Strand: Direct

Name: fumA [H]

Synonym: Cpha266_1191

Alternate gene names: 119357007

Gene position: 1345783-1347312 (Clockwise)

Preceding gene: 119357005

Following gene: 119357008

Centisome position: 42.94

GC content: 51.11

Gene sequence:

>1530_bases
ATGAAGAATTTCAGGGATTCAATCCTGCACCTTATCACTGAAACCTCGGCCAACCTGCCAAGCGATGTTCGCGCGGCCAT
TTCTCGCGCAATTGACGGGGAGGACGGTGATTCTCAGGCGGGGCTTGCCATGTCGACCATTTCGGTTAATATTGATATGG
CTGTCGACGCCGTTGCTCCAATATGTCAGGATACCGGCATGCCGACATTTTTCATCCATACGCCCGTTGGGGCGGATCAG
CTTTTAATGAAACGGGAGATTGAGGCGGCTGTCGCTGAAGCCTCGAGAACAGGAAAACTTCGCCCGAATGCCGTTGATGC
CATAAGCGGCAAAAACTCGGGAAACAATCTCGGTTGTCATGTTCCGGTTATTCATTTTGAGCCATGGGAGAAAGACGAGA
TTGACGTGAAGCTGATTCTGAAAGGGGGAGGGTGCGAAAACAAAAACATCCAGTACTCGCTGCCGTTTGATATTCCGGGT
CTTGGAAAAGCCGCGCGCGACCTTGATGGCGTTCGTAAATGCCTTCTGCATGCGGTTTATCAGGCACAAGGTCAGGGTTG
CAGTCCCGGCTTTATCGGTGTTGGTGTTGGCGGCGATCGTACGAGCGGGTATGAACTTGCAAAAAAACAGCTTCTCAGAA
CGGTTGATGATCGGAATCCGGATCCTGAACTTGATCAGCTTGAGGAAGAGATTATCAGAAAAGCAAACAGGCTTGATATC
GGACCGATGGGTTTTGGCGGAAAAACAACTCTTCTCGGCTGCAAGATCGGCAAGTCGCATCGGGTGCCGGCGAGTTTTTT
TGTCTCCGTGGCATATAACTGCTGGGCATACCGACGGCTTGGATTCCTTCTGGATCCCCTGACAGGCTCAATTATTCGGT
GGTTCTATCGTGAGGCCGATGAGATCAAGCGGATGGCTAAAGGCGCAGGAATGCCGCTAACCGGAAAAGAGGTTACTCTT
CGGGCTCCGATCAGCGAAGATGAAATCCGCAAACTCCGTGTAGGAGATGTTGTGATGATTAACGGCCCCATGCATACCGG
TCGCGACGCTTTTCATCACTATGTGATGCATCACGATCTTCCTGAAGAGATCGATACTCGCGGGGGCGTTCTCTACCATT
GCGGTCCAGTCGTTATGAAAAACGAACAGGATCACTATACCATTACCGCAGCAGGCCCGACAACGTCAATTAGGGAAGAG
CCTTATCAGGCTGACGTCATAAAAAAGCTCGATCTACGGGCAATTATCGGAAAGGGGGGAATGGGTCCTAAAACGCTGCA
GGGACTGAAAGAACATGGCGCTGTTTACCTTAACGCAATCGGCGGCGCAGCGCAGTATTATGCTCGCTGCATAACGGGCG
TTACCGGAGTTGATTTTCTTGAAGAGATGGGAGTTCCGGAAGCGATGTGGCATCTTGAGGTTCAATCATTTCCTGCGATT
GTAACCATGGACTCGCACGGCAACAGTCTGCACCAGCAGGTCGAAGAGCACTCTTTTACCATACTTGGCACGTTTGCTGA
CGAGAAATAG

Upstream 100 bases:

>100_bases
TCTCCATAACTCTTTGCAACGGTTCCGGTGTATTGCCTTCGCGTTGATTGTCCGCTTCATCTAACTTTTTTTCTTGTCTA
ACATAACCTCTTTTGTTGTT

Downstream 100 bases:

>100_bases
TGAACATTGGCGCTCCTCTGTACATGGTCGTAAGGCTTGAATGCCTGTTCTCGGGAAGGCGAAATATACAGAGGGGCCTA
TTAACAGAGATGCCATTATC

Product: fumarase

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MKNFRDSILHLITETSANLPSDVRAAISRAIDGEDGDSQAGLAMSTISVNIDMAVDAVAPICQDTGMPTFFIHTPVGADQ
LLMKREIEAAVAEASRTGKLRPNAVDAISGKNSGNNLGCHVPVIHFEPWEKDEIDVKLILKGGGCENKNIQYSLPFDIPG
LGKAARDLDGVRKCLLHAVYQAQGQGCSPGFIGVGVGGDRTSGYELAKKQLLRTVDDRNPDPELDQLEEEIIRKANRLDI
GPMGFGGKTTLLGCKIGKSHRVPASFFVSVAYNCWAYRRLGFLLDPLTGSIIRWFYREADEIKRMAKGAGMPLTGKEVTL
RAPISEDEIRKLRVGDVVMINGPMHTGRDAFHHYVMHHDLPEEIDTRGGVLYHCGPVVMKNEQDHYTITAAGPTTSIREE
PYQADVIKKLDLRAIIGKGGMGPKTLQGLKEHGAVYLNAIGGAAQYYARCITGVTGVDFLEEMGVPEAMWHLEVQSFPAI
VTMDSHGNSLHQQVEEHSFTILGTFADEK

Sequences:

>Translated_509_residues
MKNFRDSILHLITETSANLPSDVRAAISRAIDGEDGDSQAGLAMSTISVNIDMAVDAVAPICQDTGMPTFFIHTPVGADQ
LLMKREIEAAVAEASRTGKLRPNAVDAISGKNSGNNLGCHVPVIHFEPWEKDEIDVKLILKGGGCENKNIQYSLPFDIPG
LGKAARDLDGVRKCLLHAVYQAQGQGCSPGFIGVGVGGDRTSGYELAKKQLLRTVDDRNPDPELDQLEEEIIRKANRLDI
GPMGFGGKTTLLGCKIGKSHRVPASFFVSVAYNCWAYRRLGFLLDPLTGSIIRWFYREADEIKRMAKGAGMPLTGKEVTL
RAPISEDEIRKLRVGDVVMINGPMHTGRDAFHHYVMHHDLPEEIDTRGGVLYHCGPVVMKNEQDHYTITAAGPTTSIREE
PYQADVIKKLDLRAIIGKGGMGPKTLQGLKEHGAVYLNAIGGAAQYYARCITGVTGVDFLEEMGVPEAMWHLEVQSFPAI
VTMDSHGNSLHQQVEEHSFTILGTFADEK
>Mature_509_residues
MKNFRDSILHLITETSANLPSDVRAAISRAIDGEDGDSQAGLAMSTISVNIDMAVDAVAPICQDTGMPTFFIHTPVGADQ
LLMKREIEAAVAEASRTGKLRPNAVDAISGKNSGNNLGCHVPVIHFEPWEKDEIDVKLILKGGGCENKNIQYSLPFDIPG
LGKAARDLDGVRKCLLHAVYQAQGQGCSPGFIGVGVGGDRTSGYELAKKQLLRTVDDRNPDPELDQLEEEIIRKANRLDI
GPMGFGGKTTLLGCKIGKSHRVPASFFVSVAYNCWAYRRLGFLLDPLTGSIIRWFYREADEIKRMAKGAGMPLTGKEVTL
RAPISEDEIRKLRVGDVVMINGPMHTGRDAFHHYVMHHDLPEEIDTRGGVLYHCGPVVMKNEQDHYTITAAGPTTSIREE
PYQADVIKKLDLRAIIGKGGMGPKTLQGLKEHGAVYLNAIGGAAQYYARCITGVTGVDFLEEMGVPEAMWHLEVQSFPAI
VTMDSHGNSLHQQVEEHSFTILGTFADEK

Specific function: Unknown

COG id: COG1951

COG function: function code C; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1789442, Length=276, Percent_Identity=29.7101449275362, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789443, Length=172, Percent_Identity=34.8837209302326, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1787897, Length=478, Percent_Identity=24.8953974895398, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790564, Length=480, Percent_Identity=24.375, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004646
- InterPro:   IPR004647
- InterPro:   IPR011167 [H]

Pfam domain/function: PF05681 Fumerase; PF05683 Fumerase_C [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 55543; Mature: 55543

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFRDSILHLITETSANLPSDVRAAISRAIDGEDGDSQAGLAMSTISVNIDMAVDAVAP
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEHHHHHHH
ICQDTGMPTFFIHTPVGADQLLMKREIEAAVAEASRTGKLRPNAVDAISGKNSGNNLGCH
HHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCEE
VPVIHFEPWEKDEIDVKLILKGGGCENKNIQYSLPFDIPGLGKAARDLDGVRKCLLHAVY
EEEEEECCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
QAQGQGCSPGFIGVGVGGDRTSGYELAKKQLLRTVDDRNPDPELDQLEEEIIRKANRLDI
HHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
GPMGFGGKTTLLGCKIGKSHRVPASFFVSVAYNCWAYRRLGFLLDPLTGSIIRWFYREAD
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIKRMAKGAGMPLTGKEVTLRAPISEDEIRKLRVGDVVMINGPMHTGRDAFHHYVMHHDL
HHHHHHHCCCCCCCCCCEEEECCCCHHHHHEEEECCEEEECCCCCCCHHHHHHHHHHCCC
PEEIDTRGGVLYHCGPVVMKNEQDHYTITAAGPTTSIREEPYQADVIKKLDLRAIIGKGG
CHHHHCCCCEEEECCCEEECCCCCCEEEEECCCCCCHHCCCCHHHHHHHHHHHEEECCCC
MGPKTLQGLKEHGAVYLNAIGGAAQYYARCITGVTGVDFLEEMGVPEAMWHLEVQSFPAI
CCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHCCCCHHHEEEECCCCCEE
VTMDSHGNSLHQQVEEHSFTILGTFADEK
EEECCCCCHHHHHHHHCCEEEEEECCCCC
>Mature Secondary Structure
MKNFRDSILHLITETSANLPSDVRAAISRAIDGEDGDSQAGLAMSTISVNIDMAVDAVAP
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEHHHHHHH
ICQDTGMPTFFIHTPVGADQLLMKREIEAAVAEASRTGKLRPNAVDAISGKNSGNNLGCH
HHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCEE
VPVIHFEPWEKDEIDVKLILKGGGCENKNIQYSLPFDIPGLGKAARDLDGVRKCLLHAVY
EEEEEECCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
QAQGQGCSPGFIGVGVGGDRTSGYELAKKQLLRTVDDRNPDPELDQLEEEIIRKANRLDI
HHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
GPMGFGGKTTLLGCKIGKSHRVPASFFVSVAYNCWAYRRLGFLLDPLTGSIIRWFYREAD
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIKRMAKGAGMPLTGKEVTLRAPISEDEIRKLRVGDVVMINGPMHTGRDAFHHYVMHHDL
HHHHHHHCCCCCCCCCCEEEECCCCHHHHHEEEECCEEEECCCCCCCHHHHHHHHHHCCC
PEEIDTRGGVLYHCGPVVMKNEQDHYTITAAGPTTSIREEPYQADVIKKLDLRAIIGKGG
CHHHHCCCCEEEECCCEEECCCCCCEEEEECCCCCCHHCCCCHHHHHHHHHHHEEECCCC
MGPKTLQGLKEHGAVYLNAIGGAAQYYARCITGVTGVDFLEEMGVPEAMWHLEVQSFPAI
CCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHCCCCHHHEEEECCCCCEE
VTMDSHGNSLHQQVEEHSFTILGTFADEK
EEECCCCCHHHHHHHHCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8473853 [H]