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The map label for this gene is proA

Identifier: 116516154

GI number: 116516154

Start: 841614

End: 842876

Strand: Direct

Name: proA

Synonym: SPD_0823

Alternate gene names: 116516154

Gene position: 841614-842876 (Clockwise)

Preceding gene: 116516764

Following gene: 116516457

Centisome position: 41.13

GC content: 45.45

Gene sequence:

>1263_bases
ATGGTGAGTAGACAAGAACAATTTGAACAGGTACAGGCTGTTAAAAAATCGATTAACACAGCTAGTGAAGAAGTGAAAAA
CCAAGCCTTGCTAGCCATGGCTGATCACTTAGTGGCTGCTACTGAGGAAATTTTAGCGGCTAATGCCCTCGATATGGCAG
CGGCTAAGGGGAAAATCTCAGATGTGATGTTGGATCGTCTTTATTTGGATGCAGATCGTATAGAAGCGATGGCAAGAGGA
ATTCGTGAAGTGGTTGCCTTACCAGATCCAATCGGTGAAGTTTTAGAAACAAGTCAGCTTGAAAATGGTTTGGTTATCAC
AAAAAAACGTGTAGCTATGGGTGTCATCGGTATTATCTATGAAAGCCGTCCAAATGTGACGTCTGATGCGGCTGCTTTGA
CTCTTAAGAGTGGAAATGCGGTTGTTCTTCGTAGTGGTAAGGATGCCTATCAAACAACCCATGCCATTGTCACAGCCTTG
AAGAAGGGCTTGGAGACGACTACTATTCATCCAAATGTGATTCAACTGGTGGAGGATACTAGCCGTGAAAGTAGTTATGC
TATGATGAAGGCCAAGGGCTATCTAGACCTTCTCATTCCTCGTGGAGGAGCTGGCTTGATCAATGCAGTAGTTGAGAATG
CCATTGTACCTGTTATCGAGACAGGGACTGGGATTGTCCATGTCTATGTGGATAAGGATGCAGACGAAGACAAGGCGCTG
TCTATCATCAACAATGCTAAAACCAGTCGTCCTTCTGTTTGTAATGCCATGGAGGTTCTGCTGGTTCATGAAAACAAGGC
AGCAAGCATCCTTCCTCGCTTGGATCAAATGCTGGTTGCAGAGCGTAAGGAAGCTGGACTGGAACCAATTCAATTCCGCT
TGGATAGCAAAGCAAGCCAGTTTGTTTCAGGTCAAGCAGCTGAGACCCAAGACTTTGACACCGAGTTTTTAGACTATGTC
CTTGCTGTTAAGGTTGTGAGCAGTTTAGAAGAAGCGGTTGCGCACATTGAATCCCACAGCACCCATCATTCGGATGCTAT
TGTGACGGAAAATGCTGAAGCTGCAGCATACTTTACAGATCAAGTGGACTCTGCAGCGGTGTATGTTAATGCCTCAACTC
GTTTCACAGATGGAGGACAATTTGGTCTTGGTTGTGAAATGGGGATTTCTACTCAGAAATTGCACGCGCGTGGTCCAATG
GGCTTGAAAGAGTTGACCAGCTACAAGTATGTGGTTGCTGGTGATGGGCAGATAAGGGAGTAA

Upstream 100 bases:

>100_bases
GCGTTCTCAAAAAGCCAAGGGTGTCTTGATTTACCGTGACGACTGGATTTCCATTACTCCTGAAATCCAACTACTTTTTA
CAGAATTTTAGAGGTAAACT

Downstream 100 bases:

>100_bases
GAGATGAAGATTGGATTTATCGGTTTGGGGAATATGGGTGCTAGCTTGGCAAAATCTGTCTTGCAGACTAGGACGTCAGA
TGAGATTCTCCTTGCCAATC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEILAANALDMAAAKGKISDVMLDRLYLDADRIEAMARG
IREVVALPDPIGEVLETSQLENGLVITKKRVAMGVIGIIYESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTAL
KKGLETTTIHPNVIQLVEDTSRESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPVIETGTGIVHVYVDKDADEDKAL
SIINNAKTSRPSVCNAMEVLLVHENKAASILPRLDQMLVAERKEAGLEPIQFRLDSKASQFVSGQAAETQDFDTEFLDYV
LAVKVVSSLEEAVAHIESHSTHHSDAIVTENAEAAAYFTDQVDSAAVYVNASTRFTDGGQFGLGCEMGISTQKLHARGPM
GLKELTSYKYVVAGDGQIRE

Sequences:

>Translated_420_residues
MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEILAANALDMAAAKGKISDVMLDRLYLDADRIEAMARG
IREVVALPDPIGEVLETSQLENGLVITKKRVAMGVIGIIYESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTAL
KKGLETTTIHPNVIQLVEDTSRESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPVIETGTGIVHVYVDKDADEDKAL
SIINNAKTSRPSVCNAMEVLLVHENKAASILPRLDQMLVAERKEAGLEPIQFRLDSKASQFVSGQAAETQDFDTEFLDYV
LAVKVVSSLEEAVAHIESHSTHHSDAIVTENAEAAAYFTDQVDSAAVYVNASTRFTDGGQFGLGCEMGISTQKLHARGPM
GLKELTSYKYVVAGDGQIRE
>Mature_420_residues
MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEILAANALDMAAAKGKISDVMLDRLYLDADRIEAMARG
IREVVALPDPIGEVLETSQLENGLVITKKRVAMGVIGIIYESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTAL
KKGLETTTIHPNVIQLVEDTSRESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPVIETGTGIVHVYVDKDADEDKAL
SIINNAKTSRPSVCNAMEVLLVHENKAASILPRLDQMLVAERKEAGLEPIQFRLDSKASQFVSGQAAETQDFDTEFLDYV
LAVKVVSSLEEAVAHIESHSTHHSDAIVTENAEAAAYFTDQVDSAAVYVNASTRFTDGGQFGLGCEMGISTQKLHARGPM
GLKELTSYKYVVAGDGQIRE

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=418, Percent_Identity=33.4928229665072, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI21361368, Length=418, Percent_Identity=33.4928229665072, Blast_Score=248, Evalue=7e-66,
Organism=Escherichia coli, GI1786438, Length=411, Percent_Identity=46.2287104622871, Blast_Score=356, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17569969, Length=404, Percent_Identity=33.4158415841584, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17569967, Length=404, Percent_Identity=33.4158415841584, Blast_Score=231, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6324899, Length=433, Percent_Identity=38.7990762124711, Blast_Score=272, Evalue=8e-74,
Organism=Drosophila melanogaster, GI21357643, Length=386, Percent_Identity=36.2694300518135, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_STRP2 (Q04KZ2)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816306.1
- ProteinModelPortal:   Q04KZ2
- SMR:   Q04KZ2
- STRING:   Q04KZ2
- EnsemblBacteria:   EBSTRT00000018820
- GeneID:   4442516
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_0823
- eggNOG:   COG0014
- GeneTree:   EBGT00050000027638
- HOGENOM:   HBG318080
- OMA:   HRIEAMA
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45226; Mature: 45226

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEILAANALDMAAAKGKIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DVMLDRLYLDADRIEAMARGIREVVALPDPIGEVLETSQLENGLVITKKRVAMGVIGIIY
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHEEEEE
ESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTALKKGLETTTIHPNVIQLVEDT
ECCCCCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHC
SRESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPVIETGTGIVHVYVDKDADEDKAL
CCCHHEEHEEECCCEEEEECCCCCHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCHHHH
SIINNAKTSRPSVCNAMEVLLVHENKAASILPRLDQMLVAERKEAGLEPIQFRLDSKASQ
HHHHCCCCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHH
FVSGQAAETQDFDTEFLDYVLAVKVVSSLEEAVAHIESHSTHHSDAIVTENAEAAAYFTD
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECC
QVDSAAVYVNASTRFTDGGQFGLGCEMGISTQKLHARGPMGLKELTSYKYVVAGDGQIRE
CCCCEEEEEECCCEECCCCCCCCCEECCCCHHHHHCCCCCCHHHHCCEEEEEECCCCCCC
>Mature Secondary Structure
MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEILAANALDMAAAKGKIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
DVMLDRLYLDADRIEAMARGIREVVALPDPIGEVLETSQLENGLVITKKRVAMGVIGIIY
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHEEEEE
ESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTALKKGLETTTIHPNVIQLVEDT
ECCCCCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHC
SRESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPVIETGTGIVHVYVDKDADEDKAL
CCCHHEEHEEECCCEEEEECCCCCHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCHHHH
SIINNAKTSRPSVCNAMEVLLVHENKAASILPRLDQMLVAERKEAGLEPIQFRLDSKASQ
HHHHCCCCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHH
FVSGQAAETQDFDTEFLDYVLAVKVVSSLEEAVAHIESHSTHHSDAIVTENAEAAAYFTD
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECC
QVDSAAVYVNASTRFTDGGQFGLGCEMGISTQKLHARGPMGLKELTSYKYVVAGDGQIRE
CCCCEEEEEECCCEECCCCCCCCCEECCCCHHHHHCCCCCCHHHHCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA