Click here to switch to the map view.

The map label for this gene is mtlA [H]

Identifier: 116515741

GI number: 116515741

Start: 361289

End: 363058

Strand: Direct

Name: mtlA [H]

Synonym: SPD_0360

Alternate gene names: 116515741

Gene position: 361289-363058 (Clockwise)

Preceding gene: 116515867

Following gene: 116516824

Centisome position: 17.66

GC content: 40.79

Gene sequence:

>1770_bases
ATGGAAGAAAAAGTATCATTGAAAGTCAGGGTTCAAAAACTAGGGACATCGCTTTCAAATATGGTTATGCCCAATATTGG
AGCATTTATTGCTTGGGGAGTATTGACTGCCCTCTTTATCGCTGATGGCTATCTGCCAAATGAACAGTTAGCTACTGTTG
TTGGTCCTATGTTAACGTATTTATTGCCAATCCTGATTGGTTACACAGGTGGATATATGATCCATGGCCAACGTGGTGCC
GTTGTAGGATCTATTGCTACTGTTGGTGCAATCACAGGTTCTAGTGTTCCTATGTTTATCGGAGCTATGGTAATGGGCCC
ACTGGGAGGATGGACTATCAAGAAATTTGATGAGAAGTTCCAAGAAAAAATTCGTCCCGGATTTGAAATGTTAGTTAATA
ACTTCTCAGCTGGTCTCGTTGGTTTTGCATTATTGCTTTTGGCTTTCTACGCAATCGGTCCAGTCGTATCGACTCTTACT
GGAGCTGTTGGGAATGGTGTTGAGGCTATTGTCAATGCTCGCCTCCTTCCTATGGCTAATATTATCATCGAACCGGCTAA
AGTCCTTTTCCTCAATAATGCCCTCAATCATGGCATTTTTACTCCTCTGGGAGTAGAACAGGTAGCTCAAGCTGGTAAGT
CAATTCTCTTCCTATTGGAAGCTAATCCTGGACCAGGCCTGGGAATTCTATTAGCTTATGCTGTATTCGGTAAAGGTTCT
GCTAAATCTTCTTCTTGGGGGGCAATGGTTATTCATTTCTTCGGAGGGATTCATGAAATTTACTTTCCTTATGTTATGAT
GAAGCCTACTCTATTTTTAGCTGCTATGGCAGGAGGTATCTCTGGAACTTTTACTTTTCAACTCTTAGACGCTGGTCTTA
AATCTCCAGCTTCACCAGGTTCTATTATTGCGATTATGGCTACGGCGCCAAAAGGTGTTTGGCCCCATCTAAATATTCTT
TTAGGTGTTTTAGTGGCAGCAGTTGTTTCTTTCCTTATAGCAGCCCTTATTCTTCATGCAGACAAGTCAACTGAGGATTC
GCTCGAAGCTGCTCAGGCGGCTACCCAAGCAGCTAAGGCTCAGTCTAAAGGTCAGTTAGTATCAACTTCTGTTGATGCAG
TTGTTTCGACAGACTCAGTGGAAAAAATCATTTTCGCCTGCGATGCTGGTATGGGAAGCTCTGCTATGGGAGCTAGTATT
CTTCGAGATAAGGTTAAAAAAGCAGGTCTAGAGCTTCCAGTATCTAATCAGGCAATCTCAAATTTGCTTGATACACCAAA
AACATTAATTGTTACTCAGGAAGAACTGACACCAAGAGCTAAAGACAAGAGTCCAAGTGCTATTCATGTTTCTGTTGATA
ATTTCTTAGCGTCCCCTCGTTATGATGAAATTGTAGCTTCATTAACAGGAGCTTCTCCAATAGCAGAAATTGAAGGAGAT
ATACCAACTTCAGCACCAGTAGATAGTCAGGAAATTGACCTTAACCATATTGATGCTGTAGTAGTTGCTTATGGTAAAGC
ACAGGGAACTGCAACTATGGGCTGTGAAACGATTCGGGCTATCTTTAGAAACAAGAATATTCGTATTCCAGTTTCTACTG
CCAAAATTTCAGAATTAGGTGAATTTAATTCTAAAAACATAATGATTGTAACAACTATTTCTTTACAGGCAGAAGTGCAG
CAAGCAGCACCGAATTCTCAATTTCTTATTGTGGATAGTTTAGTAACAACACCAGAATATGACAAAATGGCTGCTAGAAT
GTACAAATAG

Upstream 100 bases:

>100_bases
CATCAAAAGTAATGTTTTGACACAAAATCTGTGACAAAACTTTAGTTTTAAAGGTTTTTAACTTTGTATATACTAGTTTT
AAGAAAAGGAGGATGATCTA

Downstream 100 bases:

>100_bases
AACTAGAGGTTTCTAAATTACGAATGCTATTAACCAAACGAGAAGAACAATTATTGAAGGCTTTCCTACATGTAGGGAAG
CTTTCAATGCAAGATATGAC

Product: PTS system, mannitol-specific IIBC components

Products: NA

Alternate protein names: EIICB-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component [H]

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MEEKVSLKVRVQKLGTSLSNMVMPNIGAFIAWGVLTALFIADGYLPNEQLATVVGPMLTYLLPILIGYTGGYMIHGQRGA
VVGSIATVGAITGSSVPMFIGAMVMGPLGGWTIKKFDEKFQEKIRPGFEMLVNNFSAGLVGFALLLLAFYAIGPVVSTLT
GAVGNGVEAIVNARLLPMANIIIEPAKVLFLNNALNHGIFTPLGVEQVAQAGKSILFLLEANPGPGLGILLAYAVFGKGS
AKSSSWGAMVIHFFGGIHEIYFPYVMMKPTLFLAAMAGGISGTFTFQLLDAGLKSPASPGSIIAIMATAPKGVWPHLNIL
LGVLVAAVVSFLIAALILHADKSTEDSLEAAQAATQAAKAQSKGQLVSTSVDAVVSTDSVEKIIFACDAGMGSSAMGASI
LRDKVKKAGLELPVSNQAISNLLDTPKTLIVTQEELTPRAKDKSPSAIHVSVDNFLASPRYDEIVASLTGASPIAEIEGD
IPTSAPVDSQEIDLNHIDAVVVAYGKAQGTATMGCETIRAIFRNKNIRIPVSTAKISELGEFNSKNIMIVTTISLQAEVQ
QAAPNSQFLIVDSLVTTPEYDKMAARMYK

Sequences:

>Translated_589_residues
MEEKVSLKVRVQKLGTSLSNMVMPNIGAFIAWGVLTALFIADGYLPNEQLATVVGPMLTYLLPILIGYTGGYMIHGQRGA
VVGSIATVGAITGSSVPMFIGAMVMGPLGGWTIKKFDEKFQEKIRPGFEMLVNNFSAGLVGFALLLLAFYAIGPVVSTLT
GAVGNGVEAIVNARLLPMANIIIEPAKVLFLNNALNHGIFTPLGVEQVAQAGKSILFLLEANPGPGLGILLAYAVFGKGS
AKSSSWGAMVIHFFGGIHEIYFPYVMMKPTLFLAAMAGGISGTFTFQLLDAGLKSPASPGSIIAIMATAPKGVWPHLNIL
LGVLVAAVVSFLIAALILHADKSTEDSLEAAQAATQAAKAQSKGQLVSTSVDAVVSTDSVEKIIFACDAGMGSSAMGASI
LRDKVKKAGLELPVSNQAISNLLDTPKTLIVTQEELTPRAKDKSPSAIHVSVDNFLASPRYDEIVASLTGASPIAEIEGD
IPTSAPVDSQEIDLNHIDAVVVAYGKAQGTATMGCETIRAIFRNKNIRIPVSTAKISELGEFNSKNIMIVTTISLQAEVQ
QAAPNSQFLIVDSLVTTPEYDKMAARMYK
>Mature_589_residues
MEEKVSLKVRVQKLGTSLSNMVMPNIGAFIAWGVLTALFIADGYLPNEQLATVVGPMLTYLLPILIGYTGGYMIHGQRGA
VVGSIATVGAITGSSVPMFIGAMVMGPLGGWTIKKFDEKFQEKIRPGFEMLVNNFSAGLVGFALLLLAFYAIGPVVSTLT
GAVGNGVEAIVNARLLPMANIIIEPAKVLFLNNALNHGIFTPLGVEQVAQAGKSILFLLEANPGPGLGILLAYAVFGKGS
AKSSSWGAMVIHFFGGIHEIYFPYVMMKPTLFLAAMAGGISGTFTFQLLDAGLKSPASPGSIIAIMATAPKGVWPHLNIL
LGVLVAAVVSFLIAALILHADKSTEDSLEAAQAATQAAKAQSKGQLVSTSVDAVVSTDSVEKIIFACDAGMGSSAMGASI
LRDKVKKAGLELPVSNQAISNLLDTPKTLIVTQEELTPRAKDKSPSAIHVSVDNFLASPRYDEIVASLTGASPIAEIEGD
IPTSAPVDSQEIDLNHIDAVVVAYGKAQGTATMGCETIRAIFRNKNIRIPVSTAKISELGEFNSKNIMIVTTISLQAEVQ
QAAPNSQFLIVDSLVTTPEYDKMAARMYK

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=469, Percent_Identity=55.2238805970149, Blast_Score=500, Evalue=1e-142,
Organism=Escherichia coli, GI1789301, Length=471, Percent_Identity=49.2569002123142, Blast_Score=444, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 61954; Mature: 61954

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEKVSLKVRVQKLGTSLSNMVMPNIGAFIAWGVLTALFIADGYLPNEQLATVVGPMLTY
CCCCEEHEEEHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LLPILIGYTGGYMIHGQRGAVVGSIATVGAITGSSVPMFIGAMVMGPLGGWTIKKFDEKF
HHHHHHHCCCCEEEECCCCCEEEHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
QEKIRPGFEMLVNNFSAGLVGFALLLLAFYAIGPVVSTLTGAVGNGVEAIVNARLLPMAN
HHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHH
IIIEPAKVLFLNNALNHGIFTPLGVEQVAQAGKSILFLLEANPGPGLGILLAYAVFGKGS
HHHCCHHHEEEHHHHCCCCCCCCCHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCC
AKSSSWGAMVIHFFGGIHEIYFPYVMMKPTLFLAAMAGGISGTFTFQLLDAGLKSPASPG
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCC
SIIAIMATAPKGVWPHLNILLGVLVAAVVSFLIAALILHADKSTEDSLEAAQAATQAAKA
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QSKGQLVSTSVDAVVSTDSVEKIIFACDAGMGSSAMGASILRDKVKKAGLELPVSNQAIS
HCCCCEEEECHHHHCCCCHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
NLLDTPKTLIVTQEELTPRAKDKSPSAIHVSVDNFLASPRYDEIVASLTGASPIAEIEGD
HHHCCCCEEEEEHHHCCCCCCCCCCCEEEEEHHHHHCCCCHHHHHHHHCCCCCHHHCCCC
IPTSAPVDSQEIDLNHIDAVVVAYGKAQGTATMGCETIRAIFRNKNIRIPVSTAKISELG
CCCCCCCCCCCCCHHHHCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHHHH
EFNSKNIMIVTTISLQAEVQQAAPNSQFLIVDSLVTTPEYDKMAARMYK
CCCCCCEEEEEEEEHHHHHHHCCCCCCEEEEECHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MEEKVSLKVRVQKLGTSLSNMVMPNIGAFIAWGVLTALFIADGYLPNEQLATVVGPMLTY
CCCCEEHEEEHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LLPILIGYTGGYMIHGQRGAVVGSIATVGAITGSSVPMFIGAMVMGPLGGWTIKKFDEKF
HHHHHHHCCCCEEEECCCCCEEEHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
QEKIRPGFEMLVNNFSAGLVGFALLLLAFYAIGPVVSTLTGAVGNGVEAIVNARLLPMAN
HHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHH
IIIEPAKVLFLNNALNHGIFTPLGVEQVAQAGKSILFLLEANPGPGLGILLAYAVFGKGS
HHHCCHHHEEEHHHHCCCCCCCCCHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCC
AKSSSWGAMVIHFFGGIHEIYFPYVMMKPTLFLAAMAGGISGTFTFQLLDAGLKSPASPG
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCC
SIIAIMATAPKGVWPHLNILLGVLVAAVVSFLIAALILHADKSTEDSLEAAQAATQAAKA
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QSKGQLVSTSVDAVVSTDSVEKIIFACDAGMGSSAMGASILRDKVKKAGLELPVSNQAIS
HCCCCEEEECHHHHCCCCHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHH
NLLDTPKTLIVTQEELTPRAKDKSPSAIHVSVDNFLASPRYDEIVASLTGASPIAEIEGD
HHHCCCCEEEEEHHHCCCCCCCCCCCEEEEEHHHHHCCCCHHHHHHHHCCCCCHHHCCCC
IPTSAPVDSQEIDLNHIDAVVVAYGKAQGTATMGCETIRAIFRNKNIRIPVSTAKISELG
CCCCCCCCCCCCCHHHHCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHHHH
EFNSKNIMIVTTISLQAEVQQAAPNSQFLIVDSLVTTPEYDKMAARMYK
CCCCCCEEEEEEEEHHHHHHHCCCCCCEEEEECHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]