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The map label for this gene is guaB [H]

Identifier: 116493447

GI number: 116493447

Start: 1695519

End: 1696661

Strand: Reverse

Name: guaB [H]

Synonym: PEPE_1719

Alternate gene names: 116493447

Gene position: 1696661-1695519 (Counterclockwise)

Preceding gene: 116493448

Following gene: 116493446

Centisome position: 92.59

GC content: 43.04

Gene sequence:

>1143_bases
ATGAGCAATTGGGATAACAAGTTTACAAAACAAGGTTTAACTTTTGATGATGTTTTATTAATTCCAGGCGAAAGCCATGT
ATTACCGAATGAGGCTGATGTTTCAACTCAATTAGCTGATAACATTAAGCTTAATATTCCGATTATTAGTGCAGGAATGG
ATACAGTTACTGAATCTGCAATGGGTATCTCAATGGCTCGTCAAGGTGGCTTGGGTGTCATTCATAAAAATATGAGTGCT
GAACAACAAGCTTCCGAAGTTTCAATCGTAAAAAATGCGGATGTAAATCTGGAAGACAATCCGCATGCAGCTGTAGATGA
CCAAGGTCGTCTATTAGTAGCGGCTGCCGTAGGTGTAACTAGTGATACTTTTGAACGTGCTCAAGGTTTAATCGATGCTG
GTGCTGACGCTATCGTAATTGATACAGCTCACGGACACTCAGCAGGAGTACTTCGTAAGGTAGCAGAAATTCGCGAACAT
TTTCCAAAGCAAACGTTGATTGCTGGAAACGTCGCAACTGCGGATGGAACAAGAGCATTGTTTGACGCTGGTGTTGATGT
TGTGAAAGTTGGGATTGGACCTGGTTCAATTTGTACAACTCGGGTAGTTGCCGGAGTTGGGGTACCACAAATTACCGCTA
TCTATGATGCAGCTAATGTAGCTCGTGAATATGGCAAGAAGATTATTGCTGATGGGGGAATTAAGTTCTCTGGTGATATC
GTTAAAGCCCTAGTTGCGGGTGGAGATGCAGTAATGCTTGGTAGCATGCTTTCTGGTACAGACGAAACTCCTGGTTCAAT
CATTGAAGATAATGGTAAGAAATACAAAGCCTATCGAGGAATGGGTTCGGTTGGGGCCATGGAAAAAGGTTCAGCTGATC
GTTACTTCCAAGGTGGCGTAAATGAAGCCAATAAGCTGGTTCCAGAAGGAATTGAAGCGCGGGTACAATATAAGGGTTCA
GTTGCCACAATCATCTTCCAAATGCTTGGTGGACTCCGTTCTGGAATGGGTTACGTGGGCGCAGCTACCATTGCTGAATT
GGCTGAAAAAGCACAGTTCGTGCAAATTACGAACGCTGGTTTAGTGGAATCCCATCCACATGATGTTCAAATGACTAAAA
TTGCTCCTAACTACCATAAATAG

Upstream 100 bases:

>100_bases
TGCAATATTAGCGGTTGCAGCATTCGGCGGACGGTGGTATCTTAGACGAAAGTTTCATATCGTTGGTGGCATATTTTAGT
TAAAGAAAAGGGAGAGAATG

Downstream 100 bases:

>100_bases
TAAATAAATATTCAATTTGGTATTGAATAATTAAAAACTTTAAGAGTTAATGGTCAAGGATTCGTCCTTGGCTATTAACT
TTTTTTATTTTACGATGATT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSNWDNKFTKQGLTFDDVLLIPGESHVLPNEADVSTQLADNIKLNIPIISAGMDTVTESAMGISMARQGGLGVIHKNMSA
EQQASEVSIVKNADVNLEDNPHAAVDDQGRLLVAAAVGVTSDTFERAQGLIDAGADAIVIDTAHGHSAGVLRKVAEIREH
FPKQTLIAGNVATADGTRALFDAGVDVVKVGIGPGSICTTRVVAGVGVPQITAIYDAANVAREYGKKIIADGGIKFSGDI
VKALVAGGDAVMLGSMLSGTDETPGSIIEDNGKKYKAYRGMGSVGAMEKGSADRYFQGGVNEANKLVPEGIEARVQYKGS
VATIIFQMLGGLRSGMGYVGAATIAELAEKAQFVQITNAGLVESHPHDVQMTKIAPNYHK

Sequences:

>Translated_380_residues
MSNWDNKFTKQGLTFDDVLLIPGESHVLPNEADVSTQLADNIKLNIPIISAGMDTVTESAMGISMARQGGLGVIHKNMSA
EQQASEVSIVKNADVNLEDNPHAAVDDQGRLLVAAAVGVTSDTFERAQGLIDAGADAIVIDTAHGHSAGVLRKVAEIREH
FPKQTLIAGNVATADGTRALFDAGVDVVKVGIGPGSICTTRVVAGVGVPQITAIYDAANVAREYGKKIIADGGIKFSGDI
VKALVAGGDAVMLGSMLSGTDETPGSIIEDNGKKYKAYRGMGSVGAMEKGSADRYFQGGVNEANKLVPEGIEARVQYKGS
VATIIFQMLGGLRSGMGYVGAATIAELAEKAQFVQITNAGLVESHPHDVQMTKIAPNYHK
>Mature_379_residues
SNWDNKFTKQGLTFDDVLLIPGESHVLPNEADVSTQLADNIKLNIPIISAGMDTVTESAMGISMARQGGLGVIHKNMSAE
QQASEVSIVKNADVNLEDNPHAAVDDQGRLLVAAAVGVTSDTFERAQGLIDAGADAIVIDTAHGHSAGVLRKVAEIREHF
PKQTLIAGNVATADGTRALFDAGVDVVKVGIGPGSICTTRVVAGVGVPQITAIYDAANVAREYGKKIIADGGIKFSGDIV
KALVAGGDAVMLGSMLSGTDETPGSIIEDNGKKYKAYRGMGSVGAMEKGSADRYFQGGVNEANKLVPEGIEARVQYKGSV
ATIIFQMLGGLRSGMGYVGAATIAELAEKAQFVQITNAGLVESHPHDVQMTKIAPNYHK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=353, Percent_Identity=37.6770538243626, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI50541954, Length=353, Percent_Identity=37.6770538243626, Blast_Score=204, Evalue=7e-53,
Organism=Homo sapiens, GI50541952, Length=353, Percent_Identity=37.6770538243626, Blast_Score=204, Evalue=7e-53,
Organism=Homo sapiens, GI50541948, Length=353, Percent_Identity=37.6770538243626, Blast_Score=204, Evalue=7e-53,
Organism=Homo sapiens, GI156104880, Length=354, Percent_Identity=37.0056497175141, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI34328930, Length=323, Percent_Identity=37.1517027863777, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI217035152, Length=323, Percent_Identity=37.7708978328173, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI34328928, Length=323, Percent_Identity=37.1517027863777, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI217035150, Length=323, Percent_Identity=36.8421052631579, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI217035148, Length=323, Percent_Identity=36.8421052631579, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI156616279, Length=323, Percent_Identity=37.1517027863777, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI217035146, Length=323, Percent_Identity=36.8421052631579, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI66933016, Length=325, Percent_Identity=34.4615384615385, Blast_Score=181, Evalue=9e-46,
Organism=Escherichia coli, GI1788855, Length=282, Percent_Identity=59.2198581560284, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1786293, Length=352, Percent_Identity=35.2272727272727, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17560440, Length=354, Percent_Identity=34.7457627118644, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71994385, Length=257, Percent_Identity=37.7431906614786, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71994389, Length=206, Percent_Identity=41.2621359223301, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323585, Length=305, Percent_Identity=35.7377049180328, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6323464, Length=250, Percent_Identity=39.2, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322012, Length=322, Percent_Identity=32.9192546583851, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6319352, Length=199, Percent_Identity=30.6532663316583, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319353, Length=120, Percent_Identity=39.1666666666667, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641071, Length=343, Percent_Identity=34.9854227405248, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24641073, Length=343, Percent_Identity=34.9854227405248, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI28571163, Length=343, Percent_Identity=34.9854227405248, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 39656; Mature: 39525

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNWDNKFTKQGLTFDDVLLIPGESHVLPNEADVSTQLADNIKLNIPIISAGMDTVTESA
CCCCCCHHHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCEEEEEEEEECCHHHHHHHH
MGISMARQGGLGVIHKNMSAEQQASEVSIVKNADVNLEDNPHAAVDDQGRLLVAAAVGVT
HHHHHHHCCCCEEEECCCCHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCC
SDTFERAQGLIDAGADAIVIDTAHGHSAGVLRKVAEIREHFPKQTLIAGNVATADGTRAL
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCEECCCCCHHH
FDAGVDVVKVGIGPGSICTTRVVAGVGVPQITAIYDAANVAREYGKKIIADGGIKFSGDI
HHCCCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEECCCCEECHHH
VKALVAGGDAVMLGSMLSGTDETPGSIIEDNGKKYKAYRGMGSVGAMEKGSADRYFQGGV
HHHHHCCCCCEEEHHHHCCCCCCCCCEECCCCCEEEECCCCCCCCCCCCCCCCCHHCCCC
NEANKLVPEGIEARVQYKGSVATIIFQMLGGLRSGMGYVGAATIAELAEKAQFVQITNAG
CHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEEEECCC
LVESHPHDVQMTKIAPNYHK
CCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
SNWDNKFTKQGLTFDDVLLIPGESHVLPNEADVSTQLADNIKLNIPIISAGMDTVTESA
CCCCCHHHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCEEEEEEEEECCHHHHHHHH
MGISMARQGGLGVIHKNMSAEQQASEVSIVKNADVNLEDNPHAAVDDQGRLLVAAAVGVT
HHHHHHHCCCCEEEECCCCHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCC
SDTFERAQGLIDAGADAIVIDTAHGHSAGVLRKVAEIREHFPKQTLIAGNVATADGTRAL
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCEECCCCCHHH
FDAGVDVVKVGIGPGSICTTRVVAGVGVPQITAIYDAANVAREYGKKIIADGGIKFSGDI
HHCCCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEECCCCEECHHH
VKALVAGGDAVMLGSMLSGTDETPGSIIEDNGKKYKAYRGMGSVGAMEKGSADRYFQGGV
HHHHHCCCCCEEEHHHHCCCCCCCCCEECCCCCEEEECCCCCCCCCCCCCCCCCHHCCCC
NEANKLVPEGIEARVQYKGSVATIIFQMLGGLRSGMGYVGAATIAELAEKAQFVQITNAG
CHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEEEECCC
LVESHPHDVQMTKIAPNYHK
CCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]