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The map label for this gene is parC [H]

Identifier: 117919184

GI number: 117919184

Start: 848757

End: 851033

Strand: Direct

Name: parC [H]

Synonym: Shewana3_0732

Alternate gene names: 117919184

Gene position: 848757-851033 (Clockwise)

Preceding gene: 117919183

Following gene: 117919187

Centisome position: 17.07

GC content: 51.03

Gene sequence:

>2277_bases
ATGAGTGACGCGATCAAGTTAAGCTTAGATGGCGTAGAGCAGATGCCCCTGCGGCGCTTTACCGAAGAAGCTTATCTGAA
CTATTCCATGTACGTCATCATGGACCGAGCCTTGCCCCATATCGGTGACGGGCTTAAGCCGGTGCAGCGGCGGATTATTT
ATGCCATGAGTGAGCTCGGGTTATCAGCTCAGTCAAAACATAAAAAATCAGCCCGTACCGTCGGTGACGTATTAGGTAAG
TACCATCCCCATGGCGACAGCGCGTGTTATGAGGCTATGGTACTGATGGCGCAGCCATTTTCTTACCGTTATCCGCTAGT
CGATGGTCAAGGTAACTGGGGTGCGCCAGACGATCCTAAGTCCTTCGCCGCGATGCGTTATACCGAGGCGCGCCTGTCTA
AGTTCTCCGAAGTATTATTGTCTGAGCTGGGACAAGGTACGGTCGAATGGGGCGCTAACTTCGATGGCACCTTGAAAGAA
CCTAAAGTGCTGCCCGCACGTTTGCCGCATATTTTACTCAATGGCATCACGGGTATCGCTGTCGGTATGGCGACGGATAT
TCCGCCCCATAACGCTAGAGAGTTAGTCAATGCCTGTGTGGCACTGCTTGACGATCCTAAACTCGAACTTGAGCAATTGA
TGGGCTATGTGCCTGGGCCTGATTATCCGACCGAGGCCGAGATCATCACGCCAGCGGCTGACATTGCCAAAGTCTATGAG
ACGGGCCGTGGCTCCATAAAAGCCCGCGCCGTGTATAGCGTCGATGCTGGTGAGATAGTGATCACCGCGCTGCCGCACCA
AGCCAGTAGCGGCAAAATTTTAGAGCAAATCGCCGCCCAGATGCAGGCGAAAAAGTTGCCTATGGTGGCTGACTTACGTG
ATGAGTCTGACCACGAAAACCCTGTGCGACTAGTGGTGGTGCCGCGTTCAAATCGCGTCGATTGCGATCAACTGATGGCG
CACTTGTTTGCGACCACAGATCTTGAGAAAAGCTTTAGGGTAAACCTGAACGTCTTGGGCCTAGATGGTCGTCCACGCGT
CAAAGGATTAAAAGAGCTATTAACCGAATGGTTAGAGTTCCGTGTCGATACCGTAAGGCGTCGTCTCGAGTATCGCCTCG
ATAAAGTCTTAGCACGGTTACATATCCTCGAAGCCTTGATGATAGCCTTCCTCAATATCGATGAAGTGATTGAAATCATT
CGTTTCCACGATGAGCCAAAGGCCGAGTTAATGGCGCGCTTTAACCTGACGGATAGGCAAGCCGAAGCCATCCTCGAGTT
AAAGTTACGTCATTTAGCCAAGTTAGAAGAGTTTAAAATCAAGGCCGAGCAGGATGAGCTTGAGGCCGAGCGTGAGAAAT
TAGAACAGTTATTAAGCTCAGATCGCCGCTTAAAAACCTTGATCAAGAAAGAATTAATTCAAGATGGCGAAACCTATGGC
GACGATCGCCGCTCACCGATTGTTGAGCGCCATGAATCCCGTGCCTTAACCGAGCAGGAGCTGACGCCGAGCGAGCCAGT
GACTGTAGTGTTATCTGAAAAAGGCTGGGTGCGTTGCGCTAAGGGCCATGATATCGATGCCGAGTCTTTGTCCTATAAGG
CGGGGGATCAATATCTATGCAGTGCGATGGGACGCAGTAATCAGGCGGCGGTATTTATTGATTCATCGGGACGCGCCTTT
GCGACCGACAGTCACAGCCTGCCATCGGCGAGGAGCCAAGGCGAGCCCATCACCACGCGCTTTAATATGGCGCCGGGTGA
AACCATGCAGCATGTGATTTTGGGTGAAGACGAGCAATGTTTCCTACTCGCCACCGATGCAGGTTACGGTTTTATCTGTA
CTTATAACGATATGGTGTCACGTAACAAGGCGGGTAAAGCCCTGTTAAGCTTACCGACGAATGCCAAGTCTTTGCCGCCG
AGACCTATTGACCGCAATCGCGAGATGTCGATTCTAGCCATCACCAATGAAGGGCGTATGTTACTGTTTTCATTGGAAGC
ATTGCCACAGTTGTCTAAGGGTAAGGGTAACAAGATTATCGGTATTCCGAGTGAGCGCGCTAAGAATCGTGAAGAGTTGA
TGACCCACTTACAACTTGTGCCAGCAGACACTTCGGTCACCCTATGGGCAGGTAAGCGTAAACTCACCTTAAAACCGAGC
GATTTAGAGCATTATCGGGGTGAACGTGGCCGCCGCGGCGCCAAGTTACCACGCGGGTTACAACGTGTTGATAGTGTTGA
ATTAGGCGAAGGTGCAGAGGTTTTACCTAGCATTTAA

Upstream 100 bases:

>100_bases
GATGGCGCAATGTACATCTCGGATGATTTGAAAGGTAACCTGTATCGGCTGTTCTATAAGGATGGCGATAATACTGAAGA
ACCACAGGAACTAGAAGAAA

Downstream 100 bases:

>100_bases
CGCTCATTTGAGCTTGCGTAAAGTTAGTCGCAACAAGTTAATAAAAGCCACTCAAGTGTCACTTGAGTGGCTTTTTTATG
ACAATCACTCAGTACTTTGT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 758; Mature: 757

Protein sequence:

>758_residues
MSDAIKLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELGLSAQSKHKKSARTVGDVLGK
YHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSKFSEVLLSELGQGTVEWGANFDGTLKE
PKVLPARLPHILLNGITGIAVGMATDIPPHNARELVNACVALLDDPKLELEQLMGYVPGPDYPTEAEIITPAADIAKVYE
TGRGSIKARAVYSVDAGEIVITALPHQASSGKILEQIAAQMQAKKLPMVADLRDESDHENPVRLVVVPRSNRVDCDQLMA
HLFATTDLEKSFRVNLNVLGLDGRPRVKGLKELLTEWLEFRVDTVRRRLEYRLDKVLARLHILEALMIAFLNIDEVIEII
RFHDEPKAELMARFNLTDRQAEAILELKLRHLAKLEEFKIKAEQDELEAEREKLEQLLSSDRRLKTLIKKELIQDGETYG
DDRRSPIVERHESRALTEQELTPSEPVTVVLSEKGWVRCAKGHDIDAESLSYKAGDQYLCSAMGRSNQAAVFIDSSGRAF
ATDSHSLPSARSQGEPITTRFNMAPGETMQHVILGEDEQCFLLATDAGYGFICTYNDMVSRNKAGKALLSLPTNAKSLPP
RPIDRNREMSILAITNEGRMLLFSLEALPQLSKGKGNKIIGIPSERAKNREELMTHLQLVPADTSVTLWAGKRKLTLKPS
DLEHYRGERGRRGAKLPRGLQRVDSVELGEGAEVLPSI

Sequences:

