Click here to switch to the map view.

The map label for this gene is mdmC [H]

Identifier: 116622199

GI number: 116622199

Start: 3912074

End: 3912745

Strand: Direct

Name: mdmC [H]

Synonym: Acid_3091

Alternate gene names: 116622199

Gene position: 3912074-3912745 (Clockwise)

Preceding gene: 116622198

Following gene: 116622200

Centisome position: 39.26

GC content: 64.73

Gene sequence:

>672_bases
ATGGAACCGCTCAACGAACAACTCATCGAACGTATCGACGCCTATATCGAGGCGCTCTTCACTCCGCCCGACGCGGTTCT
CTCCGAGAACCTGGCCGACGCCGAAGCGGCCGGCCTTCCGGCGATCAACGTGTCGCCCAACCAGGGCCGACTGTTGTACC
TGCTGGCGAAGATCGCAGGAGCAAGAAGGGTGCTCGAGGTCGGGACCCTGGGCGGCTACAGCACGACCTGGCTGGCTCGC
GCGCTGCCGGCGAATGGCCTGCTGGTCACGCTCGAACTCGATCCCAAACATGCCGAAGTCGCGCGGCGAAGTTTGGACCG
CGCAGGGTTGGCGCCGCGCATCGAAGTCCGGGTGGGACCTGCCGCCGGCTCGCTCCGCGACCTCATACGATCGGCCACGG
CGCCCTTCGACCTTGTCTTCCTCGATGCCAACAAGTCGGGCTACGTCGAGTACCTCGATCTGGCGTTGCAACTCTCGCGG
CCCGGCACGCTCATACTGGCGGACAACGTGATCCGCCACGGCCTGGTGCTGGACTCCAACCCGGCCGATCCCAACGATGC
GGGAGCCAGAGCTTACAATGAGGCGATCGCCGGAAACCCGCGGTTGGAATCGTTGGTCCTGCCGATTGTCCGTGCCCGAG
TGGACGGGCTTGCGATCTCGATCGTACGCTAA

Upstream 100 bases:

>100_bases
CCCGCTCTCGGCCAGCACACCGCGGAGGTCCTGGCGCGCTACGGCTACTCCGAACAGGAAGTGCGGCGGCTGCGAGAATT
CGGCGTCATCCCTGCTTGAT

Downstream 100 bases:

>100_bases
TGTTGAATCCTGATGAATGATCGTTCCAGGCTCCTGCTCGGGCTGATCGGCGCCGGCATGCAGAGCTCGCTCACTCCCGC
GATGCACGAACGCGAAGCCG

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MEPLNEQLIERIDAYIEALFTPPDAVLSENLADAEAAGLPAINVSPNQGRLLYLLAKIAGARRVLEVGTLGGYSTTWLAR
ALPANGLLVTLELDPKHAEVARRSLDRAGLAPRIEVRVGPAAGSLRDLIRSATAPFDLVFLDANKSGYVEYLDLALQLSR
PGTLILADNVIRHGLVLDSNPADPNDAGARAYNEAIAGNPRLESLVLPIVRARVDGLAISIVR

Sequences:

>Translated_223_residues
MEPLNEQLIERIDAYIEALFTPPDAVLSENLADAEAAGLPAINVSPNQGRLLYLLAKIAGARRVLEVGTLGGYSTTWLAR
ALPANGLLVTLELDPKHAEVARRSLDRAGLAPRIEVRVGPAAGSLRDLIRSATAPFDLVFLDANKSGYVEYLDLALQLSR
PGTLILADNVIRHGLVLDSNPADPNDAGARAYNEAIAGNPRLESLVLPIVRARVDGLAISIVR
>Mature_223_residues
MEPLNEQLIERIDAYIEALFTPPDAVLSENLADAEAAGLPAINVSPNQGRLLYLLAKIAGARRVLEVGTLGGYSTTWLAR
ALPANGLLVTLELDPKHAEVARRSLDRAGLAPRIEVRVGPAAGSLRDLIRSATAPFDLVFLDANKSGYVEYLDLALQLSR
PGTLILADNVIRHGLVLDSNPADPNDAGARAYNEAIAGNPRLESLVLPIVRARVDGLAISIVR

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=179, Percent_Identity=33.5195530726257, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17565612, Length=157, Percent_Identity=31.8471337579618, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25148771, Length=186, Percent_Identity=30.1075268817204, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23824; Mature: 23824

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPLNEQLIERIDAYIEALFTPPDAVLSENLADAEAAGLPAINVSPNQGRLLYLLAKIAG
CCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHCCCCEEEECCCCCHHHHHHHHHHH
ARRVLEVGTLGGYSTTWLARALPANGLLVTLELDPKHAEVARRSLDRAGLAPRIEVRVGP
HHHEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECC
AAGSLRDLIRSATAPFDLVFLDANKSGYVEYLDLALQLSRPGTLILADNVIRHGLVLDSN
CCHHHHHHHHHCCCCEEEEEEECCCCCCHHEEEEEHEECCCCEEEEECHHHHCCEEECCC
PADPNDAGARAYNEAIAGNPRLESLVLPIVRARVDGLAISIVR
CCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEEC
>Mature Secondary Structure
MEPLNEQLIERIDAYIEALFTPPDAVLSENLADAEAAGLPAINVSPNQGRLLYLLAKIAG
CCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHCCCCEEEECCCCCHHHHHHHHHHH
ARRVLEVGTLGGYSTTWLARALPANGLLVTLELDPKHAEVARRSLDRAGLAPRIEVRVGP
HHHEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECC
AAGSLRDLIRSATAPFDLVFLDANKSGYVEYLDLALQLSRPGTLILADNVIRHGLVLDSN
CCHHHHHHHHHCCCCEEEEEEECCCCCCHHEEEEEHEECCCCEEEEECHHHHCCEEECCC
PADPNDAGARAYNEAIAGNPRLESLVLPIVRARVDGLAISIVR
CCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]