Click here to switch to the map view.

The map label for this gene is gap [H]

Identifier: 118578785

GI number: 118578785

Start: 344058

End: 345503

Strand: Direct

Name: gap [H]

Synonym: Ppro_0343

Alternate gene names: 118578785

Gene position: 344058-345503 (Clockwise)

Preceding gene: 118578784

Following gene: 118578786

Centisome position: 8.58

GC content: 63.0

Gene sequence:

>1446_bases
ATGAACTTGGCAAAACAGGACGAATATCTGAATGAATGGCTGGACCACGAGGCGTGCGCCGAAGAGATGCTTCCCCTGAT
CGGCCGCCTCTACCGGGAGAAGAGCATTGTCACCACCATCTACGGTCGTTCACTGGTGCACAGCACCGCCATCGAGATCC
TGACAGCCCATCGTTTTGCCCGGCGGATCCTGGACAGGGAACTGTCGGTCCGTCAGACCTTCCCGGTTTTGCAGGCGATC
TCCAAACTGGATCTCGCTCCGGCGCGCATCGATCTGGGCAAACTGGCTGTCCGCTACGCGGGGCAGGAGGGGAGCCTCTC
CCTGGACCAGTATGTGGCACAGGAGCTGGCCACGGTCAACACCGGCTGCGGCCCCCTGCTGGACGAGCCCCAGGATATCG
TCCTCTACGGCTTCGGCCGCATCGGCCGCCTGCTGGCCCGCATCCTGGTGGAGAAGAAGGGGGGGGGCGAGAAGTTCCGC
CTCAAGGCCTTCGTGGTGCGCAAGGGAGCCGCCGACGACCTGCTCAAGCGTGCCAGCCTGCTGCAGCGCGACTCCGTGCA
CGGCCACTTCGGCGGCATCATCACCGTTGACGAAGAGGAGAACGCCATCATCGCCAACGGCAACATGATCCGCCTGATCT
ATTCCGATTCCCCCGAGAGTGTGGACTATACCCAGTATGGCATCAACAACGCCATCCTGATCGACAACACCGGCAAGTGG
CGCGACCGCGAGGGGCTGGGCAGGCACCTGAAGGCGCCCGGCATCAGCAAGGTGATCCTGACCGCTCCGGGCAAGGGGGA
CATCCCCAACGTGGTGCCGGGCATCAATAACGAGCTGATCACCCCGGAGGAGAACATCTTCTCGGCCGCCAGCTGCACCA
CCAACGCCATCGTGCCGGTGCTGAAAACCCTCAACGACCGTTTCGGCATCGTCCACTGCCACATGGAGACCTGCCACTCC
TACACCAACGACCAGAACCTGATCGACAACTACCATAAGGCATCCCGCCGCGGCAGAAGCGCTGCCCTGAACATGGTCAT
CACCGAGACCGGTGCGGCCAAGGCGGTGGCCAAGGTGGTTCCGTCGCTTGCTGGCAAGCTGACCGGCAACGCCATTCGCG
TGCCCACCCCCAACGTCTCCCTGGCGATCCTCAACATGGAGCTGACCCAGGAGGTGACGGTGGAGGAGGTCAACAACTAC
CTGCGGGACATCTCCCTGGAGTCTCCCCTGCAGAACCAGATCGGCTACACCAACTGCCCCGAGGTCGTCTCCAGCGACTT
CGTCGGCTCCCGGCAGGCCGGAGTGGTGGATTCCCTGGCCACCATCGCCGAGGGGAAGCGCTGCGTTCTCTACGTCTGGT
ACGACAACGAGTACGGCTACAGCTGCCAGGTAGTGCGCATGGTACAGAAGATGGCCGGGGTGGAGCTCCCCTCGCTGCCG
CTGTAG

Upstream 100 bases:

>100_bases
CAAGACCTATGTCGAGGATACTCTGGTTTGCGAGGCGGATTTCAAGGCAACGCTTGTGGATGCAAACCAATAATTTGAAT
ACAGAGACGGAGGGAAACGG

Downstream 100 bases:

>100_bases
GCTGAGGCGCGGTTTCGGATAGTGCCGTGGGGCCACGACCAGAGTCGTGGCCCTTTTTGTTTCAGTGGACGCTGGGCAGT
TTCGCCGCATCCGGTGATGC

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MNLAKQDEYLNEWLDHEACAEEMLPLIGRLYREKSIVTTIYGRSLVHSTAIEILTAHRFARRILDRELSVRQTFPVLQAI
SKLDLAPARIDLGKLAVRYAGQEGSLSLDQYVAQELATVNTGCGPLLDEPQDIVLYGFGRIGRLLARILVEKKGGGEKFR
LKAFVVRKGAADDLLKRASLLQRDSVHGHFGGIITVDEEENAIIANGNMIRLIYSDSPESVDYTQYGINNAILIDNTGKW
RDREGLGRHLKAPGISKVILTAPGKGDIPNVVPGINNELITPEENIFSAASCTTNAIVPVLKTLNDRFGIVHCHMETCHS
YTNDQNLIDNYHKASRRGRSAALNMVITETGAAKAVAKVVPSLAGKLTGNAIRVPTPNVSLAILNMELTQEVTVEEVNNY
LRDISLESPLQNQIGYTNCPEVVSSDFVGSRQAGVVDSLATIAEGKRCVLYVWYDNEYGYSCQVVRMVQKMAGVELPSLP
L

Sequences:

>Translated_481_residues
MNLAKQDEYLNEWLDHEACAEEMLPLIGRLYREKSIVTTIYGRSLVHSTAIEILTAHRFARRILDRELSVRQTFPVLQAI
SKLDLAPARIDLGKLAVRYAGQEGSLSLDQYVAQELATVNTGCGPLLDEPQDIVLYGFGRIGRLLARILVEKKGGGEKFR
LKAFVVRKGAADDLLKRASLLQRDSVHGHFGGIITVDEEENAIIANGNMIRLIYSDSPESVDYTQYGINNAILIDNTGKW
RDREGLGRHLKAPGISKVILTAPGKGDIPNVVPGINNELITPEENIFSAASCTTNAIVPVLKTLNDRFGIVHCHMETCHS
YTNDQNLIDNYHKASRRGRSAALNMVITETGAAKAVAKVVPSLAGKLTGNAIRVPTPNVSLAILNMELTQEVTVEEVNNY
LRDISLESPLQNQIGYTNCPEVVSSDFVGSRQAGVVDSLATIAEGKRCVLYVWYDNEYGYSCQVVRMVQKMAGVELPSLP
L
>Mature_481_residues
MNLAKQDEYLNEWLDHEACAEEMLPLIGRLYREKSIVTTIYGRSLVHSTAIEILTAHRFARRILDRELSVRQTFPVLQAI
SKLDLAPARIDLGKLAVRYAGQEGSLSLDQYVAQELATVNTGCGPLLDEPQDIVLYGFGRIGRLLARILVEKKGGGEKFR
LKAFVVRKGAADDLLKRASLLQRDSVHGHFGGIITVDEEENAIIANGNMIRLIYSDSPESVDYTQYGINNAILIDNTGKW
RDREGLGRHLKAPGISKVILTAPGKGDIPNVVPGINNELITPEENIFSAASCTTNAIVPVLKTLNDRFGIVHCHMETCHS
YTNDQNLIDNYHKASRRGRSAALNMVITETGAAKAVAKVVPSLAGKLTGNAIRVPTPNVSLAILNMELTQEVTVEEVNNY
LRDISLESPLQNQIGYTNCPEVVSSDFVGSRQAGVVDSLATIAEGKRCVLYVWYDNEYGYSCQVVRMVQKMAGVELPSLP
L

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=345, Percent_Identity=38.2608695652174, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI7657116, Length=338, Percent_Identity=36.3905325443787, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1788079, Length=341, Percent_Identity=37.2434017595308, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI1789295, Length=346, Percent_Identity=31.7919075144509, Blast_Score=168, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17534679, Length=346, Percent_Identity=35.5491329479769, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17534677, Length=346, Percent_Identity=35.5491329479769, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI32566163, Length=343, Percent_Identity=36.1516034985423, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17568413, Length=343, Percent_Identity=36.1516034985423, Blast_Score=184, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322468, Length=342, Percent_Identity=38.5964912280702, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6322409, Length=342, Percent_Identity=38.0116959064327, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321631, Length=342, Percent_Identity=38.0116959064327, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI85725000, Length=341, Percent_Identity=37.8299120234604, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI22023983, Length=341, Percent_Identity=37.8299120234604, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI17933600, Length=341, Percent_Identity=37.5366568914956, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI18110149, Length=341, Percent_Identity=37.5366568914956, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI19922412, Length=338, Percent_Identity=37.2781065088757, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 52899; Mature: 52899

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLAKQDEYLNEWLDHEACAEEMLPLIGRLYREKSIVTTIYGRSLVHSTAIEILTAHRFA
CCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRILDRELSVRQTFPVLQAISKLDLAPARIDLGKLAVRYAGQEGSLSLDQYVAQELATVN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEECCCCCCCCHHHHHHHHHHHHC
TGCGPLLDEPQDIVLYGFGRIGRLLARILVEKKGGGEKFRLKAFVVRKGAADDLLKRASL
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCHHHHHHHHHH
LQRDSVHGHFGGIITVDEEENAIIANGNMIRLIYSDSPESVDYTQYGINNAILIDNTGKW
HHHCCCCCCCCCEEEEECCCCEEEECCCEEEEEECCCCCCCCHHHHCCCCEEEEECCCCC
RDREGLGRHLKAPGISKVILTAPGKGDIPNVVPGINNELITPEENIFSAASCTTNAIVPV
CCHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHH
LKTLNDRFGIVHCHMETCHSYTNDQNLIDNYHKASRRGRSAALNMVITETGAAKAVAKVV
HHHHCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHHHCCCHHEEEEEEECCCHHHHHHHHH
PSLAGKLTGNAIRVPTPNVSLAILNMELTQEVTVEEVNNYLRDISLESPLQNQIGYTNCP
HHHHHHCCCCEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCH
EVVSSDFVGSRQAGVVDSLATIAEGKRCVLYVWYDNEYGYSCQVVRMVQKMAGVELPSLP
HHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
L
C
>Mature Secondary Structure
MNLAKQDEYLNEWLDHEACAEEMLPLIGRLYREKSIVTTIYGRSLVHSTAIEILTAHRFA
CCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRILDRELSVRQTFPVLQAISKLDLAPARIDLGKLAVRYAGQEGSLSLDQYVAQELATVN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEECCCCCCCCHHHHHHHHHHHHC
TGCGPLLDEPQDIVLYGFGRIGRLLARILVEKKGGGEKFRLKAFVVRKGAADDLLKRASL
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCHHHHHHHHHH
LQRDSVHGHFGGIITVDEEENAIIANGNMIRLIYSDSPESVDYTQYGINNAILIDNTGKW
HHHCCCCCCCCCEEEEECCCCEEEECCCEEEEEECCCCCCCCHHHHCCCCEEEEECCCCC
RDREGLGRHLKAPGISKVILTAPGKGDIPNVVPGINNELITPEENIFSAASCTTNAIVPV
CCHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHH
LKTLNDRFGIVHCHMETCHSYTNDQNLIDNYHKASRRGRSAALNMVITETGAAKAVAKVV
HHHHCCCCCEEEEEHHHHHCCCCCHHHHHHHHHHHHCCCHHEEEEEEECCCHHHHHHHHH
PSLAGKLTGNAIRVPTPNVSLAILNMELTQEVTVEEVNNYLRDISLESPLQNQIGYTNCP
HHHHHHCCCCEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCH
EVVSSDFVGSRQAGVVDSLATIAEGKRCVLYVWYDNEYGYSCQVVRMVQKMAGVELPSLP
HHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8508805; 10360571; 2401296; 7877172 [H]