Click here to switch to the map view.

The map label for this gene is silR [H]

Identifier: 117676235

GI number: 117676235

Start: 179552

End: 180232

Strand: Reverse

Name: silR [H]

Synonym: Shewana3_4296

Alternate gene names: 117676235

Gene position: 180232-179552 (Counterclockwise)

Preceding gene: 117676242

Following gene: 117676234

Centisome position: 64.61

GC content: 51.4

Gene sequence:

>681_bases
ATGAAAATATTGATCGTCGAAGACGAAATTAAAACAGGTGAATATCTCAGCAAAGGGCTTAGAGAGGCAGGGTTCGTAGT
GGATCACGCTGATAATGGTCTTACCGGATATCATCTCGCCATGACAGCCGAGTATGATTTAGTCATTCTGGACATCATGC
TGCCTGATATGAACGGCTGGGATATCATCCGGATGCTGCGCACTGCCGGAAAGGGTATGCCGGTCTTACTGCTGACGGCC
CTCGGCACGATCGAACACAGGGTCAAAGGACTGGAACTGGGTGCGGACGATTATCTGGTTAAACCCTTTGCGTTTGCCGA
ACTGCTAGCCCGGGTGAAAACCCTTCTGAGGCGGGGAAACACGATGATCACGGAAAGCCAGTTTAGGGTGGCTGGTCTCT
CGATTGATCTCGTATCCAGAAAAGTCAGTCGCGCCGGAAACCGCATTGTGCTCACCAGTAAAGAGTTCAGCCTGCTGGAA
TTTTTCATTCGCCATCAGGGAGAGGTTCTTCCCCGTTCCCTGATTGCCTCTCAGGTCTGGGACATGAATTTTGACAGCGA
CACTAACGCGATTGATGTCGCCGTAAAGCGACTCCGCGCTAAAATAGACAACGATTACGAGACAAAGCTGATCCAGACAG
TCCGGGGCGTGGGCTATATGCTGGAGGTCCCGGATGCATAG

Upstream 100 bases:

>100_bases
CGGGTGACAGGATAATGACAATGTTGTCATTTTTGCTGTAATCCGTTGATAATGATCGTGGGCGCAATAGAATGACCTTA
GCAGCCAGCCGGGGAGCAAG

Downstream 100 bases:

>100_bases
CAAACCTTCCAGGCACCCTTTCTCACTCTCCCTGCGGCTGACCTTTTTTATCAGCCTGTCCACGATACTGGCTTTTATCG
CCTTCACCTGGTTTATGCTG

Product: DNA-binding transcriptional activator CusR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MKILIVEDEIKTGEYLSKGLREAGFVVDHADNGLTGYHLAMTAEYDLVILDIMLPDMNGWDIIRMLRTAGKGMPVLLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVKTLLRRGNTMITESQFRVAGLSIDLVSRKVSRAGNRIVLTSKEFSLLE
FFIRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDNDYETKLIQTVRGVGYMLEVPDA

Sequences:

>Translated_226_residues
MKILIVEDEIKTGEYLSKGLREAGFVVDHADNGLTGYHLAMTAEYDLVILDIMLPDMNGWDIIRMLRTAGKGMPVLLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVKTLLRRGNTMITESQFRVAGLSIDLVSRKVSRAGNRIVLTSKEFSLLE
FFIRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDNDYETKLIQTVRGVGYMLEVPDA
>Mature_226_residues
MKILIVEDEIKTGEYLSKGLREAGFVVDHADNGLTGYHLAMTAEYDLVILDIMLPDMNGWDIIRMLRTAGKGMPVLLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVKTLLRRGNTMITESQFRVAGLSIDLVSRKVSRAGNRIVLTSKEFSLLE
FFIRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDNDYETKLIQTVRGVGYMLEVPDA

Specific function: Component of the sil cation-efflux system that confers resistance to silver. Probable member of a two-component regulatory system silS/silR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=85.3982300884956, Blast_Score=399, Evalue=1e-113,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=51.5981735159817, Blast_Score=234, Evalue=4e-63,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=41.6289592760181, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=36.3636363636364, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=36.1990950226244, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=34.9137931034483, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=33.1838565022422, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=35.2941176470588, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=33.6363636363636, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=35.8407079646018, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=32.7433628318584, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=34.6491228070175, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=29.646017699115, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.7359307359307, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=38.3177570093458, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790437, Length=138, Percent_Identity=31.1594202898551, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=32.1739130434783, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25327; Mature: 25327

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIVEDEIKTGEYLSKGLREAGFVVDHADNGLTGYHLAMTAEYDLVILDIMLPDMNGW
CEEEEEECCCCCHHHHHHHHHHHCCEEECCCCCCCEEEEEEECCCCEEEEEEEECCCCCH
DIIRMLRTAGKGMPVLLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVKTLLRRGN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEECCCCCEECHHHHHHHHHHHHHHHHCCC
TMITESQFRVAGLSIDLVSRKVSRAGNRIVLTSKEFSLLEFFIRHQGEVLPRSLIASQVW
CEEECCCEEEEEEEHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHH
DMNFDSDTNAIDVAVKRLRAKIDNDYETKLIQTVRGVGYMLEVPDA
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCC
>Mature Secondary Structure
MKILIVEDEIKTGEYLSKGLREAGFVVDHADNGLTGYHLAMTAEYDLVILDIMLPDMNGW
CEEEEEECCCCCHHHHHHHHHHHCCEEECCCCCCCEEEEEEECCCCEEEEEEEECCCCCH
DIIRMLRTAGKGMPVLLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVKTLLRRGN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEECCCCCEECHHHHHHHHHHHHHHHHCCC
TMITESQFRVAGLSIDLVSRKVSRAGNRIVLTSKEFSLLEFFIRHQGEVLPRSLIASQVW
CEEECCCEEEEEEEHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHH
DMNFDSDTNAIDVAVKRLRAKIDNDYETKLIQTVRGVGYMLEVPDA
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9930866 [H]