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The map label for this gene is yccK [H]

Identifier: 116622023

GI number: 116622023

Start: 3688822

End: 3689952

Strand: Direct

Name: yccK [H]

Synonym: Acid_2908

Alternate gene names: 116622023

Gene position: 3688822-3689952 (Clockwise)

Preceding gene: 116622022

Following gene: 116622024

Centisome position: 37.02

GC content: 62.95

Gene sequence:

>1131_bases
ATGCAAAAAAGAACACTGATTCCGGACCGCCGGTCCTTTCTGCTGGCGTTAGGGGGCAGCGTTTCTTTGCCTGTATTCGC
ACAGCAGAGCGGCCCTGCTTCGGTCGAACCGCAGGTGAACGGGCGGCGCAAGCTCGGGACGCTGGAGGTTTCGAGCATCG
GACTCGGGTGCCAGGACATGACGGGCGCGGTTTATGCCTCAGCCCCGAACCGGGCCGACATGATCGGCATTGCCCGCGCT
GCACATGACCGCGGCGTGACCTTCTTCGATGCGGCGGAAGCATATGGTCCGCTTGAAGTGGAACGGATCCTGGGCGAAGC
GCTGGCGCCTTTCCGCAATCAGGTGGCGATTGCCACCAAATTCGGCTGGAATATCGACCCGGAGACCGGGCGCATGGCGG
GCGGCCTGAACAGCCGGCCCGATCACATACGTACGGCCGTAGACGGCATGCTGAAGCGCCTGCGGACGGATCGCATCGAT
CTGCTGTACCAGCACCGCGTGGATCCCGCGGTCCCTATCGAAGACGTGGCCGGCACGGTCAAGGACCTGATCGCGCAGGG
CAAGGTGTTGCATTTTGGGCTTTCCGAACCGGGTCCGCAGACGGTCCGCCGCGCTCATGCGGTGCAACCCCTCGCGGCGA
TTCAGAACGAATACTCCATCATGGCGCGCGATCCGGAGGCGCAAATCCTGCCGATCTGCAAGGAACTGGGGATTGGACTG
GTATGTTGGGGTCCGCTCGCCCAGGGATTCCTGACGGGCGCTATCGACAAGGAGTCGCAGTTCCAACGCGGCGATTTTCG
CGGATCTGTGCCGTGGTTTTCAGCGGAAAATCGGCCCGGCAATCTGGCGATTGTCGAAGTCGTGAAGGAATGGGGGCGGC
GCAAGAAGGCGACACCCGCACAGATCTCGCTGGCCTGGCTATTAGCGCAAGGGCCCTCAGTGGTTCCGATTCCCGGCACG
AACAGGTTGCCGCACCTGATTGAGGATCTGGGCGCCGACGCTGTCCGCCTCACGCCTGAAGAACTCCGGGATTTCAACGC
CGCTCTGGCCCGCACTCCGGTTCAGGGCGCGCGGATGGGGCGAGGCATTTTGTCGCTCTCCGGTGTGGAAGCGCCTGCAA
AGCAGAGATGA

Upstream 100 bases:

>100_bases
CTACGAACCTGGCGGATTTCACTCCGTCTGAAGGCAATTCTCCTGAGGTTCAAGGTACGGCCGCCCGGCTCGAACCACGG
CGCTGACAAAGGGGGAGCGA

Downstream 100 bases:

>100_bases
CCAGTAGCTGCTAGAAAGGAAGGAAGAACCATGCAAAAGCGAAACCTGGGAAAGAGCGGGCTGGAAGTGTCAGCCCTTGG
CTTCGGCTGCATGGGCCTCA

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MQKRTLIPDRRSFLLALGGSVSLPVFAQQSGPASVEPQVNGRRKLGTLEVSSIGLGCQDMTGAVYASAPNRADMIGIARA
AHDRGVTFFDAAEAYGPLEVERILGEALAPFRNQVAIATKFGWNIDPETGRMAGGLNSRPDHIRTAVDGMLKRLRTDRID
LLYQHRVDPAVPIEDVAGTVKDLIAQGKVLHFGLSEPGPQTVRRAHAVQPLAAIQNEYSIMARDPEAQILPICKELGIGL
VCWGPLAQGFLTGAIDKESQFQRGDFRGSVPWFSAENRPGNLAIVEVVKEWGRRKKATPAQISLAWLLAQGPSVVPIPGT
NRLPHLIEDLGADAVRLTPEELRDFNAALARTPVQGARMGRGILSLSGVEAPAKQR

Sequences:

>Translated_376_residues
MQKRTLIPDRRSFLLALGGSVSLPVFAQQSGPASVEPQVNGRRKLGTLEVSSIGLGCQDMTGAVYASAPNRADMIGIARA
AHDRGVTFFDAAEAYGPLEVERILGEALAPFRNQVAIATKFGWNIDPETGRMAGGLNSRPDHIRTAVDGMLKRLRTDRID
LLYQHRVDPAVPIEDVAGTVKDLIAQGKVLHFGLSEPGPQTVRRAHAVQPLAAIQNEYSIMARDPEAQILPICKELGIGL
VCWGPLAQGFLTGAIDKESQFQRGDFRGSVPWFSAENRPGNLAIVEVVKEWGRRKKATPAQISLAWLLAQGPSVVPIPGT
NRLPHLIEDLGADAVRLTPEELRDFNAALARTPVQGARMGRGILSLSGVEAPAKQR
>Mature_376_residues
MQKRTLIPDRRSFLLALGGSVSLPVFAQQSGPASVEPQVNGRRKLGTLEVSSIGLGCQDMTGAVYASAPNRADMIGIARA
AHDRGVTFFDAAEAYGPLEVERILGEALAPFRNQVAIATKFGWNIDPETGRMAGGLNSRPDHIRTAVDGMLKRLRTDRID
LLYQHRVDPAVPIEDVAGTVKDLIAQGKVLHFGLSEPGPQTVRRAHAVQPLAAIQNEYSIMARDPEAQILPICKELGIGL
VCWGPLAQGFLTGAIDKESQFQRGDFRGSVPWFSAENRPGNLAIVEVVKEWGRRKKATPAQISLAWLLAQGPSVVPIPGT
NRLPHLIEDLGADAVRLTPEELRDFNAALARTPVQGARMGRGILSLSGVEAPAKQR

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436971, Length=331, Percent_Identity=29.607250755287, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4504825, Length=337, Percent_Identity=27.0029673590504, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI27436969, Length=332, Percent_Identity=27.1084337349398, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI27436966, Length=342, Percent_Identity=27.4853801169591, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI27436964, Length=342, Percent_Identity=27.4853801169591, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI27436962, Length=342, Percent_Identity=27.4853801169591, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI223718702, Length=301, Percent_Identity=27.5747508305648, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI41327764, Length=223, Percent_Identity=27.8026905829596, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI41152114, Length=132, Percent_Identity=28.030303030303, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081735, Length=325, Percent_Identity=30.1538461538462, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789375, Length=322, Percent_Identity=28.8819875776398, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788070, Length=326, Percent_Identity=28.8343558282209, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1787674, Length=311, Percent_Identity=29.5819935691318, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1788081, Length=285, Percent_Identity=25.2631578947368, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI48994888, Length=141, Percent_Identity=34.7517730496454, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319958, Length=288, Percent_Identity=26.0416666666667, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323998, Length=294, Percent_Identity=25.8503401360544, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325169, Length=326, Percent_Identity=27.6073619631902, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6322615, Length=246, Percent_Identity=27.2357723577236, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6319951, Length=316, Percent_Identity=25.3164556962025, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6325384, Length=296, Percent_Identity=26.3513513513513, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24640980, Length=340, Percent_Identity=24.1176470588235, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45549126, Length=340, Percent_Identity=24.1176470588235, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 40597; Mature: 40597

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKRTLIPDRRSFLLALGGSVSLPVFAQQSGPASVEPQVNGRRKLGTLEVSSIGLGCQDM
CCCCCCCCCCHHEEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEHHCCCCCHHC
TGAVYASAPNRADMIGIARAAHDRGVTFFDAAEAYGPLEVERILGEALAPFRNQVAIATK
CCEEEECCCCCHHHHHHHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHHHHHHCCEEEEEE
FGWNIDPETGRMAGGLNSRPDHIRTAVDGMLKRLRTDRIDLLYQHRVDPAVPIEDVAGTV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
KDLIAQGKVLHFGLSEPGPQTVRRAHAVQPLAAIQNEYSIMARDPEAQILPICKELGIGL
HHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCE
VCWGPLAQGFLTGAIDKESQFQRGDFRGSVPWFSAENRPGNLAIVEVVKEWGRRKKATPA
EEHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCH
QISLAWLLAQGPSVVPIPGTNRLPHLIEDLGADAVRLTPEELRDFNAALARTPVQGARMG
HEEEEEEEECCCCEEECCCCCCCHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCCHHHHC
RGILSLSGVEAPAKQR
CCCEEECCCCCCCCCC
>Mature Secondary Structure
MQKRTLIPDRRSFLLALGGSVSLPVFAQQSGPASVEPQVNGRRKLGTLEVSSIGLGCQDM
CCCCCCCCCCHHEEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEHHCCCCCHHC
TGAVYASAPNRADMIGIARAAHDRGVTFFDAAEAYGPLEVERILGEALAPFRNQVAIATK
CCEEEECCCCCHHHHHHHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHHHHHHCCEEEEEE
FGWNIDPETGRMAGGLNSRPDHIRTAVDGMLKRLRTDRIDLLYQHRVDPAVPIEDVAGTV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
KDLIAQGKVLHFGLSEPGPQTVRRAHAVQPLAAIQNEYSIMARDPEAQILPICKELGIGL
HHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCE
VCWGPLAQGFLTGAIDKESQFQRGDFRGSVPWFSAENRPGNLAIVEVVKEWGRRKKATPA
EEHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCH
QISLAWLLAQGPSVVPIPGTNRLPHLIEDLGADAVRLTPEELRDFNAALARTPVQGARMG
HEEEEEEEECCCCEEECCCCCCCHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCCHHHHC
RGILSLSGVEAPAKQR
CCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9106203 [H]