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The map label for this gene is apt

Identifier: 116492890

GI number: 116492890

Start: 1127923

End: 1128441

Strand: Reverse

Name: apt

Synonym: PEPE_1129

Alternate gene names: 116492890

Gene position: 1128441-1127923 (Counterclockwise)

Preceding gene: 116492891

Following gene: 116492889

Centisome position: 61.58

GC content: 37.76

Gene sequence:

>519_bases
ATGACATTAGACTTACATGACTACGTTGCAAGTATTCAAGATTTCCCAGAAAAAGGTGTAACATTCCGTGATATTTCTCC
TTTAATGGAAAATGGTGAGGCGTATCGTCAAGCAACAAATGCAATCATTAAATTTGCTAGAGATAAAGGCGTTGAAATGA
TTGTGGGACCTGAAGCACGAGGATTTATCGTGGGATGCCCGGTTGCCTATGAAATGGGAATTGGTTTTGCACCAGCACGT
AAAAAAGGAAAACTTCCCCGAGAAACCGTTAAAGCTACTTACGGTCTAGAATATGGAAAATCAGAATTGTATCTTCAAAA
GGATGCGATCAAACCCGGACAAAAGGTTTTAATTACTGATGATTTACTAGCAACGGGTGGAACAATCGCTGCTACGATTG
AATTAGTTGAAAAATTAGGTGGTATAGTTGTGGGAACTGCCTTCTTTATCGAATTAAAAGACCTCAATGGCCGTGAAAAA
ATTAAAGACTATGATACATTAAGTTTGATGGAATATTAA

Upstream 100 bases:

>100_bases
TTAATTCAAACTCAGGAAAAATTACTCTATAGTAGTGGTGATGAACTATCAGCTATAGTTGAAAGACTGATGAATGTTGA
TAACAAAGGAGTGTCGTAAA

Downstream 100 bases:

>100_bases
TTATATTCTCAAATATCTACTTATTTTAGCTTGCTAGTCCAATGACTAGGGAGCTTTTTTATTTAAAATGGTACAAAGTC
GTACAAGTCTTTTTCTTGAT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MTLDLHDYVASIQDFPEKGVTFRDISPLMENGEAYRQATNAIIKFARDKGVEMIVGPEARGFIVGCPVAYEMGIGFAPAR
KKGKLPRETVKATYGLEYGKSELYLQKDAIKPGQKVLITDDLLATGGTIAATIELVEKLGGIVVGTAFFIELKDLNGREK
IKDYDTLSLMEY

Sequences:

>Translated_172_residues
MTLDLHDYVASIQDFPEKGVTFRDISPLMENGEAYRQATNAIIKFARDKGVEMIVGPEARGFIVGCPVAYEMGIGFAPAR
KKGKLPRETVKATYGLEYGKSELYLQKDAIKPGQKVLITDDLLATGGTIAATIELVEKLGGIVVGTAFFIELKDLNGREK
IKDYDTLSLMEY
>Mature_171_residues
TLDLHDYVASIQDFPEKGVTFRDISPLMENGEAYRQATNAIIKFARDKGVEMIVGPEARGFIVGCPVAYEMGIGFAPARK
KGKLPRETVKATYGLEYGKSELYLQKDAIKPGQKVLITDDLLATGGTIAATIELVEKLGGIVVGTAFFIELKDLNGREKI
KDYDTLSLMEY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=43.7125748502994, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=46.2809917355372, Blast_Score=114, Evalue=4e-26,
Organism=Escherichia coli, GI1786675, Length=158, Percent_Identity=50, Blast_Score=169, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=44.4444444444444, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=167, Percent_Identity=40.1197604790419, Blast_Score=105, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320649, Length=154, Percent_Identity=33.1168831168831, Blast_Score=76, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136334, Length=175, Percent_Identity=43.4285714285714, Blast_Score=130, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_PEDPA (Q03F39)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804625.1
- ProteinModelPortal:   Q03F39
- SMR:   Q03F39
- STRING:   Q03F39
- GeneID:   4417098
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1129
- NMPDR:   fig|278197.10.peg.991
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q03F39
- ProtClustDB:   PRK02304
- BioCyc:   PPEN278197:PEPE_1129-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18913; Mature: 18782

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDLHDYVASIQDFPEKGVTFRDISPLMENGEAYRQATNAIIKFARDKGVEMIVGPEAR
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCCC
GFIVGCPVAYEMGIGFAPARKKGKLPRETVKATYGLEYGKSELYLQKDAIKPGQKVLITD
CEEEECCHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEC
DLLATGGTIAATIELVEKLGGIVVGTAFFIELKDLNGREKIKDYDTLSLMEY
CHHHCCCHHHHHHHHHHHHCCEEEEEEEEEEEECCCCHHHHCCCCCEEEECC
>Mature Secondary Structure 
TLDLHDYVASIQDFPEKGVTFRDISPLMENGEAYRQATNAIIKFARDKGVEMIVGPEAR
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCCC
GFIVGCPVAYEMGIGFAPARKKGKLPRETVKATYGLEYGKSELYLQKDAIKPGQKVLITD
CEEEECCHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEC
DLLATGGTIAATIELVEKLGGIVVGTAFFIELKDLNGREKIKDYDTLSLMEY
CHHHCCCHHHHHHHHHHHHCCEEEEEEEEEEEECCCCHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA