Click here to switch to the map view.

The map label for this gene is aceE [H]

Identifier: 117918883

GI number: 117918883

Start: 485256

End: 487922

Strand: Direct

Name: aceE [H]

Synonym: Shewana3_0426

Alternate gene names: 117918883

Gene position: 485256-487922 (Clockwise)

Preceding gene: 117918882

Following gene: 117918884

Centisome position: 9.76

GC content: 48.71

Gene sequence:

>2667_bases
ATGTCTGAAGATATGCTACAAGACTTAGATCCGTTAGAGACTCAGGAATGGGTTGACGCCCTGCAAGCTGTATTAGAACA
GGAAGGCCCTGAACGCGCCCATTTCTTATTAGAGAAACTGATCGATAAAGCCCGTCGCAATGGCACGCACTTGCCTTACA
CTGCGACCACGGCCTATTTGAACACCATTCCAGCGGGTCAAGAGCCGCACATGCCAGGCAACCAAGAGATGGAACGTCGC
ATTCGCGCTATCATCCGTTGGAACGCCTTAGCTATGGTGCTGCGTGGTTCTAAGAAAGATTTAGAGTTAGGCGGCCATAT
TTCGAGTTTCGCGTCGAGCGCAACCATTTATGACGTATGCTTCAACCACTTCTTCCGCGCGCCAAACGAGAAAGACGGCG
GCGACTTAGTGTATTTCCAAGGCCATATCGCCCCAGGTATCTACGCGCGTTCATTCTTGGAAGGTCGTTTAACTGAAGAC
CAACTGGCTAACTTCCGTCAAGAAGTGGATGGCAAAGGTTTATCTTCTTATCCGCACCCTAAGTTGATGCCTGACTACTG
GCAATTCCCAACGGTTTCTATGGGTCTGGGTCCAATCCAAGCGATTTACCAAGCTCGCTTCTTAAAGTACCTGACTGACC
GTGGTCTGAAAGATTGTTCTGAGCAAACCGTATACTGCTTCTTAGGTGACGGTGAGTGTGACGAGCCAGAAGCCTTAGGT
GCGATTGGTTTAGCTGCCCGTGAAGAATTAGATAACTTAGTCTTTATCATCAACTGTAACCTGCAACGTCTGGACGGCCC
AGTACGCGGTAACGGTAAGATCATCCAAGAACTGGAAGGTGAATTCCGCGGCGCTGGCTGGGAAGTCGTGAAAGTGATTT
GGGGTCGTTACTGGGATCCATTATTGGCCCGTGATACCAGTGGTAAGTTACTGCAGTTAATGGAAGAAACCGTTGACGGT
GAATACCAAAACTGTAAAGCCAAAGGTGGCGCTTATACTCGCGAACACTTCTTCGGCAAATACCCAGAAACCGCCGAAAT
GGTGGCGAACATGTCAGATGATGACATTTGGCGCTTAAACCGTGGTGGTCATGACCCAGTTAAAGTGTACGCGGCATTAG
ACCATGCACGTAAGACTAAAGGTCGCCCAACGGTGATCCTGGCGAAAACCGTTAAAGGTTACGGCCTAGGTGATGCGGGT
GAAGGTAAGAACATCGCCCACAACGTGAAGAAAATGGGTATCGAGTCTATCCGTTACTTCCGCGATCGTTTCAATATCCC
CATTCCAGACGATCAATTAGAAGATCTGCCGTTCTACCACCCAGGTCCAGATTCGGAAGAAGTGAAGTACATGATGAGCC
GTCGTGCCGCACTACATGGTAGCGTGCCACAACGTCGTCAGAAGTTCAGCGAAGAGCTGGAAATTCCTTCACTGAAGATT
TTCGACTCGATTTTGCAGGGTTCTAACGGCCGTGAAATTTCGTCAACGATGGCGTTTGTTCGCGTACTGACTGCACTGTT
AAAAGACAAGAAAATTGGCAAAAACATCGTGCCAATTATTCCTGACGAAGCGCGTACCTTCGGTATGGAAGGCCTGTTCC
GTCAAGTGGGTATTTATGCTCACGAAGGCCAAAAATACGTCCCGCAAGACTCTGACCAAGTGGCTTACTACCGTGAAGAT
AAAACTGGTCAAGTGCTGCAGGAAGGTATTAACGAACTGGGTGCAATGTCATCTTGGGTAGCTGCTGCGACCAGCTACTC
AGTCAACGATACACCGATGATTCCATTCTACATCTACTACTCAATGTTCGGTTTCCAACGTATTGGCGACATGGCATGGG
CTGCGGGTGATATGCGTGCACGTGGCTTCTTAGTCGGTGGTACTTCAGGCCGTACAACACTGAACGGTGAAGGTTTACAG
CATCAGGACGGTCACAGTCACGTACTGGCTAACACTATTCCTAACTGTATTACCTACGATCCAACTTACGGTTATGAAAT
TGCCGTTATCGTTCAAGATGGTATTCGTCGCATGTACGGCGAAAAACAAGAAGATATCTTCTACTACCTGACCACAATGA
ACGAAAACTATATTCAGCCTGAAATGCCAGAAGGTGCCGAGGAAGGTATCGTTAAAGGTATCTACAAGTTGGAAACGGTT
AGCGGTTCGGGTAAAGGCAAAGTTCAGTTAATGAGCTGTGGCACCATTCTTGAGCAAACCCGCAAAGCGGCTCAAGCACT
GGCAAAAGACTTCGGCATCACTGCCGACGTATTCAGCGTCACCAGCTTCAACGAACTGACTCGCGATGGTCAAGCGGTTG
AGCGTTGGAACATGCTGCACCCAACTGAAACGCCAAAACAAGCGTATATCAGCCAAGTGATTTCAAGTGATGCTCCGGCA
ATCGCTGCGACTGACTACATGAAGATCTACGGCGAGCAGTTACGTGCATTTATGCCAACCGATTATAAAGTGTTAGGTAC
TGACGGTTTCGGTCGTTCAGACAGCCGTGACAACCTGCGTCACCACTTCGAAGTGGACGCTAAGTTCATCGTTATCGCGG
CACTGAAATCTCTGGTTGATCGTAAAGAGCTGCCTGTTGATGTGTTAGCGAATGCCATCAAGGAATACGGCATCGACGCT
GACAAGATCAATCCACAGTACGCGTAA

Upstream 100 bases:

>100_bases
GTTTAAAGAGTGGCGCTTAAGTTCCCGACTTTAGCAATCGCTAAAGCGGAATATGCCGCAAACACCATTCATCATCATGT
ATATAGAGAAGGACAGTGTC

Downstream 100 bases:

>100_bases
GAGGCAATAAAAATGGCTGAATTAAAAGAAGTTTTTGTTCCTGATATCGGCGGCGATGAAGTACAGGTTATCGAAATCTG
TGCTTCTGTGGGCGATACCT

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 888; Mature: 887

Protein sequence:

>888_residues
MSEDMLQDLDPLETQEWVDALQAVLEQEGPERAHFLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQEMERR
IRAIIRWNALAMVLRGSKKDLELGGHISSFASSATIYDVCFNHFFRAPNEKDGGDLVYFQGHIAPGIYARSFLEGRLTED
QLANFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGLKDCSEQTVYCFLGDGECDEPEALG
AIGLAAREELDNLVFIINCNLQRLDGPVRGNGKIIQELEGEFRGAGWEVVKVIWGRYWDPLLARDTSGKLLQLMEETVDG
EYQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKVYAALDHARKTKGRPTVILAKTVKGYGLGDAG
EGKNIAHNVKKMGIESIRYFRDRFNIPIPDDQLEDLPFYHPGPDSEEVKYMMSRRAALHGSVPQRRQKFSEELEIPSLKI
FDSILQGSNGREISSTMAFVRVLTALLKDKKIGKNIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDSDQVAYYRED
KTGQVLQEGINELGAMSSWVAAATSYSVNDTPMIPFYIYYSMFGFQRIGDMAWAAGDMRARGFLVGGTSGRTTLNGEGLQ
HQDGHSHVLANTIPNCITYDPTYGYEIAVIVQDGIRRMYGEKQEDIFYYLTTMNENYIQPEMPEGAEEGIVKGIYKLETV
SGSGKGKVQLMSCGTILEQTRKAAQALAKDFGITADVFSVTSFNELTRDGQAVERWNMLHPTETPKQAYISQVISSDAPA
IAATDYMKIYGEQLRAFMPTDYKVLGTDGFGRSDSRDNLRHHFEVDAKFIVIAALKSLVDRKELPVDVLANAIKEYGIDA
DKINPQYA

Sequences:

>Translated_888_residues
MSEDMLQDLDPLETQEWVDALQAVLEQEGPERAHFLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQEMERR
IRAIIRWNALAMVLRGSKKDLELGGHISSFASSATIYDVCFNHFFRAPNEKDGGDLVYFQGHIAPGIYARSFLEGRLTED
QLANFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGLKDCSEQTVYCFLGDGECDEPEALG
AIGLAAREELDNLVFIINCNLQRLDGPVRGNGKIIQELEGEFRGAGWEVVKVIWGRYWDPLLARDTSGKLLQLMEETVDG
EYQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKVYAALDHARKTKGRPTVILAKTVKGYGLGDAG
EGKNIAHNVKKMGIESIRYFRDRFNIPIPDDQLEDLPFYHPGPDSEEVKYMMSRRAALHGSVPQRRQKFSEELEIPSLKI
FDSILQGSNGREISSTMAFVRVLTALLKDKKIGKNIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDSDQVAYYRED
KTGQVLQEGINELGAMSSWVAAATSYSVNDTPMIPFYIYYSMFGFQRIGDMAWAAGDMRARGFLVGGTSGRTTLNGEGLQ
HQDGHSHVLANTIPNCITYDPTYGYEIAVIVQDGIRRMYGEKQEDIFYYLTTMNENYIQPEMPEGAEEGIVKGIYKLETV
SGSGKGKVQLMSCGTILEQTRKAAQALAKDFGITADVFSVTSFNELTRDGQAVERWNMLHPTETPKQAYISQVISSDAPA
IAATDYMKIYGEQLRAFMPTDYKVLGTDGFGRSDSRDNLRHHFEVDAKFIVIAALKSLVDRKELPVDVLANAIKEYGIDA
DKINPQYA
>Mature_887_residues
SEDMLQDLDPLETQEWVDALQAVLEQEGPERAHFLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQEMERRI
RAIIRWNALAMVLRGSKKDLELGGHISSFASSATIYDVCFNHFFRAPNEKDGGDLVYFQGHIAPGIYARSFLEGRLTEDQ
LANFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGLKDCSEQTVYCFLGDGECDEPEALGA
IGLAAREELDNLVFIINCNLQRLDGPVRGNGKIIQELEGEFRGAGWEVVKVIWGRYWDPLLARDTSGKLLQLMEETVDGE
YQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKVYAALDHARKTKGRPTVILAKTVKGYGLGDAGE
GKNIAHNVKKMGIESIRYFRDRFNIPIPDDQLEDLPFYHPGPDSEEVKYMMSRRAALHGSVPQRRQKFSEELEIPSLKIF
DSILQGSNGREISSTMAFVRVLTALLKDKKIGKNIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDSDQVAYYREDK
TGQVLQEGINELGAMSSWVAAATSYSVNDTPMIPFYIYYSMFGFQRIGDMAWAAGDMRARGFLVGGTSGRTTLNGEGLQH
QDGHSHVLANTIPNCITYDPTYGYEIAVIVQDGIRRMYGEKQEDIFYYLTTMNENYIQPEMPEGAEEGIVKGIYKLETVS
GSGKGKVQLMSCGTILEQTRKAAQALAKDFGITADVFSVTSFNELTRDGQAVERWNMLHPTETPKQAYISQVISSDAPAI
AATDYMKIYGEQLRAFMPTDYKVLGTDGFGRSDSRDNLRHHFEVDAKFIVIAALKSLVDRKELPVDVLANAIKEYGIDAD
KINPQYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=890, Percent_Identity=66.7415730337079, Blast_Score=1280, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99564; Mature: 99433

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDMLQDLDPLETQEWVDALQAVLEQEGPERAHFLLEKLIDKARRNGTHLPYTATTAYL
CCHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
NTIPAGQEPHMPGNQEMERRIRAIIRWNALAMVLRGSKKDLELGGHISSFASSATIYDVC
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHH
FNHFFRAPNEKDGGDLVYFQGHIAPGIYARSFLEGRLTEDQLANFRQEVDGKGLSSYPHP
HHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
KLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGLKDCSEQTVYCFLGDGECDEPEALG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEECCCCCCCCHHHH
AIGLAAREELDNLVFIINCNLQRLDGPVRGNGKIIQELEGEFRGAGWEVVKVIWGRYWDP
HHHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCH
LLARDTSGKLLQLMEETVDGEYQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLN
HHHCCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHCCCCCCHHHHHHCCCCCCEEECC
RGGHDPVKVYAALDHARKTKGRPTVILAKTVKGYGLGDAGEGKNIAHNVKKMGIESIRYF
CCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RDRFNIPIPDDQLEDLPFYHPGPDSEEVKYMMSRRAALHGSVPQRRQKFSEELEIPSLKI
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHH
FDSILQGSNGREISSTMAFVRVLTALLKDKKIGKNIVPIIPDEARTFGMEGLFRQVGIYA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCEEE
HEGQKYVPQDSDQVAYYREDKTGQVLQEGINELGAMSSWVAAATSYSVNDTPMIPFYIYY
ECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRIGDMAWAAGDMRARGFLVGGTSGRTTLNGEGLQHQDGHSHVLANTIPNCITYD
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCEEHHHHCCCCEECC
PTYGYEIAVIVQDGIRRMYGEKQEDIFYYLTTMNENYIQPEMPEGAEEGIVKGIYKLETV
CCCCCEEEEEEHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHEEEE
SGSGKGKVQLMSCGTILEQTRKAAQALAKDFGITADVFSVTSFNELTRDGQAVERWNMLH
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHCCCC
PTETPKQAYISQVISSDAPAIAATDYMKIYGEQLRAFMPTDYKVLGTDGFGRSDSRDNLR
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHH
HHFEVDAKFIVIAALKSLVDRKELPVDVLANAIKEYGIDADKINPQYA
HHEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
SEDMLQDLDPLETQEWVDALQAVLEQEGPERAHFLLEKLIDKARRNGTHLPYTATTAYL
CHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
NTIPAGQEPHMPGNQEMERRIRAIIRWNALAMVLRGSKKDLELGGHISSFASSATIYDVC
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHH
FNHFFRAPNEKDGGDLVYFQGHIAPGIYARSFLEGRLTEDQLANFRQEVDGKGLSSYPHP
HHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
KLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGLKDCSEQTVYCFLGDGECDEPEALG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEECCCCCCCCHHHH
AIGLAAREELDNLVFIINCNLQRLDGPVRGNGKIIQELEGEFRGAGWEVVKVIWGRYWDP
HHHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCH
LLARDTSGKLLQLMEETVDGEYQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLN
HHHCCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHCCCCCCHHHHHHCCCCCCEEECC
RGGHDPVKVYAALDHARKTKGRPTVILAKTVKGYGLGDAGEGKNIAHNVKKMGIESIRYF
CCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RDRFNIPIPDDQLEDLPFYHPGPDSEEVKYMMSRRAALHGSVPQRRQKFSEELEIPSLKI
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHH
FDSILQGSNGREISSTMAFVRVLTALLKDKKIGKNIVPIIPDEARTFGMEGLFRQVGIYA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCEEE
HEGQKYVPQDSDQVAYYREDKTGQVLQEGINELGAMSSWVAAATSYSVNDTPMIPFYIYY
ECCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRIGDMAWAAGDMRARGFLVGGTSGRTTLNGEGLQHQDGHSHVLANTIPNCITYD
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCEEHHHHCCCCEECC
PTYGYEIAVIVQDGIRRMYGEKQEDIFYYLTTMNENYIQPEMPEGAEEGIVKGIYKLETV
CCCCCEEEEEEHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHEEEE
SGSGKGKVQLMSCGTILEQTRKAAQALAKDFGITADVFSVTSFNELTRDGQAVERWNMLH
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHCCCC
PTETPKQAYISQVISSDAPAIAATDYMKIYGEQLRAFMPTDYKVLGTDGFGRSDSRDNLR
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHH
HHFEVDAKFIVIAALKSLVDRKELPVDVLANAIKEYGIDADKINPQYA
HHEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]