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The map label for this gene is hslU [H]

Identifier: 116492725

GI number: 116492725

Start: 964898

End: 966310

Strand: Reverse

Name: hslU [H]

Synonym: PEPE_0962

Alternate gene names: 116492725

Gene position: 966310-964898 (Counterclockwise)

Preceding gene: 116492726

Following gene: 116492724

Centisome position: 52.74

GC content: 38.22

Gene sequence:

>1413_bases
ATGCAATATAATTTAACACCACAAGAAATCGTTCAAGAATTAGATCAATTTGTAATTGGTCAAAAAAGTGCTAAGCGCGC
AGTAGCAGTGGCATTACGGAATCGTTACCGTCGCTTACAACTTTCTGGTGATATGCAAGAAGATATTACACCTAAAAATT
TATTAATGATTGGACCTACCGGGGTCGGAAAAACTGAAATTGCACGGCGTTTAGCTAAAATCGTTAATGCTCCTTTTGTA
AAAGTAGAAGCCACTAAGTTTACTGAAGTAGGTTACGTGGGCCGAGATGTTGAATCAATGGTACGTGATCTAGTCGAAAA
TGCGGTGCACATCGAAGAAGAAAACTCTTTTAAAGATGTACGAGCAGAAGCTTCTAAGAATGCGGACCGTCGCATTGTAG
AACTCCTCGTTCCTGTTTCAACGGATACTCAAAATAAAAACAATGCTGCTGATATTCAAAACATGATGAACATGCTTAAT
CAATTACAGCAAGGACGTACACCGGATAACTTAAACCAAAGTTCTCAAAAAGTGCCGGATGATATCAAAGAAAAACGGAT
GAATGTTGCTAGTAAGTTAGCTAAGGGTCTCCTAGAGAATGATATGGTTACCATTGAAATGGACGATCCTAAGCAAAATA
ACAGTGGCAATATGATGAACCAAATGGGGATCGACTTAGGTGAATCTTTGAATGGCTTAATGCCTAAGAAAAAGATTACA
AGAACGGTAGCTGTTCGAGAAGCTCGTGAAATTTTAATCCGCGAAGAATCTGACAAGTTGGTTAATCATGGAGACTTGTA
TCACGCTGCTATTCAACGAGCCGAAAATACTGGAATTATCTTTATCGATGAAATTGATAAAATTACCGGTTCTGGTCAAA
ATTCATCTAGTGATGTTTCTCGTCAAGGAGTTCAACGAGATATTCTACCAATCGTTGAAGGCTCCCAAGTAAGTACGAAG
TATGGTTTAGTAGACACCAGTCATATTCTATTCATTGGTTCAGGTGCTTTCCATGAAAGTAAACCTAGTGATTTAATCGC
AGAACTACAAGGACGTTTTCCGATCCGCGTTGAACTAAACGACTTAACTAAAGAAGACTTTGTTAAGATTCTTACTGAAC
CTAAGAATGCGCTAGTTAAACAGTATATTGCATTGATTGGAACTGATAATGTGAAGATTACGTTCACGATCGAAGCCATT
GAACGCATTGCAGCTATCGCTGAACAAGTAAACCATGAAACCGAAAATATTGGTGCTCGTCGTTTGCATACCATTTTGGA
ACATCTTCTAGAAGACATCCTTTTTGAAGGTCCTTCAATGGAAATGGGCGAAGTAACGATTACTGAAAAATATGTTGATG
ACAAAATCGGTAGCATTGCACAAAATAAAGATCTGAGCGAGTTTATCTTATAG

Upstream 100 bases:

>100_bases
GAAAGAAATGGCTAAAACTGCGATTAACGTTGCGGGTGATATTGATATCTTTACGAACCACAACGTTATTGCATTGGATT
TCAAGGAGGAAGACTAAATC

Downstream 100 bases:

>100_bases
TAGGAGGATTTTGACCGATGACGGTTACTTTAAAAAATGACTATTTAACAGTCCAAATTAACGAAAAAGGGGCCGAGTTA
TCCAGTGTTAAGGCTAATGA

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MQYNLTPQEIVQELDQFVIGQKSAKRAVAVALRNRYRRLQLSGDMQEDITPKNLLMIGPTGVGKTEIARRLAKIVNAPFV
KVEATKFTEVGYVGRDVESMVRDLVENAVHIEEENSFKDVRAEASKNADRRIVELLVPVSTDTQNKNNAADIQNMMNMLN
QLQQGRTPDNLNQSSQKVPDDIKEKRMNVASKLAKGLLENDMVTIEMDDPKQNNSGNMMNQMGIDLGESLNGLMPKKKIT
RTVAVREAREILIREESDKLVNHGDLYHAAIQRAENTGIIFIDEIDKITGSGQNSSSDVSRQGVQRDILPIVEGSQVSTK
YGLVDTSHILFIGSGAFHESKPSDLIAELQGRFPIRVELNDLTKEDFVKILTEPKNALVKQYIALIGTDNVKITFTIEAI
ERIAAIAEQVNHETENIGARRLHTILEHLLEDILFEGPSMEMGEVTITEKYVDDKIGSIAQNKDLSEFIL

Sequences:

>Translated_470_residues
MQYNLTPQEIVQELDQFVIGQKSAKRAVAVALRNRYRRLQLSGDMQEDITPKNLLMIGPTGVGKTEIARRLAKIVNAPFV
KVEATKFTEVGYVGRDVESMVRDLVENAVHIEEENSFKDVRAEASKNADRRIVELLVPVSTDTQNKNNAADIQNMMNMLN
QLQQGRTPDNLNQSSQKVPDDIKEKRMNVASKLAKGLLENDMVTIEMDDPKQNNSGNMMNQMGIDLGESLNGLMPKKKIT
RTVAVREAREILIREESDKLVNHGDLYHAAIQRAENTGIIFIDEIDKITGSGQNSSSDVSRQGVQRDILPIVEGSQVSTK
YGLVDTSHILFIGSGAFHESKPSDLIAELQGRFPIRVELNDLTKEDFVKILTEPKNALVKQYIALIGTDNVKITFTIEAI
ERIAAIAEQVNHETENIGARRLHTILEHLLEDILFEGPSMEMGEVTITEKYVDDKIGSIAQNKDLSEFIL
>Mature_470_residues
MQYNLTPQEIVQELDQFVIGQKSAKRAVAVALRNRYRRLQLSGDMQEDITPKNLLMIGPTGVGKTEIARRLAKIVNAPFV
KVEATKFTEVGYVGRDVESMVRDLVENAVHIEEENSFKDVRAEASKNADRRIVELLVPVSTDTQNKNNAADIQNMMNMLN
QLQQGRTPDNLNQSSQKVPDDIKEKRMNVASKLAKGLLENDMVTIEMDDPKQNNSGNMMNQMGIDLGESLNGLMPKKKIT
RTVAVREAREILIREESDKLVNHGDLYHAAIQRAENTGIIFIDEIDKITGSGQNSSSDVSRQGVQRDILPIVEGSQVSTK
YGLVDTSHILFIGSGAFHESKPSDLIAELQGRFPIRVELNDLTKEDFVKILTEPKNALVKQYIALIGTDNVKITFTIEAI
ERIAAIAEQVNHETENIGARRLHTILEHLLEDILFEGPSMEMGEVTITEKYVDDKIGSIAQNKDLSEFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=111, Percent_Identity=36.036036036036, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790366, Length=469, Percent_Identity=47.5479744136461, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1786642, Length=238, Percent_Identity=34.0336134453782, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71982908, Length=238, Percent_Identity=30.2521008403361, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71982905, Length=238, Percent_Identity=30.2521008403361, Blast_Score=99, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6319704, Length=153, Percent_Identity=26.797385620915, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648291, Length=248, Percent_Identity=32.258064516129, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24648289, Length=248, Percent_Identity=32.258064516129, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 52560; Mature: 52560

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYNLTPQEIVQELDQFVIGQKSAKRAVAVALRNRYRRLQLSGDMQEDITPKNLLMIGPT
CCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCHHHCCCCCCEEEECCC
GVGKTEIARRLAKIVNAPFVKVEATKFTEVGYVGRDVESMVRDLVENAVHIEEENSFKDV
CCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHEECCCCCCHHHH
RAEASKNADRRIVELLVPVSTDTQNKNNAADIQNMMNMLNQLQQGRTPDNLNQSSQKVPD
HHHHHCCHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCH
DIKEKRMNVASKLAKGLLENDMVTIEMDDPKQNNSGNMMNQMGIDLGESLNGLMPKKKIT
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHCCCHHHHHHCCCCHHHHH
RTVAVREAREILIREESDKLVNHGDLYHAAIQRAENTGIIFIDEIDKITGSGQNSSSDVS
HHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCEEEEECHHHHCCCCCCCCCHHH
RQGVQRDILPIVEGSQVSTKYGLVDTSHILFIGSGAFHESKPSDLIAELQGRFPIRVELN
HHCHHHHHHHCCCCCCCCCEECCEECCEEEEEECCCCCCCCHHHHHHHHCCCCCEEEEHH
DLTKEDFVKILTEPKNALVKQYIALIGTDNVKITFTIEAIERIAAIAEQVNHETENIGAR
HCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCHHHHHHHH
RLHTILEHLLEDILFEGPSMEMGEVTITEKYVDDKIGSIAQNKDLSEFIL
HHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MQYNLTPQEIVQELDQFVIGQKSAKRAVAVALRNRYRRLQLSGDMQEDITPKNLLMIGPT
CCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCHHHCCCCCCEEEECCC
GVGKTEIARRLAKIVNAPFVKVEATKFTEVGYVGRDVESMVRDLVENAVHIEEENSFKDV
CCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHEECCCCCCHHHH
RAEASKNADRRIVELLVPVSTDTQNKNNAADIQNMMNMLNQLQQGRTPDNLNQSSQKVPD
HHHHHCCHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCH
DIKEKRMNVASKLAKGLLENDMVTIEMDDPKQNNSGNMMNQMGIDLGESLNGLMPKKKIT
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHCCCHHHHHHCCCCHHHHH
RTVAVREAREILIREESDKLVNHGDLYHAAIQRAENTGIIFIDEIDKITGSGQNSSSDVS
HHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCEEEEECHHHHCCCCCCCCCHHH
RQGVQRDILPIVEGSQVSTKYGLVDTSHILFIGSGAFHESKPSDLIAELQGRFPIRVELN
HHCHHHHHHHCCCCCCCCCEECCEECCEEEEEECCCCCCCCHHHHHHHHCCCCCEEEEHH
DLTKEDFVKILTEPKNALVKQYIALIGTDNVKITFTIEAIERIAAIAEQVNHETENIGAR
HCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCHHHHHHHH
RLHTILEHLLEDILFEGPSMEMGEVTITEKYVDDKIGSIAQNKDLSEFIL
HHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]