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The map label for this gene is pyrP [H]

Identifier: 116492886

GI number: 116492886

Start: 1123315

End: 1124607

Strand: Reverse

Name: pyrP [H]

Synonym: PEPE_1124

Alternate gene names: 116492886

Gene position: 1124607-1123315 (Counterclockwise)

Preceding gene: 116492887

Following gene: 116492885

Centisome position: 61.37

GC content: 37.51

Gene sequence:

>1293_bases
ATGGCAAAGAAAGAAGAATATCACAATCCTGAGGCAATTTTAGATATCCATGATAAAGTAAAGTTTCCTCAGTTGGTAGG
CCTATCTATTCAACATATGTTTGCAATGTTTGGTTCGACCGTTTTAGTTCCAATCTTAGTGGGTTTAAACCCAGGAATCG
CTCTTTTTAGTTCAGGTGTGGGAACGCTGTTATATATCTTGATAACCAGAGCTAAAATACCAGCTTATATGGGTTCTAGT
TTTACATTTATTGTTCCAATGCTGGCGTTAATGAAAACAACGGGCTATCAAGGTATTGCACAAGGAACTATCTCAGTTGG
GGTAGTGTATCTGATTGTGGCTTTGTTGATTAGTTGGATGGGTTCGGATTGGTTGGATAAGATATTACCACCGATTGTCG
TTGGTCCAATTATTATGGTGATTGGTTTATCATTAGCAGGAACCGCTGCTACAGATGCAACTATGCGATCCGTTGGCAGT
CAAAGCGTGTATGATATCAAATACTTCATTATCGCACTGGCAACACTGTTAATCACCATTGTATTTAATATGTATCTCAA
AGGCTTTATTAGTTTAATTCCTATTTTGTTAGGTTTAATTGCTGGTTACCTTATCGCGCTTGTCATGGGAGTGGTCGATT
TATCTACTGTTCAACAAGCTAAATGGTTAGTTGCTCCAAATTTTGAAATTCCATTTGTAAATTATCAGATGCACTTCAAC
ATCGGGGCCGTATTAAGTATGATGCCACTGGCATTCGTAACGATGACAGAGCATACTGGCCACATCATGGTTTTGAATAC
TTTAACCCATCGTAATTTCTTTAAGGATCCAGGACTACACTACACACTTTCAGGTGATGGTGTGGCATCGATTGTAGCTG
GTTTTATTGGGGGACCTCCCGTAACTAGTTATGGTGAGAATATTGGAGTACTTGCAGTTACAAAAGTTCACAGTGTCTAT
GTTTTGATGGGTGCAGCGGTGAGTGCAATTATCTTTAGTTTCGTTGGAAAATTAAGCGCATTGATTCAAAGTATTCCTAA
TCCAGTAATTGGTGGAATTAGTTTTCTACTATTTGGAACGATTGCTGCTAATGGTCTACGGATTTTAATTGATAATAAAA
TCGACTTTAATCAGAAACGTAATCTAATGATTGCTGCATCAATTTTAGTAATCGGTATTGGTAATGCTAGTTTTAATATT
GGTAATCTAAGTTTCTCAGGATTAGCAGTGGCAACCGTTTTAGGAGTCATTCTTAACCTAGTCCTTCCTAAACAAGCTTT
AAGTGAAAAATAA

Upstream 100 bases:

>100_bases
CGGTAGAACCTCGCACTTAACGGGGAATCATAGAATTTACTGAAGCCTCTTGGATCACATCGATCTAAGAGGCTTTTTCT
ATGAAAGGAAGTACGTGGTT

Downstream 100 bases:

>100_bases
TTTACTTTTCGTATATTTAAGCAAAATGGTATCATAGTATCTAAACACGAGATATTATAGGAGCTGATTTTGTTTGAAAT
GGACTGAAGTAAACGTCAAA

Product: xanthine/uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MAKKEEYHNPEAILDIHDKVKFPQLVGLSIQHMFAMFGSTVLVPILVGLNPGIALFSSGVGTLLYILITRAKIPAYMGSS
FTFIVPMLALMKTTGYQGIAQGTISVGVVYLIVALLISWMGSDWLDKILPPIVVGPIIMVIGLSLAGTAATDATMRSVGS
QSVYDIKYFIIALATLLITIVFNMYLKGFISLIPILLGLIAGYLIALVMGVVDLSTVQQAKWLVAPNFEIPFVNYQMHFN
IGAVLSMMPLAFVTMTEHTGHIMVLNTLTHRNFFKDPGLHYTLSGDGVASIVAGFIGGPPVTSYGENIGVLAVTKVHSVY
VLMGAAVSAIIFSFVGKLSALIQSIPNPVIGGISFLLFGTIAANGLRILIDNKIDFNQKRNLMIAASILVIGIGNASFNI
GNLSFSGLAVATVLGVILNLVLPKQALSEK

Sequences:

>Translated_430_residues
MAKKEEYHNPEAILDIHDKVKFPQLVGLSIQHMFAMFGSTVLVPILVGLNPGIALFSSGVGTLLYILITRAKIPAYMGSS
FTFIVPMLALMKTTGYQGIAQGTISVGVVYLIVALLISWMGSDWLDKILPPIVVGPIIMVIGLSLAGTAATDATMRSVGS
QSVYDIKYFIIALATLLITIVFNMYLKGFISLIPILLGLIAGYLIALVMGVVDLSTVQQAKWLVAPNFEIPFVNYQMHFN
IGAVLSMMPLAFVTMTEHTGHIMVLNTLTHRNFFKDPGLHYTLSGDGVASIVAGFIGGPPVTSYGENIGVLAVTKVHSVY
VLMGAAVSAIIFSFVGKLSALIQSIPNPVIGGISFLLFGTIAANGLRILIDNKIDFNQKRNLMIAASILVIGIGNASFNI
GNLSFSGLAVATVLGVILNLVLPKQALSEK
>Mature_429_residues
AKKEEYHNPEAILDIHDKVKFPQLVGLSIQHMFAMFGSTVLVPILVGLNPGIALFSSGVGTLLYILITRAKIPAYMGSSF
TFIVPMLALMKTTGYQGIAQGTISVGVVYLIVALLISWMGSDWLDKILPPIVVGPIIMVIGLSLAGTAATDATMRSVGSQ
SVYDIKYFIIALATLLITIVFNMYLKGFISLIPILLGLIAGYLIALVMGVVDLSTVQQAKWLVAPNFEIPFVNYQMHFNI
GAVLSMMPLAFVTMTEHTGHIMVLNTLTHRNFFKDPGLHYTLSGDGVASIVAGFIGGPPVTSYGENIGVLAVTKVHSVYV
LMGAAVSAIIFSFVGKLSALIQSIPNPVIGGISFLLFGTIAANGLRILIDNKIDFNQKRNLMIAASILVIGIGNASFNIG
NLSFSGLAVATVLGVILNLVLPKQALSEK

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=454, Percent_Identity=24.6696035242291, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI40316845, Length=454, Percent_Identity=24.6696035242291, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI44680145, Length=454, Percent_Identity=24.6696035242291, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI44680143, Length=458, Percent_Identity=24.4541484716157, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1788843, Length=406, Percent_Identity=42.6108374384236, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI87081818, Length=437, Percent_Identity=35.6979405034325, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI87082181, Length=459, Percent_Identity=29.1938997821351, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1790087, Length=467, Percent_Identity=25.2676659528908, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082178, Length=416, Percent_Identity=25.7211538461538, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17542262, Length=256, Percent_Identity=24.609375, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356175, Length=453, Percent_Identity=22.9580573951435, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45886; Mature: 45754

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKEEYHNPEAILDIHDKVKFPQLVGLSIQHMFAMFGSTVLVPILVGLNPGIALFSSGV
CCCCCCCCCCHHEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCH
GTLLYILITRAKIPAYMGSSFTFIVPMLALMKTTGYQGIAQGTISVGVVYLIVALLISWM
HHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GSDWLDKILPPIVVGPIIMVIGLSLAGTAATDATMRSVGSQSVYDIKYFIIALATLLITI
CCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VFNMYLKGFISLIPILLGLIAGYLIALVMGVVDLSTVQQAKWLVAPNFEIPFVNYQMHFN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCEEEEEEEEC
IGAVLSMMPLAFVTMTEHTGHIMVLNTLTHRNFFKDPGLHYTLSGDGVASIVAGFIGGPP
HHHHHHHHHHHHHEEECCCCCEEEEEEHHHCCCCCCCCCEEEECCCCHHHHHHHHCCCCC
VTSYGENIGVLAVTKVHSVYVLMGAAVSAIIFSFVGKLSALIQSIPNPVIGGISFLLFGT
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
IAANGLRILIDNKIDFNQKRNLMIAASILVIGIGNASFNIGNLSFSGLAVATVLGVILNL
HHCCCEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHH
VLPKQALSEK
HCCHHHHCCC
>Mature Secondary Structure 
AKKEEYHNPEAILDIHDKVKFPQLVGLSIQHMFAMFGSTVLVPILVGLNPGIALFSSGV
CCCCCCCCCHHEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCH
GTLLYILITRAKIPAYMGSSFTFIVPMLALMKTTGYQGIAQGTISVGVVYLIVALLISWM
HHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GSDWLDKILPPIVVGPIIMVIGLSLAGTAATDATMRSVGSQSVYDIKYFIIALATLLITI
CCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VFNMYLKGFISLIPILLGLIAGYLIALVMGVVDLSTVQQAKWLVAPNFEIPFVNYQMHFN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCEEEEEEEEC
IGAVLSMMPLAFVTMTEHTGHIMVLNTLTHRNFFKDPGLHYTLSGDGVASIVAGFIGGPP
HHHHHHHHHHHHHEEECCCCCEEEEEEHHHCCCCCCCCCEEEECCCCHHHHHHHHCCCCC
VTSYGENIGVLAVTKVHSVYVLMGAAVSAIIFSFVGKLSALIQSIPNPVIGGISFLLFGT
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
IAANGLRILIDNKIDFNQKRNLMIAASILVIGIGNASFNIGNLSFSGLAVATVLGVILNL
HHCCCEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHH
VLPKQALSEK
HCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1709162; 8206849; 9384377 [H]