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The map label for this gene is proC [H]

Identifier: 116516457

GI number: 116516457

Start: 842880

End: 843677

Strand: Direct

Name: proC [H]

Synonym: SPD_0824

Alternate gene names: 116516457

Gene position: 842880-843677 (Clockwise)

Preceding gene: 116516154

Following gene: 116516561

Centisome position: 41.19

GC content: 44.49

Gene sequence:

>798_bases
ATGAAGATTGGATTTATCGGTTTGGGGAATATGGGTGCTAGCTTGGCAAAATCTGTCTTGCAGACTAGGACGTCAGATGA
GATTCTCCTTGCCAATCGTAGTCAAGCTAAGGTAGATGCTTTCATTGCAGACTTTGGTGGTCAGGCTTCCAGCAATGAAG
AAATGTTTGCAGAAGCAGATGTGATTTTTCTAGGAGTTAAGCCTGCTCAGTTTTCTGAACTGCTTTCTCAATACCAGACC
ATCCTTGAAAAAAGAGAAAGTCTTCTTTTGATTTCGATGGCAGCTGGATTGACCTTAGAAAAACTAGCAAGTCTTATCCC
AAGTCAACACCGAATTATTCGTATGATGCCTAATACCCCTGCTTCTATCGGGCAAGGAGTGATTAGTTATGCCTTGTCTC
CTAATTGCAGGACTGAGGACAGTGAGCTCTTTTGTCAGCTTTTATCCAAGGCTGGTCTCTTGGTTGAATTAGGAGAAAGC
TTAATCAATGCAGCGACAGGTCTTGCAGGCTGTGGACCAGCCTTTGTCTATCTCTTTATTGAGGCTTTGGCAGATGCAGG
TGTTCAGACGGGATTACCACGAGAAACAGCCTTGAAAATGGCAGCCCAAACTGTGGTAGGAGCTGGGCAATTGGTCCTAG
AAAGCCAGCAACATCCTGGAGTTTTGAAAGATCAAGTTTGTAGTCCAGGCGGTTCGACTATTGCTGGCGTAGCAAGCTTA
GAAGCGCATGCTTTTCGAGGCATAGTCATGGAGGCAGTTCATCAAGCCTATAAACGAACACAAGAACTAGGTAAATAA

Upstream 100 bases:

>100_bases
TTCTACTCAGAAATTGCACGCGCGTGGTCCAATGGGCTTGAAAGAGTTGACCAGCTACAAGTATGTGGTTGCTGGTGATG
GGCAGATAAGGGAGTAAGAG

Downstream 100 bases:

>100_bases
GAGGTAGCTTTGACTGCCTCTTTTATGGTGGCTGAAATGAGAAGACACAAAAAGATTGTCACAAACTCCTATTTTTTTGA
TAGAATAGAAGTAGTAAAAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MKIGFIGLGNMGASLAKSVLQTRTSDEILLANRSQAKVDAFIADFGGQASSNEEMFAEADVIFLGVKPAQFSELLSQYQT
ILEKRESLLLISMAAGLTLEKLASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRTEDSELFCQLLSKAGLLVELGES
LINAATGLAGCGPAFVYLFIEALADAGVQTGLPRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
EAHAFRGIVMEAVHQAYKRTQELGK

Sequences:

>Translated_265_residues
MKIGFIGLGNMGASLAKSVLQTRTSDEILLANRSQAKVDAFIADFGGQASSNEEMFAEADVIFLGVKPAQFSELLSQYQT
ILEKRESLLLISMAAGLTLEKLASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRTEDSELFCQLLSKAGLLVELGES
LINAATGLAGCGPAFVYLFIEALADAGVQTGLPRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
EAHAFRGIVMEAVHQAYKRTQELGK
>Mature_265_residues
MKIGFIGLGNMGASLAKSVLQTRTSDEILLANRSQAKVDAFIADFGGQASSNEEMFAEADVIFLGVKPAQFSELLSQYQT
ILEKRESLLLISMAAGLTLEKLASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRTEDSELFCQLLSKAGLLVELGES
LINAATGLAGCGPAFVYLFIEALADAGVQTGLPRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
EAHAFRGIVMEAVHQAYKRTQELGK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=275, Percent_Identity=38.5454545454545, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI24797095, Length=275, Percent_Identity=38.5454545454545, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI21361454, Length=275, Percent_Identity=37.8181818181818, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=31.5789473684211, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1786585, Length=269, Percent_Identity=40.1486988847584, Blast_Score=184, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=39.9253731343284, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=33.5714285714286, Blast_Score=130, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6320861, Length=214, Percent_Identity=35.981308411215, Blast_Score=135, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24648116, Length=279, Percent_Identity=38.3512544802867, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21358587, Length=274, Percent_Identity=36.1313868613139, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=41.6666666666667, Blast_Score=134, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27981; Mature: 27981

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGLGNMGASLAKSVLQTRTSDEILLANRSQAKVDAFIADFGGQASSNEEMFAEAD
CEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCHHHHCCC
VIFLGVKPAQFSELLSQYQTILEKRESLLLISMAAGLTLEKLASLIPSQHRIIRMMPNTP
EEEEECCHHHHHHHHHHHHHHHHHHHHEEEEHHHHCCCHHHHHHHCCCCCCEEEECCCCC
ASIGQGVISYALSPNCRTEDSELFCQLLSKAGLLVELGESLINAATGLAGCGPAFVYLFI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EALADAGVQTGLPRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
HHHHHCCHHCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCHHHHHCCCCCCHHHHHHHH
EAHAFRGIVMEAVHQAYKRTQELGK
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIGFIGLGNMGASLAKSVLQTRTSDEILLANRSQAKVDAFIADFGGQASSNEEMFAEAD
CEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCHHHHCCC
VIFLGVKPAQFSELLSQYQTILEKRESLLLISMAAGLTLEKLASLIPSQHRIIRMMPNTP
EEEEECCHHHHHHHHHHHHHHHHHHHHEEEEHHHHCCCHHHHHHHCCCCCCEEEECCCCC
ASIGQGVISYALSPNCRTEDSELFCQLLSKAGLLVELGESLINAATGLAGCGPAFVYLFI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EALADAGVQTGLPRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASL
HHHHHCCHHCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCHHHHHCCCCCCHHHHHHHH
EAHAFRGIVMEAVHQAYKRTQELGK
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]