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The map label for this gene is tyrS [H]

Identifier: 116515016

GI number: 116515016

Start: 82139

End: 83425

Strand: Direct

Name: tyrS [H]

Synonym: BCc_075

Alternate gene names: 116515016

Gene position: 82139-83425 (Clockwise)

Preceding gene: 116515014

Following gene: 116515018

Centisome position: 19.73

GC content: 19.04

Gene sequence:

>1287_bases
ATGAGAAATAAAACGAATATTTTAGATTTTTTAAATAAAAAAAATTTTTTTTCAAAAATTTTTAATCAATTTGAATTAAA
TAATTATTTAAAAAATAAAAATGTTTTTTTATATTGTGGATTTGATCCAACTGAAAATAGTTTGCATATAGGTCATTTAC
TTCCAATTATATGTTTAAAGCATTTTCAAAATTTCGGATATACACCGATAATTTTAATTGGTGGAGCAACTAGTATAGTT
GGTGATCCAAGTTTTAAAATATATGAAAGGAAAAAACAATCATTAGATTTATTAAGATTTAATCAAATTTGTTTAGAAAA
ACAATTATTATTTTTTTTTAATAATCAAGAGTGTTTGAATAATAAAGTTATTATATTAAATAATTATTCTTGGTTTAAAA
ATTTTTCAATTTTATCTTTTTTAAGAAAAATAGGAATTTATTTTTCTGTTAATTATATGATTCATAAAGAGTCTGTAAAA
AAAAGATTAATTAAAGAAAAAACAGGTATGTCTTTTACCGAGTTTTCTTATAGTTTATTACAAGCTTATGATTTTTTAAA
ATTATATGAAAAATATGGAGTTAAATTACAAATTGGTGGATCAGATCAATGGGGAAATATTTTATCTGGTATTCGATTAA
TTAAAAAATTGTATAAAGATGATGTATTTGGTGCAACAAACTCTTTATTAGTTAAATCTAATGGAGAAAAATTTGGAAAA
ACAGAAACTGATACTATATGGTTAGATGCTAAAAAAACAAGTCCTTTTAAGTTTTATCAATTTTGGGTAAATATTTCAGA
TGAAGATATTGATAATTTTTTACAATGGTTTACTTTTATAGATGAAAAAAAAATAAATATTTTATTTCATGATAACAATT
TTATAAAAAATATAATTAATAAAAAAATTTTTTTAGCAGAATTTTTAACGAAATTAGTACATGGAAAAGATGTTTTAATT
TCTGTTAAACGTATTATATTTTTTTTATTTGGAAATGGTTCAATTACAAATATTAAAGAAGAAGATTGTATACAATTATT
AAAAGATGGCATTCCTTCTATAATTTGTAATAGTTTTTTAGATTTACCACATATTTTAGTAAAAACTTTATTAGTAAATT
CTTTAAATAAAGCACGAAATATGATTATTTCTGGAGCTATCAAAATTAATGGTATTGTGCAAACTCAAAAAGATTATAAT
TTTTCAAAATCAGATTTATTATTTAATAAATATACTTTTATATCTAAAGGTAAAAAAAATTATTTTTTAATTTATTGGAA
AATATAA

Upstream 100 bases:

>100_bases
AAAAAATCTTTTTTTATATAAAAATTAAGATTTTATTTTAGGTAAAATATACTAATTTTCTGAGTATTTTTAAAAATTTT
ATATATAAGTAGGTTATATT

Downstream 100 bases:

>100_bases
ATATATATAAAATATTTTTAATGTTATTAAATAGTAATTTTTATATATTAAAACTTTCACCACATCCACAAATTGTAGAA
TGATTAGAATTAATGAATTT

Product: hypothetical protein

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MRNKTNILDFLNKKNFFSKIFNQFELNNYLKNKNVFLYCGFDPTENSLHIGHLLPIICLKHFQNFGYTPIILIGGATSIV
GDPSFKIYERKKQSLDLLRFNQICLEKQLLFFFNNQECLNNKVIILNNYSWFKNFSILSFLRKIGIYFSVNYMIHKESVK
KRLIKEKTGMSFTEFSYSLLQAYDFLKLYEKYGVKLQIGGSDQWGNILSGIRLIKKLYKDDVFGATNSLLVKSNGEKFGK
TETDTIWLDAKKTSPFKFYQFWVNISDEDIDNFLQWFTFIDEKKINILFHDNNFIKNIINKKIFLAEFLTKLVHGKDVLI
SVKRIIFFLFGNGSITNIKEEDCIQLLKDGIPSIICNSFLDLPHILVKTLLVNSLNKARNMIISGAIKINGIVQTQKDYN
FSKSDLLFNKYTFISKGKKNYFLIYWKI

Sequences:

>Translated_428_residues
MRNKTNILDFLNKKNFFSKIFNQFELNNYLKNKNVFLYCGFDPTENSLHIGHLLPIICLKHFQNFGYTPIILIGGATSIV
GDPSFKIYERKKQSLDLLRFNQICLEKQLLFFFNNQECLNNKVIILNNYSWFKNFSILSFLRKIGIYFSVNYMIHKESVK
KRLIKEKTGMSFTEFSYSLLQAYDFLKLYEKYGVKLQIGGSDQWGNILSGIRLIKKLYKDDVFGATNSLLVKSNGEKFGK
TETDTIWLDAKKTSPFKFYQFWVNISDEDIDNFLQWFTFIDEKKINILFHDNNFIKNIINKKIFLAEFLTKLVHGKDVLI
SVKRIIFFLFGNGSITNIKEEDCIQLLKDGIPSIICNSFLDLPHILVKTLLVNSLNKARNMIISGAIKINGIVQTQKDYN
FSKSDLLFNKYTFISKGKKNYFLIYWKI
>Mature_428_residues
MRNKTNILDFLNKKNFFSKIFNQFELNNYLKNKNVFLYCGFDPTENSLHIGHLLPIICLKHFQNFGYTPIILIGGATSIV
GDPSFKIYERKKQSLDLLRFNQICLEKQLLFFFNNQECLNNKVIILNNYSWFKNFSILSFLRKIGIYFSVNYMIHKESVK
KRLIKEKTGMSFTEFSYSLLQAYDFLKLYEKYGVKLQIGGSDQWGNILSGIRLIKKLYKDDVFGATNSLLVKSNGEKFGK
TETDTIWLDAKKTSPFKFYQFWVNISDEDIDNFLQWFTFIDEKKINILFHDNNFIKNIINKKIFLAEFLTKLVHGKDVLI
SVKRIIFFLFGNGSITNIKEEDCIQLLKDGIPSIICNSFLDLPHILVKTLLVNSLNKARNMIISGAIKINGIVQTQKDYN
FSKSDLLFNKYTFISKGKKNYFLIYWKI

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=432, Percent_Identity=33.1018518518519, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1787925, Length=423, Percent_Identity=46.8085106382979, Blast_Score=406, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI25145802, Length=412, Percent_Identity=33.0097087378641, Blast_Score=201, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI25145805, Length=334, Percent_Identity=30.8383233532934, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6325160, Length=406, Percent_Identity=32.7586206896552, Blast_Score=208, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20130383, Length=444, Percent_Identity=31.5315315315315, Blast_Score=242, Evalue=4e-64,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 50124; Mature: 50124

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNKTNILDFLNKKNFFSKIFNQFELNNYLKNKNVFLYCGFDPTENSLHIGHLLPIICLK
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHHHH
HFQNFGYTPIILIGGATSIVGDPSFKIYERKKQSLDLLRFNQICLEKQLLFFFNNQECLN
HHHHCCCCEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHC
NKVIILNNYSWFKNFSILSFLRKIGIYFSVNYMIHKESVKKRLIKEKTGMSFTEFSYSLL
CCEEEEECCHHHHHHHHHHHHHHCCEEEEEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHH
QAYDFLKLYEKYGVKLQIGGSDQWGNILSGIRLIKKLYKDDVFGATNSLLVKSNGEKFGK
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCC
TETDTIWLDAKKTSPFKFYQFWVNISDEDIDNFLQWFTFIDEKKINILFHDNNFIKNIIN
CCCCEEEEECCCCCCEEEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHH
KKIFLAEFLTKLVHGKDVLISVKRIIFFLFGNGSITNIKEEDCIQLLKDGIPSIICNSFL
HHHHHHHHHHHHHCCCHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
DLPHILVKTLLVNSLNKARNMIISGAIKINGIVQTQKDYNFSKSDLLFNKYTFISKGKKN
CHHHHHHHHHHHHHHHHHHHHEEECEEEEEEEEEECCCCCCCHHHEEEEEEHEEECCCCC
YFLIYWKI
EEEEEEEC
>Mature Secondary Structure
MRNKTNILDFLNKKNFFSKIFNQFELNNYLKNKNVFLYCGFDPTENSLHIGHLLPIICLK
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHHHH
HFQNFGYTPIILIGGATSIVGDPSFKIYERKKQSLDLLRFNQICLEKQLLFFFNNQECLN
HHHHCCCCEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHC
NKVIILNNYSWFKNFSILSFLRKIGIYFSVNYMIHKESVKKRLIKEKTGMSFTEFSYSLL
CCEEEEECCHHHHHHHHHHHHHHCCEEEEEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHH
QAYDFLKLYEKYGVKLQIGGSDQWGNILSGIRLIKKLYKDDVFGATNSLLVKSNGEKFGK
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCC
TETDTIWLDAKKTSPFKFYQFWVNISDEDIDNFLQWFTFIDEKKINILFHDNNFIKNIIN
CCCCEEEEECCCCCCEEEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHH
KKIFLAEFLTKLVHGKDVLISVKRIIFFLFGNGSITNIKEEDCIQLLKDGIPSIICNSFL
HHHHHHHHHHHHHCCCHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
DLPHILVKTLLVNSLNKARNMIISGAIKINGIVQTQKDYNFSKSDLLFNKYTFISKGKKN
CHHHHHHHHHHHHHHHHHHHHEEECEEEEEEEEEECCCCCCCHHHEEEEEEHEEECCCCC
YFLIYWKI
EEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA