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The map label for this gene is hutU [H]

Identifier: 116624291

GI number: 116624291

Start: 6536259

End: 6537893

Strand: Reverse

Name: hutU [H]

Synonym: Acid_5209

Alternate gene names: 116624291

Gene position: 6537893-6536259 (Counterclockwise)

Preceding gene: 116624292

Following gene: 116624290

Centisome position: 65.6

GC content: 68.07

Gene sequence:

>1635_bases
ATGAGCGTCTCTACCGTCATCCGCGCCCCGCGTGGCGCGTCCATCACCTGCAAGGGCTGGCACCAGGAAGCCGCCCTCCG
CATGCTCCACAACAATCTCGATCCCGAGGTCGCCGAGCGCCCTGACGATCTCATCGTTTATGGCGGCACGGGCCGCGCCG
CCCGCGATTGGCCCAGCTTTCACGCCATCGTCCGCGCCCTGCGCTCGCTCGAAAACGACGAGACCCTGCTCATCCAATCC
GGCAAGCCGGTCGGCATCTTCCGCACCCATCCCGAGTCGCCGCGCGTCCTCCTCGCCAATTCCAACCTGGTCGGACACTG
GTCCAACTGGGACGAATTCAACCGCCTCGAAAAACTCGGCCTCACCATGTACGGTCAGATGACCGCCGGTTCCTGGATCT
ACATCGGCAGCCAGGGGATCGTGCAGGGCACCTACGAAACCTTCGCCGCGCTCGCCAAAAAGCACTTCGCCGGTTCGCTC
GCGGGCAAGCTCGTCGTGTCCGGCGGCATGGGCGGCATGGGTGGCGCCCAGCCCCTCGCCGCCACCATGAACGGCGCGCG
CTTCCTCGGCATCGACGTCGATGCCGCCCGCATTCAGCGCCGCATCGATAGTGGCTACTGCGACCGCATCGCCCACTCGC
TCGAGGAAGCCCTCGCCCTGCTCGCCGGCCCCGATGCGCTCTCCGTCGGCCTGGTCGGCAACTGCGCCGACGTACTCCCC
GAACTGGTCCGCCGCGGCATCACGCCCGATGTCCTCACCGACCAGACCAGCGCTCACGATCCCCTGAACGGCTACGTCCC
CAACGGCATGCCGCTCGCCGACGCGCTCCTGCTTCGCGTCCGCCACCCCCAGGAATACGTGGCGCGCTCTGTCGCCGCCA
TGGGCGTTCACGTGGAAGCCATGCTCGATCTCCGCGCCGCCGGTTCCATCACGTTCGATTACGGCAACAACATCCGCACC
CACGCGAAAAACGCCGGCGTCGAACGCGCCTTCGAAATCCCCGGCTTCGTTCCCGAATACATCCGCCCCCTCTTCTGTGA
AGGCCGCGGCCCCTTCCGCTGGGTCGCGCTCTCCGGCGACCCCGCCGATATCTATCGCACCGACCGCCTCGCCGCCGAGA
TGTTCCCGCACGATGAGACCCTCGCCCGCTGGCTCCCTCTCGCAAGTCAGCGCATCCAGTTTCAGGGCCTGCCCGCGCGT
ATCTGCTGGCTCGGATATGGCGACCGCGCCAGGTTCGGCCTCGCCATCAACGATCTCGTCCGCACCGGCGAAATCTCCGC
CCCCATCGTGATCGGCCGCGACCACCTCGACACCGGCTCCGTCGCCTCCCCTTACCGCGAAACCGAAGGCATGCGCGACG
GCTCCGACGCCATCGCCGATTGGCCCCTCCTCAACGCCCTGGTCAACACCGCCGCCGGCGCCAGTTGGGTCAGCATCCAT
AACGGAGGCGGCGTCGGCATCGGCTACTCCCAACACGCCGGCATGGTCGTCGTCGCCGATGGCACCGACCAATCCGCCCG
CCGCCTCGAACGCGTCCTCACCTCCGACCCCGGCATCGGCGTCCTCCGCCACGCCGACGCCGGCTACCCCGAAGCCATCG
CCTTCGCCACCACCCACGGCCTCACCCGCCCCTGA

Upstream 100 bases:

>100_bases
TCTCTTACGATATCGAGGCCGTCGCGCTCGCCATCCGCGAAGGCAAATTCGACGAATGGGCCATCCCGGAATCGCTTCCG
GCTCCAATGGGAGTACTGCA

Downstream 100 bases:

>100_bases
CATGTTTTCCACTCGCCCCGACGCATCACCCTCGCCTACATGTCACCTTCGTCCCACGATCACCCGCGCCCCACGTATCA
CCCTCGCCCCACGCATCACC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MSVSTVIRAPRGASITCKGWHQEAALRMLHNNLDPEVAERPDDLIVYGGTGRAARDWPSFHAIVRALRSLENDETLLIQS
GKPVGIFRTHPESPRVLLANSNLVGHWSNWDEFNRLEKLGLTMYGQMTAGSWIYIGSQGIVQGTYETFAALAKKHFAGSL
AGKLVVSGGMGGMGGAQPLAATMNGARFLGIDVDAARIQRRIDSGYCDRIAHSLEEALALLAGPDALSVGLVGNCADVLP
ELVRRGITPDVLTDQTSAHDPLNGYVPNGMPLADALLLRVRHPQEYVARSVAAMGVHVEAMLDLRAAGSITFDYGNNIRT
HAKNAGVERAFEIPGFVPEYIRPLFCEGRGPFRWVALSGDPADIYRTDRLAAEMFPHDETLARWLPLASQRIQFQGLPAR
ICWLGYGDRARFGLAINDLVRTGEISAPIVIGRDHLDTGSVASPYRETEGMRDGSDAIADWPLLNALVNTAAGASWVSIH
NGGGVGIGYSQHAGMVVVADGTDQSARRLERVLTSDPGIGVLRHADAGYPEAIAFATTHGLTRP

Sequences:

>Translated_544_residues
MSVSTVIRAPRGASITCKGWHQEAALRMLHNNLDPEVAERPDDLIVYGGTGRAARDWPSFHAIVRALRSLENDETLLIQS
GKPVGIFRTHPESPRVLLANSNLVGHWSNWDEFNRLEKLGLTMYGQMTAGSWIYIGSQGIVQGTYETFAALAKKHFAGSL
AGKLVVSGGMGGMGGAQPLAATMNGARFLGIDVDAARIQRRIDSGYCDRIAHSLEEALALLAGPDALSVGLVGNCADVLP
ELVRRGITPDVLTDQTSAHDPLNGYVPNGMPLADALLLRVRHPQEYVARSVAAMGVHVEAMLDLRAAGSITFDYGNNIRT
HAKNAGVERAFEIPGFVPEYIRPLFCEGRGPFRWVALSGDPADIYRTDRLAAEMFPHDETLARWLPLASQRIQFQGLPAR
ICWLGYGDRARFGLAINDLVRTGEISAPIVIGRDHLDTGSVASPYRETEGMRDGSDAIADWPLLNALVNTAAGASWVSIH
NGGGVGIGYSQHAGMVVVADGTDQSARRLERVLTSDPGIGVLRHADAGYPEAIAFATTHGLTRP
>Mature_543_residues
SVSTVIRAPRGASITCKGWHQEAALRMLHNNLDPEVAERPDDLIVYGGTGRAARDWPSFHAIVRALRSLENDETLLIQSG
KPVGIFRTHPESPRVLLANSNLVGHWSNWDEFNRLEKLGLTMYGQMTAGSWIYIGSQGIVQGTYETFAALAKKHFAGSLA
GKLVVSGGMGGMGGAQPLAATMNGARFLGIDVDAARIQRRIDSGYCDRIAHSLEEALALLAGPDALSVGLVGNCADVLPE
LVRRGITPDVLTDQTSAHDPLNGYVPNGMPLADALLLRVRHPQEYVARSVAAMGVHVEAMLDLRAAGSITFDYGNNIRTH
AKNAGVERAFEIPGFVPEYIRPLFCEGRGPFRWVALSGDPADIYRTDRLAAEMFPHDETLARWLPLASQRIQFQGLPARI
CWLGYGDRARFGLAINDLVRTGEISAPIVIGRDHLDTGSVASPYRETEGMRDGSDAIADWPLLNALVNTAAGASWVSIHN
GGGVGIGYSQHAGMVVVADGTDQSARRLERVLTSDPGIGVLRHADAGYPEAIAFATTHGLTRP

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=550, Percent_Identity=34.3636363636364, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI260306182, Length=337, Percent_Identity=32.9376854599407, Blast_Score=155, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71997891, Length=555, Percent_Identity=33.1531531531532, Blast_Score=305, Evalue=5e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 58573; Mature: 58442

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSTVIRAPRGASITCKGWHQEAALRMLHNNLDPEVAERPDDLIVYGGTGRAARDWPSF
CCCCCEEECCCCCEEEECCCHHHHHHHHHHCCCCCHHHCCCCCEEEECCCCCCCCCCHHH
HAIVRALRSLENDETLLIQSGKPVGIFRTHPESPRVLLANSNLVGHWSNWDEFNRLEKLG
HHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCEEECCCCHHHHHHHHHHC
LTMYGQMTAGSWIYIGSQGIVQGTYETFAALAKKHFAGSLAGKLVVSGGMGGMGGAQPLA
CEEEEEECCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHH
ATMNGARFLGIDVDAARIQRRIDSGYCDRIAHSLEEALALLAGPDALSVGLVGNCADVLP
HHCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHH
ELVRRGITPDVLTDQTSAHDPLNGYVPNGMPLADALLLRVRHPQEYVARSVAAMGVHVEA
HHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCEEHHH
MLDLRAAGSITFDYGNNIRTHAKNAGVERAFEIPGFVPEYIRPLFCEGRGPFRWVALSGD
HHHHHCCCEEEEECCCCCEEHHHCCCCCCEECCCCCCHHHHHHHEECCCCCEEEEEECCC
PADIYRTDRLAAEMFPHDETLARWLPLASQRIQFQGLPARICWLGYGDRARFGLAINDLV
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEECCCCEEEEEEECCCCCEECEEHHHHH
RTGEISAPIVIGRDHLDTGSVASPYRETEGMRDGSDAIADWPLLNALVNTAAGASWVSIH
HCCCCCCCEEEECCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
NGGGVGIGYSQHAGMVVVADGTDQSARRLERVLTSDPGIGVLRHADAGYPEAIAFATTHG
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEECCCC
LTRP
CCCC
>Mature Secondary Structure 
SVSTVIRAPRGASITCKGWHQEAALRMLHNNLDPEVAERPDDLIVYGGTGRAARDWPSF
CCCCEEECCCCCEEEECCCHHHHHHHHHHCCCCCHHHCCCCCEEEECCCCCCCCCCHHH
HAIVRALRSLENDETLLIQSGKPVGIFRTHPESPRVLLANSNLVGHWSNWDEFNRLEKLG
HHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCEEECCCCHHHHHHHHHHC
LTMYGQMTAGSWIYIGSQGIVQGTYETFAALAKKHFAGSLAGKLVVSGGMGGMGGAQPLA
CEEEEEECCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHH
ATMNGARFLGIDVDAARIQRRIDSGYCDRIAHSLEEALALLAGPDALSVGLVGNCADVLP
HHCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHH
ELVRRGITPDVLTDQTSAHDPLNGYVPNGMPLADALLLRVRHPQEYVARSVAAMGVHVEA
HHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCEEHHH
MLDLRAAGSITFDYGNNIRTHAKNAGVERAFEIPGFVPEYIRPLFCEGRGPFRWVALSGD
HHHHHCCCEEEEECCCCCEEHHHCCCCCCEECCCCCCHHHHHHHEECCCCCEEEEEECCC
PADIYRTDRLAAEMFPHDETLARWLPLASQRIQFQGLPARICWLGYGDRARFGLAINDLV
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEECCCCEEEEEEECCCCCEECEEHHHHH
RTGEISAPIVIGRDHLDTGSVASPYRETEGMRDGSDAIADWPLLNALVNTAAGASWVSIH
HCCCCCCCEEEECCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
NGGGVGIGYSQHAGMVVVADGTDQSARRLERVLTSDPGIGVLRHADAGYPEAIAFATTHG
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEECCCC
LTRP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA