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The map label for this gene is msrA [H]

Identifier: 118477306

GI number: 118477306

Start: 1767995

End: 1768594

Strand: Reverse

Name: msrA [H]

Synonym: BALH_1621

Alternate gene names: 118477306

Gene position: 1768594-1767995 (Counterclockwise)

Preceding gene: 118477307

Following gene: 118477304

Centisome position: 33.64

GC content: 35.67

Gene sequence:

>600_bases
TTGCGCAATAAAACTTTTTATATAATACTATTTAAAACATATATATTTAGGAGGATTACAATAATGTCCGAAAAAACATA
CGAACTCGCAACCTTCGCAGGCGGTTGCTTTTGGTGCATGGTAAAGCCATTTGATGAACTTCCTGGTATTCATAAAGTAC
TTTCTGGTTATGCAGGTGGTCATGTAGAAAACCCAACATATGAACAAGTAAAAGCTGGTACATCTGGTCATTTAGAAGTT
GTACAAATTACATTCGATCCTTCTATTTTTCCATATGAAAAATTACTAGATTTATATTGGCCACAAATCGATCCAACTGA
TGATGGCGGACAATTCTTTGACCGCGGTCCCTCTTATCGCACTGCTATTTTTTATCATAGTGAAACGCAAAAAGAGCTTG
CTGAAAAATCAAAACAAGCTCTTGCAGAAAGCGGTATGTTTAAAGATCCAATCGTAACTGAAATTCGCCCAGCTGCACCT
TTTTATGAAGCCGAAGAATACCACCAACATTTCTATAAAAAGAACCCTGAGAAATATGCTACTGAGCAAAAAGAATCTGG
CCGTGAAGACTTTATAAAAGAAAATTGGCAAAAAAAATAA

Upstream 100 bases:

>100_bases
ATTTCTCGCTTCTCCAGACAGCCGCTGGGTTACTGGACAATTAATTGATGTTAGCGGAGGCTCTTGTTTATAAAAAACAT
ATATTTTCGAATCTTTTTTA

Downstream 100 bases:

>100_bases
TAAAAACGCATCGTGCTCTCTTTTCAAAGTGCGATGCGTTTTTATCTTTGAAAAAAGTACCATACAATGATGAGAACAAC
CGCTGTTAATGTCCAAAGTG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MRNKTFYIILFKTYIFRRITIMSEKTYELATFAGGCFWCMVKPFDELPGIHKVLSGYAGGHVENPTYEQVKAGTSGHLEV
VQITFDPSIFPYEKLLDLYWPQIDPTDDGGQFFDRGPSYRTAIFYHSETQKELAEKSKQALAESGMFKDPIVTEIRPAAP
FYEAEEYHQHFYKKNPEKYATEQKESGREDFIKENWQKK

Sequences:

>Translated_199_residues
MRNKTFYIILFKTYIFRRITIMSEKTYELATFAGGCFWCMVKPFDELPGIHKVLSGYAGGHVENPTYEQVKAGTSGHLEV
VQITFDPSIFPYEKLLDLYWPQIDPTDDGGQFFDRGPSYRTAIFYHSETQKELAEKSKQALAESGMFKDPIVTEIRPAAP
FYEAEEYHQHFYKKNPEKYATEQKESGREDFIKENWQKK
>Mature_199_residues
MRNKTFYIILFKTYIFRRITIMSEKTYELATFAGGCFWCMVKPFDELPGIHKVLSGYAGGHVENPTYEQVKAGTSGHLEV
VQITFDPSIFPYEKLLDLYWPQIDPTDDGGQFFDRGPSYRTAIFYHSETQKELAEKSKQALAESGMFKDPIVTEIRPAAP
FYEAEEYHQHFYKKNPEKYATEQKESGREDFIKENWQKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. May deal with oxidative damage to alpha/beta-type SASP in sp

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=40.1273885350318, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=40.1273885350318, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI208609993, Length=153, Percent_Identity=37.9084967320261, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=41.4473684210526, Blast_Score=124, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=36.3013698630137, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=163, Percent_Identity=33.7423312883436, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=35.2112676056338, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664631, Length=142, Percent_Identity=34.5070422535211, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=34.3065693430657, Blast_Score=77, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23242; Mature: 23242

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNKTFYIILFKTYIFRRITIMSEKTYELATFAGGCFWCMVKPFDELPGIHKVLSGYAGG
CCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEEECCHHHCCHHHHHHHCCCCC
HVENPTYEQVKAGTSGHLEVVQITFDPSIFPYEKLLDLYWPQIDPTDDGGQFFDRGPSYR
CCCCCCHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCEE
TAIFYHSETQKELAEKSKQALAESGMFKDPIVTEIRPAAPFYEAEEYHQHFYKKNPEKYA
EEEEEECHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHCCCHHHH
TEQKESGREDFIKENWQKK
HHHHHCCHHHHHHHHCCCC
>Mature Secondary Structure
MRNKTFYIILFKTYIFRRITIMSEKTYELATFAGGCFWCMVKPFDELPGIHKVLSGYAGG
CCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEEECCHHHCCHHHHHHHCCCCC
HVENPTYEQVKAGTSGHLEVVQITFDPSIFPYEKLLDLYWPQIDPTDDGGQFFDRGPSYR
CCCCCCHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCEE
TAIFYHSETQKELAEKSKQALAESGMFKDPIVTEIRPAAPFYEAEEYHQHFYKKNPEKYA
EEEEEECHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHCCCHHHH
TEQKESGREDFIKENWQKK
HHHHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9573155 [H]