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The map label for this gene is ykvO [H]

Identifier: 116689489

GI number: 116689489

Start: 1621250

End: 1621963

Strand: Reverse

Name: ykvO [H]

Synonym: Bcen2424_1467

Alternate gene names: 116689489

Gene position: 1621963-1621250 (Counterclockwise)

Preceding gene: 116689490

Following gene: 116689486

Centisome position: 46.56

GC content: 71.43

Gene sequence:

>714_bases
ATGGACGATCCGCTCCACGGAAAGACAGTACTCGTCGTCGGCGGCAGCTCCGGCATCGGCGCCGCCACCGCAGCGGCATT
CGCGCGGCGCGGCGCGCGGGTGACGATCGCTTCGCGCGATCCACGCAGGTTCGACATCGACGCCCTGCCGGGCGCGGACG
TGCGGACCGAAACGCTCGACATCACCGATACGGCGGACGTCGATGCGTTCTGCGCACGCGCCGGCCGGTTCGACCACGTC
GTGATTTCTGCCGCGAAGACGGCCACGGGCGCGGTCCGTGCGCTGCCGCTCGCCGACGCGCAGGCAGCGATGGACAGCAA
GTTCTGGGGCGCCTACCGCATCGCCCGCGCGATCGATATCGCGCCCGGCGGCTCGCTGACGTTCGTGTCGGGCTACCTGA
GCGTACGGCCGAGCGCGTCGTCGGTGCTGCAAGGCGCGATCAACGCAGCGCTCGAAGCCCTCGCCCGCGGGCTGGCGCTC
GAGCTGGCGCCGGTGCGCGTGAATACCGTGTCGCCCGGCCTGATCGCGACGCCGCTGTGGGACAAGCTCGCGCCCGACGC
ACGTGACGCGATGTACGCCGGCGCCGCCCAGCGGCTTCCGGCACGCAGGGTCGGCCAGCCGGAGGATGTCGCGAATGCGA
TCCTATATCTGGCGGCCACGCCCTACGCAACCGGCTCGACGGTGCTGATCGACGGCGGCGGCGCGATTGCGTGA

Upstream 100 bases:

>100_bases
ACGACATTGCGCGCTTCGCGCTGCACAGCCCGTCGACGCTGCGCGAGACCGAAACGATCTGACCGGATTCCGTTCAACTC
ATCACCCAGGAGAGACTTTC

Downstream 100 bases:

>100_bases
CGCCTGCGCGCACGACAAAACGCCCGCGTTCCGTCAGTCAGGAACGCGGGCGTCGGGGATGACGCAACAGCGTGACGCTC
AGGCCACGGCGCTGACGTCG

Product: short chain dehydrogenase

Products: 2,3-Dihydroxybenzoate; H+; Nicotinamide adenine dinucleotide - reduced [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MDDPLHGKTVLVVGGSSGIGAATAAAFARRGARVTIASRDPRRFDIDALPGADVRTETLDITDTADVDAFCARAGRFDHV
VISAAKTATGAVRALPLADAQAAMDSKFWGAYRIARAIDIAPGGSLTFVSGYLSVRPSASSVLQGAINAALEALARGLAL
ELAPVRVNTVSPGLIATPLWDKLAPDARDAMYAGAAQRLPARRVGQPEDVANAILYLAATPYATGSTVLIDGGGAIA

Sequences:

>Translated_237_residues
MDDPLHGKTVLVVGGSSGIGAATAAAFARRGARVTIASRDPRRFDIDALPGADVRTETLDITDTADVDAFCARAGRFDHV
VISAAKTATGAVRALPLADAQAAMDSKFWGAYRIARAIDIAPGGSLTFVSGYLSVRPSASSVLQGAINAALEALARGLAL
ELAPVRVNTVSPGLIATPLWDKLAPDARDAMYAGAAQRLPARRVGQPEDVANAILYLAATPYATGSTVLIDGGGAIA
>Mature_237_residues
MDDPLHGKTVLVVGGSSGIGAATAAAFARRGARVTIASRDPRRFDIDALPGADVRTETLDITDTADVDAFCARAGRFDHV
VISAAKTATGAVRALPLADAQAAMDSKFWGAYRIARAIDIAPGGSLTFVSGYLSVRPSASSVLQGAINAALEALARGLAL
ELAPVRVNTVSPGLIATPLWDKLAPDARDAMYAGAAQRLPARRVGQPEDVANAILYLAATPYATGSTVLIDGGGAIA

Specific function: Siderophore biosynthesis; enterobactin biosynthesis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=237, Percent_Identity=26.1603375527426, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=29.7709923664122, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI10190704, Length=250, Percent_Identity=31.2, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI126723750, Length=254, Percent_Identity=29.5275590551181, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI59889578, Length=235, Percent_Identity=31.063829787234, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI7705925, Length=251, Percent_Identity=30.6772908366534, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI66933014, Length=251, Percent_Identity=27.4900398406374, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1786812, Length=252, Percent_Identity=31.3492063492063, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=28.740157480315, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1787335, Length=243, Percent_Identity=28.8065843621399, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=26.1044176706827, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI2367365, Length=240, Percent_Identity=30.8333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082160, Length=245, Percent_Identity=26.9387755102041, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789378, Length=264, Percent_Identity=28.4090909090909, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=30.6451612903226, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=258, Percent_Identity=28.6821705426357, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=258, Percent_Identity=29.0697674418605, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=26.8939393939394, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=256, Percent_Identity=29.6875, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=252, Percent_Identity=26.5873015873016, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=29.1338582677165, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=254, Percent_Identity=26.3779527559055, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=244, Percent_Identity=32.3770491803279, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21357041, Length=244, Percent_Identity=30.327868852459, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571526, Length=246, Percent_Identity=29.2682926829268, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24643142, Length=241, Percent_Identity=26.1410788381743, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=27.8884462151394, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24639444, Length=246, Percent_Identity=26.8292682926829, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.3.1.28 [C]

Molecular weight: Translated: 24251; Mature: 24251

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDPLHGKTVLVVGGSSGIGAATAAAFARRGARVTIASRDPRRFDIDALPGADVRTETLD
CCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCEEEEEE
ITDTADVDAFCARAGRFDHVVISAAKTATGAVRALPLADAQAAMDSKFWGAYRIARAIDI
CCCCCCHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEE
APGGSLTFVSGYLSVRPSASSVLQGAINAALEALARGLALELAPVRVNTVSPGLIATPLW
CCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCEEECCCH
DKLAPDARDAMYAGAAQRLPARRVGQPEDVANAILYLAATPYATGSTVLIDGGGAIA
HHHCCCHHHHHHHCHHHCCCHHHCCCHHHHHHHEEEEEECCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MDDPLHGKTVLVVGGSSGIGAATAAAFARRGARVTIASRDPRRFDIDALPGADVRTETLD
CCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCEEEEEE
ITDTADVDAFCARAGRFDHVVISAAKTATGAVRALPLADAQAAMDSKFWGAYRIARAIDI
CCCCCCHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEE
APGGSLTFVSGYLSVRPSASSVLQGAINAALEALARGLALELAPVRVNTVSPGLIATPLW
CCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCEEECCCH
DKLAPDARDAMYAGAAQRLPARRVGQPEDVANAILYLAATPYATGSTVLIDGGGAIA
HHHCCCHHHHHHHCHHHCCCHHHCCCHHHHHHHEEEEEECCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): 5550 [C]

Specific activity: 66

Km value (mM): 0.26 {methyl-2,3-dehydro-3-hydroxybenzoate}} 0.2 {3-oxocyclohexane-1-carboxylic} 0.3 {2,3-dihydro-2,3-dihydroxybenzoate}} [C]

Substrates: 2,3-Dihydro-2,3-dihydroxybenzoate; Nicotinamide adenine dinucleotide [C]

Specific reaction: 2,3-Dihydro-2,3-dihydroxybenzoate + Nicotinamide adenine dinucleotide <==> 2,3-Dihydroxybenzoate + H+ + Nicotinamide adenine dinucleotide - reduced [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]