Click here to switch to the map view.

The map label for this gene is ung

Identifier: 116492271

GI number: 116492271

Start: 522258

End: 522950

Strand: Direct

Name: ung

Synonym: PEPE_0469

Alternate gene names: 116492271

Gene position: 522258-522950 (Clockwise)

Preceding gene: 116492267

Following gene: 116492272

Centisome position: 28.5

GC content: 41.85

Gene sequence:

>693_bases
ATGAAAAAAATAATCCATAACGATTGGCAAGATGTTTTACAAGGTGAATTTGAACAAGCATATTATGCTAAATTGCATGA
GTTTTTGAAACATGAATATGCTACTCAAAATATTCATCCTGACATGTACCATATTTTTCAAGCCTTTGAATGGACTCCTT
TTTCAAAAGTAAAGGTGGTAATCTTGGGGCAAGATCCATATCATGGACAAAATCAAGCGCACGGACTAAGTTTTTCAGTG
CAACCTGGGGTGCAAGTTCCACCATCGTTACAAAATATCTACAAAGAACTCCAAAGTGATTTGGGAATTGCTCCAGTCCA
ACACGGTTATCTAAAAAAGTGGGCAGACCAAGGAGTGCTACTTTTGAATTCTGTGTTGACCGTTCGTGACGGACAAGCTT
ATTCCCATCAAGGGCATGGTTGGGAACGGTTGACTGACACGGCGATTCAGGCCTTATCGGAAAGAGAGCAGCCCGTTGTG
TTTATTTTATGGGGAAAAGCGGCCCGCGACAAGATTAAGTTAATTGATCAATCCCGCAATATTATTATTCAATCAGCCCA
TCCCAGTCCCTTATCGGCATACCGGGGCTTCTTTGGCTCAAAGCCATTTTCAAAAACCAACGAAGCGCTTGAAGCGATGG
GAGAGACACCAATTGACTGGCAGTTGCCAACGGAAGTTTTGGAGGAAAAATAA

Upstream 100 bases:

>100_bases
ATCCAATCCATGTATTTATGTTAATTCTAACATGACATAGCTTTTTTTTTACTAAATCAGTTAGAATAGAAGTAATAAAA
TTGTATTAAGGAGTTACGAA

Downstream 100 bases:

>100_bases
TCATGGAAACCTATCAACTAAATGACGAAGCCGAAACGATTAAATTTGGCAAAATTATCGGGGAATTACTGGAAGCTAAC
GACGTGGTCTTATTAGATGG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKKIIHNDWQDVLQGEFEQAYYAKLHEFLKHEYATQNIHPDMYHIFQAFEWTPFSKVKVVILGQDPYHGQNQAHGLSFSV
QPGVQVPPSLQNIYKELQSDLGIAPVQHGYLKKWADQGVLLLNSVLTVRDGQAYSHQGHGWERLTDTAIQALSEREQPVV
FILWGKAARDKIKLIDQSRNIIIQSAHPSPLSAYRGFFGSKPFSKTNEALEAMGETPIDWQLPTEVLEEK

Sequences:

>Translated_230_residues
MKKIIHNDWQDVLQGEFEQAYYAKLHEFLKHEYATQNIHPDMYHIFQAFEWTPFSKVKVVILGQDPYHGQNQAHGLSFSV
QPGVQVPPSLQNIYKELQSDLGIAPVQHGYLKKWADQGVLLLNSVLTVRDGQAYSHQGHGWERLTDTAIQALSEREQPVV
FILWGKAARDKIKLIDQSRNIIIQSAHPSPLSAYRGFFGSKPFSKTNEALEAMGETPIDWQLPTEVLEEK
>Mature_230_residues
MKKIIHNDWQDVLQGEFEQAYYAKLHEFLKHEYATQNIHPDMYHIFQAFEWTPFSKVKVVILGQDPYHGQNQAHGLSFSV
QPGVQVPPSLQNIYKELQSDLGIAPVQHGYLKKWADQGVLLLNSVLTVRDGQAYSHQGHGWERLTDTAIQALSEREQPVV
FILWGKAARDKIKLIDQSRNIIIQSAHPSPLSAYRGFFGSKPFSKTNEALEAMGETPIDWQLPTEVLEEK

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=51.1627906976744, Blast_Score=216, Evalue=1e-56,
Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=51.1627906976744, Blast_Score=216, Evalue=1e-56,
Organism=Escherichia coli, GI1788934, Length=221, Percent_Identity=51.131221719457, Blast_Score=221, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17556304, Length=215, Percent_Identity=49.7674418604651, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323620, Length=248, Percent_Identity=43.5483870967742, Blast_Score=181, Evalue=6e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_PEDPA (Q03GV8)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804006.1
- ProteinModelPortal:   Q03GV8
- SMR:   Q03GV8
- STRING:   Q03GV8
- GeneID:   4418332
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0469
- NMPDR:   fig|278197.10.peg.436
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- PhylomeDB:   Q03GV8
- ProtClustDB:   PRK05254
- BioCyc:   PPEN278197:PEPE_0469-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 26275; Mature: 26275

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIIHNDWQDVLQGEFEQAYYAKLHEFLKHEYATQNIHPDMYHIFQAFEWTPFSKVKVV
CCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEE
ILGQDPYHGQNQAHGLSFSVQPGVQVPPSLQNIYKELQSDLGIAPVQHGYLKKWADQGVL
EEECCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCE
LLNSVLTVRDGQAYSHQGHGWERLTDTAIQALSEREQPVVFILWGKAARDKIKLIDQSRN
EHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCCC
IIIQSAHPSPLSAYRGFFGSKPFSKTNEALEAMGETPIDWQLPTEVLEEK
EEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCC
>Mature Secondary Structure
MKKIIHNDWQDVLQGEFEQAYYAKLHEFLKHEYATQNIHPDMYHIFQAFEWTPFSKVKVV
CCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEE
ILGQDPYHGQNQAHGLSFSVQPGVQVPPSLQNIYKELQSDLGIAPVQHGYLKKWADQGVL
EEECCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCE
LLNSVLTVRDGQAYSHQGHGWERLTDTAIQALSEREQPVVFILWGKAARDKIKLIDQSRN
EHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCCC
IIIQSAHPSPLSAYRGFFGSKPFSKTNEALEAMGETPIDWQLPTEVLEEK
EEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA