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The map label for this gene is pyrH

Identifier: 116515084

GI number: 116515084

Start: 169040

End: 169759

Strand: Direct

Name: pyrH

Synonym: BCc_144

Alternate gene names: 116515084

Gene position: 169040-169759 (Clockwise)

Preceding gene: 116515083

Following gene: 116515085

Centisome position: 40.6

GC content: 21.11

Gene sequence:

>720_bases
ATGAAAAAAAAAATTAAATATAATAGAATTTTATTAAAAATTAGTGGGGAATTTTTAAGTAGTAAAAAAACATTTAATAT
AAATACTATTTTTATTACTAAATTAATTAAACAAATAAAATTATTAACAAATTTAGGAGTTCAAATTGGTTTAGTAATAG
GAGGAGGTAATTTATTTAGAGGGTCAGATTTAGAAAAAATAGGTATGAGACGTTCAATATCAGATAAAATTGGAATGTTA
TCTACAGTCATGAATGGATTGTTATTACATGAATTTATGCAAACAGCTAATATAAAATCAAAAATTTTTTCATCAACTTT
ACTTGAAGGTATTTGTGAACGATATCATATTGATAAAGCTATTAAATGTTTAGAAAAAAAATCAGTTGCAATTTTTTGTT
TTGGTCTAGGTATTCCTTTTTTTACAACAGATTCAGCTGCATGTATTTATGGAACTGAAATAAAAGCAAATATCTTACTA
AAAGCAACTAAAGTAGATGGTGTTTATTCATCTGATCCTATACTTAATAAATCAGCTATATTATATAAAAATTTATCATA
TAAAGATATTTTAAGAAAAGAATTAAAGGTAATGGATTACACATCATTAATTTTAGCTTATGAAAATAAATTACCTATAT
TAGTTTTTAATATGTATGATCCAGAAATTTTATATAAAATTATTATAGAAAAAAGTAATATTGGAACTTTAATTAAATAA

Upstream 100 bases:

>100_bases
TAATTAATAATATTAATATTTAAGAAAATATAATTATTTTTTATATTTTTTTAAATAAATTTTTTATATAGTTATGTACA
TTTGATATATTTTGATATTT

Downstream 100 bases:

>100_bases
TAATTTTTAATGATTTTTCATCAATTATAATTATAATAAGAATGAGATTATTTTATGATTAACGTTTTACAAGAAAAAAC
TTATATTAAAATGAATAAAT

Product: hypothetical protein

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MKKKIKYNRILLKISGEFLSSKKTFNINTIFITKLIKQIKLLTNLGVQIGLVIGGGNLFRGSDLEKIGMRRSISDKIGML
STVMNGLLLHEFMQTANIKSKIFSSTLLEGICERYHIDKAIKCLEKKSVAIFCFGLGIPFFTTDSAACIYGTEIKANILL
KATKVDGVYSSDPILNKSAILYKNLSYKDILRKELKVMDYTSLILAYENKLPILVFNMYDPEILYKIIIEKSNIGTLIK

Sequences:

>Translated_239_residues
MKKKIKYNRILLKISGEFLSSKKTFNINTIFITKLIKQIKLLTNLGVQIGLVIGGGNLFRGSDLEKIGMRRSISDKIGML
STVMNGLLLHEFMQTANIKSKIFSSTLLEGICERYHIDKAIKCLEKKSVAIFCFGLGIPFFTTDSAACIYGTEIKANILL
KATKVDGVYSSDPILNKSAILYKNLSYKDILRKELKVMDYTSLILAYENKLPILVFNMYDPEILYKIIIEKSNIGTLIK
>Mature_239_residues
MKKKIKYNRILLKISGEFLSSKKTFNINTIFITKLIKQIKLLTNLGVQIGLVIGGGNLFRGSDLEKIGMRRSISDKIGML
STVMNGLLLHEFMQTANIKSKIFSSTLLEGICERYHIDKAIKCLEKKSVAIFCFGLGIPFFTTDSAACIYGTEIKANILL
KATKVDGVYSSDPILNKSAILYKNLSYKDILRKELKVMDYTSLILAYENKLPILVFNMYDPEILYKIIIEKSNIGTLIK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=47.4137931034483, Blast_Score=235, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_BUCCC (Q057S9)

Other databases:

- EMBL:   CP000263
- RefSeq:   YP_802713.1
- ProteinModelPortal:   Q057S9
- SMR:   Q057S9
- STRING:   Q057S9
- EnsemblBacteria:   EBBUCT00000001439
- GeneID:   4440885
- GenomeReviews:   CP000263_GR
- KEGG:   bcc:BCc_144
- eggNOG:   COG0528
- GeneTree:   EBGT00050000007735
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- BioCyc:   BAPH372461:BCC_144-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26952; Mature: 26952

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: NA

Important sites: BINDING 55-55 BINDING 56-56 BINDING 60-60 BINDING 75-75 BINDING 163-163 BINDING 169-169 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKIKYNRILLKISGEFLSSKKTFNINTIFITKLIKQIKLLTNLGVQIGLVIGGGNLFR
CCCCEEEEEEEEEEECCHHCCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEC
GSDLEKIGMRRSISDKIGMLSTVMNGLLLHEFMQTANIKSKIFSSTLLEGICERYHIDKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IKCLEKKSVAIFCFGLGIPFFTTDSAACIYGTEIKANILLKATKVDGVYSSDPILNKSAI
HHHHHCCCEEEEEEECCCCEEECCCCEEEEECEEEEEEEEEEEEECCCCCCCCCCCCCEE
LYKNLSYKDILRKELKVMDYTSLILAYENKLPILVFNMYDPEILYKIIIEKSNIGTLIK
EEECCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCHHHEEHEEEECCCCCCCCC
>Mature Secondary Structure
MKKKIKYNRILLKISGEFLSSKKTFNINTIFITKLIKQIKLLTNLGVQIGLVIGGGNLFR
CCCCEEEEEEEEEEECCHHCCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEC
GSDLEKIGMRRSISDKIGMLSTVMNGLLLHEFMQTANIKSKIFSSTLLEGICERYHIDKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IKCLEKKSVAIFCFGLGIPFFTTDSAACIYGTEIKANILLKATKVDGVYSSDPILNKSAI
HHHHHCCCEEEEEEECCCCEEECCCCEEEEECEEEEEEEEEEEEECCCCCCCCCCCCCEE
LYKNLSYKDILRKELKVMDYTSLILAYENKLPILVFNMYDPEILYKIIIEKSNIGTLIK
EEECCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCHHHEEHEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA