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The map label for this gene is msrA [H]

Identifier: 116492716

GI number: 116492716

Start: 954317

End: 954832

Strand: Reverse

Name: msrA [H]

Synonym: PEPE_0953

Alternate gene names: 116492716

Gene position: 954832-954317 (Counterclockwise)

Preceding gene: 116492717

Following gene: 116492714

Centisome position: 52.11

GC content: 39.34

Gene sequence:

>516_bases
ATGGAAGAAACTGCTATTTTTGCCGGTGGGTGTTTTTGGTGCATGGTAGAACCTTTTGAAACTCAACCTGGTATTATCAA
CGTTGTTTCAGGTTATACAGGAGGGCATGTCGCCAACCCGACCTATGAACAAGTTACTAGTCATACTACAGGACATACAG
AAGCCGTTAAAATCACGTATGATCCGGAAATTATTTCGTATCGCCAATTAGTCCAAATCTACTGGCAACAAACTGATCCA
ACTGATGCAATGGGGCAGTTCCAGGACCGTGGCGATAATTACCGACCAGTAATTTTTGTGAATAGTGCTGAACAGCGTGA
AATTGCTGAAAAATCTAGGGAACAATTAGCCAAATCTGAAATGTTTGATGACCCTATTGTTACTAAAATTGAAGATGCTC
AACCATTTTATCCAGCTGAAGAAGAACACCAAGAATTTTATAAGAAAAATCCCCTTCGTTACCAAATTCAAGAAGCGGGT
GGACGATCAGAATTTCAGAAAAAATATTGGAAATAA

Upstream 100 bases:

>100_bases
TATCAATTCGGCTGCCCTGAAATTCATTGCATATGACGATTTAGAAGCGCATAATCTAGGTTATTTAAAGAAACTATTTA
ATTAGGAGCGTGATTTACTT

Downstream 100 bases:

>100_bases
AAAAGATGAGGGTTCATTTTAAATGAACTCTCATCTTTTAGTTTTTAATTAAATATTTTTATTTTTTTCTCTTCTAACCA
AGAAGATCCAAGCAATAATA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MEETAIFAGGCFWCMVEPFETQPGIINVVSGYTGGHVANPTYEQVTSHTTGHTEAVKITYDPEIISYRQLVQIYWQQTDP
TDAMGQFQDRGDNYRPVIFVNSAEQREIAEKSREQLAKSEMFDDPIVTKIEDAQPFYPAEEEHQEFYKKNPLRYQIQEAG
GRSEFQKKYWK

Sequences:

>Translated_171_residues
MEETAIFAGGCFWCMVEPFETQPGIINVVSGYTGGHVANPTYEQVTSHTTGHTEAVKITYDPEIISYRQLVQIYWQQTDP
TDAMGQFQDRGDNYRPVIFVNSAEQREIAEKSREQLAKSEMFDDPIVTKIEDAQPFYPAEEEHQEFYKKNPLRYQIQEAG
GRSEFQKKYWK
>Mature_171_residues
MEETAIFAGGCFWCMVEPFETQPGIINVVSGYTGGHVANPTYEQVTSHTTGHTEAVKITYDPEIISYRQLVQIYWQQTDP
TDAMGQFQDRGDNYRPVIFVNSAEQREIAEKSREQLAKSEMFDDPIVTKIEDAQPFYPAEEEHQEFYKKNPLRYQIQEAG
GRSEFQKKYWK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=154, Percent_Identity=40.9090909090909, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI6912516, Length=154, Percent_Identity=40.9090909090909, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=42.9906542056075, Blast_Score=91, Evalue=5e-19,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=45.3947368421053, Blast_Score=141, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=31.7241379310345, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=29.6296296296296, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24664627, Length=143, Percent_Identity=30.0699300699301, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=29.1970802919708, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24664631, Length=143, Percent_Identity=29.3706293706294, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19818; Mature: 19818

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEETAIFAGGCFWCMVEPFETQPGIINVVSGYTGGHVANPTYEQVTSHTTGHTEAVKITY
CCCCEEEECCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEEEEEE
DPEIISYRQLVQIYWQQTDPTDAMGQFQDRGDNYRPVIFVNSAEQREIAEKSREQLAKSE
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
MFDDPIVTKIEDAQPFYPAEEEHQEFYKKNPLRYQIQEAGGRSEFQKKYWK
CCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MEETAIFAGGCFWCMVEPFETQPGIINVVSGYTGGHVANPTYEQVTSHTTGHTEAVKITY
CCCCEEEECCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEEEEEE
DPEIISYRQLVQIYWQQTDPTDAMGQFQDRGDNYRPVIFVNSAEQREIAEKSREQLAKSE
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
MFDDPIVTKIEDAQPFYPAEEEHQEFYKKNPLRYQIQEAGGRSEFQKKYWK
CCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA