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The map label for this gene is mvk [H]

Identifier: 116492690

GI number: 116492690

Start: 925309

End: 926391

Strand: Reverse

Name: mvk [H]

Synonym: PEPE_0925

Alternate gene names: 116492690

Gene position: 926391-925309 (Counterclockwise)

Preceding gene: 116492691

Following gene: 116492689

Centisome position: 50.56

GC content: 38.23

Gene sequence:

>1083_bases
TTGATAACAGAAAAAGCTCCCGGAAAATTATATATTGCTGGTGAATATGCCATTGTCGAACCTGGCAATAATGCCGTGCT
AGTGGCAATTAATCAATTCGTCACTGCCAGCCTTGAACCTAGTAAATTAACCGTCGGAAATATTATTTCTAAACAATATC
AAAATAATGTTCTTTCCTGGCGACGTCGTGGTAGTGAATTAGTGGTTGATAACCGGGACAACCCTTATCACTATATCCTT
TCAGCTATTTCGATTATTGAAGAACTAGCTGTTTTGCTTAATCGTAAATTAAAAACTTATAATTTATACATCAATAGTGA
TTTAGATAGCAGTGATGGTAAAAAATATGGTCTAGGAAGTTCTGCGGCCGTAACCGTCGCCACCATTAAAGTTGTGGCCA
AATTTTATAATATTCCGTTAACTAAAGAACTACTCTTCAAACTTGCATCAATTGCACATTTAGATGTGCAAGGAAACGGT
TCTTTGGGAGATATTGCAGCTAGCGTTTATGGCGGTTGGATTGCTTACCAATCTTTCAATCGAGACTGGTTAAACAGTAT
GCGTCGTACTAAAGATTTAGAAACAATTTTAAGAACGCCTTGGCCTCAATTAAAAATTGAATTACTCACTCCTCCATCAG
ATTTACGCCTTTACATTGGCTGGACAGGCTCCCCAGCCTCCACTTCTGATTTAGTTGATCAAGTTGCTACAACCAGTTAT
CAAGAAACGGATAGCTATCATGAGTTTTTGACCAAAAACGCATCTTGTATCAATAAGATGATTGATGGTTTTCGTGATGC
TGATATTACAGTTATTCAACGTGAGATCACTAACAATCGGCACCTATTACAAGAGTTAAGCTTATTTAGTGGCGTTTCGA
TTGAGACCACGACGCTTACCAACTTTTGCGATATTGCTGAAAAATTTGATGGAGCTGCTAAGTCTTCTGGTGCCGGTGGT
GGTGATTGTGGCATTGTCATTATGCCCAATTCCACGAAGACAGCAAAAATGTTTGCTGAATGGGAGAAACATGATATCAA
ACCCCTTGATTTAGATGTTCACCATGTCACAGAAATTAATTAG

Upstream 100 bases:

>100_bases
GTTAAGCGGTTCTTTGCCAGCTACTTTGATCAAGATCAATTAGTCGTGGCTAAGCCTGGTAGTGGAATTAAATTTACTAA
AAACTAAGAGGAATTTTAAA

Downstream 100 bases:

>100_bases
GAGTTGTCATGAAAAATATTCATTCTCATCGTAAAGATGAACACATTTCATTGGCTGAAAAATTTTACAGCCCGACTGCC
AGTGCTGGGTTTGATACAAT

Product: phosphomevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MITEKAPGKLYIAGEYAIVEPGNNAVLVAINQFVTASLEPSKLTVGNIISKQYQNNVLSWRRRGSELVVDNRDNPYHYIL
SAISIIEELAVLLNRKLKTYNLYINSDLDSSDGKKYGLGSSAAVTVATIKVVAKFYNIPLTKELLFKLASIAHLDVQGNG
SLGDIAASVYGGWIAYQSFNRDWLNSMRRTKDLETILRTPWPQLKIELLTPPSDLRLYIGWTGSPASTSDLVDQVATTSY
QETDSYHEFLTKNASCINKMIDGFRDADITVIQREITNNRHLLQELSLFSGVSIETTTLTNFCDIAEKFDGAAKSSGAGG
GDCGIVIMPNSTKTAKMFAEWEKHDIKPLDLDVHHVTEIN

Sequences:

>Translated_360_residues
MITEKAPGKLYIAGEYAIVEPGNNAVLVAINQFVTASLEPSKLTVGNIISKQYQNNVLSWRRRGSELVVDNRDNPYHYIL
SAISIIEELAVLLNRKLKTYNLYINSDLDSSDGKKYGLGSSAAVTVATIKVVAKFYNIPLTKELLFKLASIAHLDVQGNG
SLGDIAASVYGGWIAYQSFNRDWLNSMRRTKDLETILRTPWPQLKIELLTPPSDLRLYIGWTGSPASTSDLVDQVATTSY
QETDSYHEFLTKNASCINKMIDGFRDADITVIQREITNNRHLLQELSLFSGVSIETTTLTNFCDIAEKFDGAAKSSGAGG
GDCGIVIMPNSTKTAKMFAEWEKHDIKPLDLDVHHVTEIN
>Mature_360_residues
MITEKAPGKLYIAGEYAIVEPGNNAVLVAINQFVTASLEPSKLTVGNIISKQYQNNVLSWRRRGSELVVDNRDNPYHYIL
SAISIIEELAVLLNRKLKTYNLYINSDLDSSDGKKYGLGSSAAVTVATIKVVAKFYNIPLTKELLFKLASIAHLDVQGNG
SLGDIAASVYGGWIAYQSFNRDWLNSMRRTKDLETILRTPWPQLKIELLTPPSDLRLYIGWTGSPASTSDLVDQVATTSY
QETDSYHEFLTKNASCINKMIDGFRDADITVIQREITNNRHLLQELSLFSGVSIETTTLTNFCDIAEKFDGAAKSSGAGG
GDCGIVIMPNSTKTAKMFAEWEKHDIKPLDLDVHHVTEIN

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 39845; Mature: 39845

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITEKAPGKLYIAGEYAIVEPGNNAVLVAINQFVTASLEPSKLTVGNIISKQYQNNVLSW
CCCCCCCCEEEEEEEEEEEECCCCEEEEEEECCEECCCCCCCCHHHHHHHHHHHHHHHHH
RRRGSELVVDNRDNPYHYILSAISIIEELAVLLNRKLKTYNLYINSDLDSSDGKKYGLGS
HHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCC
SAAVTVATIKVVAKFYNIPLTKELLFKLASIAHLDVQGNGSLGDIAASVYGGWIAYQSFN
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCEEECCC
RDWLNSMRRTKDLETILRTPWPQLKIELLTPPSDLRLYIGWTGSPASTSDLVDQVATTSY
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCC
QETDSYHEFLTKNASCINKMIDGFRDADITVIQREITNNRHLLQELSLFSGVSIETTTLT
HHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEEHHCCCHHHHHHHHHHCCCCEEEEHHH
NFCDIAEKFDGAAKSSGAGGGDCGIVIMPNSTKTAKMFAEWEKHDIKPLDLDVHHVTEIN
HHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEECCHHEEEECC
>Mature Secondary Structure
MITEKAPGKLYIAGEYAIVEPGNNAVLVAINQFVTASLEPSKLTVGNIISKQYQNNVLSW
CCCCCCCCEEEEEEEEEEEECCCCEEEEEEECCEECCCCCCCCHHHHHHHHHHHHHHHHH
RRRGSELVVDNRDNPYHYILSAISIIEELAVLLNRKLKTYNLYINSDLDSSDGKKYGLGS
HHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCC
SAAVTVATIKVVAKFYNIPLTKELLFKLASIAHLDVQGNGSLGDIAASVYGGWIAYQSFN
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCEEECCC
RDWLNSMRRTKDLETILRTPWPQLKIELLTPPSDLRLYIGWTGSPASTSDLVDQVATTSY
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCC
QETDSYHEFLTKNASCINKMIDGFRDADITVIQREITNNRHLLQELSLFSGVSIETTTLT
HHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEEHHCCCHHHHHHHHHHCCCCEEEEHHH
NFCDIAEKFDGAAKSSGAGGGDCGIVIMPNSTKTAKMFAEWEKHDIKPLDLDVHHVTEIN
HHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEECCHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10497066 [H]