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The map label for this gene is kynA

Identifier: 118478119

GI number: 118478119

Start: 2640200

End: 2641039

Strand: Reverse

Name: kynA

Synonym: BALH_2476

Alternate gene names: 118478119

Gene position: 2641039-2640200 (Counterclockwise)

Preceding gene: 118478120

Following gene: 118478118

Centisome position: 50.24

GC content: 36.55

Gene sequence:

>840_bases
ATGAAAGAAAATGAAAAGGTAATTATGGAAAAAGGGATTCATACGGACTTTAAAGAGAATATGACGTACGGGGAATATTT
ACAATTAGATAGTTTACTATCTTCTCAAAAGAGATTATCAGACCACCATGATGAAATGTTGTTCATCGTTATTCACCAAG
CAAGCGAACTTTGGATGAAGCTTATTTTACATGAGTTAAACGCAGCAATTGAATCTATTAAACAAGACAAATTACAACCA
GCTTTTAAAATGTTAGCACGTGTATCAAAAATTCAATCACAAATCATTCAATCTTGGGATATTCTTGCGACATTAACGCC
ATCCGAGTACATTGAGTTTCGTGACTCGCTCGGTCAAGCTTCAGGTTTTCAATCGTATCAATATCGTATGATTGAGTATG
CGCTTGGTTATAAAACGCCGCATGCCTTAAAAATTTATGAAAAAGATCCAGAATTACACGCTCGACTTCATACAGCGCTA
CATGCACCAAGTTTATATGATGTGGCAATTCAAGCTCTTGTAAAAGAAGGATTCCCAATTCATAAAGACGTGTTAAATCG
TGATATTACGCAGCCTTACGAAGAAGATGCAACAGTAGAAGCAGCATGGCTTGAAGTGTATGCGGATGTGAAAAAATATT
GGAATTTATATCAGCTTGCTGAAAAACTTATCGATATTGAAGATTGGCTACAACAATGGCGTTTCCGTCATATGAAAACG
GTAGAACGCATTATCGGACATAAAATGGGAACAGGCGGCTCTTCAGGTGTATCTTATTTAAAACGAGTACTTGATCAACG
TTTCTTCCCAGAGCTTTGGAATGTTCGCACGAAATTATAA

Upstream 100 bases:

>100_bases
CGCATTACCACTTGCCTTATCAGATGCAGATGGAAGTCCAGTTCGAGCAGTTATTAGACCAATATAAGTAGAAATATATA
TAAAGGGGCGTTTTGCTAAT

Downstream 100 bases:

>100_bases
AAACAAACCTGTCAGTTCATTACTGGCAGGTTTGTTTTTTATTTGAACACAAGTATGTTTTAATTAAAGCTACAAGATAT
AATAAATTAGGTAATGATTT

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MKENEKVIMEKGIHTDFKENMTYGEYLQLDSLLSSQKRLSDHHDEMLFIVIHQASELWMKLILHELNAAIESIKQDKLQP
AFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQASGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTAL
HAPSLYDVAIQALVKEGFPIHKDVLNRDITQPYEEDATVEAAWLEVYADVKKYWNLYQLAEKLIDIEDWLQQWRFRHMKT
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL

Sequences:

>Translated_279_residues
MKENEKVIMEKGIHTDFKENMTYGEYLQLDSLLSSQKRLSDHHDEMLFIVIHQASELWMKLILHELNAAIESIKQDKLQP
AFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQASGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTAL
HAPSLYDVAIQALVKEGFPIHKDVLNRDITQPYEEDATVEAAWLEVYADVKKYWNLYQLAEKLIDIEDWLQQWRFRHMKT
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL
>Mature_279_residues
MKENEKVIMEKGIHTDFKENMTYGEYLQLDSLLSSQKRLSDHHDEMLFIVIHQASELWMKLILHELNAAIESIKQDKLQP
AFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQASGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTAL
HAPSLYDVAIQALVKEGFPIHKDVLNRDITQPYEEDATVEAAWLEVYADVKKYWNLYQLAEKLIDIEDWLQQWRFRHMKT
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family

Homologues:

Organism=Homo sapiens, GI5032165, Length=138, Percent_Identity=37.6811594202899, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI32564651, Length=136, Percent_Identity=38.9705882352941, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17552370, Length=136, Percent_Identity=38.9705882352941, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17530891, Length=331, Percent_Identity=31.7220543806647, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): T23O_BACAH (A0REX0)

Other databases:

- EMBL:   CP000485
- RefSeq:   YP_895270.1
- ProteinModelPortal:   A0REX0
- SMR:   A0REX0
- STRING:   A0REX0
- EnsemblBacteria:   EBBACT00000066914
- GeneID:   4542617
- GenomeReviews:   CP000485_GR
- KEGG:   btl:BALH_2476
- NMPDR:   fig|412694.5.peg.2404
- eggNOG:   COG3483
- GeneTree:   EBGT00050000004238
- HOGENOM:   HBG647485
- OMA:   HWELYEL
- ProtClustDB:   CLSK904616
- BioCyc:   BTHU412694:BALH_2476-MONOMER
- InterPro:   IPR017485
- InterPro:   IPR004981
- PANTHER:   PTHR10138
- TIGRFAMs:   TIGR03036

Pfam domain/function: PF03301 Trp_dioxygenase

EC number: =1.13.11.11

Molecular weight: Translated: 32759; Mature: 32759

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: BINDING 110-110 BINDING 114-114 BINDING 121-121 BINDING 251-251

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKENEKVIMEKGIHTDFKENMTYGEYLQLDSLLSSQKRLSDHHDEMLFIVIHQASELWMK
CCCCHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHH
LILHELNAAIESIKQDKLQPAFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCC
SGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTALHAPSLYDVAIQALVKEGFPI
CCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCH
HKDVLNRDITQPYEEDATVEAAWLEVYADVKKYWNLYQLAEKLIDIEDWLQQWRFRHMKT
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCC
>Mature Secondary Structure
MKENEKVIMEKGIHTDFKENMTYGEYLQLDSLLSSQKRLSDHHDEMLFIVIHQASELWMK
CCCCHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHH
LILHELNAAIESIKQDKLQPAFKMLARVSKIQSQIIQSWDILATLTPSEYIEFRDSLGQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCC
SGFQSYQYRMIEYALGYKTPHALKIYEKDPELHARLHTALHAPSLYDVAIQALVKEGFPI
CCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCH
HKDVLNRDITQPYEEDATVEAAWLEVYADVKKYWNLYQLAEKLIDIEDWLQQWRFRHMKT
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VERIIGHKMGTGGSSGVSYLKRVLDQRFFPELWNVRTKL
HHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA