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The map label for this gene is rmlA1 [H]

Identifier: 117919839

GI number: 117919839

Start: 1606171

End: 1607109

Strand: Direct

Name: rmlA1 [H]

Synonym: Shewana3_1391

Alternate gene names: 117919839

Gene position: 1606171-1607109 (Clockwise)

Preceding gene: 117919838

Following gene: 117919840

Centisome position: 32.3

GC content: 45.47

Gene sequence:

>939_bases
ATGCTACAATCATCCCTTCACTTTGACTCACTAATCCTTGATATATCAATGAGAAAAGGCATTTTATTGGCGGGCGGGAC
CGGTTCTCGCCTATATCCGATGACACAGGTTGTATGTAAGCAATTATTGCCTATTTACGATAAGCCAATGATTTATTATC
CACTTGTTACCTTAATGCAGGCGGGCATAAAAGAGATTCTGATTATCTGTACTCGCGCTGATTTGCCTCTTTTTCAGGCA
TTGCTTGGTGATGGTCACTGTTGGGGCATTCAGCTTGAATATGCGGTACAGCCTTCTCCAAAGGGATTAGCCGAAGCACT
TATTATCGGAGAGGCTTTTTTGGCGGGAGAGGCCTGTGCGTTGATTCTGGGCGATAACTTATTTTACGGGCAACAACTGA
GCACAAACTTGTATAGAGCTTCTCTACTCGAAGTGGGGGCGACCGTTTTTGGCTACCATGTGGCTAATCCGAATGCCTAC
GGTGTTGTCGAATTTGATATGAGCGGAAAAGCGATTTCTATCGAAGAGAAACCCCGAGTTGCGCGTTCTTCCTATGCTAT
TCCTGGATTGTATTTCTTTGATAATAGGGCTAGTGAGTGGGCTAAAAAAGTAATGCCTTCGGCGCGGGGCGAGTTGGAGA
TCGTTGATCTAATCAATCAATATCTTCTGCTGGGGGAATTGCAGGTAGAAATAATGGGGCGGGGCACTGCTTGGCTCGAT
ACGGGAACGCCGGATGCGATGGCTGAAGCAACACAATTTATTGCTGCCATAGAGAAACGCCAAGGGTTGAAAGTGAACTG
CCCTGAAGAGGTTGCTTTTCATTCTGGTTGGATAGATGCTGCGCAGCTTACCGCTTTAGCACAACCTTTGCTTAAAAGCG
GTTATGGTGAGTATCTTTTGGGCTTATTAAATAAGCAGGTGTTCAATGAAGTGCATTGA

Upstream 100 bases:

>100_bases
GGTCGAAATACAGATCCCTGAGAAATAAGCTTAGATATTGTTTAGGCGACAATGCGATCTTGTTGAAGACCTCGTGCCAT
TCAGCTTTATCGGCATTTAT

Downstream 100 bases:

>100_bases
AACCGAGCTTGCAGAAGTATTGGTGTTCGAACCTCAAGTTTTTGGTGATGAACGCGGTTTTTTTATGGAAACCTTTAGAC
AATCGTTTTTCTCCGAGTGT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MLQSSLHFDSLILDISMRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQAGIKEILIICTRADLPLFQA
LLGDGHCWGIQLEYAVQPSPKGLAEALIIGEAFLAGEACALILGDNLFYGQQLSTNLYRASLLEVGATVFGYHVANPNAY
GVVEFDMSGKAISIEEKPRVARSSYAIPGLYFFDNRASEWAKKVMPSARGELEIVDLINQYLLLGELQVEIMGRGTAWLD
TGTPDAMAEATQFIAAIEKRQGLKVNCPEEVAFHSGWIDAAQLTALAQPLLKSGYGEYLLGLLNKQVFNEVH

Sequences:

>Translated_312_residues
MLQSSLHFDSLILDISMRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQAGIKEILIICTRADLPLFQA
LLGDGHCWGIQLEYAVQPSPKGLAEALIIGEAFLAGEACALILGDNLFYGQQLSTNLYRASLLEVGATVFGYHVANPNAY
GVVEFDMSGKAISIEEKPRVARSSYAIPGLYFFDNRASEWAKKVMPSARGELEIVDLINQYLLLGELQVEIMGRGTAWLD
TGTPDAMAEATQFIAAIEKRQGLKVNCPEEVAFHSGWIDAAQLTALAQPLLKSGYGEYLLGLLNKQVFNEVH
>Mature_312_residues
MLQSSLHFDSLILDISMRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQAGIKEILIICTRADLPLFQA
LLGDGHCWGIQLEYAVQPSPKGLAEALIIGEAFLAGEACALILGDNLFYGQQLSTNLYRASLLEVGATVFGYHVANPNAY
GVVEFDMSGKAISIEEKPRVARSSYAIPGLYFFDNRASEWAKKVMPSARGELEIVDLINQYLLLGELQVEIMGRGTAWLD
TGTPDAMAEATQFIAAIEKRQGLKVNCPEEVAFHSGWIDAAQLTALAQPLLKSGYGEYLLGLLNKQVFNEVH

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=285, Percent_Identity=62.1052631578947, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1790224, Length=288, Percent_Identity=57.6388888888889, Blast_Score=341, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI133931050, Length=182, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=286, Percent_Identity=22.027972027972, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 34208; Mature: 34208

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQSSLHFDSLILDISMRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQ
CCCCCCCHHHHEEEEECCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
AGIKEILIICTRADLPLFQALLGDGHCWGIQLEYAVQPSPKGLAEALIIGEAFLAGEACA
HHHHHEEEEEECCCCHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEE
LILGDNLFYGQQLSTNLYRASLLEVGATVFGYHVANPNAYGVVEFDMSGKAISIEEKPRV
EEEECCEEECCHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEECCCCCEEEECCCCCH
ARSSYAIPGLYFFDNRASEWAKKVMPSARGELEIVDLINQYLLLGELQVEIMGRGTAWLD
HHCCCCCCCEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEEECCEEEEC
TGTPDAMAEATQFIAAIEKRQGLKVNCPEEVAFHSGWIDAAQLTALAQPLLKSGYGEYLL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHH
GLLNKQVFNEVH
HHHHHHHHHHCC
>Mature Secondary Structure
MLQSSLHFDSLILDISMRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQ
CCCCCCCHHHHEEEEECCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
AGIKEILIICTRADLPLFQALLGDGHCWGIQLEYAVQPSPKGLAEALIIGEAFLAGEACA
HHHHHEEEEEECCCCHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEE
LILGDNLFYGQQLSTNLYRASLLEVGATVFGYHVANPNAYGVVEFDMSGKAISIEEKPRV
EEEECCEEECCHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEECCCCCEEEECCCCCH
ARSSYAIPGLYFFDNRASEWAKKVMPSARGELEIVDLINQYLLLGELQVEIMGRGTAWLD
HHCCCCCCCEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEEECCEEEEC
TGTPDAMAEATQFIAAIEKRQGLKVNCPEEVAFHSGWIDAAQLTALAQPLLKSGYGEYLL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHH
GLLNKQVFNEVH
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]