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The map label for this gene is qacC [H]

Identifier: 116492714

GI number: 116492714

Start: 951916

End: 952242

Strand: Reverse

Name: qacC [H]

Synonym: PEPE_0951

Alternate gene names: 116492714

Gene position: 952242-951916 (Counterclockwise)

Preceding gene: 116492716

Following gene: 116492712

Centisome position: 51.97

GC content: 28.75

Gene sequence:

>327_bases
ATGAATGGATATGTTTATTTGTTAGTAGCGATTGTCGCTGAATTATTAGGTACTAATTTTTTGAAACTTACCAACGGTTT
TACTAAACTATTGCCAACACTGATTTCTTTGCTATCGTATGGTTTTGCATTTTATTTTTTATCTTTGGTCGTTAAAAATA
TACCAATAAACATAGCTTATGCAATTTGGAGCGGAGTGGGAATTATATTAATGACAGTTATATCTGTTTTTGTATTTCAT
AATCCCATTAATGTACCAACAGTACTTGGAATATTATTTATAACTCTGGGTGTTATTTTAGTTAATTTATTTGGCGTTTC
ACATTAA

Upstream 100 bases:

>100_bases
ATACGACTTCTTTTTTTATAGCAGCCTGGGAGACTCTTTGGTAATGATAAGTTGTTAGTTTGAATGTTACTAGCAACCTA
TTTGAAAAGGAGTTTTTATT

Downstream 100 bases:

>100_bases
TTGATACTTTAAAAAAGCTTTTAGTGAAAAAAAACTAAAAGCTTTTTTAATTTTATTTGAGCAAACTTTGTTAAAAGTTA
AGATATTAATGATAGACACA

Product: membrane transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Ethidium bromide resistance protein; Multidrug resistance protein; Quaternary ammonium determinant C [H]

Number of amino acids: Translated: 108; Mature: 108

Protein sequence:

>108_residues
MNGYVYLLVAIVAELLGTNFLKLTNGFTKLLPTLISLLSYGFAFYFLSLVVKNIPINIAYAIWSGVGIILMTVISVFVFH
NPINVPTVLGILFITLGVILVNLFGVSH

Sequences:

>Translated_108_residues
MNGYVYLLVAIVAELLGTNFLKLTNGFTKLLPTLISLLSYGFAFYFLSLVVKNIPINIAYAIWSGVGIILMTVISVFVFH
NPINVPTVLGILFITLGVILVNLFGVSH
>Mature_108_residues
MNGYVYLLVAIVAELLGTNFLKLTNGFTKLLPTLISLLSYGFAFYFLSLVVKNIPINIAYAIWSGVGIILMTVISVFVFH
NPINVPTVLGILFITLGVILVNLFGVSH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds and ethidium bromide [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=107, Percent_Identity=41.1214953271028, Blast_Score=95, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11805; Mature: 11805

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGYVYLLVAIVAELLGTNFLKLTNGFTKLLPTLISLLSYGFAFYFLSLVVKNIPINIAY
CCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AIWSGVGIILMTVISVFVFHNPINVPTVLGILFITLGVILVNLFGVSH
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNGYVYLLVAIVAELLGTNFLKLTNGFTKLLPTLISLLSYGFAFYFLSLVVKNIPINIAY
CCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AIWSGVGIILMTVISVFVFHNPINVPTVLGILFITLGVILVNLFGVSH
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2602117; 1615062; 1840534; 1505735; 2778425; 7751293 [H]