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The map label for this gene is glmU

Identifier: 116492097

GI number: 116492097

Start: 337445

End: 338848

Strand: Direct

Name: glmU

Synonym: PEPE_0293

Alternate gene names: 116492097

Gene position: 337445-338848 (Clockwise)

Preceding gene: 116492096

Following gene: 116492099

Centisome position: 18.42

GC content: 38.03

Gene sequence:

>1404_bases
ATGGAAAAAAATACAATCATTTTAGCTGCAGGTCAAGGTACTCGAATGAAATCAAAACTATATAAAGTTTTGCATCAAGT
TTGTGGAAAAGCCATGGTGGATCATATGCTAACTCAAGTTGAAAAAACGAATATGGATCATATTGTTACCATTGTTGGGC
ATGGGGCAGAAAAGGTTCGTGAACTTTTAGGTGATCGTACAGAATATGCAATTCAAGAACAACAATTGGGTACGGGACAT
GCCGTTTTACAAGCTGAAAAAATTTTAGGTGATAAAGATGGAATGACCATGATCGTTAGTGGTGATACACCTTTATTTAC
AGCTAAAACTTTTGAAAATCTTTTTGAATATCACCGTCAAAAAGGAGCGGCTGCTACAATTTTAACCGCGCGTACTGAAA
ATCCATTCTCATATGGACGAATTGTCCGTAATGAGGTTGGCGTTGTTTCTAAAATTGTAGAACAGAAAGATGCTACCACT
GAAGAAGCAGAAATTAAGGAAATTAATACCGGTGTATATTGTTTCGATAACCAAAAGCTTTTTGCGGCACTTCATCAAGT
GAAAAACGATAATGCTCAAGGTGAATACTATCTTCCAGACGTAATCGGTATCATGAAAGATGCTGGCGAAATTGTTGCCG
CTTATGAAATGGCTGATTTCTCAGAATCAATGGGAGTTAACGATCGTTTAGCACTTTCTAAAGCTACTAAGGTTATGCAA
CGCCGAATTAACGAAGAACATATGGTTAATGGTGTTACAATCATTGACCCCGAAAATACCTACATTGATTATGGAGTAGA
AATCGGTCCAGATACCATCATTGAACCGGGTGTTCAAATACAAGGTAATACTAAGATTGGTTCTAGTTCAGTGATTGGAG
CGCATTCGAAGATTGTTGATTCAACAATTGGAAATCGTGTAACGGTAACTTCATCACAAATTGAAAGTGCCATCATGCAT
GATGATAGTAACATTGGTCCACACAGTCATTTACGCCCTCAAGCTGAGATTGGTGAATTTGCACATGTTGGTAACTATTG
TGAAGTTAAGAACGCTAAGTTAGGTGCACGGACTAAAATGGGGCATTTGAGTTACGTTGGAGATGCAGATCTTGGTACGG
ATATTAACATTGGTTGCGGAGTGGTATTTGTTAATTACGATGGTATGAATAAACATCACTCAACAGTTGGAGATTATGCC
TTCATTGGAAGTAATTCTAACATTGTTGCTCCAGTTACCATCGCTGATCACAGTTATGTAGCTGCTGGCTCAACCATTAC
GAACGACGTTAATAAGTTTGAAATGGGTATTGCCCGCGGACGCCAAGTTAATAAAGAAGGCTACTTTAAAAAGCTTCCAG
TTTACGATGCGGCATTAAAAGCGGAAGAAGAAAATAATAAATAA

Upstream 100 bases:

>100_bases
CCTTGTTAAATGTCGATACATCTCAAGATGGACAGGTCCAAATTAAGGCCGGAAATTATTTTGAAAGAAACTTTAAGGAT
ATTGAGGAGCGCTAGTAATA

Downstream 100 bases:

