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The map label for this gene is pdhR [H]

Identifier: 117918882

GI number: 117918882

Start: 484423

End: 485175

Strand: Direct

Name: pdhR [H]

Synonym: Shewana3_0425

Alternate gene names: 117918882

Gene position: 484423-485175 (Clockwise)

Preceding gene: 117918881

Following gene: 117918883

Centisome position: 9.74

GC content: 50.2

Gene sequence:

>753_bases
ATGGCCTATAGTAAAATTAATCAGCCAAAAATTTCTGATGTGATCATGGCGCAACTCGAGCAGATGATCCTCGAAGGCAG
TTTACAGCCGGGTCAGAAATTACCGCCGGAGCGCGAACTGGCCATCCAGTTTGAAGTGTCTCGCCCTTCCTTGCGTGAAG
CCATTCAAAAGCTTGAGGCGAAAGGGCTATTAATGCGCCGTCAAGGCGGTGGCACTTATGTCAAAGAACAACTCTGGCAG
AGTCTTGCCGATCCTATCGTTGAATTAATGACTGCCGATCCAGAAAGCCAATACGACTTGCTGGAATTTCGTCATGCGAC
CGAAGGCATGATGGCCTATTTTGCCGCGTTGCGTGGCACAGACGCCGATATGCAAAATATCAAGCGTATGATCCTTGAGG
TGGAAGCCGCCACCAATATCGAACAACAAGCCGCTGCCATTGTGCGTTTTTACCGCGCAGTAGCTGAAGCGTCACACAAT
GTGGCTATGTTGCATCTCGTACTCAGTTTAACCCCTGTGCTGCATAAGAATGTGGCGCAAAACTTGGAGCTTTTAAGCCG
CCGCGAAGAAGCCTCCACTATGGCCAACGATCACAGACGTGCTCTGCTCGCTGCTATCGTTCGTCGTGATCCTGAAGCCG
CCAGAGAAGCCTCGAATGAACACTTAAGTTACATCGAAGAGGTGATGTTATCTGTGCGGGAAGAAGATAGCCGGTTGCAG
CGAAGTTTGCGCCGTTTAAAGAGTGGCGCTTAA

Upstream 100 bases:

>100_bases
TAAGGTCGATTTTCAATCTAGACATCAAAAGTATGATTTGATAAAGTGCGCTCACTCATAAAAATTGGTAAGACCAATTT
ACAACGGAGCTGAGCGCCAA

Downstream 100 bases:

>100_bases
GTTCCCGACTTTAGCAATCGCTAAAGCGGAATATGCCGCAAACACCATTCATCATCATGTATATAGAGAAGGACAGTGTC
ATGTCTGAAGATATGCTACA

Product: transcriptional regulator PdhR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MAYSKINQPKISDVIMAQLEQMILEGSLQPGQKLPPERELAIQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQ
SLADPIVELMTADPESQYDLLEFRHATEGMMAYFAALRGTDADMQNIKRMILEVEAATNIEQQAAAIVRFYRAVAEASHN
VAMLHLVLSLTPVLHKNVAQNLELLSRREEASTMANDHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
RSLRRLKSGA

Sequences:

>Translated_250_residues
MAYSKINQPKISDVIMAQLEQMILEGSLQPGQKLPPERELAIQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQ
SLADPIVELMTADPESQYDLLEFRHATEGMMAYFAALRGTDADMQNIKRMILEVEAATNIEQQAAAIVRFYRAVAEASHN
VAMLHLVLSLTPVLHKNVAQNLELLSRREEASTMANDHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
RSLRRLKSGA
>Mature_249_residues
AYSKINQPKISDVIMAQLEQMILEGSLQPGQKLPPERELAIQFEVSRPSLREAIQKLEAKGLLMRRQGGGTYVKEQLWQS
LADPIVELMTADPESQYDLLEFRHATEGMMAYFAALRGTDADMQNIKRMILEVEAATNIEQQAAAIVRFYRAVAEASHNV
AMLHLVLSLTPVLHKNVAQNLELLSRREEASTMANDHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQR
SLRRLKSGA

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=233, Percent_Identity=57.5107296137339, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1790032, Length=239, Percent_Identity=34.3096234309623, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1789353, Length=238, Percent_Identity=28.1512605042017, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790780, Length=230, Percent_Identity=29.1304347826087, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082208, Length=226, Percent_Identity=29.2035398230088, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI48994955, Length=216, Percent_Identity=28.2407407407407, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1789621, Length=233, Percent_Identity=27.4678111587983, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28261; Mature: 28130

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSKINQPKISDVIMAQLEQMILEGSLQPGQKLPPERELAIQFEVSRPSLREAIQKLEA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
KGLLMRRQGGGTYVKEQLWQSLADPIVELMTADPESQYDLLEFRHATEGMMAYFAALRGT
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
DADMQNIKRMILEVEAATNIEQQAAAIVRFYRAVAEASHNVAMLHLVLSLTPVLHKNVAQ
CHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
NLELLSRREEASTMANDHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RSLRRLKSGA
HHHHHHHCCC
>Mature Secondary Structure 
AYSKINQPKISDVIMAQLEQMILEGSLQPGQKLPPERELAIQFEVSRPSLREAIQKLEA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
KGLLMRRQGGGTYVKEQLWQSLADPIVELMTADPESQYDLLEFRHATEGMMAYFAALRGT
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
DADMQNIKRMILEVEAATNIEQQAAAIVRFYRAVAEASHNVAMLHLVLSLTPVLHKNVAQ
CHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
NLELLSRREEASTMANDHRRALLAAIVRRDPEAAREASNEHLSYIEEVMLSVREEDSRLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RSLRRLKSGA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]