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The map label for this gene is fabB [H]

Identifier: 117919923

GI number: 117919923

Start: 1714724

End: 1715959

Strand: Direct

Name: fabB [H]

Synonym: Shewana3_1475

Alternate gene names: 117919923

Gene position: 1714724-1715959 (Clockwise)

Preceding gene: 117919921

Following gene: 117919924

Centisome position: 34.49

GC content: 48.22

Gene sequence:

>1236_bases
ATGTACACAATGGATAGCAATAAAATGAAAAGAGTCGTGATCACCGGAATGGGTGTTGTTTCAAGTATCGGTAATAACAA
GCAAGAAGTGACTGAGTCACTTAAAGCGGGCCGTAGTGGTATTACACATTCCGCTCAGTTTGAAGAAATGCAACTACGCA
GTCATGTATGGGGCAATATCAAATTAGATCCTTCTGAGCTGATTGACCGTAAAGCGCTGCGTTTTATGGGCGATGCTGCG
GCATATGCTTACATTGCAATGCAAGAAGCCATTAAGGATGCTCAGTTAACTGAAGAGCAGTATTCAAATCCTCGCGTAGG
TTTGATTGTGGGCACAGGCGGCGCTTCGTCTTCTAACCAAGTCCAAGCGGCGGATATTTTGCGCGAAAAAGGCGTAAAAC
GCGTCGGTCCTTATATTGTGCCACGCATTATGTCGAGCACTGCCAGCGCGTGTTTGGCGACACCCTTCAAAATCAAAGGC
ATGAACTATTCAATCAGTTCAGCCTGTGCGACCAGTGCTCACTGTATCGGTCACGCCGTTGAACTTATCCAAATGGGTAA
GCAAGATATGGTGTTTGCGGGCGGTTCGGAAGAAGTGGATTGGACCCTGACCATGGGCTTCGATGCAATGGGCGCACTGT
CGACTAAATATAACGACACTCCAGAAAAAGCCTCTCGTACCTATGATGCAGACCGTGATGGTTTCGTGATCTCCGGCGGC
GGCGGCATCTTAATCGTTGAAGAGTTAGAGCATGCTCTGGCTCGTGGCGCGAAGATTTACGCTGAAGTGATTGGTTATGG
CGCATCATCAGACGGTTACGACATGGTTGCTCCGTCTGGCGAAGGTGCGGTGCGTTGTATGCAAATGGCTCTGGCCGATG
TGGACACGCCAATTGATTTCATCAACACCCACGGTACTTCTACCCCAGTCGGTGACGTACGTGAGTTAGAAGCACTGCGT
GAAGTCTTTAAAGACAAGTGCCCACCAGTTGCATCGACTAAGTCTATGACTGGTCATGCATTAGGCGCGGCGGGTGTACA
CGAAGCCATCTACAGCTTGATCATGATGGAAAACAGCTTTATTGCGCCTAGCATCAACATCGATAACTTAGATGAAGCTG
CGAAGGACATGCCAATCGTGCGTGAATACCGCGATGCAGAGTTAAACACTGTCATGAGCAACAGCTTTGGTTTTGGTGGC
ACTAACGCAACATTAGTGATGCGTAAATATAAGTAA

Upstream 100 bases:

>100_bases
GGTCTCATATTGGGCATTATTTTACCCGCCTTTATGGAAAGCTGACCACTTAATTGAAGCAAAACAGATACTATTGGCTC
AGCAAAAAGTAGGTACTGAC

Downstream 100 bases:

>100_bases
GCCATTATTTTCGTTAAAAAAGGAAGCCTAGGCTTCCTTTTTTATTGGCTGAAATTGAGTAATACCAATCACAGTAAATA
TCTAATCAGTTCAGAGCCTC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MYTMDSNKMKRVVITGMGVVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGNIKLDPSELIDRKALRFMGDAA
AYAYIAMQEAIKDAQLTEEQYSNPRVGLIVGTGGASSSNQVQAADILREKGVKRVGPYIVPRIMSSTASACLATPFKIKG
MNYSISSACATSAHCIGHAVELIQMGKQDMVFAGGSEEVDWTLTMGFDAMGALSTKYNDTPEKASRTYDADRDGFVISGG
GGILIVEELEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAVRCMQMALADVDTPIDFINTHGTSTPVGDVRELEALR
EVFKDKCPPVASTKSMTGHALGAAGVHEAIYSLIMMENSFIAPSINIDNLDEAAKDMPIVREYRDAELNTVMSNSFGFGG
TNATLVMRKYK

Sequences:

>Translated_411_residues
MYTMDSNKMKRVVITGMGVVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGNIKLDPSELIDRKALRFMGDAA
AYAYIAMQEAIKDAQLTEEQYSNPRVGLIVGTGGASSSNQVQAADILREKGVKRVGPYIVPRIMSSTASACLATPFKIKG
MNYSISSACATSAHCIGHAVELIQMGKQDMVFAGGSEEVDWTLTMGFDAMGALSTKYNDTPEKASRTYDADRDGFVISGG
GGILIVEELEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAVRCMQMALADVDTPIDFINTHGTSTPVGDVRELEALR
EVFKDKCPPVASTKSMTGHALGAAGVHEAIYSLIMMENSFIAPSINIDNLDEAAKDMPIVREYRDAELNTVMSNSFGFGG
TNATLVMRKYK
>Mature_411_residues
MYTMDSNKMKRVVITGMGVVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGNIKLDPSELIDRKALRFMGDAA
AYAYIAMQEAIKDAQLTEEQYSNPRVGLIVGTGGASSSNQVQAADILREKGVKRVGPYIVPRIMSSTASACLATPFKIKG
MNYSISSACATSAHCIGHAVELIQMGKQDMVFAGGSEEVDWTLTMGFDAMGALSTKYNDTPEKASRTYDADRDGFVISGG
GGILIVEELEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAVRCMQMALADVDTPIDFINTHGTSTPVGDVRELEALR
EVFKDKCPPVASTKSMTGHALGAAGVHEAIYSLIMMENSFIAPSINIDNLDEAAKDMPIVREYRDAELNTVMSNSFGFGG
TNATLVMRKYK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=35.0710900473934, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=38.9221556886228, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI41872631, Length=338, Percent_Identity=26.0355029585799, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1788663, Length=405, Percent_Identity=70.3703703703704, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=38.0487804878049, Blast_Score=255, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI71983541, Length=418, Percent_Identity=35.6459330143541, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=40, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17550940, Length=362, Percent_Identity=25.9668508287293, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI212642053, Length=354, Percent_Identity=25.1412429378531, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=31.1804008908686, Blast_Score=192, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=38.1294964028777, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI19920632, Length=342, Percent_Identity=26.9005847953216, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221330659, Length=342, Percent_Identity=26.9005847953216, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24581345, Length=344, Percent_Identity=22.093023255814, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 44155; Mature: 44155

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTMDSNKMKRVVITGMGVVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGNI
CCCCCCCCCEEEEEECCHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCE
KLDPSELIDRKALRFMGDAAAYAYIAMQEAIKDAQLTEEQYSNPRVGLIVGTGGASSSNQ
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
VQAADILREKGVKRVGPYIVPRIMSSTASACLATPFKIKGMNYSISSACATSAHCIGHAV
HHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHH
ELIQMGKQDMVFAGGSEEVDWTLTMGFDAMGALSTKYNDTPEKASRTYDADRDGFVISGG
HHHHCCCCCEEEECCCCCEEEEEEECCCCHHHCCCCCCCCHHHHHCCCCCCCCCEEEECC
GGILIVEELEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAVRCMQMALADVDTPIDF
CCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCHHH
INTHGTSTPVGDVRELEALREVFKDKCPPVASTKSMTGHALGAAGVHEAIYSLIMMENSF
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHCCCC
IAPSINIDNLDEAAKDMPIVREYRDAELNTVMSNSFGFGGTNATLVMRKYK
CCCCCCCCCHHHHHHCCCHHHHHCCCHHHHHHHCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MYTMDSNKMKRVVITGMGVVSSIGNNKQEVTESLKAGRSGITHSAQFEEMQLRSHVWGNI
CCCCCCCCCEEEEEECCHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCE
KLDPSELIDRKALRFMGDAAAYAYIAMQEAIKDAQLTEEQYSNPRVGLIVGTGGASSSNQ
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
VQAADILREKGVKRVGPYIVPRIMSSTASACLATPFKIKGMNYSISSACATSAHCIGHAV
HHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHH
ELIQMGKQDMVFAGGSEEVDWTLTMGFDAMGALSTKYNDTPEKASRTYDADRDGFVISGG
HHHHCCCCCEEEECCCCCEEEEEEECCCCHHHCCCCCCCCHHHHHCCCCCCCCCEEEECC
GGILIVEELEHALARGAKIYAEVIGYGASSDGYDMVAPSGEGAVRCMQMALADVDTPIDF
CCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCHHH
INTHGTSTPVGDVRELEALREVFKDKCPPVASTKSMTGHALGAAGVHEAIYSLIMMENSF
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHCCCC
IAPSINIDNLDEAAKDMPIVREYRDAELNTVMSNSFGFGGTNATLVMRKYK
CCCCCCCCCHHHHHHCCCHHHHHCCCHHHHHHHCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]