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The map label for this gene is vanR [H]

Identifier: 116493445

GI number: 116493445

Start: 1694119

End: 1694808

Strand: Reverse

Name: vanR [H]

Synonym: PEPE_1717

Alternate gene names: 116493445

Gene position: 1694808-1694119 (Counterclockwise)

Preceding gene: 116493446

Following gene: 116493444

Centisome position: 92.49

GC content: 38.41

Gene sequence:

>690_bases
ATGAAAATTTTAGTTGTTGACGATGATAAAGAAATTGTTGAATTATTAGACATTTATATTAAAAATGAAGGTTACGAACC
AGTATCTGCTTACAATGGAAAAGAAGCTTTGTCTAAATTACGTACCGATCCGGATATTAGCTTAATGATTTTAGACATTA
TGATGCCGGAAATGGACGGGATGCAAGTGGTTCGGGAAGTGCGTAAGGATTCATCCTTACCAATCTTAATGTTGTCTGCT
AAAACAGATGATATGGACAAGATTAAGGGGCTCTTGACTGGAGCGGATGATTACGTAGCTAAACCTTTCAATCCACTAGA
AGTCATGGCTCGTGTAAAATCACTTCTACGTCGTAGTGAAAAAGATATGACAGCTGATGAACCAGAAATTTTGGACATTG
GTTCATTAATCATCAACAGTGATTCACATGAAGTTCGGACTTTAGCTGGAAAAGATGTGCAATTAACAGCACTTGAATTC
GGTATTTTATATCTTTTAGCTAGCCATCCTAACCGAGTGTTCTCAGCAGATGAGATTTTTGAACGTGTTTGGCAACAGGA
GAGTGTGATTTCAGCTAAAACAGTAATGGTACACGTTAGTCATTTACGCGACAAGATTGAAGAAGCTACGGGTGGTGAAA
AGGTTATTGAAACCGTCTGGGGCGTTGGATATAAAGTAGTCGCGCACTAG

Upstream 100 bases:

>100_bases
GGTTTTCTTAAAGATTAATAAAATCCAGCCCTAGTAACGGGTGTTTTGAACGAAATTTGCTAGACTGGTAAAAAAGACAG
TAAAAAGGGGAGATTCACCA

Downstream 100 bases:

>100_bases
GAGAGATTCAAATGAAGTTAACGGGGCGTGAAAAATATGAATTGTTTGGTGAAGGAGTTATTACGGTAATTCTCTTACTA
TTACTCAATTTATCAGTTTT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MKILVVDDDKEIVELLDIYIKNEGYEPVSAYNGKEALSKLRTDPDISLMILDIMMPEMDGMQVVREVRKDSSLPILMLSA
KTDDMDKIKGLLTGADDYVAKPFNPLEVMARVKSLLRRSEKDMTADEPEILDIGSLIINSDSHEVRTLAGKDVQLTALEF
GILYLLASHPNRVFSADEIFERVWQQESVISAKTVMVHVSHLRDKIEEATGGEKVIETVWGVGYKVVAH

Sequences:

>Translated_229_residues
MKILVVDDDKEIVELLDIYIKNEGYEPVSAYNGKEALSKLRTDPDISLMILDIMMPEMDGMQVVREVRKDSSLPILMLSA
KTDDMDKIKGLLTGADDYVAKPFNPLEVMARVKSLLRRSEKDMTADEPEILDIGSLIINSDSHEVRTLAGKDVQLTALEF
GILYLLASHPNRVFSADEIFERVWQQESVISAKTVMVHVSHLRDKIEEATGGEKVIETVWGVGYKVVAH
>Mature_229_residues
MKILVVDDDKEIVELLDIYIKNEGYEPVSAYNGKEALSKLRTDPDISLMILDIMMPEMDGMQVVREVRKDSSLPILMLSA
KTDDMDKIKGLLTGADDYVAKPFNPLEVMARVKSLLRRSEKDMTADEPEILDIGSLIINSDSHEVRTLAGKDVQLTALEF
GILYLLASHPNRVFSADEIFERVWQQESVISAKTVMVHVSHLRDKIEEATGGEKVIETVWGVGYKVVAH

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=36.0869565217391, Blast_Score=152, Evalue=1e-38,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=35.2173913043478, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=33.3333333333333, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=34.6320346320346, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=33.1858407079646, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=32.5991189427313, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786911, Length=233, Percent_Identity=29.6137339055794, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=33.4782608695652, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=35.1111111111111, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=29.8701298701299, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=33.1858407079646, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=28.448275862069, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=28.3898305084746, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788550, Length=105, Percent_Identity=36.1904761904762, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790437, Length=103, Percent_Identity=33.0097087378641, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25703; Mature: 25703

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVVDDDKEIVELLDIYIKNEGYEPVSAYNGKEALSKLRTDPDISLMILDIMMPEMDG
CEEEEECCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHCCCCCHHEEEEEHHCCCCCH
MQVVREVRKDSSLPILMLSAKTDDMDKIKGLLTGADDYVAKPFNPLEVMARVKSLLRRSE
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHH
KDMTADEPEILDIGSLIINSDSHEVRTLAGKDVQLTALEFGILYLLASHPNRVFSADEIF
CCCCCCCCCCEEHHHHEECCCCCHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCHHHHH
ERVWQQESVISAKTVMVHVSHLRDKIEEATGGEKVIETVWGVGYKVVAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MKILVVDDDKEIVELLDIYIKNEGYEPVSAYNGKEALSKLRTDPDISLMILDIMMPEMDG
CEEEEECCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHCCCCCHHEEEEEHHCCCCCH
MQVVREVRKDSSLPILMLSAKTDDMDKIKGLLTGADDYVAKPFNPLEVMARVKSLLRRSE
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHH
KDMTADEPEILDIGSLIINSDSHEVRTLAGKDVQLTALEFGILYLLASHPNRVFSADEIF
CCCCCCCCCCEEHHHHEECCCCCHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCHHHHH
ERVWQQESVISAKTVMVHVSHLRDKIEEATGGEKVIETVWGVGYKVVAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]