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The map label for this gene is ykwC [H]

Identifier: 118477304

GI number: 118477304

Start: 1765845

End: 1766732

Strand: Reverse

Name: ykwC [H]

Synonym: BALH_1619

Alternate gene names: 118477304

Gene position: 1766732-1765845 (Counterclockwise)

Preceding gene: 118477306

Following gene: 118477300

Centisome position: 33.61

GC content: 54.28

Gene sequence:

>888_bases
GTGATGGAGAACCCGCACCGTTCACCTGTTACAGTTATCGGCTTAGGTCCGATGGGCCAGGCGCTAGCTGGTGCATTCCT
GATGAACGGTCACCCTACGACATTATGGAACCGAACTGCCGAAAAAGCCGATTACCTTATTTCTCAGGGGGCGACCCTTT
CAAATTCAGTCACCGGCGCGGTCTCTGCAAGCCCCCTGGTGATCATTTGTGTTCTGGACTATAATGTCGTCCATGAAGTC
CTTGGCCCCGTGGGAGATGCCCTGAAGGGACGGACACTGGTGAACCTCACTGCCGACTCGCCCAAACGTGCCCGTGAAAT
GGCCACATGGGCTGCCCAACACGGAGTCGATTACCTCGATGGGGCAATTATGACCCCTACTCCGACCATCGGGACACCTG
CGGCTTCCGTCCTGTATAGTGGACCAGAATCCATCTTTAAGGTCCACCAACCGACCTTAGCAAGCTTAGGTGGCACTACT
TCTTATCTTGGGGCGGATCCTGGTCGGGCGGCGGCATATGATGTGGCCCTACTCGATCTATTTTGGACATCCATGAGCGG
TTACGCTCACGCTCTCGCACTTGCCACTGCCGAGAATATTCCGGCAAAGGAGTTCGCTATCTATGCCCAGGGTATCATAG
ACATCTTGCCCGACATCATGGCTTATTTGGCAAGCGAAGTAGACTCGGGTCACTACCCTGGTGACAAGTCCAATATCATC
TCAGCCTCGGCAGGAATGGAACACATTATCCATGCTGCTCAACACCACGGCCTCGACGTTAGCGTTCTGAGTGCTGCAAT
GGCCGTAACCCAGCAGGCCATCAACGAGGGCTATGGAACCGACGGATTCTCACGCTTGACCGAACTGCTAAAAAAACCGT
CTGCATAA

Upstream 100 bases:

>100_bases
AATTAAGTTTGAACATCTGAAAGGAGGCATTTTCATTGAAGAAAAATAACCAAAGTGAGAAAAAAAAAATATCAGTCAAG
TATCAGATACAGATGTATCT

Downstream 100 bases:

>100_bases
CATCATAGTCGTCTGTAGGGATCCCGGGTTCCGCCATGGTCGCGGACTGGGATCTTCAATTATTCCGTTGTTTCAACTAA
GGGAATTTCCATTTCTCATT

Product: dehydrogenase, 3-hydroxyisobutyrate dehydrogenase

Products: (R)-Glycerate; Nicotinamide adenine dinucleotide [C]

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MMENPHRSPVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEV
LGPVGDALKGRTLVNLTADSPKRAREMATWAAQHGVDYLDGAIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTT
SYLGADPGRAAAYDVALLDLFWTSMSGYAHALALATAENIPAKEFAIYAQGIIDILPDIMAYLASEVDSGHYPGDKSNII
SASAGMEHIIHAAQHHGLDVSVLSAAMAVTQQAINEGYGTDGFSRLTELLKKPSA

Sequences:

>Translated_295_residues
MMENPHRSPVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEV
LGPVGDALKGRTLVNLTADSPKRAREMATWAAQHGVDYLDGAIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTT
SYLGADPGRAAAYDVALLDLFWTSMSGYAHALALATAENIPAKEFAIYAQGIIDILPDIMAYLASEVDSGHYPGDKSNII
SASAGMEHIIHAAQHHGLDVSVLSAAMAVTQQAINEGYGTDGFSRLTELLKKPSA
>Mature_295_residues
MMENPHRSPVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEV
LGPVGDALKGRTLVNLTADSPKRAREMATWAAQHGVDYLDGAIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTT
SYLGADPGRAAAYDVALLDLFWTSMSGYAHALALATAENIPAKEFAIYAQGIIDILPDIMAYLASEVDSGHYPGDKSNII
SASAGMEHIIHAAQHHGLDVSVLSAAMAVTQQAINEGYGTDGFSRLTELLKKPSA

Specific function: Glyoxylate catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=195, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574115, Length=217, Percent_Identity=24.8847926267281, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: 1.1.1.60 [C]

Molecular weight: Translated: 30853; Mature: 30853

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMENPHRSPVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGA
CCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
VSASPLVIICVLDYNVVHEVLGPVGDALKGRTLVNLTADSPKRAREMATWAAQHGVDYLD
CCCCCEEEEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHC
GAIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTTSYLGADPGRAAAYDVALLDL
CEEECCCCCCCCCHHHHHHCCHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
FWTSMSGYAHALALATAENIPAKEFAIYAQGIIDILPDIMAYLASEVDSGHYPGDKSNII
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
SASAGMEHIIHAAQHHGLDVSVLSAAMAVTQQAINEGYGTDGFSRLTELLKKPSA
EHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MMENPHRSPVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGA
CCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
VSASPLVIICVLDYNVVHEVLGPVGDALKGRTLVNLTADSPKRAREMATWAAQHGVDYLD
CCCCCEEEEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHC
GAIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTTSYLGADPGRAAAYDVALLDL
CEEECCCCCCCCCHHHHHHCCHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
FWTSMSGYAHALALATAENIPAKEFAIYAQGIIDILPDIMAYLASEVDSGHYPGDKSNII
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
SASAGMEHIIHAAQHHGLDVSVLSAAMAVTQQAINEGYGTDGFSRLTELLKKPSA
EHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Hydroxy-3-oxopropanoate; H+; Nicotinamide adenine dinucleotide - reduced [C]

Specific reaction: 2-Hydroxy-3-oxopropanoate + H+ + Nicotinamide adenine dinucleotide - reduced --> (R)-Glycerate + Nicotinamide adenine dinucleotide [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]