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The map label for this gene is hmgA

Identifier: 118475990

GI number: 118475990

Start: 239400

End: 240581

Strand: Direct

Name: hmgA

Synonym: BALH_0227

Alternate gene names: NA

Gene position: 239400-240581 (Clockwise)

Preceding gene: 118475989

Following gene: 118475991

Centisome position: 4.55

GC content: 39.59

Gene sequence:

>1182_bases
GTGATGAGCATGTTTTATCGTCACATGGGGGAGCTACCTCATAAACGACATGTACAATTCCGTAAAAAAGATGGATCGCT
TTATCGTGAACAGGTAATGGGAACAAAAGGTTTTTCTGGTACGCAATCTATTTTGTATCATCATTATATGCCAACGGAAG
TAGGGCATGCGGCATTATCACATTCTTGTCAGTTGCAGTATGAAGAAGATGTTGCTCTTTCTCATCGTCACTTTCGCACG
AAAGAAAATAAAAAAAGTGGTGATGCAGTAAGTGGAAGAAACTTTATACTTGGAAATGAAGATTTATTAATCGGAGTAGT
GACTCCAACAGAAAAAATGGACTATTTCTACCGTAACGGTGATGGCGATGAAATGTTGTTTGTCCATTACGGAACAGGGA
AAATTGAAACAATGTTCGGAACGATTCACTATCGAAAAGGTGATTATGTAACAATCCCAATTGGAACGATTTATCGTGTT
ATTCCAGATGAAGGAGAGACTAAGTTTCTTGTTTTAGAGGCAAATAGTCAAATTACTACACCGCGGCGCTATCGTAATGA
ATATGGACAATTGTTAGAGCATAGCCCGTTTTGTGAGAGGGATATTCGTGGCCCTGAAAAATTAGAGACGTATGATGAAA
AAGGTGAGTTTGTCGTAATGACAAAGTCGCGAGGGTATATGCATAAACATGTTTTAGGGCATCATCCGTTAGATGTTGTT
GGTTGGGATGGTTATTTATATCCGTGGGTCTTTAATGTTGAGGACTTTGAGCCAATCACAGGTCGTATTCATCAGCCACC
TCCAGTACATCAAACGTTCGAGGGTCACAATTTCGTTATTTGTTCTTTCGTACCACGTTTATATGACTATCATCCAGAAT
CTATTCCGGCACCGTATTATCATAGTAACGTGAATAGCGATGAAGTACTGTACTATGTAGAAGGTAACTTTATGAGCCGA
AAAGGTGTGGAGGAAGGGTCTATTACACTTCATCCGAGCGGCATTCCTCACGGTCCACATCCTGGGAAAACAGAGGCGAG
TATAGGGAAAAAAGAAACGCTTGAATTAGCTGTTATGATAGATACATTCCGTCCGCTTCGTATTGTAAAACAAGCACATG
AAACAGAAGATGAAAAATATATGTATAGCTGGATTGAAGAGGGATCATACACTGTGAAATAA

Upstream 100 bases:

>100_bases
CTAGGTACAGAAGAGTGGCTGCAAGATGGTGATGTGGTAGAGCTTACGATTACTGGTTTAGGTACATTACGTAATACGGT
CAAAAAAGAAAAGGAAGCAG

Downstream 100 bases:

>100_bases
ATAAAAAGAGGCATGCTCAATAACGGAGCATGCCTCTTTTATGGAATCGACATGTATAATAATACCAAAAAAAGTTATAG
AAAGATATATAGAAAGGATG

Product: homogentisate 1,2-dioxygenase

Products: 4-maleylacetoacetate

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MMSMFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHAALSHSCQLQYEEDVALSHRHFRT
KENKKSGDAVSGRNFILGNEDLLIGVVTPTEKMDYFYRNGDGDEMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRV
IPDEGETKFLVLEANSQITTPRRYRNEYGQLLEHSPFCERDIRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVV
GWDGYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYYHSNVNSDEVLYYVEGNFMSR
KGVEEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMIDTFRPLRIVKQAHETEDEKYMYSWIEEGSYTVK

Sequences:

>Translated_393_residues
MMSMFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHAALSHSCQLQYEEDVALSHRHFRT
KENKKSGDAVSGRNFILGNEDLLIGVVTPTEKMDYFYRNGDGDEMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRV
IPDEGETKFLVLEANSQITTPRRYRNEYGQLLEHSPFCERDIRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVV
GWDGYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYYHSNVNSDEVLYYVEGNFMSR
KGVEEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMIDTFRPLRIVKQAHETEDEKYMYSWIEEGSYTVK
>Mature_393_residues
MMSMFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHAALSHSCQLQYEEDVALSHRHFRT
KENKKSGDAVSGRNFILGNEDLLIGVVTPTEKMDYFYRNGDGDEMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRV
IPDEGETKFLVLEANSQITTPRRYRNEYGQLLEHSPFCERDIRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVV
GWDGYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYYHSNVNSDEVLYYVEGNFMSR
KGVEEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMIDTFRPLRIVKQAHETEDEKYMYSWIEEGSYTVK

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR014710 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: 1.13.11.5

Molecular weight: Translated: 45480; Mature: 45480

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSMFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHAALS
CHHHHHHHHCCCCCHHCCEEECCCCHHHHHHHCCCCCCCCCHHHEEEECCCHHHHHHHHC
HSCQLQYEEDVALSHRHFRTKENKKSGDAVSGRNFILGNEDLLIGVVTPTEKMDYFYRNG
CCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCHHHCCEEEECC
DGDEMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRVIPDEGETKFLVLEANSQITT
CCCEEEEEEECCCEEEEEEEEEEEECCCEEEEEHHHEEEEECCCCCEEEEEEECCCCCCC
PRRYRNEYGQLLEHSPFCERDIRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVV
CHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCEEE
GWDGYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYY
ECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCCE
HSNVNSDEVLYYVEGNFMSRKGVEEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMI
ECCCCCCEEEEEEECCEECCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
DTFRPLRIVKQAHETEDEKYMYSWIEEGSYTVK
ECCCHHHHHHHHHCCCCHHHHHHHHHCCCEECC
>Mature Secondary Structure
MMSMFYRHMGELPHKRHVQFRKKDGSLYREQVMGTKGFSGTQSILYHHYMPTEVGHAALS
CHHHHHHHHCCCCCHHCCEEECCCCHHHHHHHCCCCCCCCCHHHEEEECCCHHHHHHHHC
HSCQLQYEEDVALSHRHFRTKENKKSGDAVSGRNFILGNEDLLIGVVTPTEKMDYFYRNG
CCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCHHHCCEEEECC
DGDEMLFVHYGTGKIETMFGTIHYRKGDYVTIPIGTIYRVIPDEGETKFLVLEANSQITT
CCCEEEEEEECCCEEEEEEEEEEEECCCEEEEEHHHEEEEECCCCCEEEEEEECCCCCCC
PRRYRNEYGQLLEHSPFCERDIRGPEKLETYDEKGEFVVMTKSRGYMHKHVLGHHPLDVV
CHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCEEE
GWDGYLYPWVFNVEDFEPITGRIHQPPPVHQTFEGHNFVICSFVPRLYDYHPESIPAPYY
ECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCCE
HSNVNSDEVLYYVEGNFMSRKGVEEGSITLHPSGIPHGPHPGKTEASIGKKETLELAVMI
ECCCCCCEEEEEEECCEECCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
DTFRPLRIVKQAHETEDEKYMYSWIEEGSYTVK
ECCCHHHHHHHHHCCCCHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: homogentisate; O2

Specific reaction: homogentisate + O2 = 4-maleylacetoacetate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]