>100_bases
TAAAAAAGGATTGCTATAGTGATAGTGACCGCTAAGAGTTAGACTAAATTCTAACTTTTAGGGTGGCTATCATGGCAATC
CTTTTTTTGGTATTTAAATT

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MEKNTIILAAGQGTRMKSKLYKVLHQVCGKAMVDHMLTQVEKTNMDHIVTIVGHGAEKVRELLGDRTEYAIQEQQLGTGH
AVLQAEKILGDKDGMTMIVSGDTPLFTAKTFENLFEYHRQKGAAATILTARTENPFSYGRIVRNEVGVVSKIVEQKDATT
EEAEIKEINTGVYCFDNQKLFAALHQVKNDNAQGEYYLPDVIGIMKDAGEIVAAYEMADFSESMGVNDRLALSKATKVMQ
RRINEEHMVNGVTIIDPENTYIDYGVEIGPDTIIEPGVQIQGNTKIGSSSVIGAHSKIVDSTIGNRVTVTSSQIESAIMH
DDSNIGPHSHLRPQAEIGEFAHVGNYCEVKNAKLGARTKMGHLSYVGDADLGTDINIGCGVVFVNYDGMNKHHSTVGDYA
FIGSNSNIVAPVTIADHSYVAAGSTITNDVNKFEMGIARGRQVNKEGYFKKLPVYDAALKAEEENNK

Sequences:

>Translated_467_residues
MEKNTIILAAGQGTRMKSKLYKVLHQVCGKAMVDHMLTQVEKTNMDHIVTIVGHGAEKVRELLGDRTEYAIQEQQLGTGH
AVLQAEKILGDKDGMTMIVSGDTPLFTAKTFENLFEYHRQKGAAATILTARTENPFSYGRIVRNEVGVVSKIVEQKDATT
EEAEIKEINTGVYCFDNQKLFAALHQVKNDNAQGEYYLPDVIGIMKDAGEIVAAYEMADFSESMGVNDRLALSKATKVMQ
RRINEEHMVNGVTIIDPENTYIDYGVEIGPDTIIEPGVQIQGNTKIGSSSVIGAHSKIVDSTIGNRVTVTSSQIESAIMH
DDSNIGPHSHLRPQAEIGEFAHVGNYCEVKNAKLGARTKMGHLSYVGDADLGTDINIGCGVVFVNYDGMNKHHSTVGDYA
FIGSNSNIVAPVTIADHSYVAAGSTITNDVNKFEMGIARGRQVNKEGYFKKLPVYDAALKAEEENNK
>Mature_467_residues
MEKNTIILAAGQGTRMKSKLYKVLHQVCGKAMVDHMLTQVEKTNMDHIVTIVGHGAEKVRELLGDRTEYAIQEQQLGTGH
AVLQAEKILGDKDGMTMIVSGDTPLFTAKTFENLFEYHRQKGAAATILTARTENPFSYGRIVRNEVGVVSKIVEQKDATT
EEAEIKEINTGVYCFDNQKLFAALHQVKNDNAQGEYYLPDVIGIMKDAGEIVAAYEMADFSESMGVNDRLALSKATKVMQ
RRINEEHMVNGVTIIDPENTYIDYGVEIGPDTIIEPGVQIQGNTKIGSSSVIGAHSKIVDSTIGNRVTVTSSQIESAIMH
DDSNIGPHSHLRPQAEIGEFAHVGNYCEVKNAKLGARTKMGHLSYVGDADLGTDINIGCGVVFVNYDGMNKHHSTVGDYA
FIGSNSNIVAPVTIADHSYVAAGSTITNDVNKFEMGIARGRQVNKEGYFKKLPVYDAALKAEEENNK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Homo sapiens, GI11761621, Length=329, Percent_Identity=23.1003039513678, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI11761619, Length=329, Percent_Identity=23.4042553191489, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790168, Length=451, Percent_Identity=39.2461197339246, Blast_Score=320, Evalue=9e-89,
Organism=Caenorhabditis elegans, GI133931050, Length=335, Percent_Identity=25.3731343283582, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21355443, Length=333, Percent_Identity=24.9249249249249, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24644084, Length=333, Percent_Identity=24.9249249249249, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_PEDPA (Q03HD2)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_803832.1
- ProteinModelPortal:   Q03HD2
- SMR:   Q03HD2
- STRING:   Q03HD2
- GeneID:   4418689
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0293
- NMPDR:   fig|278197.10.peg.268
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   Q03HD2
- ProtClustDB:   PRK14354
- BioCyc:   PPEN278197:PEPE_0293-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 51017; Mature: 51017

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 362-362 BINDING 72-72 BINDING 139-139 BINDING 154-154 BINDING 169-169 BINDING 386-386 BINDING 404-404 BINDING 422-422 BINDING 439-439

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKNTIILAAGQGTRMKSKLYKVLHQVCGKAMVDHMLTQVEKTNMDHIVTIVGHGAEKVR
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHH
ELLGDRTEYAIQEQQLGTGHAVLQAEKILGDKDGMTMIVSGDTPLFTAKTFENLFEYHRQ
HHHCCCHHHHHHHHHCCCCHHHEEHHHHCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHH
KGAAATILTARTENPFSYGRIVRNEVGVVSKIVEQKDATTEEAEIKEINTGVYCFDNQKL
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCCHH
FAALHQVKNDNAQGEYYLPDVIGIMKDAGEIVAAYEMADFSESMGVNDRLALSKATKVMQ
HHHHHHHHCCCCCCCEECHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHHHH
RRINEEHMVNGVTIIDPENTYIDYGVEIGPDTIIEPGVQIQGNTKIGSSSVIGAHSKIVD
HHCCHHHHHCCEEEECCCCCEEEECEEECCCCEECCCCEEECCCCCCCCCCCCCHHHHHH
STIGNRVTVTSSQIESAIMHDDSNIGPHSHLRPQAEIGEFAHVGNYCEVKNAKLGARTKM
HHCCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCC
GHLSYVGDADLGTDINIGCGVVFVNYDGMNKHHSTVGDYAFIGSNSNIVAPVTIADHSYV
CCEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEEECCCCEE
AAGSTITNDVNKFEMGIARGRQVNKEGYFKKLPVYDAALKAEEENNK
ECCCHHHCCHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHCCCCCCC
>Mature Secondary Structure
MEKNTIILAAGQGTRMKSKLYKVLHQVCGKAMVDHMLTQVEKTNMDHIVTIVGHGAEKVR
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHH
ELLGDRTEYAIQEQQLGTGHAVLQAEKILGDKDGMTMIVSGDTPLFTAKTFENLFEYHRQ
HHHCCCHHHHHHHHHCCCCHHHEEHHHHCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHH
KGAAATILTARTENPFSYGRIVRNEVGVVSKIVEQKDATTEEAEIKEINTGVYCFDNQKL
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCCHH
FAALHQVKNDNAQGEYYLPDVIGIMKDAGEIVAAYEMADFSESMGVNDRLALSKATKVMQ
HHHHHHHHCCCCCCCEECHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHHHH
RRINEEHMVNGVTIIDPENTYIDYGVEIGPDTIIEPGVQIQGNTKIGSSSVIGAHSKIVD
HHCCHHHHHCCEEEECCCCCEEEECEEECCCCEECCCCEEECCCCCCCCCCCCCHHHHHH
STIGNRVTVTSSQIESAIMHDDSNIGPHSHLRPQAEIGEFAHVGNYCEVKNAKLGARTKM
HHCCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCC
GHLSYVGDADLGTDINIGCGVVFVNYDGMNKHHSTVGDYAFIGSNSNIVAPVTIADHSYV
CCEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEEECCCCEE
AAGSTITNDVNKFEMGIARGRQVNKEGYFKKLPVYDAALKAEEENNK
ECCCHHHCCHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA