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The map label for this gene is hutH [H]

Identifier: 116624292

GI number: 116624292

Start: 6537890

End: 6539434

Strand: Reverse

Name: hutH [H]

Synonym: Acid_5210

Alternate gene names: 116624292

Gene position: 6539434-6537890 (Counterclockwise)

Preceding gene: 116624294

Following gene: 116624291

Centisome position: 65.62

GC content: 68.16

Gene sequence:

>1545_bases
ATGCTGGAACTCAGTGGACAGGCCCTCAAGCTCTCCGAAATCGCGGCCATTGCGGATCATTCGTTACAACTCTGCATCCC
GGAGTCCGCCGTTGCGCAGATGGAGCAGTCCCGTGAAGTCGTGCGCCGCGTATCCCACGATCGCGCGCCTGTCTACGGCA
TCAACACCGGCTTCGGCAAGCTCTGCGAAGTCCGTATACCCGATGGCGCCATCGATCGTCTGCAGCTCAATCTCGTCCGC
AGCCACGCGTGCGGCCTCGGGCAGCCCCTCTCCGAACCCGAGACCCGCGTCATGATGGCCCTCCGCGCCAACACCCTCGC
GCTGGGCTACAGCGGCGTCCGCCCCCTGATCGCCGAGACCCTTGCGCTCATGCTCAACCGCGGCGTCCATCCCGTCATCC
CTGAGAAAGGCTCCGTCGGAGCCAGCGGCGACCTCGCCCCGCTCGCCCACCTCGCCCTTTGCGTCATCGGCGAAGGCGAA
GCCGTCTATCGCGGCGAGCGCCTCAACGGCCGCGAAGCCCTACGCCGCGCCGCAATCGATCCCGTCCATCTCGAAAGCAA
GGAAGGCCTAGCCCTCCTCAACGGCACGCAGGCCCTCACCGCCGTCGGCGCCCTCGCCCTCTGGCGCGCCACCCGCCTCG
CAGGACTCGCCGATATCGCCGGCGCCATGACGCTCGAAGCTCTCCTCGGCACCCCTGTCGCCTTCGACCAGCGTATCCAC
GCCGCGCGCCCGCATCCGGGGCAGGGGATCGCTGCCGCCCGCCTCCGCTCCCTGCTCGCCGCCAGCGACGTCGATCCCGC
CCGCCGCACCTCACCCGCCCGCGTACAGGACGCCTACAGCCTGCGCTGTATGCCCCAAGTCCACGGCGCCGTCCGCGGTG
CCCTCCGCTTCGCCCGCTCCACCGTCGAAATCGAAACCGGCTCCGCTACCGATAACCCGCTCGTCTTCCCGGAGTCGGGC
GACGTCATATCCGGCGGCAACTTCCACGGCGCGCCCCTCGCCCTCGCCTTCGATTCCGCGTCGATCGCCCTCACCACCCT
CGCGTCTATCGCCGAACGCCGCATCGATCGTCTCGTGAATCCCGATCTCAACCAGGGACTCCCCGCCTTCCTCGCCGCCG
ACCCCGGCGTTTCCAGCGGCTTCATGATCGCGCACGTCGCCGCCGTCTCCCTCCTTGCCGAATGCAAGGTTCTCGCCCAC
CCAGCCAGCGTTGACAATGTCCCGACCTCCGGCGGCCAGGAGGACCACGTCTCCATGGGCATGACTGCCGCACTCAAATT
CCGCGCCATCGTGGAAAACGCCGAGCGCATCGCCGCCATCGAACTGCTCGCCGCCGCCGAGGCTCTGCGCTACCGCGAGC
CCTTCGAGCCCGGCATGCACCTCCGCCGCGTTCGCGACGTTCTCCGCTCCATCTCCCCGCCGCTCGGCGAAGACCGCGCG
CTCTCTTACGATATCGAGGCCGTCGCGCTCGCCATCCGCGAAGGCAAATTCGACGAATGGGCCATCCCGGAATCGCTTCC
GGCTCCAATGGGAGTACTGCAATGA

Upstream 100 bases:

>100_bases
GGTTTCGTCCAATAAGGCGCTTGATTCAACGGCCATATGGCCATTCTACAATCGAATCCCTATTCAAAAATCGTTCAGAG
GGAGCTATCATTCCCCCAGA

Downstream 100 bases:

>100_bases
GCGTCTCTACCGTCATCCGCGCCCCGCGTGGCGCGTCCATCACCTGCAAGGGCTGGCACCAGGAAGCCGCCCTCCGCATG
CTCCACAACAATCTCGATCC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MLELSGQALKLSEIAAIADHSLQLCIPESAVAQMEQSREVVRRVSHDRAPVYGINTGFGKLCEVRIPDGAIDRLQLNLVR
SHACGLGQPLSEPETRVMMALRANTLALGYSGVRPLIAETLALMLNRGVHPVIPEKGSVGASGDLAPLAHLALCVIGEGE
AVYRGERLNGREALRRAAIDPVHLESKEGLALLNGTQALTAVGALALWRATRLAGLADIAGAMTLEALLGTPVAFDQRIH
AARPHPGQGIAAARLRSLLAASDVDPARRTSPARVQDAYSLRCMPQVHGAVRGALRFARSTVEIETGSATDNPLVFPESG
DVISGGNFHGAPLALAFDSASIALTTLASIAERRIDRLVNPDLNQGLPAFLAADPGVSSGFMIAHVAAVSLLAECKVLAH
PASVDNVPTSGGQEDHVSMGMTAALKFRAIVENAERIAAIELLAAAEALRYREPFEPGMHLRRVRDVLRSISPPLGEDRA
LSYDIEAVALAIREGKFDEWAIPESLPAPMGVLQ

Sequences:

>Translated_514_residues
MLELSGQALKLSEIAAIADHSLQLCIPESAVAQMEQSREVVRRVSHDRAPVYGINTGFGKLCEVRIPDGAIDRLQLNLVR
SHACGLGQPLSEPETRVMMALRANTLALGYSGVRPLIAETLALMLNRGVHPVIPEKGSVGASGDLAPLAHLALCVIGEGE
AVYRGERLNGREALRRAAIDPVHLESKEGLALLNGTQALTAVGALALWRATRLAGLADIAGAMTLEALLGTPVAFDQRIH
AARPHPGQGIAAARLRSLLAASDVDPARRTSPARVQDAYSLRCMPQVHGAVRGALRFARSTVEIETGSATDNPLVFPESG
DVISGGNFHGAPLALAFDSASIALTTLASIAERRIDRLVNPDLNQGLPAFLAADPGVSSGFMIAHVAAVSLLAECKVLAH
PASVDNVPTSGGQEDHVSMGMTAALKFRAIVENAERIAAIELLAAAEALRYREPFEPGMHLRRVRDVLRSISPPLGEDRA
LSYDIEAVALAIREGKFDEWAIPESLPAPMGVLQ
>Mature_514_residues
MLELSGQALKLSEIAAIADHSLQLCIPESAVAQMEQSREVVRRVSHDRAPVYGINTGFGKLCEVRIPDGAIDRLQLNLVR
SHACGLGQPLSEPETRVMMALRANTLALGYSGVRPLIAETLALMLNRGVHPVIPEKGSVGASGDLAPLAHLALCVIGEGE
AVYRGERLNGREALRRAAIDPVHLESKEGLALLNGTQALTAVGALALWRATRLAGLADIAGAMTLEALLGTPVAFDQRIH
AARPHPGQGIAAARLRSLLAASDVDPARRTSPARVQDAYSLRCMPQVHGAVRGALRFARSTVEIETGSATDNPLVFPESG
DVISGGNFHGAPLALAFDSASIALTTLASIAERRIDRLVNPDLNQGLPAFLAADPGVSSGFMIAHVAAVSLLAECKVLAH
PASVDNVPTSGGQEDHVSMGMTAALKFRAIVENAERIAAIELLAAAEALRYREPFEPGMHLRRVRDVLRSISPPLGEDRA
LSYDIEAVALAIREGKFDEWAIPESLPAPMGVLQ

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=507, Percent_Identity=45.1676528599605, Blast_Score=417, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17567831, Length=476, Percent_Identity=43.4873949579832, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54410; Mature: 54410

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00626 RCC1_2 ; PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELSGQALKLSEIAAIADHSLQLCIPESAVAQMEQSREVVRRVSHDRAPVYGINTGFGK
CCCCCCCEEEHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC
LCEVRIPDGAIDRLQLNLVRSHACGLGQPLSEPETRVMMALRANTLALGYSGVRPLIAET
EEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCEEEECCCCCHHHHHHH
LALMLNRGVHPVIPEKGSVGASGDLAPLAHLALCVIGEGEAVYRGERLNGREALRRAAID
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHCCC
PVHLESKEGLALLNGTQALTAVGALALWRATRLAGLADIAGAMTLEALLGTPVAFDQRIH
CEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AARPHPGQGIAAARLRSLLAASDVDPARRTSPARVQDAYSLRCMPQVHGAVRGALRFARS
CCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHEECCHHHHHHHHHHHHHHHH
TVEIETGSATDNPLVFPESGDVISGGNFHGAPLALAFDSASIALTTLASIAERRIDRLVN
EEEEECCCCCCCCEEECCCCCEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCC
PDLNQGLPAFLAADPGVSSGFMIAHVAAVSLLAECKVLAHPASVDNVPTSGGQEDHVSMG
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHH
MTAALKFRAIVENAERIAAIELLAAAEALRYREPFEPGMHLRRVRDVLRSISPPLGEDRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
LSYDIEAVALAIREGKFDEWAIPESLPAPMGVLQ
EEECHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLELSGQALKLSEIAAIADHSLQLCIPESAVAQMEQSREVVRRVSHDRAPVYGINTGFGK
CCCCCCCEEEHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC
LCEVRIPDGAIDRLQLNLVRSHACGLGQPLSEPETRVMMALRANTLALGYSGVRPLIAET
EEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCEEEECCCCCHHHHHHH
LALMLNRGVHPVIPEKGSVGASGDLAPLAHLALCVIGEGEAVYRGERLNGREALRRAAID
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHCCC
PVHLESKEGLALLNGTQALTAVGALALWRATRLAGLADIAGAMTLEALLGTPVAFDQRIH
CEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AARPHPGQGIAAARLRSLLAASDVDPARRTSPARVQDAYSLRCMPQVHGAVRGALRFARS
CCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHEECCHHHHHHHHHHHHHHHH
TVEIETGSATDNPLVFPESGDVISGGNFHGAPLALAFDSASIALTTLASIAERRIDRLVN
EEEEECCCCCCCCEEECCCCCEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCC
PDLNQGLPAFLAADPGVSSGFMIAHVAAVSLLAECKVLAHPASVDNVPTSGGQEDHVSMG
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHH
MTAALKFRAIVENAERIAAIELLAAAEALRYREPFEPGMHLRRVRDVLRSISPPLGEDRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
LSYDIEAVALAIREGKFDEWAIPESLPAPMGVLQ
EEECHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA