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The map label for this gene is hemK [H]

Identifier: 116515053

GI number: 116515053

Start: 128516

End: 129349

Strand: Direct

Name: hemK [H]

Synonym: BCc_112

Alternate gene names: 116515053

Gene position: 128516-129349 (Clockwise)

Preceding gene: 116515052

Following gene: 116515054

Centisome position: 30.87

GC content: 20.5

Gene sequence:

>834_bases
ATGAATATTATAACTTGGTTATCATATGCTAGAAAAAAATTATCTAATAGTTTAACAGCTAAATTAGATTCTGAAGTATT
ATTATGTTTTGTATTAAAAATTTCAAAAAAAGATTTATTTTATAAAAATAAGAAAAAAATAAAAATAAAATATTTATTAA
TTTTAAATAATTTTTTATTTCGTAGAGTTTTAGGAGAACCTATAGCATATATTATAAAAAAAAAAGAATTTTGGTCATTA
TCTTTATTTGTTTCTTCTTATGTATTAATTCCCAGACCAGAAACAGAAATTTTAGTAGAACAAGTGTTATTGAAAGTTTC
TTCTACTAAAAATTCTATTTTAGAATTAGGTACCGGAAGTGGCGCTATATCTTTAGCATTAGCTTCTGAAAATTCTCAAT
TAAAAATAATTGGAACAGATATTAGCTTATATGCATTATTAATAGCTAAATATAATGCTGATAAATTAAATTTAAATAAT
GTTAAGTTTATTTATAGTAATTGGTTTCAAAATATACCAATAAAAAAATTTCATATTATTGTATGTAATCCACCTTATTT
GTCAAGAAAAGATTTTAAAAATTCTTGTTCTAACATTTCTTTTGAACCGTATTCAGCATTAGTTTCTGGAAACAGTGGAA
TTGAATGTATTGAATATATTATAAAAAATTCGTTTCAATATTTTGTTTCTTCAGGATGGTTGTATATTGAACATTGTTAC
AAGCAAACTAAATTAGTACATAATATTTTTAAAAACAATTTTTTTATTAACATTGTATCTGTAAAAGATTATTCTAATAG
AAATAGAATTACTTATGGTTATTTAAATAAATAA

Upstream 100 bases:

>100_bases
TTGTTAGGAAAATTAGATTTATTAATTGAACCATTATTACAAGAGCATCAAGCAGATTTATTATCAATAATAGATTAAAA
TAATAGTGATATATAAAACA

Downstream 100 bases:

>100_bases
GAATAATGTTATTTATATTAATTTTTTAAGGATTATTTATGATGGATTTAAAAGATATTGTTTCATCTGATTTACCATTA
TTTGAAATTTTTATAAAGAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MNIITWLSYARKKLSNSLTAKLDSEVLLCFVLKISKKDLFYKNKKKIKIKYLLILNNFLFRRVLGEPIAYIIKKKEFWSL
SLFVSSYVLIPRPETEILVEQVLLKVSSTKNSILELGTGSGAISLALASENSQLKIIGTDISLYALLIAKYNADKLNLNN
VKFIYSNWFQNIPIKKFHIIVCNPPYLSRKDFKNSCSNISFEPYSALVSGNSGIECIEYIIKNSFQYFVSSGWLYIEHCY
KQTKLVHNIFKNNFFINIVSVKDYSNRNRITYGYLNK

Sequences:

>Translated_277_residues
MNIITWLSYARKKLSNSLTAKLDSEVLLCFVLKISKKDLFYKNKKKIKIKYLLILNNFLFRRVLGEPIAYIIKKKEFWSL
SLFVSSYVLIPRPETEILVEQVLLKVSSTKNSILELGTGSGAISLALASENSQLKIIGTDISLYALLIAKYNADKLNLNN
VKFIYSNWFQNIPIKKFHIIVCNPPYLSRKDFKNSCSNISFEPYSALVSGNSGIECIEYIIKNSFQYFVSSGWLYIEHCY
KQTKLVHNIFKNNFFINIVSVKDYSNRNRITYGYLNK
>Mature_277_residues
MNIITWLSYARKKLSNSLTAKLDSEVLLCFVLKISKKDLFYKNKKKIKIKYLLILNNFLFRRVLGEPIAYIIKKKEFWSL
SLFVSSYVLIPRPETEILVEQVLLKVSSTKNSILELGTGSGAISLALASENSQLKIIGTDISLYALLIAKYNADKLNLNN
VKFIYSNWFQNIPIKKFHIIVCNPPYLSRKDFKNSCSNISFEPYSALVSGNSGIECIEYIIKNSFQYFVSSGWLYIEHCY
KQTKLVHNIFKNNFFINIVSVKDYSNRNRITYGYLNK

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=247, Percent_Identity=30.3643724696356, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1787463, Length=273, Percent_Identity=37.3626373626374, Blast_Score=204, Evalue=4e-54,
Organism=Escherichia coli, GI87082085, Length=183, Percent_Identity=31.1475409836066, Blast_Score=95, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324266, Length=233, Percent_Identity=25.7510729613734, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24582226, Length=225, Percent_Identity=25.7777777777778, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 32031; Mature: 32031

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIITWLSYARKKLSNSLTAKLDSEVLLCFVLKISKKDLFYKNKKKIKIKYLLILNNFLF
CCHHHHHHHHHHHHCCHHHHHCCCCEEEEEEEHHCCCHHEECCCCEEEEEEEEEHHHHHH
RRVLGEPIAYIIKKKEFWSLSLFVSSYVLIPRPETEILVEQVLLKVSSTKNSILELGTGS
HHHHCCHHEEHEECCCCEEEEEEHHCEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCC
GAISLALASENSQLKIIGTDISLYALLIAKYNADKLNLNNVKFIYSNWFQNIPIKKFHII
CEEEEEEECCCCEEEEEECCHHHEEHHHHHCCCCEECCCCEEEEEEHHHCCCCCEEEEEE
VCNPPYLSRKDFKNSCSNISFEPYSALVSGNSGIECIEYIIKNSFQYFVSSGWLYIEHCY
EECCCCCCHHHHHHHHCCCCCCCHHHEECCCCCHHHHHHHHHCCHHHHHHCCEEEEHHHH
KQTKLVHNIFKNNFFINIVSVKDYSNRNRITYGYLNK
HHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEECCC
>Mature Secondary Structure
MNIITWLSYARKKLSNSLTAKLDSEVLLCFVLKISKKDLFYKNKKKIKIKYLLILNNFLF
CCHHHHHHHHHHHHCCHHHHHCCCCEEEEEEEHHCCCHHEECCCCEEEEEEEEEHHHHHH
RRVLGEPIAYIIKKKEFWSLSLFVSSYVLIPRPETEILVEQVLLKVSSTKNSILELGTGS
HHHHCCHHEEHEECCCCEEEEEEHHCEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCC
GAISLALASENSQLKIIGTDISLYALLIAKYNADKLNLNNVKFIYSNWFQNIPIKKFHII
CEEEEEEECCCCEEEEEECCHHHEEHHHHHCCCCEECCCCEEEEEEHHHCCCCCEEEEEE
VCNPPYLSRKDFKNSCSNISFEPYSALVSGNSGIECIEYIIKNSFQYFVSSGWLYIEHCY
EECCCCCCHHHHHHHHCCCCCCCHHHEECCCCCHHHHHHHHHCCHHHHHHCCEEEEHHHH
KQTKLVHNIFKNNFFINIVSVKDYSNRNRITYGYLNK
HHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]