>Translated_758_residues
MSDAIKLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELGLSAQSKHKKSARTVGDVLGK
YHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSKFSEVLLSELGQGTVEWGANFDGTLKE
PKVLPARLPHILLNGITGIAVGMATDIPPHNARELVNACVALLDDPKLELEQLMGYVPGPDYPTEAEIITPAADIAKVYE
TGRGSIKARAVYSVDAGEIVITALPHQASSGKILEQIAAQMQAKKLPMVADLRDESDHENPVRLVVVPRSNRVDCDQLMA
HLFATTDLEKSFRVNLNVLGLDGRPRVKGLKELLTEWLEFRVDTVRRRLEYRLDKVLARLHILEALMIAFLNIDEVIEII
RFHDEPKAELMARFNLTDRQAEAILELKLRHLAKLEEFKIKAEQDELEAEREKLEQLLSSDRRLKTLIKKELIQDGETYG
DDRRSPIVERHESRALTEQELTPSEPVTVVLSEKGWVRCAKGHDIDAESLSYKAGDQYLCSAMGRSNQAAVFIDSSGRAF
ATDSHSLPSARSQGEPITTRFNMAPGETMQHVILGEDEQCFLLATDAGYGFICTYNDMVSRNKAGKALLSLPTNAKSLPP
RPIDRNREMSILAITNEGRMLLFSLEALPQLSKGKGNKIIGIPSERAKNREELMTHLQLVPADTSVTLWAGKRKLTLKPS
DLEHYRGERGRRGAKLPRGLQRVDSVELGEGAEVLPSI
>Mature_757_residues
SDAIKLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELGLSAQSKHKKSARTVGDVLGKY
HPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSKFSEVLLSELGQGTVEWGANFDGTLKEP
KVLPARLPHILLNGITGIAVGMATDIPPHNARELVNACVALLDDPKLELEQLMGYVPGPDYPTEAEIITPAADIAKVYET
GRGSIKARAVYSVDAGEIVITALPHQASSGKILEQIAAQMQAKKLPMVADLRDESDHENPVRLVVVPRSNRVDCDQLMAH
LFATTDLEKSFRVNLNVLGLDGRPRVKGLKELLTEWLEFRVDTVRRRLEYRLDKVLARLHILEALMIAFLNIDEVIEIIR
FHDEPKAELMARFNLTDRQAEAILELKLRHLAKLEEFKIKAEQDELEAEREKLEQLLSSDRRLKTLIKKELIQDGETYGD
DRRSPIVERHESRALTEQELTPSEPVTVVLSEKGWVRCAKGHDIDAESLSYKAGDQYLCSAMGRSNQAAVFIDSSGRAFA
TDSHSLPSARSQGEPITTRFNMAPGETMQHVILGEDEQCFLLATDAGYGFICTYNDMVSRNKAGKALLSLPTNAKSLPPR
PIDRNREMSILAITNEGRMLLFSLEALPQLSKGKGNKIIGIPSERAKNREELMTHLQLVPADTSVTLWAGKRKLTLKPSD
LEHYRGERGRRGAKLPRGLQRVDSVELGEGAEVLPSI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=344, Percent_Identity=23.8372093023256, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1789396, Length=739, Percent_Identity=67.7943166441137, Blast_Score=1060, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=703, Percent_Identity=35.9886201991465, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645845, Length=501, Percent_Identity=23.1536926147705, Blast_Score=79, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=391, Percent_Identity=23.0179028132992, Blast_Score=77, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84538; Mature: 84407

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAIKLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELG
CCCCEEEECCCCHHHHHHHHHHHHHHCEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHHC
LSAQSKHKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPK
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCH
SFAAMRYTEARLSKFSEVLLSELGQGTVEWGANFDGTLKEPKVLPARLPHILLNGITGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCHHHHH
VGMATDIPPHNARELVNACVALLDDPKLELEQLMGYVPGPDYPTEAEIITPAADIAKVYE
HHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEECCHHHHHHHHH
TGRGSIKARAVYSVDAGEIVITALPHQASSGKILEQIAAQMQAKKLPMVADLRDESDHEN
CCCCCEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCC
PVRLVVVPRSNRVDCDQLMAHLFATTDLEKSFRVNLNVLGLDGRPRVKGLKELLTEWLEF
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHH
RVDTVRRRLEYRLDKVLARLHILEALMIAFLNIDEVIEIIRFHDEPKAELMARFNLTDRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHCCCCHHH
AEAILELKLRHLAKLEEFKIKAEQDELEAEREKLEQLLSSDRRLKTLIKKELIQDGETYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCC
DDRRSPIVERHESRALTEQELTPSEPVTVVLSEKGWVRCAKGHDIDAESLSYKAGDQYLC
CCCCCCHHHHHHHHCCHHHCCCCCCCEEEEECCCCCEEECCCCCCCHHHCCCCCCHHHHH
SAMGRSNQAAVFIDSSGRAFATDSHSLPSARSQGEPITTRFNMAPGETMQHVILGEDEQC
HHHCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHEEECCCCCE
FLLATDAGYGFICTYNDMVSRNKAGKALLSLPTNAKSLPPRPIDRNREMSILAITNEGRM
EEEEECCCCEEEEECHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCE
LLFSLEALPQLSKGKGNKIIGIPSERAKNREELMTHLQLVPADTSVTLWAGKRKLTLKPS
EEEEHHHCCCHHCCCCCEEEECCCHHHCCHHHHHHHHEEECCCCEEEEEECCEEEEECCC
DLEHYRGERGRRGAKLPRGLQRVDSVELGEGAEVLPSI
HHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCHHCCCC
>Mature Secondary Structure 
SDAIKLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELG
CCCEEEECCCCHHHHHHHHHHHHHHCEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHHC
LSAQSKHKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPK
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCH
SFAAMRYTEARLSKFSEVLLSELGQGTVEWGANFDGTLKEPKVLPARLPHILLNGITGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCHHHHH
VGMATDIPPHNARELVNACVALLDDPKLELEQLMGYVPGPDYPTEAEIITPAADIAKVYE
HHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEECCHHHHHHHHH
TGRGSIKARAVYSVDAGEIVITALPHQASSGKILEQIAAQMQAKKLPMVADLRDESDHEN
CCCCCEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCC
PVRLVVVPRSNRVDCDQLMAHLFATTDLEKSFRVNLNVLGLDGRPRVKGLKELLTEWLEF
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHH
RVDTVRRRLEYRLDKVLARLHILEALMIAFLNIDEVIEIIRFHDEPKAELMARFNLTDRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHCCCCHHH
AEAILELKLRHLAKLEEFKIKAEQDELEAEREKLEQLLSSDRRLKTLIKKELIQDGETYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCC
DDRRSPIVERHESRALTEQELTPSEPVTVVLSEKGWVRCAKGHDIDAESLSYKAGDQYLC
CCCCCCHHHHHHHHCCHHHCCCCCCCEEEEECCCCCEEECCCCCCCHHHCCCCCCHHHHH
SAMGRSNQAAVFIDSSGRAFATDSHSLPSARSQGEPITTRFNMAPGETMQHVILGEDEQC
HHHCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHEEECCCCCE
FLLATDAGYGFICTYNDMVSRNKAGKALLSLPTNAKSLPPRPIDRNREMSILAITNEGRM
EEEEECCCCEEEEECHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCE
LLFSLEALPQLSKGKGNKIIGIPSERAKNREELMTHLQLVPADTSVTLWAGKRKLTLKPS
EEEEHHHCCCHHCCCCCEEEECCCHHHCCHHHHHHHHEEECCCCEEEEEECCEEEEECCC
DLEHYRGERGRRGAKLPRGLQRVDSVELGEGAEVLPSI
HHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]