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The map label for this gene is hpcE [H]

Identifier: 118475989

GI number: 118475989

Start: 238484

End: 239443

Strand: Direct

Name: hpcE [H]

Synonym: BALH_0226

Alternate gene names: 118475989

Gene position: 238484-239443 (Clockwise)

Preceding gene: 118475988

Following gene: 118475990

Centisome position: 4.54

GC content: 39.69

Gene sequence:

>960_bases
ATGATGAAATTTGTTACATTTCGTCTTCCTTCAAAAGAAATGCGAGCTGGATGGCTTGAAGGTGACAAAGTAATCGATAT
GAATCTTGCTAGTGATGGGAAATTACCTTCTTCTATGTTCGCCTTTTTAGAGAAAGCGGATGAGTATGTAGAAGTATTGC
GTAATATTAAGAACCCGGAAAAGGGCATATATTCTTTAGAGGAAGTGCAATTAGCAGCAGCGATTCCTAATCCGAGTAGT
ATTCGGGATTTTTACGCGTTTGAGCAGCATGTAAAAACGGCACGTGGCCGAAGAGGGCTAGATGTTGTACCAGAATGGTA
TGATATCCCGGTTTTTTATTTTACGAACCATCGTGCTGTAATTGGTCCGAATGATGTTGTAATTGGTCCGAAAAAATCTG
AAAAACTTGATTATGAGTTAGAGATTGCTTGCGTAATCGGGAAAGAAGGAAGAAATATTTCTCGTGAGCAAGCAGAGGAA
TACATTTTTGGTTATTGTATTATGAATGATTGGAGTGCAAGGGACTTACAAGCAACAGAAATGAAGGTAGGACTTGGTCC
AGCGAAAGGAAAAGATTTTGCAACTTCATTAGGAGCGCACCTTGTTACGAAAGAGGAATTAGATATTTATCGCAACGGTG
ACCGTTATGAGTTAGAGATGACTGCTCATGTGAATGGAAAGCTATTATCAAAAGGGAACTTCCAAGATATTTACTATACA
TTTGCTGAAATGATTGAACGTGCTTCGGAAGATGTTACGTTATACCCAGGTGATGTGATTGGTTCTGGGACAGTAGGAAC
AGGTTGTATTTTAGAACTAGGTACAGAAGAGTGGCTGCAAGATGGTGATGTGGTAGAGCTTACGATTACTGGTTTAGGTA
CATTACGTAATACGGTCAAAAAAGAAAAGGAAGCAGGTGATGAGCATGTTTTATCGTCACATGGGGGAGCTACCTCATAA

Upstream 100 bases:

>100_bases
AATTGAAAGAGAACAAGAGCGTCGCGGGAATTTATAAAATTTATATCCACCAGCAATAATTCTTTTGCTGGTGGAAATTT
CATTTTCATAGGGAGGAATC

Downstream 100 bases:

>100_bases
ACGACATGTACAATTCCGTAAAAAAGATGGATCGCTTTATCGTGAACAGGTAATGGGAACAAAAGGTTTTTCTGGTACGC
AATCTATTTTGTATCATCAT

Product: fumarylacetoacetate hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MMKFVTFRLPSKEMRAGWLEGDKVIDMNLASDGKLPSSMFAFLEKADEYVEVLRNIKNPEKGIYSLEEVQLAAAIPNPSS
IRDFYAFEQHVKTARGRRGLDVVPEWYDIPVFYFTNHRAVIGPNDVVIGPKKSEKLDYELEIACVIGKEGRNISREQAEE
YIFGYCIMNDWSARDLQATEMKVGLGPAKGKDFATSLGAHLVTKEELDIYRNGDRYELEMTAHVNGKLLSKGNFQDIYYT
FAEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELTITGLGTLRNTVKKEKEAGDEHVLSSHGGATS

Sequences:

>Translated_319_residues
MMKFVTFRLPSKEMRAGWLEGDKVIDMNLASDGKLPSSMFAFLEKADEYVEVLRNIKNPEKGIYSLEEVQLAAAIPNPSS
IRDFYAFEQHVKTARGRRGLDVVPEWYDIPVFYFTNHRAVIGPNDVVIGPKKSEKLDYELEIACVIGKEGRNISREQAEE
YIFGYCIMNDWSARDLQATEMKVGLGPAKGKDFATSLGAHLVTKEELDIYRNGDRYELEMTAHVNGKLLSKGNFQDIYYT
FAEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELTITGLGTLRNTVKKEKEAGDEHVLSSHGGATS
>Mature_319_residues
MMKFVTFRLPSKEMRAGWLEGDKVIDMNLASDGKLPSSMFAFLEKADEYVEVLRNIKNPEKGIYSLEEVQLAAAIPNPSS
IRDFYAFEQHVKTARGRRGLDVVPEWYDIPVFYFTNHRAVIGPNDVVIGPKKSEKLDYELEIACVIGKEGRNISREQAEE
YIFGYCIMNDWSARDLQATEMKVGLGPAKGKDFATSLGAHLVTKEELDIYRNGDRYELEMTAHVNGKLLSKGNFQDIYYT
FAEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELTITGLGTLRNTVKKEKEAGDEHVLSSHGGATS

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=310, Percent_Identity=30.3225806451613, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI40786394, Length=305, Percent_Identity=30.4918032786885, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4557587, Length=289, Percent_Identity=28.3737024221453, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI13654274, Length=194, Percent_Identity=28.3505154639175, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI215422413, Length=156, Percent_Identity=29.4871794871795, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI66348062, Length=156, Percent_Identity=29.4871794871795, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17568863, Length=270, Percent_Identity=28.8888888888889, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28572127, Length=190, Percent_Identity=36.8421052631579, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24657182, Length=274, Percent_Identity=28.8321167883212, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24663695, Length=305, Percent_Identity=24.2622950819672, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571789, Length=197, Percent_Identity=25.8883248730964, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 35598; Mature: 35598

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKFVTFRLPSKEMRAGWLEGDKVIDMNLASDGKLPSSMFAFLEKADEYVEVLRNIKNPE
CCEEEEEECCCHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
KGIYSLEEVQLAAAIPNPSSIRDFYAFEQHVKTARGRRGLDVVPEWYDIPVFYFTNHRAV
HHCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCEEE
IGPNDVVIGPKKSEKLDYELEIACVIGKEGRNISREQAEEYIFGYCIMNDWSARDLQATE
ECCCCEEECCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHEEEEEEEECCCCCCCCEEEE
MKVGLGPAKGKDFATSLGAHLVTKEELDIYRNGDRYELEMTAHVNGKLLSKGNFQDIYYT
EEECCCCCCCCHHHHHHHHHHEEHHHHHHEECCCEEEEEEEEECCCEEECCCCCHHHHHH
FAEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELTITGLGTLRNTVK
HHHHHHHCCCCEEEECCCCCCCCCCCCCEEEEECCHHHHCCCCEEEEEEECCHHHHHHHH
KEKEAGDEHVLSSHGGATS
HHHHCCCHHHHHCCCCCCC
>Mature Secondary Structure
MMKFVTFRLPSKEMRAGWLEGDKVIDMNLASDGKLPSSMFAFLEKADEYVEVLRNIKNPE
CCEEEEEECCCHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
KGIYSLEEVQLAAAIPNPSSIRDFYAFEQHVKTARGRRGLDVVPEWYDIPVFYFTNHRAV
HHCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCEEE
IGPNDVVIGPKKSEKLDYELEIACVIGKEGRNISREQAEEYIFGYCIMNDWSARDLQATE
ECCCCEEECCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHEEEEEEEECCCCCCCCEEEE
MKVGLGPAKGKDFATSLGAHLVTKEELDIYRNGDRYELEMTAHVNGKLLSKGNFQDIYYT
EEECCCCCCCCHHHHHHHHHHEEHHHHHHEECCCEEEEEEEEECCCEEECCCCCHHHHHH
FAEMIERASEDVTLYPGDVIGSGTVGTGCILELGTEEWLQDGDVVELTITGLGTLRNTVK
HHHHHHHCCCCEEEECCCCCCCCCCCCCEEEEECCHHHHCCCCEEEEEEECCHHHHHHHH
KEKEAGDEHVLSSHGGATS
HHHHCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]