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The map label for this gene is glyA

Identifier: 116515114

GI number: 116515114

Start: 207123

End: 208376

Strand: Direct

Name: glyA

Synonym: BCc_178

Alternate gene names: 116515114

Gene position: 207123-208376 (Clockwise)

Preceding gene: 116515113

Following gene: 116515117

Centisome position: 49.74

GC content: 24.72

Gene sequence:

>1254_bases
ATGATAAACACAAATTTAAAAAATTATGATCCAAAAATTTGGAAACTAATTATAAAAGAAAAAAAAAGGCAAGAATCATA
TATTAATTTAATTGCATCAGAAAATTATGTTAGTTCTTCTATTCTTGAAGCTCAGGGATCATGTTTAACAAATAAGTATG
CTGAGGGATATATTGGAAATCGTTTCTATAACGGATGTAATATCATTGATAAAATTGAAAAAATTGCAATTAAAAGAGCT
AAAAAATTATTTAATGTTGAATATGTAAACGTTCAACCTCATTCAGGATCACAAGCTAATTTTTCGGTATTTAATGCTTT
ATTAAAACCTAATGATATAATTTTAGGAATGAACTTAAATCATGGAGGACATTTAACTCATGGATCAACAGTAAATTTTT
CAGGAAAACTATATAAATCATTTTCTTACGGAGTAAATAAATGTGGTGAAATTGATTATGACGCATTAAAATATTTATCA
CATTTGCATCGTCCTAAAATGATTATTGGAGGATTCTCTGCTTATTCAGGAATTTGTGATTGGAAATATATGAGAAAAAT
AGCAGATGAAATTAATGCATATTTTTTTGTTGATATTTCACATATTGTAGGTTTAATTGTTGCAGGTATTTATCCTAATC
CATTAAAATATGCACATGTTGTAAGTACTACAACACATAAAACTTTAGGAGGTCCAAGAGGGGGTTTAATTATTTCAAAT
TGTGGTAATAAAAAAATTTATTCTAAATTAGATTCATCAGTATTTCCTGGAAGCCAAGGTGGACCTTTAATGCATGTTAT
TGCTGCTAAAGCAATTTCTTTTAAAGAAGCTTTAGAACCAAAATTTTTTTTATTACAAAAAAATATTTTATTTTTTTCTA
AAAAAATGGTTAAAATATTTTTAAAAAGAAATTTTTCTGTTATTTCTGGAAAAACTAATAATCATTTATTTTTAATCGAT
TTGTCTGAAAAAAAAATTTCGGGTAAAGAGGCTAGTAATATTTTAGCTTTAGCACGAATTATAGTAAATAAAAATACCAT
TCCTAATGATTCTCAAAGTCCGTATATTACTTCAGGTATTCGTATTGGTACTCCTGCTATAGTTAAACGAGGCATAAGTA
TTAAGTATGTTATTAAAATTACTAATTGGATTTGTGATATCTTAAATGAACCTAATAATTTAATAAAAATAAAAAAAATT
AGTAAAAAGATAAAAAAAATTTGTTATAAATATCCCATATATAACAAGATTTAA

Upstream 100 bases:

>100_bases
GTTATTTTTATATTTTTAAAAATTTTAATATTATTAAATAAATATATATTAAATAATATAAATTTATTATCATTTTTAAA
ATAAATATAAGAAAATTCTT

Downstream 100 bases:

>100_bases
AAATTTAAATATTTAATTTATATTAAAAATTTTTATTCATATAAATATAAATTTTATATATATATTATACTATAAAAAAT
TTTATTTATATTTTTTATTT

Product: hypothetical protein

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MINTNLKNYDPKIWKLIIKEKKRQESYINLIASENYVSSSILEAQGSCLTNKYAEGYIGNRFYNGCNIIDKIEKIAIKRA
KKLFNVEYVNVQPHSGSQANFSVFNALLKPNDIILGMNLNHGGHLTHGSTVNFSGKLYKSFSYGVNKCGEIDYDALKYLS
HLHRPKMIIGGFSAYSGICDWKYMRKIADEINAYFFVDISHIVGLIVAGIYPNPLKYAHVVSTTTHKTLGGPRGGLIISN
CGNKKIYSKLDSSVFPGSQGGPLMHVIAAKAISFKEALEPKFFLLQKNILFFSKKMVKIFLKRNFSVISGKTNNHLFLID
LSEKKISGKEASNILALARIIVNKNTIPNDSQSPYITSGIRIGTPAIVKRGISIKYVIKITNWICDILNEPNNLIKIKKI
SKKIKKICYKYPIYNKI

Sequences:

>Translated_417_residues
MINTNLKNYDPKIWKLIIKEKKRQESYINLIASENYVSSSILEAQGSCLTNKYAEGYIGNRFYNGCNIIDKIEKIAIKRA
KKLFNVEYVNVQPHSGSQANFSVFNALLKPNDIILGMNLNHGGHLTHGSTVNFSGKLYKSFSYGVNKCGEIDYDALKYLS
HLHRPKMIIGGFSAYSGICDWKYMRKIADEINAYFFVDISHIVGLIVAGIYPNPLKYAHVVSTTTHKTLGGPRGGLIISN
CGNKKIYSKLDSSVFPGSQGGPLMHVIAAKAISFKEALEPKFFLLQKNILFFSKKMVKIFLKRNFSVISGKTNNHLFLID
LSEKKISGKEASNILALARIIVNKNTIPNDSQSPYITSGIRIGTPAIVKRGISIKYVIKITNWICDILNEPNNLIKIKKI
SKKIKKICYKYPIYNKI
>Mature_417_residues
MINTNLKNYDPKIWKLIIKEKKRQESYINLIASENYVSSSILEAQGSCLTNKYAEGYIGNRFYNGCNIIDKIEKIAIKRA
KKLFNVEYVNVQPHSGSQANFSVFNALLKPNDIILGMNLNHGGHLTHGSTVNFSGKLYKSFSYGVNKCGEIDYDALKYLS
HLHRPKMIIGGFSAYSGICDWKYMRKIADEINAYFFVDISHIVGLIVAGIYPNPLKYAHVVSTTTHKTLGGPRGGLIISN
CGNKKIYSKLDSSVFPGSQGGPLMHVIAAKAISFKEALEPKFFLLQKNILFFSKKMVKIFLKRNFSVISGKTNNHLFLID
LSEKKISGKEASNILALARIIVNKNTIPNDSQSPYITSGIRIGTPAIVKRGISIKYVIKITNWICDILNEPNNLIKIKKI
SKKIKKICYKYPIYNKI

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=407, Percent_Identity=40.5405405405405, Blast_Score=327, Evalue=9e-90,
Organism=Homo sapiens, GI261862350, Length=407, Percent_Identity=40.5405405405405, Blast_Score=327, Evalue=9e-90,
Organism=Homo sapiens, GI261862348, Length=407, Percent_Identity=40.5405405405405, Blast_Score=327, Evalue=9e-90,
Organism=Homo sapiens, GI19923315, Length=409, Percent_Identity=40.3422982885086, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI261862346, Length=408, Percent_Identity=39.2156862745098, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI22547186, Length=406, Percent_Identity=40.3940886699507, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI22547189, Length=394, Percent_Identity=38.0710659898477, Blast_Score=255, Evalue=4e-68,
Organism=Escherichia coli, GI1788902, Length=410, Percent_Identity=57.0731707317073, Blast_Score=514, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI25144729, Length=401, Percent_Identity=39.9002493765586, Blast_Score=301, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI25144732, Length=401, Percent_Identity=39.9002493765586, Blast_Score=301, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6323087, Length=406, Percent_Identity=40.3940886699507, Blast_Score=301, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6319739, Length=438, Percent_Identity=36.7579908675799, Blast_Score=297, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24640005, Length=405, Percent_Identity=39.7530864197531, Blast_Score=317, Evalue=9e-87,
Organism=Drosophila melanogaster, GI221329721, Length=405, Percent_Identity=39.7530864197531, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_BUCCC (Q057P9)

Other databases:

- EMBL:   CP000263
- RefSeq:   YP_802743.1
- ProteinModelPortal:   Q057P9
- SMR:   Q057P9
- STRING:   Q057P9
- EnsemblBacteria:   EBBUCT00000001463
- GeneID:   4440789
- GenomeReviews:   CP000263_GR
- KEGG:   bcc:BCc_178
- eggNOG:   COG0112
- GeneTree:   EBGT00050000008150
- HOGENOM:   HBG301263
- OMA:   KAMARTF
- BioCyc:   BAPH372461:BCC_178-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 46862; Mature: 46862

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINTNLKNYDPKIWKLIIKEKKRQESYINLIASENYVSSSILEAQGSCLTNKYAEGYIGN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCCHHHHHHHCCCCCC
RFYNGCNIIDKIEKIAIKRAKKLFNVEYVNVQPHSGSQANFSVFNALLKPNDIILGMNLN
CCCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECC
HGGHLTHGSTVNFSGKLYKSFSYGVNKCGEIDYDALKYLSHLHRPKMIIGGFSAYSGICD
CCCCCCCCCEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHCCCCC
WKYMRKIADEINAYFFVDISHIVGLIVAGIYPNPLKYAHVVSTTTHKTLGGPRGGLIISN
HHHHHHHHHHCCEEEEEEHHHHHHHHHHCCCCCCCCEEEEEECCCHHHCCCCCCCEEEEC
CGNKKIYSKLDSSVFPGSQGGPLMHVIAAKAISFKEALEPKFFLLQKNILFFSKKMVKIF
CCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHH
LKRNFSVISGKTNNHLFLIDLSEKKISGKEASNILALARIIVNKNTIPNDSQSPYITSGI
HHCCCEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEECCE
RIGTPAIVKRGISIKYVIKITNWICDILNEPNNLIKIKKISKKIKKICYKYPIYNKI
EECCHHHHHCCCCEEEEEEHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MINTNLKNYDPKIWKLIIKEKKRQESYINLIASENYVSSSILEAQGSCLTNKYAEGYIGN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCCHHHHHHHCCCCCC
RFYNGCNIIDKIEKIAIKRAKKLFNVEYVNVQPHSGSQANFSVFNALLKPNDIILGMNLN
CCCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECC
HGGHLTHGSTVNFSGKLYKSFSYGVNKCGEIDYDALKYLSHLHRPKMIIGGFSAYSGICD
CCCCCCCCCEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHCCCCC
WKYMRKIADEINAYFFVDISHIVGLIVAGIYPNPLKYAHVVSTTTHKTLGGPRGGLIISN
HHHHHHHHHHCCEEEEEEHHHHHHHHHHCCCCCCCCEEEEEECCCHHHCCCCCCCEEEEC
CGNKKIYSKLDSSVFPGSQGGPLMHVIAAKAISFKEALEPKFFLLQKNILFFSKKMVKIF
CCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHH
LKRNFSVISGKTNNHLFLIDLSEKKISGKEASNILALARIIVNKNTIPNDSQSPYITSGI
HHCCCEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEECCE
RIGTPAIVKRGISIKYVIKITNWICDILNEPNNLIKIKKISKKIKKICYKYPIYNKI
EECCHHHHHCCCCEEEEEEHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA